EKS-MUP-00109

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00109

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	493.4	1.1E-148	370	620	251

Status

Unreviewed

Ensembl Protein

ENSMPUP00000005349

UniProt Accession

G9KSV6;

Protein Name

Protein Synonyms/Alias

Tec protein tyrosine kinase;

Gene Name

Tec

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000005388	ENSMPUP00000005349	ENSMPUT00000005438

Organism

Mustela putorius furo

Functional Description

Protein Length

631

Protein Sequence
(FASTA)

MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRPEKKYR KGFIDVAKIK 60

CVEIVKNDEG VVPCQNKYPF QVVHDANTLY IFAPSAQSRD RWVKKLKEEI KNNNNIMIKY 120

HPKFWADGSY QCCRQTEKLA PGCEKYNLFE SSIKKALPPA PETKKRRPPP PIPPEEEDNS 180

EEIVVAMYDF QATEAHDLRL ERGQEYIILE KNDVHWWKAR DKYGCEGYIP SNYVTGKKSN 240

NLDQYEWYCR NTNRSKAEQL LRSEDKEGGF MVRDSSQPGM YTVSLYTKFG GEGSSGFRHY 300

HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSTKGK NAPTTAGFSY 360

EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL 420

THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMDYL 480

ERNSFIHRDL AARNCLVNEA GIVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS 540

RFSSKSDVWS FGVLMWEIFT EGKMPFEKNT NYEVVTMVTR GHRLYRPKLA SKHVYEVMLR 600

CWQEKPEGRP SFEDLLRTID ELVEYEETSG R 631

Nucleotide Sequence
(FASTA)

ATGAATTTTA ACACTATTCT AGAAGAGATT CTTATTAAAA GATCACAACA GAAAAAGAAG 60

ACATCACCCT TAAACTATAA AGAGAGACTT TTTGTGCTAA CAAAGTCCAT GTTAACCTAC 120

TATGAAGGTC GACCAGAGAA AAAATACAGA AAGGGATTTA TTGATGTTGC AAAAATCAAG 180

TGTGTGGAAA TAGTGAAGAA TGATGAGGGT GTTGTCCCCT GCCAAAATAA ATATCCATTT 240

CAGGTTGTTC ATGATGCTAA CACACTTTAC ATTTTTGCAC CTAGTGCGCA AAGCAGGGAC 300

CGGTGGGTGA AGAAGTTAAA AGAAGAAATA AAGAACAACA ATAATATCAT GATTAAATAT 360

CATCCTAAAT TTTGGGCAGA TGGAAGTTAT CAGTGTTGCC GACAAACTGA AAAATTAGCA 420

CCTGGATGCG AAAAATATAA CCTTTTTGAG AGTAGTATAA AAAAAGCACT ACCTCCAGCA 480

CCAGAAACAA AGAAGCGAAG GCCTCCCCCA CCAATTCCAC CTGAAGAAGA AGACAATAGT 540

GAAGAAATCG TTGTAGCCAT GTATGATTTC CAAGCAACGG AGGCGCATGA TCTCAGATTA 600

GAGAGAGGCC AAGAATATAT TATATTAGAA AAGAATGATG TTCATTGGTG GAAAGCAAGA 660

GATAAATACG GGTGTGAAGG ATATATCCCA AGTAACTATG TAACAGGAAA GAAATCAAAC 720

AACTTAGACC AATATGAGTG GTACTGCAGA AACACAAACA GAAGCAAAGC AGAGCAGCTC 780

CTCAGAAGTG AGGATAAAGA AGGTGGTTTT ATGGTAAGGG ATTCCAGTCA ACCAGGCATG 840

TACACGGTCT CCCTTTATAC AAAGTTTGGA GGCGAGGGCT CGTCAGGTTT CAGGCATTAT 900

CATATAAAGG AAACAACAAC TTCCCCCAAG AAGTATTATC TGGCAGAAAA ACATGCATTT 960

GGTTCCATTC CTGAGATCAT TGAATATCAC AAGCACAACG CAGCAGGACT TGTCACAAGA 1020

CTGCGGTACC CAGTCAGTAC GAAGGGGAAA AATGCTCCAA CCACTGCAGG CTTCAGCTAT 1080

GAAAAATGGG AGATCAATCC CTCAGAGCTG ACCTTTATGA GGGAACTGGG GAGCGGACTG 1140

TTTGGAGTGG TGAGGCTGGG CAAGTGGAGG GCTCAGTACA AGGTGGCAAT CAAAGCCATT 1200

AGGGAAGGTG CCATGTGCGA GGAAGACTTT ATAGAAGAAG CTAAAGTGAT GATGAAGCTG 1260

ACACACCCGA AGCTAGTACA GCTGTACGGT GTATGCACCC AGCAGAAACC GATTTACATT 1320

GTTACCGAGT TCATGGAGAG GGGCTGTCTT CTGAATTTCC TCCGACAGAG ACAAGGTCAT 1380

TTTAGTCGAG ATGTGCTGCT GAGCATGTGT CAAGATGTGT GTGAAGGCAT GGACTACCTG 1440

GAGAGAAACA GCTTCATCCA CAGAGATCTG GCTGCCAGAA ATTGCCTCGT TAATGAGGCC 1500

GGAATTGTAA AAGTATCAGA TTTTGGAATG GCAAGGTATG TTCTGGACGA TCAATACACA 1560

AGTTCTTCCG GTGCAAAATT TCCAGTGAAG TGGTGTCCAC CTGAGGTGTT TAACTACAGT 1620

CGCTTCAGTA GCAAATCAGA TGTCTGGTCA TTTGGTGTTT TAATGTGGGA AATATTCACT 1680

GAAGGCAAAA TGCCTTTCGA GAAAAACACC AACTACGAAG TGGTAACCAT GGTTACGCGG 1740

GGCCACCGAC TCTACAGGCC GAAGCTGGCA TCCAAACATG TGTATGAGGT GATGCTGAGA 1800

TGTTGGCAGG AGAAACCAGA GGGAAGGCCT TCCTTTGAAG ATTTGCTGCG TACAATAGAT 1860

GAACTAGTCG AGTATGAAGA AACTTCTGGA AGATGA 1896

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam+eedfieeakvmmkl+hpklvqly

Q: 370   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY  429

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr++++++++++ll+mc+dvcegm+yler+sfihrd

Q: 430   GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMDYLERNSFIHRD  489

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e+ +vkvsdfg+aryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 490   LAARNCLVNEAGIVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  549

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwe+f+egk+p+ek++n+evv++v+rg+rlyrpklask+vyevm +cw+ekpe+r

Q: 550   SFGVLMWEIFTEGKMPFEKNTNYEVVTMVTRGHRLYRPKLASKHVYEVMLRCWQEKPEGR  609

         ************************************************************

S: 241   ptfkellsale  251

         p+f++ll+++

Q: 610   PSFEDLLRTID  620

         ********995

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMCEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQKPIY IVTEFMERGC LLNFLRQRQG HFSRDVLLSM CQDVCEGMDY LERNSFIHRD 120

LAARNCLVNE AGIVKVSDFG MARYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEIF TEGKMPFEKN TNYEVVTMVT RGHRLYRPKL ASKHVYEVML RCWQEKPEGR 240

PSFEDLLRTI D 251

Keyword

Kinase; SH3 domain; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0010543	; P:regulation of platelet activation

KEGG

InterPros

IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.

Created Date

20-Feb-2013