EPS-MUP-00016

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUP-00016

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	292.3	3.9E-87	96	362	267

Status

Unreviewed

Ensembl Protein

ENSMPUP00000006257

UniProt Accession

G9KI29;

Protein Name

Protein Synonyms/Alias

Protein phosphatase 1A , magnesium-dependent, alpha isoform;

Gene Name

PPM1A

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000006311	ENSMPUP00000006257	ENSMPUT00000006366

Organism

Mustela putorius furo

Functional Description

Protein Length

455

Protein Sequence
(FASTA)

MYYFRRKWVA EAVIWTKLGK SEKRRMGKRR TKGTKKEQKK GRRVIRKKER RGGHMKRIFG 60

KKTRGTDLEY QDIMGAFLDK PKMEKHNAQG QGNGLRYGLS SMQGWRVEME DAHTAVIGLP 120

SGLETWSFFA VYDGHAGSQV AKYCCEHLLD HITNNQDFKG SAGAPSVENV KNGIRTGFLE 180

IDEHMRVMSE KKHGADRSGS TAVGVLISPQ HTYFINCGDS RGLLCRNRKV HFFTQDHKPS 240

NPLEKERIQN AGGSVMIQRV NGSLAVSRAL GDFDYKCVHG KGPTEQLVSP EPEVHDIERS 300

EEDDQFIILA CDGIWDVMGN EELCDFVRSR LEVTDDLEKV CNEVVDTCLY KGSRDNMSVI 360

LICFPNAPKV SPEAVKKEAE LDKYLESRVE EIIKKQGEGV PDLVHVMRTL ASENIPSLPP 420

GGELASKRNV IEAVYNRLNP YKNDDTDSTS TDDMW 455

Nucleotide Sequence
(FASTA)

ATGTACTACT TCAGGAGAAA GTGGGTAGCA GAGGCTGTAA TTTGGACTAA GCTAGGAAAA 60

AGTGAGAAAA GAAGAATGGG GAAAAGAAGG ACAAAGGGGA CTAAGAAAGA ACAGAAGAAA 120

GGGAGAAGAG TGATAAGGAA AAAAGAGAGA AGAGGAGGCC ATATGAAGAG GATATTTGGG 180

AAAAAGACAC GTGGAACAGA CCTAGAATAT CAAGACATAA TGGGAGCATT TTTAGACAAG 240

CCAAAGATGG AAAAACATAA CGCCCAGGGG CAGGGTAATG GGTTGCGGTA TGGGCTAAGC 300

AGTATGCAAG GTTGGCGAGT TGAAATGGAG GATGCACATA CGGCTGTGAT CGGTTTGCCA 360

AGTGGACTTG AAACATGGTC ATTCTTTGCT GTGTATGATG GGCATGCTGG TTCTCAGGTT 420

GCCAAATACT GCTGTGAGCA TTTGTTAGAT CACATCACCA ATAACCAGGA TTTTAAAGGG 480

TCTGCAGGAG CACCTTCTGT GGAAAATGTA AAGAATGGAA TCAGAACAGG TTTTCTGGAG 540

ATTGATGAAC ACATGAGAGT TATGTCAGAG AAGAAACATG GTGCAGATAG AAGTGGGTCA 600

ACAGCTGTGG GTGTCTTAAT TTCTCCTCAA CATACTTATT TCATTAACTG TGGAGACTCG 660

AGAGGTTTAC TTTGTAGAAA CAGGAAAGTT CACTTCTTCA CACAAGATCA CAAACCAAGT 720

AATCCGCTGG AAAAAGAACG AATTCAGAAT GCAGGTGGTT CTGTCATGAT TCAGCGTGTG 780

AATGGCTCTC TGGCTGTATC GAGGGCCCTC GGGGACTTTG ATTACAAATG TGTCCACGGA 840

AAAGGTCCTA CAGAGCAGCT TGTCTCACCA GAGCCTGAAG TCCATGATAT TGAAAGATCT 900

GAAGAAGATG ATCAGTTCAT TATCCTTGCA TGTGATGGTA TTTGGGATGT TATGGGAAAT 960

GAAGAGCTCT GTGATTTTGT AAGATCCAGA CTTGAAGTCA CTGATGACCT TGAGAAAGTT 1020

TGCAATGAAG TAGTCGACAC CTGTTTGTAT AAGGGAAGTC GAGACAACAT GAGTGTGATA 1080

TTGATCTGTT TTCCAAATGC ACCCAAAGTA TCACCAGAAG CAGTGAAGAA GGAGGCAGAA 1140

TTGGACAAGT ACCTGGAAAG CAGAGTAGAA GAAATCATAA AGAAGCAGGG GGAAGGCGTC 1200

CCTGACTTAG TCCATGTGAT GCGCACATTA GCAAGTGAGA ACATCCCCAG CCTCCCACCA 1260

GGGGGTGAAT TGGCAAGCAA GCGGAATGTA ATTGAAGCCG TTTACAATAG ACTGAATCCT 1320

TACAAAAATG ATGACACTGA CTCTACATCA ACTGATGACA TGTGGTAA 1368

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++ +     + ++ff+vyDGh+gs+vak+c e+l +++

Q: 96    RYGLSSMQGWRVEMEDAHTAVIGLPSGL---ETWSFFAVYDGHAGSQVAKYCCEHLLDHI  152

         69****************9855554444...45***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         +++ +    +++++ ++vk+ ++++Fl++de+++v++ek++  d+sGstav +li++++

Q: 153   TNNQDfkgsAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHT  212

         ***9999999999***********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 213   YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  269

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev+ +++++ed+ f+iLa+DG+wdv+ nee++++vr+

Q: 270   LGDFDYKcvhgkgpteQLVSPEPEVHDIERSEEDDqFIILACDGIWDVMGNEELCDFVRS  329

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++++++++v+++l +gs+dn+s+i++

Q: 330   RLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILI  362

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPSGLET WSFFAVYDGH AGSQVAKYCC EHLLDHITNN 60

QDFKGSAGAP SVENVKNGIR TGFLEIDEHM RVMSEKKHGA DRSGSTAVGV LISPQHTYFI 120

NCGDSRGLLC RNRKVHFFTQ DHKPSNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVH DIERSEEDDQ FIILACDGIW DVMGNEELCD FVRSRLEVTD 240

DLEKVCNEVV DTCLYKGSRD NMSVILI 267

Keyword

Hydrolase; Magnesium; Metal-binding; Protein phosphatase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004871	; F:signal transducer activity
GO:0010991	; P:negative regulation of SMAD protein complex assembly
GO:0030512	; P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0030177	; P:positive regulation of Wnt receptor signaling pathway
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013