EKS-MUP-00112
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00112
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec479.81.5E-144295545251
StatusUnreviewed
Ensembl ProteinENSMPUP00000005329
UniProt AccessionG9KW15;
Protein Name
Protein Synonyms/Alias TXK tyrosine kinase;
Gene NameTxk
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000005368ENSMPUP00000005329ENSMPUT00000005418
OrganismMustela putorius furo
Functional Description
Protein Length551
Protein Sequence
(FASTA)
MCFCDWSVAE ELKAVWCAPC RVTAMILSTY NTIQSIFCCC CCCSLQKRQV RTQISLSKDE 60
EFPEKYTRHR RPWFRELPSK KRSNRDHGQP SKRKPLPPLP PSEVPEEKIQ VKALYDFLPR 120
EPCDLALKRS EEYLILEKYN PHWWKARDRL GNEGLIPSNY VTENKRSNLE IYEWYHKNIT 180
RNQAERILRQ ESKEGAFIVR DSRHLGSYTI SVFIKARRNM EATIKHYQIK KNDSGQWYVA 240
ERHLFQSIPD LIWYHQHNAA GLMTRLRYPV GLMGSCLPTT AGFSYEKWEI DPAELAFVKE 300
IGSGQFGVVH LGEWRAHIRV AIKAISEGSM SEEDFIEEAK VMMKLSHPRL VQLYGVCIQQ 360
KPLYIVTEFM ENGCLLKYVR DRRGALTKEM LLSMCQDVCE GMEYLERNCF IHRDLAARNC 420
LVSAASIVKI SDFGMTRYVL DDEYISSSGA KFPIKWSPPE VFHFNKYSSK SDVWSFGVLM 480
WEVFTEGKMP FENKSNLQVV EAISQGFRLY RPQLAPMCVY EVMYSCWHEK AKGRPTFAEL 540
LQVLAEIAET W 551
Nucleotide Sequence
(FASTA)
ATGTGTTTTT GTGACTGGAG CGTCGCTGAA GAACTGAAGG CTGTCTGGTG TGCTCCCTGC 60
AGAGTCACAG CCATGATTCT TTCCACCTAT AATACCATCC AGTCGATTTT CTGTTGCTGT 120
TGCTGCTGTT CCTTGCAGAA GCGACAAGTC AGAACACAAA TAAGCCTGAG CAAGGATGAA 180
GAATTTCCAG AAAAATATAC ACGGCATCGC AGGCCATGGT TCAGGGAATT GCCAAGCAAG 240
AAGCGATCCA ACAGAGACCA CGGGCAACCA TCGAAACGTA AGCCACTGCC TCCCCTCCCC 300
CCATCCGAGG TTCCCGAAGA GAAGATCCAA GTAAAGGCAC TGTATGATTT CCTGCCCAGA 360
GAGCCCTGTG ATTTAGCATT GAAGAGATCA GAGGAATACC TCATACTGGA GAAGTATAAC 420
CCTCACTGGT GGAAGGCAAG AGACCGTTTA GGGAACGAAG GCTTAATCCC AAGCAACTAT 480
GTGACTGAAA ACAAACGAAG CAATCTGGAA ATATATGAGT GGTATCATAA AAACATTACC 540
AGAAATCAGG CAGAACGTAT TTTGAGACAA GAGTCAAAAG AAGGTGCATT TATCGTCAGA 600
GATTCCAGAC ATTTGGGATC CTACACAATT TCTGTGTTTA TAAAAGCTAG AAGGAATATG 660
GAGGCTACCA TCAAACATTA CCAGATTAAA AAGAATGACT CAGGACAGTG GTACGTGGCT 720
GAGAGACACC TCTTTCAATC AATCCCTGAC TTGATCTGGT ATCACCAGCA CAATGCGGCG 780
GGTCTCATGA CCCGTCTCCG CTACCCAGTT GGACTGATGG GCAGCTGTTT GCCAACCACA 840
GCTGGCTTTA GCTATGAAAA ATGGGAGATC GATCCTGCTG AGCTCGCTTT TGTAAAGGAG 900
