EKS-MUP-00271

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00271

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.4	1.7E-140	182	469	288

Status

Unreviewed

Ensembl Protein

ENSMPUP00000006622

UniProt Accession

G9KT45;

Protein Name

Protein Synonyms/Alias

TGF-beta receptor type I;

Gene Name

TGFBR1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000006676	ENSMPUP00000006622	ENSMPUT00000006735

Organism

Mustela putorius furo

Functional Description

Protein Length

480

Protein Sequence
(FASTA)

MCYRSPEGKA LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP 60

FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT VGKPSSGLGP VELAAVIAGP VCFVCISLML 120

MVYICHNRTV IHHRVPNEED PSLDRPFISE GTTLKDLIYD MTTSGSGSGL PLLVQRTIAR 180

TIVLQESIGK GRFGEVWRGK WRGEEVAVKI FSSREERSWF REAEIYQTVM LRHENILGFI 240

AADNKDNGTW TQLWLVSDYH EHGSLFDYLN RYTVTVEGMI KLALSTASGL AHLHMEIVGT 300

QGKPAIAHRD LKSKNILVKK NGTCCIADLG LAVRHDSATD TIDIAPNHRV GTKRYMAPEV 360

LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGGIHED YQLPYYDLVP SDPSVEEMRK 420

VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL TALRIKKTLS QLSQQEGIKM 480

Nucleotide Sequence
(FASTA)

ATGTGTTATA GGTCCCCAGA GGGCAAAGCA TTACAGTGTT TTTGCCACCT TTGTACAAAA 60

GACAATTTTA CTTGTGTGAC AGATGGGCTC TGCTTTGTCT CTGTCACAGA GACCACCGAC 120

AAAGTTATAC ACAATAGCAT GTGTATAGCT GAAATTGACC TAATTCCTCG AGACAGACCA 180

TTTGTATGTG CACCGTCTTC AAAAACTGGG TCTGTTACTA CAACCTATTG CTGCAACCAG 240

GACCATTGCA ATAAAATAGA ACTCCCAACT GTTGGAAAGC CATCATCTGG CCTTGGTCCC 300

GTTGAACTGG CAGCTGTCAT TGCTGGACCA GTCTGCTTCG TCTGCATCTC ACTCATGTTG 360

ATGGTTTATA TCTGCCATAA CCGTACTGTG ATTCACCATC GAGTGCCAAA TGAAGAGGAT 420

CCTTCCTTAG ATCGCCCTTT TATTTCGGAG GGCACCACAT TAAAAGATTT AATTTATGAT 480

ATGACGACAT CGGGTTCTGG ATCAGGTTTA CCATTGCTTG TTCAGAGAAC AATTGCAAGA 540

ACTATTGTGT TACAAGAAAG TATTGGCAAA GGTCGATTTG GGGAAGTTTG GCGGGGAAAG 600

TGGAGAGGAG AAGAAGTTGC TGTTAAAATA TTTTCCTCTA GAGAAGAGCG CTCATGGTTC 660

CGTGAGGCAG AGATTTATCA GACCGTAATG TTACGTCATG AAAACATCCT GGGATTTATA 720

GCAGCAGACA ATAAAGACAA TGGTACATGG ACTCAGCTCT GGTTGGTGTC AGATTATCAT 780

GAGCATGGAT CCCTTTTTGA TTATTTGAAC AGATATACAG TTACTGTGGA AGGAATGATA 840

AAACTTGCCT TGTCCACAGC AAGCGGACTT GCCCATCTCC ACATGGAGAT TGTTGGTACC 900

CAAGGGAAAC CAGCCATTGC TCATAGAGAT TTGAAATCCA AGAATATCTT GGTAAAGAAG 960

AATGGAACTT GCTGTATTGC AGACTTAGGA CTGGCAGTGA GACATGATTC AGCCACAGAT 1020

ACGATAGATA TTGCTCCAAA TCACAGAGTG GGAACAAAAA GGTACATGGC CCCTGAAGTT 1080

CTAGATGATT CCATAAATAT GAAACACTTT GAATCCTTCA AACGTGCTGA CATCTATGCA 1140

ATGGGCTTAG TATTCTGGGA AATAGCTCGA CGATGTTCCA TTGGTGGAAT TCATGAAGAT 1200

TACCAGCTGC CTTATTATGA TCTCGTACCT TCTGATCCAT CAGTTGAAGA AATGAGAAAA 1260

GTTGTTTGTG AACAGAAGTT AAGGCCAAAT ATTCCAAACA GATGGCAGAG TTGTGAAGCC 1320

TTGAGAGTAA TGGCTAAAAT TATGAGAGAA TGTTGGTATG CCAATGGAGC AGCAAGACTT 1380

ACGGCTTTGC GTATTAAGAA AACACTGTCA CAACTCAGTC AACAGGAAGG CATCAAAATG 1440

TAG 1443

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 182   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  241

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 242   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  301

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 302   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  359

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 360   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  418

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 419   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  469

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Kinase; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000186	; P:activation of MAPKK activity
GO:0001525	; P:angiogenesis
GO:0009952	; P:anterior/posterior pattern specification
GO:0048844	; P:artery morphogenesis
GO:0001824	; P:blastocyst development
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0043542	; P:endothelial cell migration
GO:0001837	; P:epithelial to mesenchymal transition
GO:0008354	; P:germ cell migration
GO:0007507	; P:heart development
GO:0006917	; P:induction of apoptosis
GO:0001822	; P:kidney development
GO:0002088	; P:lens development in camera-type eye
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0048663	; P:neuron fate commitment
GO:0060021	; P:palate development
GO:0060017	; P:parathyroid gland development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0051272	; P:positive regulation of cellular component movement
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0009791	; P:post-embryonic development
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0048538	; P:thymus development
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013