EKS-MUP-00034
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00034
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak323.41.2E-968921162271
StatusUnreviewed
Ensembl ProteinENSMPUP00000006638
UniProt AccessionG9KW40;
Protein Name
Protein Synonyms/Alias Tyrosine kinase 2;
Gene NameTyk2
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000006692ENSMPUP00000006638ENSMPUT00000006751
OrganismMustela putorius furo
Functional Description
Protein Length1182
Protein Sequence
(FASTA)
MSLCHWGATT RDSRPDGNGA QPMATRGGLK VLLHWAGPGG GDPWVTFSEA TLTAEEVCIH 60
IAQKVGITPS CLNLFALFDA QAQVWLPPNH VLEIPRDMSL TLYFRMRFYF RNWHGTNPQE 120
PAVYRCGPPG PKSSSEQAEQ GMQLLDPASF EYLFEQGKHE FVNDVASLWE LSGEEEIRHF 180
KNESLGMAFL HLCHLALCRG VPLEKVAKKI SFKDCIPRSF RLQIRRHNAL TRLRLRNIFR 240
RFVRAFQPGH VSQQVVMVKY LATLEQLAPR FGTERLPVCH LELLAQAVGE PYYLRDAGQA 300
PPEPGPELAT GPPTHEVLVT GTGGIQWRPV RAEDPRGDGS SRNPCAGPSG KGTKAPAAGD 360
QPADRPQEAL WTYFCDFQDI THVVLKECHV SVHSQDNKSL ELTLPSRAMA LSLVSLVDGY 420
FRLTADSSHY LCREVAPPRL VMSIQDGIHG PLLEPFVLAK LRPEDGLYLI HWSTSHLNRL 480
ILTVAQREQA PGTQHVHLRK FPIELQAGVF TLEGWDRSFP SVRELRAALQ GCCLRAGNDC 540
FALRRCCLPR PGEISNLIIM RGSRASAAPP NLSQLSFHRI SQDDITQLSH LGQGTRTNVY 600
EGILRVGGRD PKEGTADSED PPTPSGDCGQ ELRVVLKVLD PSHHDIALAF YETASLMSQV 660
SHVHLAFVHG ICVHGSENIM VAEYVEHGPL DVWLRREKGH VPVAWKVVVA QQLASALSYL 720
EDKSLVHGNV CGRNILLARL GLTEGTSPFI KLSDPGVGLG ALSREERVER IPWTAPECLS 780
GGANSLTTAA DKWGFGATLL EICFDGEAPL QGRGPSEKEC FYQKQHQLPQ PSCPELATLT 840
SQCLTYEPTQ RPSFRTILRD LTQLQPQNLA DVLAVNPDSP ASDPTVFHKR YLKKIRDLGE 900
GHFGKVSLYC YDPTNDGTGE MVAVKTLKAD CGPQLRTSWR REIDILRTLY HKHIVKYKGC 960
CEDAGEKSVP LVMEYVPLGS LRDYLPRHSV GLAQLLLFAQ QICEGMAYLH AQHYVHRDLA 1020
ARNVLLDNDR LVKIGDFGLA KAVPEGHEYY RVREDGDSPV FWYAPECLKE CKFYYASDVW 1080
SFGVTMYELL TYCDSSQSPP SKFMELIGLT HGQMTVLRLT ELLERGERLP RPERCPCEIY 1140
LLMKNCWQAE ASFRPTFQNL IPILKTIQEK YQGQAASVFN VC 1182
Nucleotide Sequence
(FASTA)
ATGTCTCTGT GCCACTGGGG TGCCACCACC AGGGACAGCA GGCCTGATGG CAATGGAGCT 60
CAGCCCATGG CCACCAGGGG AGGCCTGAAG GTCCTTCTGC ACTGGGCTGG CCCTGGCGGC 120
GGGGACCCCT GGGTCACCTT CAGCGAGGCC ACACTGACCG CAGAGGAGGT CTGCATCCAC 180
ATTGCACAAA AAGTCGGCAT CACTCCATCC TGCCTCAATC TCTTCGCCCT CTTCGATGCC 240
CAGGCCCAGG TCTGGCTGCC CCCAAACCAT GTCTTGGAGA TCCCCAGAGA CATGAGCCTC 300
ACGCTGTACT TCCGCATGAG GTTTTATTTC CGGAACTGGC ATGGCACAAA CCCCCAGGAG 360
CCAGCTGTGT ACCGCTGTGG GCCCCCAGGG CCCAAGTCTT CCTCTGAACA GGCAGAGCAG 420
GGCATGCAAC TACTGGACCC GGCCTCCTTT GAGTACCTCT TTGAGCAGGG CAAGCATGAG 480
TTTGTGAATG ACGTAGCATC GCTGTGGGAG CTGTCCGGCG AGGAGGAGAT CCGCCATTTT 540
AAGAATGAGA GTCTGGGCAT GGCCTTTCTG CACCTGTGCC ACCTTGCCCT GTGCCGTGGC 600
GTCCCCCTGG AGAAGGTGGC CAAGAAGATC AGCTTCAAGG ACTGCATCCC ACGCTCCTTC 660
CGGCTGCAGA TCCGGCGGCA CAATGCGCTG ACCCGACTGC GCCTGCGGAA CATCTTCCGC 720
AGGTTCGTGC GGGCCTTCCA GCCGGGCCAC GTCTCACAGC AGGTCGTCAT GGTCAAATAC 780
CTGGCCACGC TCGAGCAGCT GGCACCCCGC TTCGGCACGG AGCGCCTGCC CGTGTGCCAC 840
