EKS-MUP-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	365.6	1.6E-109	65	326	262

Status

Unreviewed

Ensembl Protein

ENSMPUP00000003869

UniProt Accession

G9KLV5;

Protein Name

Protein Synonyms/Alias

Ribosomal protein S6 kinase, 70kDa, polypeptide 2;

Gene Name

RPS6KB2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000003899	ENSMPUP00000003869	ENSMPUT00000003938

Organism

Mustela putorius furo

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEPE SSPSDVCPLA ESRAAGLEPV GRCEEVELTE TSVNLGPERI 60

GPHCFELLRV LGKGGYGKVF QVRKVQGTNS GKIYAMKVLR KAKIVRNAKD TAHTRAERNI 120

LESVKHPFIV ELAYAFQTGG KLYLILECLS GGELFTHLER EGIFLEDTAC FYLAEITLAL 180

GHLHSQGIIY RDLKPENIML NSQGHIKLTD FGLCKESIHE DAVTHTFCGT IEYMAPEILV 240

RSGHNRAVDW WSLGALMYDM LTGSPPFTAE NRKKTMDKII KGKLALPPYL TPDARDLVKK 300

FLKRNPSQRI GGGPGDAADV QRHPFFRQIN WDDLLACRVD PPIRPSLQSE EDVSQFDTHF 360

TRQTPVDSPD DTALSESANQ AFLGFTYVAP SVLDSIKEGF SFQPKLRSPR RLNSSPRTPV 420

SPLKFSPFEG FRPSSGPLEP TEPSLAPLPP PPPSSSAPLP IRPPSGTKKS KRGRGRPGR 479

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGACCT GGACCTGGAG ACGGAGGAAG GCAGCGAGGG TGAGCCAGAG 60

TCGAGCCCCT CGGACGTGTG TCCCCTTGCC GAGTCGAGGG CGGCTGGCCT GGAGCCTGTG 120

GGACGCTGTG AGGAGGTGGA GCTGACCGAG ACCAGTGTGA ACCTGGGCCC TGAGCGCATC 180

GGGCCCCACT GCTTCGAGCT GCTGCGTGTG CTGGGCAAGG GGGGCTATGG CAAGGTGTTC 240

CAAGTGCGAA AGGTGCAAGG CACCAACTCG GGCAAAATAT ATGCCATGAA AGTCCTGAGG 300

AAGGCCAAAA TTGTGCGCAA CGCCAAGGAC ACAGCACACA CGCGGGCTGA ACGGAACATT 360

CTAGAGTCAG TGAAGCACCC CTTCATTGTG GAACTGGCCT ATGCCTTCCA GACTGGTGGC 420

AAACTCTACC TCATCCTCGA GTGCCTCAGT GGCGGTGAGC TCTTCACGCA TCTGGAGCGA 480

GAGGGCATCT TCCTGGAAGA CACAGCCTGT TTCTACTTGG CGGAGATCAC ACTGGCCCTG 540

GGCCACCTGC ACTCCCAAGG CATCATCTAC CGGGACCTCA AACCCGAGAA CATCATGCTC 600

AACAGCCAGG GCCACATCAA ACTGACGGAC TTCGGACTCT GCAAGGAGTC AATCCACGAG 660

GATGCGGTCA CCCACACTTT CTGTGGCACC ATTGAGTACA TGGCCCCTGA GATTCTGGTG 720

CGCAGTGGCC ACAACCGGGC GGTGGACTGG TGGAGCCTGG GTGCCCTGAT GTATGACATG 780

CTCACCGGCT CGCCTCCCTT CACGGCAGAG AACCGGAAGA AGACGATGGA CAAGATCATC 840

AAAGGGAAGC TGGCGCTGCC CCCCTACCTC ACCCCGGATG CCCGGGACCT TGTCAAAAAG 900

TTTCTGAAAC GGAATCCCAG CCAGCGGATT GGGGGTGGCC CCGGGGACGC TGCTGATGTG 960

CAGAGGCACC CTTTCTTCCG GCAAATTAAC TGGGACGACC TCCTGGCTTG CCGCGTCGAC 1020

CCTCCTATCA GGCCGTCTCT GCAGTCAGAG GAGGACGTGA GCCAGTTCGA CACCCACTTC 1080

ACGCGGCAGA CGCCAGTGGA CAGTCCCGAC GACACGGCCC TCAGCGAGAG CGCCAACCAG 1140

GCTTTCTTGG GCTTCACATA TGTGGCCCCC TCCGTCCTGG ACAGCATCAA GGAGGGCTTC 1200

TCCTTTCAGC CTAAGCTGCG CTCCCCCAGG CGCCTCAACA GCAGCCCCCG GACCCCAGTC 1260

AGCCCCCTGA AGTTCTCGCC CTTTGAGGGA TTCCGGCCCA GCTCTGGCCC ACTGGAGCCC 1320

ACGGAGCCCT CTCTCGCCCC TCTCCCACCC CCGCCACCCT CGAGCTCTGC TCCCCTCCCC 1380

ATCCGACCCC CCTCAGGGAC CAAGAAGTCT AAGAGGGGCC GTGGGCGCCC GGGACGCTGA 1440

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv+++++gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 65    FELLRVLGKGGYGKVFQVRKVQGTNSGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  124

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 125   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  184

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 185   SQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESI-HEDAVTHTFCGTIEYMAPEILVRSG  243

         **********************************.7777788******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dlvk

Q: 244   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LALPPY--LTPDARDLVK  299

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 300   KFLKRNPSQRIGGgpgDAADVQRHPFF  326

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNSGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLNSQG HIKLTDFGLC KESIHEDAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL ALPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.

Pfam

PF00433

; Pkinase_C; 1.

SMARTs

SM00133

; S_TK_X; 1.

Prosites

PS51285

; AGC_KINASE_CTER; 1.

Prints

Created Date

20-Feb-2013