EKS-MUP-00377
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00377
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK287.96.8E-861222222
StatusUnreviewed
Ensembl ProteinENSMPUP00000005704
UniProt AccessionG9L128;
Protein Name
Protein Synonyms/Alias Mixed lineage kinase 4;
Gene NameBC021891
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000005751ENSMPUP00000005704ENSMPUT00000005803
OrganismMustela putorius furo
Functional Description
Protein Length860
Protein Sequence
(FASTA)
MLRHPNIIEL RGVCLQQPHL CLVLEFARGG ALNRALAAAN VAPDPRAPGP RRARRIPPHV 60
LVNWAVQIAR GMLYLHEEAV VSILHRDLKS SNILLLEKIE HDDFCNKTLK ITDFGLAREW 120
HRTTKMSAAG TYAWMAPEVI KSSLFSKGSD IWSYGVLLWE LLTGEVPYRG IDGLAVAYGV 180
AVNKLTLPIP STCPEPFAKL MKECWQQDPH IRPSFALILE QLTAIEGTVM TEMPQESFHS 240
MQDDWKLEIQ QMFDELRTKE KELRSREEEL TRAALQQKSQ EALLRRREQQ LAEREIDVLE 300
RELNILIFQL NQEKPNVKKR KGKFRRSRLK LKDGHRISLP SDFQHKITVQ ASPNLDKRKS 360
VNSNGSSPPS SPTVIPRLRA IQLTSDESNK TWGRNTVSRQ EEFEDVKKNF RKKGCTWGPN 420
SIQMKERSDS KERIRPLSDG NSPWSALLIK NPKTTPLASL FVDQPGASEE PKLSPDGSEH 480
RKPKQIKSPS QAYVDLPLWK DGQREDPVEP GSWEEGPSSS SAASPPQVTP TSSRSRSPQR 540
KKTESALYGC TVLLASVALG LDIRELHQAQ AAGGLLPKEE RKKREGIFQW APKSRGGASP 600
STRPPSMGER ASSPPLLPPP GAMSLLSGPS LSTRCLLQTD SADLSEGSPR VASDPEMPAP 660
GFCVAIGGRS HEPTSTPRLE TDRSPWKNPS PPFLEWTCRN VPYSASSKER ASHHRRTLSE 720
GNACQTPTAA AGATLSSDPG ASDLPPKWTL GTPRCSPPRE APLEKQRVGA LVPPPCLLTF 780
RSRSDSQPAR QAQVLSVGPG PTPPTACPPG GAEDRTTPHV PSLLDVDAQG QSRDSPVPLG 840
RMMSRASRPS VRQLEEEFLS 860
Nucleotide Sequence
(FASTA)
ATGCTGCGGC ACCCCAACAT CATCGAGCTG CGCGGCGTGT GCCTGCAGCA GCCGCACCTC 60
TGCCTGGTGC TCGAGTTCGC CCGCGGCGGA GCGCTCAACC GCGCTCTGGC AGCCGCCAAC 120
GTCGCCCCGG ACCCCCGCGC GCCAGGCCCG CGCCGCGCGC GCCGCATCCC CCCACACGTG 180
CTGGTCAACT GGGCGGTGCA GATCGCCCGC GGCATGCTCT ACCTGCACGA GGAGGCCGTC 240
GTGTCCATCC TGCACCGGGA CCTCAAGTCC AGCAACATTT TGCTGCTTGA GAAGATAGAG 300
CATGATGACT TCTGCAATAA AACGTTGAAG ATTACAGATT TTGGGCTGGC GAGAGAATGG 360
CACAGGACGA CCAAGATGAG TGCCGCGGGC ACCTATGCCT GGATGGCGCC GGAAGTCATC 420
AAGTCTTCCC TGTTTTCTAA GGGGAGTGAC ATCTGGAGCT ATGGAGTCCT GCTATGGGAG 480
CTGCTCACGG GAGAAGTCCC CTACCGTGGC ATCGACGGGC TCGCCGTGGC CTATGGGGTG 540
GCCGTCAATA AGCTCACTTT GCCCATTCCA TCCACCTGCC CGGAGCCATT TGCCAAGCTC 600