CTGGAGTTAC TGGCCCAGGC CGTGGGGGAG CCCTACTACC TCCGGGACGC CGGGCAGGCT 900
CCCCCAGAGC CTGGGCCGGA GTTGGCCACC GGGCCACCCA CTCACGAGGT GCTGGTGACG 960
GGCACAGGTG GCATCCAGTG GCGGCCGGTG CGGGCAGAGG ATCCCAGAGG CGATGGCAGC 1020
AGCAGGAATC CCTGTGCTGG CCCATCTGGG AAGGGAACCA AGGCCCCAGC AGCAGGCGAC 1080
CAGCCAGCAG ACAGGCCTCA GGAAGCGCTG TGGACCTACT TCTGTGACTT CCAGGACATC 1140
ACACACGTGG TGCTGAAGGA ATGCCACGTC AGCGTCCACT CTCAGGACAA CAAGAGCCTG 1200
GAGCTGACCC TGCCTTCCCG GGCCATGGCC CTGTCCTTGG TGTCACTGGT GGACGGCTAT 1260
TTCCGCCTGA CCGCAGACTC AAGCCACTAC CTGTGCCGCG AGGTGGCGCC GCCACGGCTG 1320
GTGATGAGCA TCCAGGACGG GATCCATGGA CCCCTGCTGG AGCCATTTGT GCTGGCCAAG 1380
CTGCGGCCCG AGGACGGCCT CTACCTCATC CACTGGAGCA CCAGCCACCT CAACCGCCTC 1440
ATCCTCACGG TGGCGCAGAG AGAGCAAGCC CCAGGCACAC AGCACGTGCA CCTGCGCAAA 1500
TTCCCCATTG AGCTGCAGGC CGGGGTCTTC ACGCTGGAGG GCTGGGACCG GTCCTTCCCC 1560
AGCGTGCGGG AGCTGCGAGC TGCCCTGCAG GGTTGCTGCC TGCGGGCTGG CAACGACTGC 1620
TTCGCCCTGC GCCGCTGTTG CCTGCCACGG CCTGGAGAGA TCTCCAACCT CATCATCATG 1680
CGGGGGTCTC GGGCCAGCGC CGCTCCGCCC AACCTCAGCC AGCTCAGCTT CCACCGGATC 1740
AGCCAGGATG ACATCACCCA GCTGTCCCAC TTGGGCCAAG GCACCAGGAC CAACGTGTAC 1800
GAGGGCATCT TACGAGTGGG GGGCAGAGAC CCCAAGGAGG GCACGGCAGA CAGTGAGGAC 1860
CCCCCCACAC CCAGTGGGGA CTGCGGGCAA GAGCTCCGGG TGGTCCTCAA GGTGCTGGAC 1920
CCCAGTCACC ACGACATCGC GCTGGCCTTC TACGAGACAG CCAGTCTCAT GAGCCAGGTC 1980
TCCCACGTGC ACCTGGCCTT TGTACATGGC ATCTGCGTGC ATGGCTCCGA GAACATCATG 2040
GTGGCAGAGT ACGTGGAGCA CGGGCCCCTG GACGTGTGGC TGCGGCGAGA GAAGGGCCAC 2100
GTGCCTGTGG CCTGGAAGGT GGTGGTGGCC CAGCAGCTGG CCAGCGCCCT CAGCTACCTG 2160
GAAGACAAGA GCCTGGTTCA TGGTAATGTG TGTGGCCGGA ACATCCTGTT GGCACGGCTA 2220
GGGCTGACGG AGGGCACCAG CCCCTTCATC AAGCTGAGTG ACCCCGGTGT GGGCCTGGGT 2280
GCCCTTTCCA GGGAGGAGCG GGTGGAGCGG ATCCCCTGGA CAGCCCCTGA GTGCCTCTCC 2340
GGCGGAGCCA ACAGTCTGAC CACTGCGGCT GATAAATGGG GCTTTGGTGC CACCCTCCTG 2400
GAGATCTGCT TCGATGGGGA GGCCCCTCTG CAGGGCCGTG GCCCCTCCGA GAAAGAGTGC 2460
TTCTACCAAA AGCAGCACCA GCTTCCTCAG CCCTCCTGCC CGGAGCTGGC CACACTCACC 2520
AGCCAGTGCC TGACTTACGA ACCAACTCAG CGGCCCTCCT TCCGCACTAT CCTGCGGGAC 2580
CTCACTCAGC TGCAGCCCCA GAATCTTGCT GACGTCTTGG CTGTGAACCC TGACTCACCT 2640
GCGTCAGACC CCACCGTGTT CCACAAGCGC TATTTGAAAA AGATCCGAGA TCTGGGCGAG 2700
GGCCATTTCG GCAAGGTCAG TCTGTACTGC TACGACCCCA CGAACGACGG CACCGGCGAG 2760
ATGGTGGCCG TGAAGACCCT CAAGGCGGAC TGCGGCCCCC AGCTCCGCAC CAGCTGGCGG 2820
CGGGAGATCG ACATCCTGCG CACGCTGTAC CACAAGCACA TTGTCAAGTA CAAGGGCTGC 2880
TGCGAGGACG CAGGAGAGAA GTCGGTACCG CTGGTCATGG AGTATGTGCC CCTGGGAAGC 2940
CTGCGGGACT ACCTGCCCCG GCACAGCGTG GGGCTGGCGC AGCTGCTGCT CTTCGCCCAG 3000
CAGATCTGTG AGGGCATGGC CTACCTCCAT GCACAGCACT ACGTGCACCG AGACCTGGCG 3060
GCCCGCAACG TGCTGCTGGA CAACGACAGG CTGGTCAAAA TCGGGGACTT TGGTCTAGCC 3120
AAGGCTGTGC CTGAAGGCCA TGAGTACTAC CGCGTGCGCG AGGATGGGGA CAGCCCCGTA 3180
TTCTGGTATG CCCCAGAGTG CCTGAAGGAG TGTAAGTTCT ACTATGCCTC TGATGTCTGG 3240
