EKS-MUP-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	347.4	5.9E-104	1198	1456	259

Status

Unreviewed

Ensembl Protein

ENSMPUP00000004577

UniProt Accession

G9K9I4;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 4;

Gene Name

Map3k4

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000004612	ENSMPUP00000004577	ENSMPUT00000004656

Organism

Mustela putorius furo

Functional Description

Protein Length

1463

Protein Sequence
(FASTA)

MKRMSIKHQR NSVGKPAGRA GVKEKTNAPN QPPHKDTGKT VENVEEYSYK QEKKIRAALR 60

TTERDHKKNV QCSFMLDSVG GSLPKKSIPD VDLNKPYLSL GCSNAKLPVS VPMPIARTAR 120

QTSRTDCPAD RLKFFETLRL LLKLTSVSKK KDREQRGQEN TSAFWFNRSN ELIWLELQAW 180

HAGRTINDQD LFLYTARQAI PDIINEILTF KVNYGSFAFV RNGASFNGTS VEGQCRAPHG 240

TKLVGYSTYH EHLQRQRVSF EQVKRIMELL EYIEALYPSL QALQKDYEKY AAKDFQDRVQ 300

ALCLWLNITK DLNQKLRIMG TVLGIKNLSD IGWPVFEIPS PRSSKGNEPE DEGDYTEGDL 360

RELASSADES EEEQLSGPRA PEPTQPAASS CGVRSQDCVR KKLERLESEE ESVGWGAPDC 420

SAEAGFSRHC LTSIYRPFVD KALKQMGLRK LILRLHKLMD GSLQRARIAL VKSDRPVEFS 480

EFPHPMWGSD YVQLSRKPPS SEQKCSTVSW DELKSMDLPS FEPAFLVLCR VLLNVIHECL 540

KLRLEQRPAG EPSLLSIKQL ARECKEVLKG GLLMKQYYQF MLHEVLDQLD GTDCNMDAFE 600

EDLHKMLMVY FDYMRSWIQM LQQLPQASHS LKNLLEEEWN FTKEITHYIR GGEAQAGKLF 660

CDIAGMLLKS TGSFLEVGLQ ESCAEFWTSA DDSSASDEIR RSVIEISRAL KELFHEARER 720

ASKALGFAKM LRKDLEIAAE FIFSAPVRDL LDVLKSKQYV KVQIPGLENL QVFVPGNLAT 780

EKSTILQFLN AAAGKDCSKE SDDALIDAHL LLTKHSDRTL GPEDSWATWE AQPVKIVPQV 840

ETVDTLRSMQ VDNLLLVVMQ SAQLTSQRKT FQPSIEGLLT LRQEQTSSQP VIARALQQLK 900

NDALELCNRI SDAIDQVDHM FTSEFDAEVD ESESVTLQQY YREAMIQGYN FGFEYHKEVV 960

RLMSGEFRQK IGDKYISFAR KWMNYVLTKC ESGRGTRPRW ATQGFDFLQA IEPAFISALP 1020

EDDFLSLQAL MNECIGHVIG KPHSPVTAIH RNSPRPVKVP RCHSDPPNPH LIIPTPEGFR 1080

GSSVPENDRL ASIAAELQFR SLSRHSSPTE ERDEPAYPKG DSSGSARRSW ELRTLISQSK 1140

DGASKQGPIE AIQKSVRLFE EKRYREMRRK NIIGQVCDTP KSYDNVMHVG LRKVTFKWQR 1200

GNKIGEGQYG KVYTCISVDT GELMAMKEIR FQPNDHKTIK ETADELKIFE GIKHPNLVRY 1260

FGVELHREEM YIFMEYCDEG TLEEVSRLGL QEHVIRLYSK QITVAINVLH EHGIVHRDIK 1320

GANIFLTSSG LIKLGDFGCS VKLKNNAQTM PGEVNSTLGT AAYMAPEVIT RAKGEGHGRA 1380

ADIWSLGCVV IEMVTGKRPW HEYEHNFQIM YKVGMGHKPP IPERLSPEGK DFLSHCLESE 1440

PRMRWTASQL LDHSFVKVCT DEE 1463

Nucleotide Sequence
(FASTA)

