EKS-MUP-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	318.6	2.5E-95	5	240	236

Status

Unreviewed

Ensembl Protein

ENSMPUP00000007189

UniProt Accession

G9KII4;

Protein Name

Protein Synonyms/Alias

5-AMP-activated protein kinase, catalytic alpha-2 chain;

Gene Name

Prkaa2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000007247	ENSMPUP00000007189	ENSMPUT00000007308

Organism

Mustela putorius furo

Functional Description

Protein Length

524

Protein Sequence
(FASTA)

MNLVGEHQLT GHKVAVKILN RQKIRSLDVV GKIKREIQNL KLFRHPHIIK LYQVISTPTD 60

FFMVMEYVSG GELFDYICKH GRVEEVEARR LFQQILSAVD YCHRHMVVHR DLKPENVLLD 120

AHMNAKIADF GLSNMMSDGE FLRTSCGSPN YAAPEVISGR LYAGPEVDIW SCGVILYALL 180

CGTLPFDDEH VPTLFKKIRG GVFYIPEYLN RSVATLLMHM LQVDPLKRAT IKDIREHEWF 240

KQDLPSYLFP EDPSYDANVI DDEAVKEVCE KFECTESEVM NSLYSGDPQD QLAVAYHLII 300

DNRRIMNQAS EFYLASSPPS GSFMDDSTMH IPPGLKPHPE RMPPLIADSP KARCPLDALN 360

TTKPKSLAVK KAKWHLGIRS QSKPYDIMAE VYRAMKQLDF EWKVVNAYHL RVRRKNPVTG 420

NYVKMSLQLY LVDNRSYLLD FKSIDDEVVE QRSGSSTPQR SCSAAGLHRP RSSFDSVTAE 480

SHSLSGSLTG SLTGSTLSSV PPRLGSHTMD FFEMCASLIT TLAR 524

Nucleotide Sequence
(FASTA)

