EKS-MUP-00226

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00226

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	381.2	2.6E-114	73	369	297

Status

Unreviewed

Ensembl Protein

ENSMPUP00000004678

UniProt Accession

G9K9F8;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase 2;

Gene Name

Map2k2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000004715	ENSMPUP00000004678	ENSMPUT00000004759

Organism

Mustela putorius furo

Functional Description

Protein Length

400

Protein Sequence
(FASTA)

MLARRKPVLP ALTINPAIAE GPSPTSEGAS EANLVDLQKK LAELELDEQQ KKRLEAFLTQ 60

KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ 120

VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG 180

LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ 240

GTHYSVQSDI WSMGLSLVEL SIGRYPIPPP DAKELEAIFG RPVVDGVEGE PHSISPRPRP 300

PGRPISGHGT DSRPAMAIFE LLDYIVNEPP PKLPSGVFTQ DFQEFVNKCL IKNPAERADL 360

KMLTSHAFIK RSEVEEVDFA GWLCKTLRLK QPSTPTRTAV 400

Nucleotide Sequence
(FASTA)

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACTA TCAACCCCGC CATCGCCGAG 60

GGCCCGTCCC CCACCAGCGA GGGCGCCTCC GAAGCAAACT TGGTGGACCT CCAGAAGAAG 120

CTGGCAGAGC TAGAACTGGA TGAGCAGCAG AAGAAGCGAC TGGAAGCCTT CCTCACCCAG 180

AAGGCCAAGG TCGGGGAGCT CAAGGACGAT GACTTTGAAC GGATCTCGGA GCTGGGAGCT 240

GGGAACGGCG GGGTGGTCAC CAAGGTCCAG CACAGACCGT CCGGACTCAT CATGGCGAGA 300

AAGCTGATCC ACCTGGAGAT CAAGCCGGCC ATTCGGAACC AGATCATCCG CGAGCTGCAG 360

GTGCTACACG AGTGTAACTC TCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGCGAC 420

GGCGAGATCA GCATCTGCAT GGAGCACATG GATGGTGGCT CCCTGGACCA GGTGTTGAAA 480

GAAGCCAAGA GAATTCCCGA GGAGATCCTG GGGAAGGTCA GCATTGCGGT TCTCCGGGGT 540

TTGGCGTATC TCCGGGAAAA GCACCAGATC ATGCACCGAG ATGTGAAACC TTCCAACATC 600

CTCGTCAACT CCCGAGGGGA GATCAAGCTG TGCGATTTTG GGGTGAGCGG ACAGCTCATC 660

GACTCCATGG CCAACTCCTT CGTGGGAACG CGGTCCTACA TGTCTCCGGA GCGGCTGCAG 720

GGCACGCACT ACTCCGTGCA GTCGGACATC TGGAGCATGG GGCTGTCGCT GGTGGAGCTG 780

TCCATCGGAA GGTACCCCAT CCCCCCGCCG GACGCCAAGG AGCTGGAGGC CATATTTGGC 840

CGGCCCGTGG TGGACGGGGT AGAAGGAGAG CCTCACAGCA TCTCGCCGCG GCCGAGACCC 900

CCCGGACGCC CCATCAGCGG TCACGGGACA GACAGCCGGC CGGCCATGGC CATCTTCGAG 960

CTGCTGGACT ATATTGTGAA CGAGCCGCCT CCCAAGCTCC CCAGTGGCGT CTTCACCCAG 1020

GATTTCCAGG AGTTTGTAAA TAAATGCCTA ATAAAGAACC CAGCAGAGCG AGCAGATCTG 1080

AAGATGCTCA CGAGCCACGC CTTCATCAAG CGCTCCGAGG TGGAAGAAGT GGATTTTGCC 1140

GGCTGGTTGT GTAAAACGCT GCGGCTGAAG CAGCCCAGCA CACCCACGCG CACGGCCGTG 1200

TGA 1203

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e+++elGaGnggvV+kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 73    ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  131

         789**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    +kripe++lgk+++av+++l+yl+ek

Q: 132   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYLREK  187

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 188   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  246

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lvel +gryp++++++

Q: 247   QSDIWSMGLSLVELSIGRYPIPPPDAkeleaifgrpvvdgvegephsisprprppgrpis  306

         ************************999*********************************

S: 208   ...........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkh  256

                    i+ell++ivne+ppklp+  f+++fqefv+kCl+k+++eR++lk+l++h

Q: 307   ghgtdsrpamaIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLIKNPAERADLKMLTSH  366

         ************************************************************

S: 257   afi  259

afi

Q: 367   AFI  369

*97

Domain Sequence
(FASTA)

ERISELGAGN GGVVTKVQHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVELSI GRYPIPPPDA KELEAIFGRP VVDGVEGEPH SISPRPRPPG RPISGHGTDS 240

RPAMAIFELL DYIVNEPPPK LPSGVFTQDF QEFVNKCLIK NPAERADLKM LTSHAFI 297

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005778	; C:peroxisomal membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:2000147	; P:positive regulation of cell motility

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013