ATGAAACGCA TGTCCATCAA GCACCAGAGG AATAGCGTAG GGAAGCCTGC CGGTCGAGCT 60

GGTGTGAAAG AAAAAACGAA TGCACCGAAC CAGCCTCCAC ACAAAGACAC TGGAAAAACG 120

GTGGAGAATG TGGAAGAATA CAGCTATAAG CAGGAGAAAA AGATCCGAGC AGCTCTTAGG 180

ACAACAGAGC GCGATCATAA GAAAAATGTG CAGTGCTCGT TCATGTTGGA CTCAGTGGGT 240

GGGTCTTTGC CCAAAAAATC AATTCCAGAT GTGGATCTTA ATAAGCCTTA CCTCAGTCTT 300

GGCTGCAGCA ACGCTAAGCT TCCGGTATCC GTGCCCATGC CTATAGCCAG AACTGCACGC 360

CAGACTTCTA GGACTGACTG TCCAGCAGAT CGCTTAAAGT TTTTTGAGAC TTTGCGACTC 420

CTGCTAAAGC TTACCTCAGT CTCAAAGAAG AAGGACAGGG AGCAAAGAGG ACAGGAAAAT 480

ACGTCCGCTT TCTGGTTTAA CCGATCTAAT GAACTGATCT GGTTAGAGCT ACAAGCCTGG 540

CATGCAGGAC GGACCATTAA TGACCAGGAC CTCTTTTTAT ATACAGCCCG TCAAGCCATC 600

CCAGATATTA TCAATGAAAT CCTTACTTTC AAAGTTAATT ACGGGAGCTT TGCCTTTGTT 660

AGAAACGGAG CTAGTTTTAA TGGTACTTCA GTAGAAGGGC AGTGCAGAGC CCCTCATGGA 720

ACAAAGCTGG TGGGTTACTC GACGTACCAC GAGCATCTCC AACGCCAGAG GGTGTCGTTT 780

GAGCAGGTAA AGCGGATAAT GGAGCTGCTG GAGTACATAG AAGCACTTTA TCCATCGTTG 840

CAGGCTCTTC AAAAGGACTA CGAAAAATAT GCTGCGAAAG ACTTCCAGGA CAGGGTGCAG 900

GCACTCTGTC TGTGGTTAAA CATCACGAAA GACTTAAATC AGAAGTTAAG GATTATGGGC 960

ACTGTTTTGG GCATCAAGAA TTTATCAGAC ATCGGCTGGC CAGTGTTTGA AATCCCTTCT 1020

CCTCGGTCAT CCAAAGGCAA TGAGCCGGAA GATGAGGGTG ATTACACAGA AGGGGACTTG 1080

CGGGAGCTGG CAAGTAGCGC GGACGAGAGT GAGGAAGAGC AGCTCTCAGG ACCGAGGGCC 1140

CCGGAGCCCA CACAGCCCGC TGCCAGCAGT TGCGGCGTCC GCTCGCAGGA CTGTGTGCGG 1200

AAGAAGCTGG AGAGGCTCGA GTCTGAGGAG GAGTCCGTTG GCTGGGGAGC GCCAGACTGC 1260

AGCGCAGAAG CAGGCTTTAG CAGACATTGT CTGACTTCTA TTTATAGACC ATTTGTAGAC 1320

AAAGCACTGA AGCAAATGGG GTTAAGAAAG CTAATCTTAA GACTTCACAA GCTGATGGAC 1380

GGTTCCTTGC AAAGGGCACG TATAGCACTG GTAAAGAGTG ACCGTCCAGT GGAGTTTTCC 1440

GAATTTCCAC ACCCTATGTG GGGTTCCGAT TATGTGCAGT TATCCAGGAA GCCACCTTCC 1500

TCGGAGCAGA AGTGTAGCAC TGTGTCGTGG GATGAGCTGA AGTCCATGGA CTTACCCTCC 1560

TTCGAGCCTG CCTTCCTGGT GCTCTGTCGA GTCCTTCTGA ATGTGATACA CGAGTGTCTG 1620

AAGTTAAGAT TGGAACAGAG ACCAGCTGGG GAACCGTCTC TCTTGAGTAT TAAGCAGCTG 1680

GCGAGGGAGT GTAAAGAGGT GCTCAAGGGC GGCCTGCTGA TGAAGCAGTA CTACCAGTTC 1740