ATTGGAAGCG GTCAGTTTGG GGTGGTCCAT TTAGGTGAAT GGCGGGCGCA CATCCGGGTG 960
GCTATCAAGG CCATCAGTGA AGGCTCCATG TCGGAAGAGG ACTTCATCGA GGAGGCTAAA 1020
GTGATGATGA AATTATCTCA TCCCAGGCTG GTCCAGCTCT ATGGAGTGTG CATACAGCAG 1080
AAGCCGCTGT ACATAGTGAC CGAGTTTATG GAGAACGGCT GCCTGCTGAA ATATGTCAGG 1140
GACAGAAGGG GAGCGCTTAC CAAGGAGATG CTGCTGAGCA TGTGCCAGGA TGTCTGTGAA 1200
GGGATGGAGT ATCTGGAGAG GAACTGCTTC ATCCACAGGG ACTTAGCAGC AAGGAATTGT 1260
CTGGTCAGTG CTGCAAGTAT AGTAAAAATA TCAGACTTCG GAATGACGAG GTACGTTTTG 1320
GATGATGAAT ATATCAGTTC TTCTGGAGCC AAGTTCCCCA TCAAGTGGTC CCCTCCTGAA 1380
GTTTTCCATT TCAACAAGTA CAGCAGCAAA TCTGATGTCT GGTCATTTGG AGTTTTGATG 1440
TGGGAAGTGT TCACAGAAGG AAAAATGCCG TTTGAGAATA AGTCAAATTT GCAAGTCGTG 1500
GAAGCCATTT CTCAAGGCTT CCGCCTGTAC CGTCCTCAAC TGGCTCCAAT GTGCGTCTAT 1560
GAAGTCATGT ACAGCTGTTG GCACGAGAAA GCTAAAGGCC GCCCTACATT TGCTGAGTTG 1620
CTGCAGGTTC TCGCAGAGAT TGCGGAAACC TGGTGA 1656
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         l+++ke+gsgqfgvv+lg+wra+i+vaikai eg+mseedfieeakvmmklshp+lvqly
Q: 295   LAFVKEIGSGQFGVVHLGEWRAHIRVAIKAISEGSMSEEDFIEEAKVMMKLSHPRLVQLY  354
         68**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++qkp+yivte++engcll+y+r++++ l+ke+ll+mc+dvcegmeyler++fihrd
Q: 355   GVCIQQKPLYIVTEFMENGCLLKYVRDRRGALTKEMLLSMCQDVCEGMEYLERNCFIHRD  414
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+ +++vk+sdfg++ryvldd+y+ss+gakfp+kwsppev++++kyssksdvw
Q: 415   LAARNCLVSAASIVKISDFGMTRYVLDDEYISSSGAKFPIKWSPPEVFHFNKYSSKSDVW  474
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e+ksn +vve++s+g+rlyrp+la++ vyevm+scw+ek+++r
Q: 475   SFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPQLAPMCVYEVMYSCWHEKAKGR  534
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ell+ l+
Q: 535   PTFAELLQVLA  545
         *******9885
Domain Sequence
(FASTA)
LAFVKEIGSG QFGVVHLGEW RAHIRVAIKA ISEGSMSEED FIEEAKVMMK LSHPRLVQLY 60
GVCIQQKPLY IVTEFMENGC LLKYVRDRRG ALTKEMLLSM CQDVCEGMEY LERNCFIHRD 120
LAARNCLVSA ASIVKISDFG MTRYVLDDEY ISSSGAKFPI KWSPPEVFHF NKYSSKSDVW 180
SFGVLMWEVF TEGKMPFENK SNLQVVEAIS QGFRLYRPQL APMCVYEVMY SCWHEKAKGR 240
PTFAELLQVL A 251
KeywordATP-binding; Kinase; Nucleotide-binding; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0001865; P:NK T cell differentiation
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013