TCCTTCGGGG TCACCATGTA CGAGCTGCTG ACCTACTGTG ACTCCAGCCA GAGCCCCCCC 3300
TCGAAATTCA TGGAGCTCAT AGGCCTCACC CATGGGCAGA TGACGGTGCT GAGGCTCACT 3360
GAGCTGCTGG AACGCGGGGA GAGGCTGCCC CGGCCGGAGA GATGTCCTTG TGAGATCTAT 3420
CTCCTCATGA AGAACTGCTG GCAGGCGGAG GCCTCATTCC GCCCCACCTT CCAGAACCTC 3480
ATACCCATTC TCAAGACCAT CCAGGAGAAA TACCAAGGCC AGGCTGCCTC AGTGTTCAAT 3540
GTGTGCTGA 3549
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59
         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k Lk ++g++ ++++ re++il++l+h
Q: 892   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKTLKaDCGPQLRTSWRREIDILRTLYH  951
         6899********************************************************
S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         +hivk+kg+c + ge+   lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL
Q: 952   KHIVKYKGCCEDAGEKsvPLVMEYVPLGSLRDYLPRH--SVGLAQLLLFAQQICEGMAYL  1009
         ***************9999******************..*********************
S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176
         +++++vhrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+
Q: 1010  HAQHYVHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  1063
         **********************......********************************
S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224
         apecl+e+k +++asdvWsFgvt+yellt c++++sp    ++ ++l+       r++el
Q: 1064  APECLKECK-FYYASDVWSFGVTMYELLTyCDSSQSPpskfMELIGLThgqmtvlRLTEL  1122
         *********.***************************988844444446666688*****
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
         le++erlp+p+ cp+e++ lm+nc+++e+s+rp+F++++ 
Q: 1123  LERGERLPRPErCPCEIYLLMKNCWQAEASFRPTFQNLIP  1162
         ************************************9975
Domain Sequence
(FASTA)
LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKTLKADC GPQLRTSWRR EIDILRTLYH 60
KHIVKYKGCC EDAGEKSVPL VMEYVPLGSL RDYLPRHSVG LAQLLLFAQQ ICEGMAYLHA 120
QHYVHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEC 180
KFYYASDVWS FGVTMYELLT YCDSSQSPPS KFMELIGLTH GQMTVLRLTE LLERGERLPR 240
PERCPCEIYL LMKNCWQAEA SFRPTFQNLI P 271
KeywordKinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00028
EKS-ANC-00027
EKS-BOT-00034
EKS-CAJ-00031
EKS-CAF-00033
EKS-CAP-00033
EKS-DAR-00045
EKS-EQC-00392
EKS-FEC-00030
EKS-GAM-00233
EKS-GAA-00049
EKS-GOG-00031
EKS-HOS-00033
EKS-ICT-00028
EKS-LOA-00031
EKS-MAM-00032
EKS-MEG-00026
EKS-MOD-00031
EKS-MUM-00034
EKS-MYL-00034
EKS-NOL-00030
EKS-OCP-00021
EKS-ORN-00049
EKS-ORC-00032
EKS-ORL-00046
EKS-OTG-00034
EKS-PAT-00030
EKS-POA-00029
EKS-PRC-00015
EKS-PTV-00032
EKS-RAN-00033
EKS-SAH-00031
EKS-TAR-00049
EKS-XET-00032
EKS-XIM-00047
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0005634; C:nucleus
GO:0016301; F:kinase activity
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
Pfam
SMARTs
SM00295; B41; 1.
Prosites
PS50057; FERM_3; 1.
Prints
PR01827; YKINASETYK2.
Created Date20-Feb-2013