ATGAAAGAGT GCTGGCAGCA AGACCCCCAC ATTCGTCCTT CATTTGCCTT AATTCTTGAA 660
CAACTGACAG CTATTGAAGG GACGGTTATG ACCGAAATGC CTCAAGAATC TTTTCATTCC 720
ATGCAAGATG ACTGGAAGCT GGAAATTCAA CAAATGTTTG ATGAACTGAG AACAAAGGAG 780
AAGGAGCTGC GGTCCCGAGA GGAGGAGCTG ACCCGAGCCG CGCTGCAGCA GAAGTCCCAG 840
GAGGCGCTGC TCAGGCGGCG GGAGCAGCAG CTGGCAGAGC GGGAGATCGA CGTGCTGGAG 900
CGGGAGCTGA ACATTTTGAT ATTCCAGTTA AACCAGGAGA AGCCCAATGT CAAGAAGAGG 960
AAGGGAAAGT TCAGGAGAAG TCGGCTGAAG CTCAAAGACG GCCATCGAAT CAGTTTACCC 1020
TCAGACTTCC AGCATAAAAT CACCGTCCAG GCCTCTCCCA ACTTGGACAA ACGGAAGAGT 1080
GTGAACAGCA ATGGCTCCAG CCCACCCAGC AGCCCCACAG TGATCCCTCG GCTCCGAGCG 1140
ATACAGTTGA CTTCAGACGA AAGCAATAAA ACCTGGGGAA GGAACACAGT CAGTCGACAA 1200
GAAGAATTTG AGGATGTGAA AAAGAACTTC AGGAAAAAAG GTTGTACCTG GGGACCCAAC 1260
TCAATTCAAA TGAAAGAAAG AAGTGACAGC AAAGAAAGAA TACGACCTCT CTCAGACGGC 1320
AACAGCCCTT GGTCAGCTCT CTTAATAAAG AATCCGAAAA CCACGCCGTT GGCTTCATTA 1380
TTTGTGGACC AGCCAGGTGC TTCTGAAGAG CCAAAACTTT CCCCCGATGG ATCAGAACAC 1440
AGAAAACCAA AGCAAATAAA ATCTCCTAGC CAAGCCTATG TTGATCTACC TCTTTGGAAA 1500
GATGGCCAGA GAGAGGATCC AGTAGAGCCA GGAAGCTGGG AGGAGGGCCC CTCTTCAAGC 1560
TCTGCTGCAA GCCCTCCTCA GGTGACCCCT ACAAGTAGTC GGAGCAGGTC CCCCCAGAGG 1620
AAGAAGACGG AGTCTGCCCT GTACGGCTGC ACCGTGCTGC TGGCGTCAGT CGCTCTGGGG 1680
CTTGATATCA GAGAGCTTCA TCAAGCACAG GCTGCCGGAG GACTGTTGCC CAAAGAAGAA 1740
AGGAAGAAAC GTGAGGGGAT CTTCCAGTGG GCTCCCAAGT CCCGAGGTGG GGCCAGTCCT 1800
TCCACAAGAC CACCATCTAT GGGCGAGAGG GCCAGCAGCC CACCCTTACT CCCTCCACCA 1860
GGTGCCATGA GCCTTCTCTC CGGGCCGTCT CTTTCCACCA GGTGCTTGCT GCAGACGGAC 1920
AGCGCAGATC TGTCCGAGGG CAGCCCACGC GTTGCTTCGG ACCCCGAGAT GCCCGCTCCA 1980
GGTTTTTGTG TGGCCATCGG AGGACGTAGT CATGAGCCGA CCTCCACGCC AAGACTTGAG 2040
ACTGATCGGA GTCCATGGAA AAACCCATCT CCTCCTTTCC TAGAGTGGAC GTGCAGGAAT 2100
GTGCCTTATT CTGCTTCTTC AAAAGAACGA GCATCACATC ACAGACGAAC CCTCTCCGAG 2160
GGAAATGCTT GTCAGACCCC AACAGCTGCT GCGGGTGCAA CTCTCAGCTC AGACCCCGGA 2220
GCCTCAGACC TGCCCCCGAA GTGGACTCTG GGAACGCCCC GGTGCTCCCC GCCAAGGGAG 2280
GCCCCGCTGG AAAAACAAAG AGTGGGCGCC CTGGTGCCCC CACCTTGCCT GCTGACCTTC 2340
AGGAGCCGCT CAGACTCACA GCCCGCCAGG CAGGCACAGG TTCTCTCCGT CGGGCCTGGT 2400
CCGACTCCCC CCACCGCTTG TCCCCCCGGG GGGGCCGAGG ACAGGACTAC ACCCCACGTG 2460
CCTTCCCTCC TGGACGTTGA CGCCCAAGGC CAGAGCAGGG ACAGCCCGGT GCCTTTGGGC 2520
