EKS-MUP-00387

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00387

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.3	3.4E-97	1074	1338	265

Status

Unreviewed

Ensembl Protein

ENSMPUP00000007437

UniProt Accession

G9K9G9;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 1;

Gene Name

MAP3K1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000007493	ENSMPUP00000007437	ENSMPUT00000007557

Organism

Mustela putorius furo

Functional Description

Protein Length

1343

Protein Sequence
(FASTA)

MESKETLKGL HKMDDRPEER MIREKLKATC MPAWKHEWLE RRNRRGPVVV KPIPIKGDGS 60

EIHNLATESQ GEGQASTMSP APKGRRSPSP GSSPSGRSVK SESPGVRRKR VSPVPFQSGR 120

VTPPRRAPSP DGFSPYSPEE TNRRVNKVMR ARLYLLQQIG PNSFLIGGDS PDNKYRVFIG 180

PQNCSCGRGT FCIHLLFVML RVFQLEPSDP MLWRKTLKNF EVESLFQKYH SRRSSRIKAP 240

SRNTIQKFVS RMSNSHTLSS SSTSTSSSEN SIKDEEEQMC PICLLGMLDE ESLTVCEDGC 300

RNKLHHHCMS IWAEECRRNR EPLICPLCRS KWRSHDFYSH ELSSPVDSPS SLRAAQQQTV 360

HQQSLAGSQR RSQESNFNLT HYGTQQIPPA YKDLAEPWIQ VFGMELVGCL FSRNWNIREM 420

ALRRLSHDVS GALLLANGES TGNSGSNGRS SPSAGASGSS QTSISGDVVE ACCNVLSMVC 480

ADPVYKVYVA ALKTLRAMLV YTPCHSLAER IKLQRLLRPV VDTILVKCAD ANSRTSQLSI 540

STLLELCKGQ AGELAVGREI LKAGSIGIGG VDYVLSCILG NQTESNNWQE LLGRLCLIDR 600

LLLEFPAEFY PHIVSTDVSQ AEPVDVRYKK LLSLLTFALQ SIDNSHSMVG KLSRRIYLSS 660

ARMVTAVPHV FSKLLEMLNV SSSTHFTRMR RRLIAIADEV EIAEAIQLGV GDALEDRHDS 720

FLQVAVPTSY PETTENSSLE HTDHLEKTGK GLCATKLSAT SEDITDRLGS ISVGLPSSTT 780

MEQPKPMVQT KGRPHSQCLN TSPLSHHSPL MFPPLSTPPS SAPSAPTGTG TDVSKHRPQG 840

FIPCKIPSAS PQTQRKFSLQ FQRNCSENRD SDKSSPIFTQ SRPLPSSNIH RPKPSRPSPG 900

NSSKQGEVSK NSMTLDLNST AKCEDSFGSS NSSNAVIPSD ETVFTPVEEK CRLDVNTELN 960

SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE KDENDDTYKD DVNHNQKCKE KMEAEEEEAL 1020

AIAMAMSASQ DALPIVPQLQ VENGEDIIII QQDTPETLPG HTKAKQPYRE DTEWLKGQQI 1080

GLGAFSSCYQ AQDVGTGTLM AVKQVTYVRN TSSEQEEVVE ALREEIRMMS HLNHPNIIRM 1140

LGATCEKSNY NLFIEWMAGG SVAHLLSKYG AFKESVVINY TEQLLRGLSY LHENQIIHRD 1200

VKGANLLIDS TGQRLRIADF GAAARLASKG TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS 1260

CDVWSVGCAI IEMACAKPPW NAEKHSNHLA LIFKIASATT APSIPSHLSP GLRDVALRCL 1320

ELQPQDRPPS RELLKHPVFR TTW 1343

Nucleotide Sequence
(FASTA)

