EKS-MUP-00361

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00361

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	447.4	1.3E-134	275	524	250

Status

Unreviewed

Ensembl Protein

ENSMPUP00000005355

UniProt Accession

G9KYC0;

Protein Name

Protein Synonyms/Alias

Proto-oncoprotein tyrosine-protein kinase YES;

Gene Name

Yes1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000005394	ENSMPUP00000005355	ENSMPUT00000005444

Organism

Mustela putorius furo

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

MGCIKSKENK SPTIKYRTEN TPEPVSSSVS HYGAEHTAVA PSSSTKGASV NFSSLSMTPF 60

GGSSGVTPFG GASSSFSVVP SSYPAGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120

NTEGDWWEAR SIATGKNGYI PSNYVAPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF 180

LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFDT LQKLVKHYTE 240

HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300

AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMS KGSLLDFLKE 360

GDGKYLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGENLVCKI ADFGLARLIE 420

DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILQ TELVTKGRVP YPGMVNREVL 480

EQVERGYRMP CPQGCPESLH ELMNLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGEN 540

L 541

Nucleotide Sequence
(FASTA)

ATGGGCTGCA TTAAAAGTAA AGAGAACAAA AGTCCAACCA TTAAATATAG AACCGAAAAC 60

ACTCCAGAAC CTGTCAGTAG CAGTGTCAGC CATTATGGAG CAGAACACAC TGCAGTGGCA 120

CCATCATCTT CAACAAAGGG AGCATCTGTT AATTTTAGCA GTCTTTCCAT GACACCATTT 180

GGAGGATCCT CAGGGGTGAC ACCTTTTGGA GGAGCATCTT CTTCATTCTC AGTGGTGCCA 240

AGTTCATATC CTGCTGGTTT AACAGGTGGT GTTACTATAT TTGTGGCCTT ATATGATTAT 300

GAAGCTAGAA CTACAGAAGA CCTTTCATTC AAGAAAGGTG AACGGTTTCA AATAATTAAC 360

AACACGGAAG GAGACTGGTG GGAAGCAAGA TCTATTGCTA CAGGAAAGAA TGGCTATATC 420

CCTAGCAATT ATGTAGCCCC TGCAGATTCC ATTCAGGCAG AAGAATGGTA TTTTGGCAAA 480

ATGGGCAGAA AAGACGCCGA AAGATTACTT TTGAATCCTG GGAATCAACG AGGTATTTTC 540

TTAGTAAGAG AGAGTGAAAC TACTAAAGGT GCTTATTCTC TCTCTATTCG TGATTGGGAT 600

GAGGTAAGAG GTGACAATGT GAAACACTAT AAAATTAGGA AACTTGACAA CGGTGGATAC 660

TATATCACAA CCAGAGCACA ATTTGATACT CTGCAGAAGT TGGTAAAACA CTACACAGAA 720

CATGCTGATG GTTTATGCCA TAAGTTAACA ACCGTGTGTC CTACTGTGAA ACCCCAGACT 780

CAAGGTCTAG CAAAAGATGC TTGGGAAATT CCTCGAGAAT CTTTGCGACT AGAGGTTAAA 840

TTAGGACAAG GATGTTTTGG TGAAGTATGG ATGGGGACAT GGAATGGAAC CACGAAAGTA 900

GCAATCAAAA CACTAAAGCC AGGTACAATG ATGCCAGAAG CTTTTCTTCA AGAGGCTCAG 960

ATAATGAAAA AATTAAGACA TGATAAACTT GTTCCACTAT ATGCTGTTGT TTCTGAAGAG 1020

CCAATTTACA TTGTCACTGA GTTCATGTCA AAAGGGAGTT TATTGGATTT CCTGAAGGAG 1080

GGAGATGGAA AGTATTTGAA GCTCCCACAA CTGGTTGATA TGGCTGCTCA GATTGCTGAT 1140

GGTATGGCGT ATATTGAAAG AATGAATTAT ATTCACCGAG ATCTTCGGGC TGCTAATATT 1200

CTTGTAGGAG AAAATCTTGT TTGCAAAATA GCAGATTTTG GTTTAGCAAG GTTAATTGAA 1260

GACAATGAAT ATACAGCAAG ACAAGGTGCA AAGTTTCCAA TCAAATGGAC AGCTCCCGAG 1320

GCTGCACTAT ATGGTCGATT TACAATAAAG TCTGATGTAT GGTCATTTGG TATTCTACAG 1380

ACAGAGCTGG TAACAAAGGG CAGAGTGCCA TATCCAGGTA TGGTAAACCG TGAAGTGCTA 1440

GAGCAGGTGG AACGAGGATA CAGGATGCCT TGCCCTCAGG GCTGCCCAGA ATCCCTACAT 1500

GAATTGATGA ACCTTTGTTG GAAGAAGGAC CCTGATGAAA GACCAACATT TGAATATATT 1560

CAGTCCTTCT TGGAAGACTA CTTCACTGCT ACAGAGCCAC AGTACCAGCC AGGAGAAAAT 1620

TTATAA 1626

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 275   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  334

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 335   AVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  393

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 394   DLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  453

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGil te+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+el++ cwkkdp+e

Q: 454   WSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDE  513

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 514   RPTFEYIQSFL  524

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMSKGSL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGE NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILQTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHELMN LCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Kinase; Nucleotide-binding; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0015758	; P:glucose transport

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013