ATGAATTTGG TTGGAGAACA TCAATTGACA GGCCATAAAG TGGCAGTTAA AATCTTAAAT 60

AGACAGAAGA TTCGCAGTTT AGATGTTGTT GGAAAAATAA AACGAGAAAT TCAAAACCTA 120

AAACTCTTTC GTCATCCTCA TATTATCAAA CTATACCAGG TGATCAGCAC TCCAACAGAT 180

TTTTTTATGG TAATGGAATA TGTGTCTGGT GGTGAATTAT TTGACTACAT CTGTAAACAT 240

GGACGGGTTG AAGAGGTGGA AGCAAGGCGG CTCTTTCAGC AGATTCTGTC AGCTGTGGAT 300

TACTGCCATA GGCATATGGT GGTTCATCGA GACCTGAAAC CAGAGAATGT GCTGTTGGAT 360

GCTCACATGA ATGCCAAGAT AGCCGATTTT GGATTGTCTA ATATGATGTC AGATGGTGAA 420

TTTCTGCGAA CTAGTTGTGG GTCTCCAAAT TATGCAGCAC CTGAAGTCAT CTCAGGCAGA 480

TTGTATGCAG GTCCTGAGGT TGATATCTGG AGCTGTGGTG TTATTTTATA TGCCCTTCTT 540

TGTGGCACCC TCCCATTTGA TGATGAGCAT GTACCTACGT TATTTAAGAA GATCCGAGGG 600

GGTGTTTTTT ATATCCCAGA ATATCTCAAT CGTTCTGTTG CCACTCTTTT GATGCATATG 660

CTGCAGGTTG ATCCCCTGAA ACGAGCAACC ATCAAAGATA TAAGAGAGCA TGAATGGTTT 720

AAACAAGATT TGCCCAGTTA CTTATTTCCT GAAGACCCCT CCTATGATGC TAACGTCATT 780

GATGATGAGG CTGTGAAAGA AGTGTGTGAA AAATTTGAGT GTACAGAATC AGAAGTAATG 840

AACAGTTTAT ATAGTGGTGA CCCTCAAGAC CAGCTTGCAG TGGCTTATCA TCTTATCATT 900

GACAATCGGA GAATAATGAA CCAAGCCAGT GAGTTCTACC TCGCCTCTAG TCCCCCATCT 960

GGTTCTTTTA TGGATGATAG TACCATGCAT ATTCCCCCAG GCCTGAAACC TCATCCAGAA 1020

AGGATGCCAC CCCTTATAGC AGACAGTCCT AAAGCGAGAT GTCCATTGGA TGCACTGAAT 1080

ACAACTAAGC CCAAATCTTT AGCTGTGAAA AAAGCCAAGT GGCATCTTGG AATCAGAAGT 1140

CAAAGCAAAC CGTATGACAT TATGGCTGAA GTCTACCGAG CTATGAAGCA GCTGGATTTT 1200

GAATGGAAGG TAGTGAATGC ATACCATCTT CGTGTAAGAA GAAAAAATCC AGTGACTGGC 1260

AATTATGTGA AAATGAGCTT ACAACTTTAT CTGGTTGACA ACAGAAGCTA TCTTTTGGAC 1320

TTTAAAAGCA TTGATGATGA GGTGGTGGAG CAGAGGTCTG GTTCTTCAAC ACCTCAGCGT 1380

TCCTGTTCTG CTGCTGGCTT ACATAGACCA AGATCAAGTT TTGATTCTGT AACTGCGGAG 1440

AGCCATTCAC TTTCTGGCTC TCTCACTGGC TCTTTGACTG GAAGCACATT GTCTTCAGTT 1500

CCACCCCGTC TAGGCAGTCA CACCATGGAT TTTTTTGAAA TGTGTGCCAG TCTTATCACT 1560

ACTTTAGCCC GTTGA 1575

Domain Profile

S: 18    akhketkekvavKiikkkkl.seeslekikrEieilkklkhpniikllevietkkklylv  76

          +h++t++kvavKi++++k+ s + + kikrEi+ lk ++hp+iikl++vi+t +++++v

Q: 5     GEHQLTGHKVAVKILNRQKIrSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMV  64

         5799***************96667788*********************************

S: 77    leyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkken  136

         +ey+sggeLfdyi ++gr++e ear+lf+q++sav+Y+h++ +vHrDlKpeN+lld+++n

Q: 65    MEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMN  124

         ************************************************************

S: 137   ikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgkl  196

          kiaDFGl+n++++g+ l+t+cGsp+YaaPe+++g+ Y gp+vD+Ws+Gv+Lyal++g+l

Q: 125   AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTL  184

         ************************************************************

S: 197   PfdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         Pfd+e++ +l++ki  g + ip++l++++++Ll ++L+vdp kRati++i++hew+

Q: 185   PFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF  240

         *******************************************************7

Domain Sequence
(FASTA)

GEHQLTGHKV AVKILNRQKI RSLDVVGKIK REIQNLKLFR HPHIIKLYQV ISTPTDFFMV 60

MEYVSGGELF DYICKHGRVE EVEARRLFQQ ILSAVDYCHR HMVVHRDLKP ENVLLDAHMN 120

AKIADFGLSN MMSDGEFLRT SCGSPNYAAP EVISGRLYAG PEVDIWSCGV ILYALLCGTL 180

PFDDEHVPTL FKKIRGGVFY IPEYLNRSVA TLLMHMLQVD PLKRATIKDI REHEWF 236

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0004679	; F:AMP-activated protein kinase activity
GO:0003682	; F:chromatin binding
GO:0035174	; F:histone serine kinase activity
GO:0042149	; P:cellular response to glucose starvation
GO:0042593	; P:glucose homeostasis
GO:0008610	; P:lipid biosynthetic process
GO:0043066	; P:negative regulation of apoptotic process
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0010508	; P:positive regulation of autophagy
GO:0042752	; P:regulation of circadian rhythm

KEGG

InterPros

Pfam

SMARTs

Prosites

Prints

Created Date

20-Feb-2013