ATGCTGCACG AGGTGCTCGA CCAGCTGGAC GGGACGGACT GCAACATGGA CGCCTTCGAG 1800

GAGGACCTGC ATAAAATGCT GATGGTGTAT TTTGATTACA TGAGAAGCTG GATCCAAATG 1860

CTGCAGCAGT TACCTCAAGC ATCCCATAGT CTAAAAAACC TGTTAGAAGA AGAATGGAAT 1920

TTCACCAAAG AAATAACCCA TTACATCCGG GGAGGAGAAG CACAGGCTGG AAAGCTTTTC 1980

TGTGACATTG CGGGGATGCT GCTCAAGTCG ACGGGAAGTT TTTTAGAGGT CGGCTTGCAG 2040

GAGAGCTGCG CGGAGTTCTG GACCAGCGCT GATGACAGCA GTGCCTCTGA CGAAATCAGG 2100

AGATCGGTTA TAGAGATTAG TCGAGCACTG AAGGAGCTCT TTCACGAAGC TAGGGAAAGA 2160

GCCTCCAAAG CACTTGGATT TGCTAAAATG TTGAGAAAGG ACCTGGAGAT AGCAGCAGAG 2220

TTCATATTTT CAGCCCCAGT TAGAGACCTT CTGGACGTTC TGAAATCAAA ACAGTATGTT 2280

AAGGTACAGA TTCCTGGCTT AGAAAACTTG CAGGTGTTTG TTCCAGGCAA TCTTGCCACG 2340

GAGAAGAGCA CTATTTTGCA GTTCCTCAAT GCAGCCGCGG GAAAGGATTG CTCGAAAGAG 2400

TCAGATGACG CCCTGATTGA TGCCCATCTC CTGCTCACCA AGCACAGTGA CCGCACTCTG 2460

GGTCCGGAAG ACAGCTGGGC CACGTGGGAA GCTCAGCCGG TCAAAATCGT GCCTCAGGTG 2520

GAGACTGTTG ACACCCTGAG AAGCATGCAG GTGGATAATC TTTTACTAGT GGTCATGCAG 2580

TCGGCCCAGC TCACCAGCCA GAGAAAAACC TTCCAGCCGT CCATCGAGGG ACTCCTGACT 2640

CTCCGCCAGG AGCAGACATC CAGTCAGCCG GTCATTGCCA GAGCTTTGCA GCAGCTAAAG 2700

AATGATGCAC TAGAGCTTTG CAACAGAATA AGCGATGCCA TTGACCAAGT GGACCACATG 2760

TTCACTTCAG AATTCGATGC CGAAGTCGAT GAGTCTGAGT CCGTCACGTT GCAGCAGTAC 2820

TACCGGGAAG CGATGATTCA GGGTTACAAC TTTGGGTTCG AGTATCATAA AGAAGTTGTT 2880

CGTTTGATGT CTGGAGAGTT TAGACAGAAG ATAGGAGACA AATATATAAG CTTTGCCCGG 2940

AAATGGATGA ACTATGTCCT CACTAAATGT GAGAGTGGTC GAGGTACAAG ACCCAGGTGG 3000

GCAACCCAAG GTTTTGACTT TCTACAAGCC ATTGAACCTG CCTTTATTTC AGCTTTGCCA 3060

GAAGATGACT TCTTGAGTCT TCAAGCCCTG ATGAATGAGT GCATTGGCCA TGTGATAGGA 3120

AAGCCACACA GTCCTGTTAC AGCTATTCAT CGGAACAGCC CCCGTCCTGT GAAGGTGCCG 3180

CGGTGCCACA GCGACCCTCC TAACCCGCAT CTGATCATCC CGACTCCAGA GGGATTCAGG 3240

GGTTCCAGCG TCCCTGAGAA CGACCGGTTG GCTTCCATAG CTGCCGAGTT ACAGTTTCGG 3300

TCCCTGAGCC GCCACTCAAG CCCCACTGAG GAGCGCGACG AACCAGCTTA TCCAAAAGGT 3360

GATTCAAGTG GGTCAGCTCG AAGAAGCTGG GAACTTCGGA CACTTATCAG CCAGTCGAAG 3420