ATGGAGAGTA AAGAAACTCT CAAGGGCTTG CACAAGATGG ACGATCGCCC AGAAGAACGA 60

ATGATCAGGG AGAAACTGAA GGCAACCTGT ATGCCAGCCT GGAAGCATGA GTGGCTGGAA 120

AGGAGAAACC GGAGAGGCCC TGTGGTGGTA AAACCAATCC CTATTAAAGG AGATGGTTCT 180

GAAATTCACA ACTTGGCAAC TGAGTCACAA GGAGAGGGCC AGGCGAGCAC CATGTCACCC 240

GCTCCCAAAG GCCGACGTAG TCCTTCTCCT GGCAGCTCCC CATCGGGTCG CTCAGTGAAG 300

TCGGAATCTC CAGGAGTTCG GAGAAAAAGA GTTTCTCCAG TGCCTTTTCA GAGTGGGCGA 360

GTCACACCAC CTCGAAGAGC CCCTTCACCA GATGGCTTCT CACCATACAG CCCTGAGGAG 420

ACAAACCGCC GTGTAAACAA AGTTATGCGG GCCAGGCTGT ACTTATTGCA ACAAATAGGA 480

CCCAACTCTT TCCTAATTGG AGGAGACAGC CCAGACAACA AATACCGGGT GTTTATTGGG 540

CCTCAGAACT GCAGCTGTGG CCGTGGAACT TTTTGTATTC ATCTGTTGTT TGTTATGCTC 600

CGGGTGTTTC AACTAGAACC TTCAGACCCA ATGTTATGGA GAAAAACTTT AAAGAATTTT 660

GAGGTTGAAA GTTTGTTCCA GAAATACCAC AGTAGGCGTA GCTCAAGGAT CAAAGCTCCA 720

TCTCGTAACA CCATCCAGAA GTTTGTTTCA CGCATGTCAA ATTCTCATAC ATTGTCATCA 780

TCTAGTACTT CTACATCTAG TTCAGAAAAC AGTATAAAAG ATGAGGAGGA ACAGATGTGT 840

CCTATATGCT TGTTGGGCAT GCTTGATGAA GAGAGTCTTA CCGTGTGTGA AGATGGCTGC 900

AGGAACAAGC TGCATCATCA CTGCATGTCA ATCTGGGCAG AAGAATGTAG AAGAAATAGA 960

GAACCTTTGA TATGTCCTCT TTGTAGGTCT AAGTGGAGAT CTCATGATTT CTACAGCCAC 1020

GAGCTGTCAA GCCCTGTGGA TTCCCCTTCT TCCCTGCGAG CTGCACAGCA GCAAACAGTA 1080

CATCAGCAAT CTTTGGCTGG ATCCCAACGG AGGAGTCAGG AGAGCAATTT TAACCTTACA 1140

CATTATGGAA CTCAGCAGAT TCCCCCTGCT TACAAAGATT TAGCTGAGCC ATGGATTCAG 1200

GTATTTGGAA TGGAACTCGT TGGCTGCTTA TTTTCTAGAA ACTGGAATAT AAGAGAGATG 1260

GCTCTCAGGC GTCTTTCCCA CGATGTTAGT GGGGCTCTGC TATTGGCAAA TGGGGAGAGC 1320

ACTGGAAATT CTGGGAGCAA CGGTAGAAGC AGCCCAAGTG CTGGGGCCAG CGGGTCTTCC 1380

CAGACCAGTA TCTCAGGAGA CGTGGTAGAG GCATGCTGCA ACGTTTTGTC AATGGTCTGT 1440

GCCGACCCTG TCTACAAAGT GTACGTTGCT GCTTTAAAAA CATTGAGAGC CATGCTAGTA 1500

TATACCCCTT GCCATAGTTT GGCAGAAAGA ATCAAACTGC AGAGACTTCT CCGGCCAGTT 1560

GTAGACACCA TCCTAGTCAA GTGTGCAGAT GCCAATAGTC GTACAAGTCA GCTGTCTATA 1620

TCGACACTGT TGGAATTATG CAAAGGCCAA GCAGGAGAGT TGGCAGTTGG CAGAGAAATA 1680

CTTAAAGCTG GATCCATTGG TATTGGTGGT GTTGATTATG TCTTAAGTTG TATTCTTGGA 1740

AACCAAACTG AATCAAACAA CTGGCAAGAA CTTCTGGGCC GCCTTTGCCT TATAGACAGA 1800

CTGCTCTTGG AATTTCCTGC TGAATTTTAC CCTCATATTG TCAGTACTGA TGTTTCACAA 1860

GCTGAGCCTG TTGATGTCAG GTATAAAAAG CTGCTGTCCC TCTTAACCTT TGCTTTGCAG 1920

TCCATTGATA ATTCCCACTC AATGGTTGGT AAACTCTCCC GAAGGATATA TCTGAGTTCC 1980

GCAAGAATGG TTACTGCAGT CCCCCACGTA TTTTCAAAAC TATTAGAAAT GCTGAATGTT 2040

TCCAGTTCCA CTCATTTTAC CAGGATGCGT CGTCGTTTGA TAGCTATTGC AGATGAGGTG 2100

GAAATTGCTG AGGCCATCCA GCTAGGCGTA GGAGACGCTT TGGAGGATCG ACATGACAGC 2160

TTTTTACAGG TGGCTGTCCC AACCAGTTAC CCAGAAACCA CAGAGAACAG CTCCCTTGAG 2220

CACACAGACC ATTTAGAGAA AACTGGAAAA GGACTATGTG CTACAAAACT GAGTGCCACT 2280