AGGATGATGA GCAGAGCCAG CCGGCCGTCC GTGCGGCAGC TGGAGGAGGA GTTTCTGTCT 2580
TAA 2583
Domain Profile
S: 52    klshpniiellGvcleepnlllvmeyveggsLsnvlhe............kskreidlev  99
         +l+hpniiel+Gvcl++p+l+lv+e+++gg+L+++l++            ++ r+i+++v
Q: 1     MLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAanvapdprapgpRRARRIPPHV  60
         589**********************************99*********************
S: 100   lvswalqiArGmaYLhseapkkiihrdLksknvLl.......seekktlkicdFGtarel  152
         lv+wa+qiArGm YLh+ea+++i+hrdLks+n+Ll       ++ +ktlki+dFG are+
Q: 61    LVNWAVQIARGMLYLHEEAVVSILHRDLKSSNILLlekiehdDFCNKTLKITDFGLAREW  120
         ****************************************9999****************
S: 153   skstkmsaagtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykdlselaiaykv  212
         +++tkmsaagt+awmaPEv+k++ +s+ sD+wSygv+LWellt+evPy++++ la+ay+v
Q: 121   HRTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGV  180
         ************************************************************
S: 213   alkglrlpipsscpeklkkLmkecwnedpekRpsfseivksl  254
         a+++l+lpips+cpe+++kLmkecw++dp+ Rpsf+ i+++l
Q: 181   AVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL  222
         **************************************9986
Domain Sequence
(FASTA)
MLRHPNIIEL RGVCLQQPHL CLVLEFARGG ALNRALAAAN VAPDPRAPGP RRARRIPPHV 60
LVNWAVQIAR GMLYLHEEAV VSILHRDLKS SNILLLEKIE HDDFCNKTLK ITDFGLAREW 120
HRTTKMSAAG TYAWMAPEVI KSSLFSKGSD IWSYGVLLWE LLTGEVPYRG IDGLAVAYGV 180
AVNKLTLPIP STCPEPFAKL MKECWQQDPH IRPSFALILE QL 222
KeywordKinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00353
EKS-ANC-00364
EKS-BOT-00378
EKS-CAJ-00380
EKS-CAF-00378
EKS-CHH-00044
EKS-CII-00213
EKS-DAR-00756
EKS-EQC-00376
EKS-FEC-00372
EKS-GAM-00227
EKS-GAG-00324
EKS-GAA-00459
EKS-GOG-00368
EKS-LOA-00393
EKS-MAM-00377
EKS-MAE-00045
EKS-MEG-00317
EKS-MIM-00054
EKS-MOD-00367
EKS-MUM-00410
EKS-NOL-00350
EKS-ORN-00484
EKS-ORC-00354
EKS-OTG-00381
EKS-PAT-00358
EKS-PES-00340
EKS-POA-00375
EKS-RAN-00392
EKS-SAH-00346
EKS-SOA-00062
EKS-SUS-00330
EKS-TAG-00454
EKS-TAR-00481
EKS-TEN-00489
EKS-XIM-00475
Gene Ontology
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR015785; MAPKKK9/10/11-like.
Pfam
SMARTs
Prosites
Prints
Created Date20-Feb-2013