EPS-MUP-00120

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUP-00120

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP1	414.9	4.4E-125	58	251	194

Status

Unreviewed

Ensembl Protein

ENSMPUP00000003770

UniProt Accession

G9KI44;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP1CA

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000003801	ENSMPUP00000003770	ENSMPUT00000003839

Organism

Mustela putorius furo

Functional Description

Protein Length

330

Protein Sequence
(FASTA)

MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK 60

ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 120

LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 180

QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD 240

LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD 300

KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK 330

Nucleotide Sequence
(FASTA)

ATGTCCGACA GCGAGAAGCT CAACCTGGAC TCTATCATCG GGCGCCTGCT GGAAGTGCAG 60

GGCTCGCGGC CTGGAAAGAA TGTACAGCTC ACAGAGAACG AGATCCGTGG TCTGTGTCTC 120

AAATCACGGG AGATCTTCTT GAGCCAGCCC ATCCTTCTGG AGCTGGAGGC ACCCCTCAAG 180

ATCTGCGGTG ACATCCATGG CCAGTACTAC GACCTCCTGC GGCTATTTGA GTACGGTGGC 240

TTCCCTCCAG AGAGCAACTA CCTCTTCCTG GGGGACTACG TTGACCGGGG CAAGCAGTCT 300

TTGGAGACCA TCTGCTTGCT GCTAGCCTAT AAGATCAAGT ACCCTGAGAA CTTCTTCCTG 360

CTCCGTGGAA ACCACGAGTG TGCCAGCATC AACCGCATCT ACGGCTTCTA TGATGAGTGC 420

AAGAGACGCT ACAACATTAA ACTGTGGAAA ACCTTTACCG ACTGCTTCAA CTGCCTGCCC 480

ATTGCTGCCA TCGTGGACGA GAAGATCTTC TGCTGCCACG GAGGCCTGTC CCCAGACTTG 540

CAGTCCATGG AACAGATTCG GCGTATCATG CGGCCCACAG ACGTGCCTGA CCAGGGCCTG 600

CTGTGTGACC TGCTGTGGTC TGATCCTGAC AAGGACGTGC AGGGCTGGGG CGAGAATGAC 660

CGTGGTGTCT CTTTCACGTT TGGGGCGGAA GTGGTGGCCA AGTTCCTGCA CAAGCACGAC 720

TTGGATCTCA TCTGCCGGGC ACACCAGGTG GTGGAAGACG GCTATGAGTT CTTTGCCAAG 780

CGGCAGCTGG TGACACTCTT CTCGGCTCCC AACTACTGTG GCGAGTTTGA CAACGCAGGC 840

GCCATGATGA GTGTGGACGA GACGCTCATG TGCTCTTTCC AGATCCTCAA GCCCGCGGAC 900

AAGAACAAGG GGAAATACGG GCAGTTCAGT GGCTTGAACC CTGGAGGCCG GCCCATCACC 960

CCGCCCCGCA ACTCCGCCAA AGCCAAGAAA TAG 993

Domain Profile

S: 1     pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen  60

         p+kicgdihgqy+dllrlfeyggfppe+nylflgdyvdrgkqsleticlllaykikypen

Q: 58    PLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN  117

         89**********************************************************

S: 61    ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls  120

         ffllrgnhe+asinriygfydeckrryn+klwktftdcfnclp+aai+deki+c+hggls

Q: 118   FFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLS  177

         ************************************************************

S: 121   pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk  180

         pdl+s+eqirri+rptdvpd+gllcdllwsdpdkdv+gwgendrgvsftfga+vvakfl+

Q: 178   PDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLH  237

         ************************************************************

S: 181   khdldlicrahqvv  194

         khdldlicrahqvv

Q: 238   KHDLDLICRAHQVV  251

         *************8

Domain Sequence
(FASTA)

PLKICGDIHG QYYDLLRLFE YGGFPPESNY LFLGDYVDRG KQSLETICLL LAYKIKYPEN 60

FFLLRGNHEC ASINRIYGFY DECKRRYNIK LWKTFTDCFN CLPIAAIVDE KIFCCHGGLS 120

PDLQSMEQIR RIMRPTDVPD QGLLCDLLWS DPDKDVQGWG ENDRGVSFTF GAEVVAKFLH 180

KHDLDLICRA HQVV 194

Keyword

Hydrolase; Iron.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0072357	; C:PTW/PP1 phosphatase complex
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0048754	; P:branching morphogenesis of a tube
GO:0030324	; P:lung development
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013