GACGGTGCTT CCAAACAAGG ACCCATAGAA GCTATCCAGA AGTCAGTCCG ATTGTTTGAA 3480

GAAAAGAGGT ATCGAGAGAT GAGGAGAAAG AATATCATTG GTCAAGTTTG TGACACCCCT 3540

AAATCTTACG ATAACGTCAT GCACGTGGGC TTGAGGAAGG TGACCTTCAA GTGGCAAAGA 3600

GGAAACAAAA TTGGGGAGGG GCAGTACGGG AAGGTCTACA CCTGCATCAG TGTGGACACC 3660

GGTGAGCTGA TGGCTATGAA GGAGATTCGA TTTCAACCAA ATGACCATAA AACTATCAAG 3720

GAAACTGCAG ACGAATTGAA AATCTTTGAG GGCATCAAAC ACCCCAACCT GGTTCGGTAT 3780

TTTGGTGTGG AGCTTCATAG AGAAGAAATG TACATTTTCA TGGAGTACTG TGACGAGGGG 3840

ACATTAGAAG AGGTGTCCAG GCTGGGGCTT CAGGAACATG TCATCAGGCT GTATTCAAAG 3900

CAGATCACCG TCGCCATCAA TGTCCTCCAT GAGCACGGCA TAGTTCACCG TGACATCAAA 3960

GGTGCCAACA TCTTCCTCAC CTCCTCCGGA CTCATCAAGC TGGGCGACTT CGGGTGCTCC 4020

GTCAAGCTCA AGAACAACGC GCAGACCATG CCCGGCGAAG TGAACAGCAC CCTGGGGACA 4080

GCAGCATACA TGGCTCCTGA GGTCATCACT CGAGCAAAAG GAGAAGGCCA TGGGCGTGCT 4140

GCGGACATCT GGAGTCTGGG GTGTGTCGTC ATAGAGATGG TGACCGGCAA GAGGCCTTGG 4200

CATGAATATG AACACAACTT TCAGATTATG TATAAAGTGG GAATGGGGCA CAAGCCACCG 4260

ATCCCTGAAA GATTAAGCCC GGAGGGAAAG GACTTCCTCT CCCACTGCCT TGAGAGTGAG 4320

CCCCGGATGA GGTGGACGGC CAGCCAGCTC CTCGACCACT CCTTCGTCAA GGTCTGCACA 4380

GATGAAGAAT GA 4392

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1198  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1254

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1255  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITVAINVLHEH  1312

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1313  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1372

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls+egkd

Q: 1373  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKD  1431

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle++p+ r++a++LL+h+f+

Q: 1432  FLSHCLESEPRMRWTASQLLDHSFV  1456

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITVAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSP EGKDFLSHCL 240

ESEPRMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0019100	; P:male germ-line sex determination
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013