TCAGAGGACA TTACTGACAG ACTGGGCAGC ATTTCAGTAG GACTTCCCAG TTCAACAACA 2340

ATGGAGCAAC CAAAGCCAAT GGTTCAAACA AAAGGCAGAC CCCACAGTCA GTGTTTGAAC 2400

ACCTCTCCTT TATCTCATCA TTCCCCATTA ATGTTTCCAC CCTTGTCAAC TCCTCCTTCA 2460

TCTGCCCCCT CTGCACCAAC TGGCACTGGA ACGGATGTCT CTAAGCATAG ACCTCAGGGA 2520

TTCATTCCCT GCAAAATACC TTCCGCATCT CCTCAGACAC AGCGAAAATT TTCTCTACAG 2580

TTCCAGAGAA ACTGTTCGGA AAACAGAGAC TCAGATAAAT CTTCCCCCAT CTTTACTCAG 2640

TCCAGACCCC TGCCCTCTAG TAATATACAC AGGCCAAAGC CATCTCGACC TTCCCCAGGT 2700

AATTCAAGTA AACAGGGAGA GGTCTCAAAG AATAGCATGA CACTTGATCT GAACAGTACT 2760

GCCAAATGTG AGGACAGCTT TGGCAGCAGC AATAGCAGTA ATGCTGTCAT ACCCAGTGAT 2820

GAGACAGTGT TCACCCCAGT AGAAGAGAAA TGCAGACTAG ATGTCAATAC AGAGCTCAAC 2880

TCCAGTATTG AGGACCTTCT TGAAGCATCT ATGCCTTCAA GTGATACAAC AGTAACTTTT 2940

AAGTCAGAAG TTGCTGTGCT CTCCCCTGAA AAGGATGAAA ATGATGATAC CTACAAAGAT 3000

GACGTGAATC ATAATCAAAA ATGCAAAGAA AAGATGGAAG CTGAAGAAGA AGAAGCTTTA 3060

GCAATTGCCA TGGCAATGTC AGCGTCTCAG GATGCCCTCC CCATAGTTCC TCAACTACAA 3120

GTTGAAAATG GAGAAGATAT CATCATTATT CAACAGGATA CACCAGAAAC TCTACCAGGA 3180

CATACCAAAG CAAAACAACC TTACAGAGAA GACACTGAAT GGCTGAAGGG TCAGCAGATA 3240

GGCCTTGGAG CATTTTCTTC CTGTTACCAG GCTCAAGATG TGGGAACTGG AACATTAATG 3300

GCTGTTAAAC AGGTGACATA TGTCAGAAAT ACATCTTCTG AGCAAGAGGA AGTAGTGGAA 3360

GCATTAAGAG AAGAGATCAG AATGATGAGC CATTTGAATC ATCCCAACAT CATTAGGATG 3420

TTGGGAGCCA CATGTGAGAA AAGCAATTAT AATCTCTTCA TCGAATGGAT GGCAGGGGGA 3480

TCTGTGGCTC ATTTGCTCAG TAAATATGGA GCCTTCAAGG AATCAGTAGT TATTAATTAT 3540

ACTGAACAGT TACTTCGTGG CCTTTCATAT CTCCATGAAA ACCAGATCAT TCATAGAGAT 3600

GTCAAAGGTG CCAATTTGCT AATTGACAGC ACAGGTCAGA GACTGAGAAT TGCAGATTTC 3660

GGAGCTGCAG CCAGGTTGGC ATCAAAAGGA ACTGGTGCAG GAGAGTTTCA GGGACAGTTA 3720

TTGGGGACAA TTGCATTTAT GGCACCTGAG GTACTAAGAG GTCAGCAGTA TGGTAGGAGC 3780

TGTGACGTAT GGAGTGTTGG CTGTGCCATT ATAGAAATGG CTTGTGCTAA ACCACCTTGG 3840

AATGCAGAAA AACACTCCAA TCATCTTGCT TTGATATTTA AGATTGCAAG TGCAACTACT 3900

GCTCCATCGA TCCCTTCACA TTTGTCTCCT GGTTTACGAG ATGTGGCTCT TCGGTGTTTA 3960

GAACTTCAAC CTCAGGACCG ACCTCCGTCA AGAGAGCTAC TGAAGCATCC AGTCTTCCGT 4020

ACTACTTGGT AG 4032

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1074  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1133

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1134  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1193

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1194  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1253

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1254  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1311

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1312  LRDVALRCLELQPQDRPPSRELLKHPV  1338

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013