EKS-MUP-00299

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00299

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	321.8	2.0E-96	1471	1689	219

Status

Unreviewed

Ensembl Protein

ENSMPUP00000007803

UniProt Accession

G9KVC2;

Protein Name

Protein Synonyms/Alias

Transient receptor potential cation channel, subfamily M, member 7;

Gene Name

Trpm7

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000007861	ENSMPUP00000007803	ENSMPUT00000007928

Organism

Mustela putorius furo

Functional Description

Protein Length

1738

Protein Sequence
(FASTA)

MELPKLVISV HGGMQKFELH PRIKQLLGKG LIKAAVTTGA WILTGGVNTG VAKHVGDALK 60

EHASRSSRKI CTIGIAPWGV IENRNDLVGR DVVAPYQTLL NPLSKLNVLN NLHSHFILVD 120

DGTVGKYGAE VRLRRELEKT INQQRIHARI GQGVPVVALI FEGGPNVILT VLEYLQESPP 180

VPVVVCEGTG RAADLLAYIH KQTEEGGNLP DAAEPDIIST IKKTFNFGQS EAVHLFQTLM 240

ECMKRKELIT VFHIGSDEHQ DIDVAILTAL LKGTNASAFD QLILTLAWDR VDIAKNHVFV 300

YGQQWLVGSL EQAMLDALVM DRVAFVKLLI ENGVSMHKFL TIPRLEELYN TKQGPTNPML 360

FHLVRDVKQG NLPPGYKITL IDIGLVIEYL MGGTYRCTYT RKRFRLIYNS LGGNNRRSGR 420

NTSSSTPQLR KSHESFGNRA DKKEKMRHNH FIKTAQPYRP KIDTAVEEGK KKRAKDEIVD 480

IDDPETKRFP YPLNELLIWA CLMKRQVMAR FLWQHGEESM AKALVACKIY RSMAYEAKQS 540

DLVDDTSEEL KQYSNDFGQL AVELLEQSFR QDETMAMKLL TYELKNWSNS TCLKLAVSSR 600

LRPFVAHTCT QMLLSDMWMG RLNMRKNSWY KVILSILVPP AILMLEYKTK AEMSHIPQSQ 660

DAHQMTMEDS ENNFQNIAEE IPMEVFKEVR ILDSNEGKNE MEIQIKSKKL PITRKFYAFY 720

HAPIVKFWFN TLAYLGFLML YTFVVLVQME RLPSVQEWIV IAYIFTYAIE KVREIFMSEA 780

GKISQKIKVW FSDYFNISDT IAIISFFIGF GLRFGAKWNF ENAYDNHVFV AGRLIYCLNI 840

IFWYVRLLDF LAVNQQAGPY VMMIGKMVAN MFYIVVIMAL VLLSFGVPRK AILYPREAPS 900

WTLAKDIVFH PYWMIFGEVY AYEIDVCAND STISQICGPG TWLTPFLQAV YLFVQYIIMV 960

NLLIAFFNNV YLQVKAISNI VWKYQRYHFI MAYHEKPVLP PPLIILSHIV SLFCCICKRR 1020

KKDKTSDGPK LFLTEEDQKK LHDFEEQCVE MYFNEKDDKF HSGSEERIRV TFERVEQMCI 1080

QIKEVGDRVN YIKRSLQSLD SQIGHLQDLS ALTVDTLKTL TAQKASEASK VHNEITRELS 1140

ISKHLAQNLI DDGPVRPSVW KKHSVVNTLS TSLPQGGLES TNPFLCNIFM KDEKDPQCNI 1200

FGQDLPVIPQ RKEFNFPEAG SSCGALFPSA ISPPELRQRI HGVEMLKMFS KNQKLGSSSN 1260

SIPHLSSPPT KFFVSTPSQP SCKSHLETVT KDQEIVCAKA AEGDNVEFGA FVGHRDSIDY 1320

LQKFKEASNK IKEILSNDVP SENTLKHVSS HGGFTECRKT SIPLHSEQVE SSSRRPSTQE 1380

THEVDSKAAL LPDWLQDRPS NRDLPTEEGT LNGLASPFKP VMDTNYYYSA VERNNLMRLS 1440

QSIPFTPVPP RGEPVTVYRL EESSPSILNN SMSSWSQLGL CAKIEFLSKE EMGGGLRRAV 1500

KVQCTWSEHD ILKSGHLYII KSFLPEVVNT WSSIYKEDTV LHLCLREIQQ QRAAQKLTFA 1560

FNQMKPKSIP YSPRFLEVFL LYCHSAGQWF AVEECMTGEF RKYNNNNGDE IIPTNTLEEI 1620

MLAFSHWTYE YTRGELLVLD LQGVGENLTD PSVIKAEEKR SCDMVFGPAN LGEDAIKNFR 1680

AKHHCNSCCR KLKLPDLKRN DYTPDKILFP QDEPSDLTLQ PGNSTKESES TNSIRLML 1738

Nucleotide Sequence
(FASTA)

ATGGAATTAC CCAAACTTGT TATCTCTGTG CATGGGGGCA TGCAGAAATT TGAGCTTCAC 60

CCACGAATCA AGCAGCTGCT TGGAAAGGGT CTCATTAAAG CTGCAGTTAC AACCGGAGCC 120

TGGATTTTAA CTGGAGGAGT AAACACAGGT GTGGCAAAAC ATGTTGGTGA TGCCCTCAAA 180

GAACATGCTT CCAGATCATC TCGAAAGATT TGCACTATTG GAATAGCACC CTGGGGTGTG 240

ATTGAAAACA GAAATGATCT TGTCGGGAGA GATGTGGTTG CTCCTTATCA AACCTTGTTG 300

AACCCTCTGA GCAAATTGAA TGTTCTGAAT AATCTGCATT CCCATTTCAT ATTGGTGGAT 360

GATGGCACTG TTGGAAAGTA TGGGGCAGAA GTCAGATTGA GAAGAGAACT TGAAAAAACT 420

ATTAATCAGC AAAGAATTCA TGCTAGAATT GGACAAGGTG TCCCTGTGGT GGCACTTATA 480

TTTGAGGGCG GGCCAAATGT TATCCTCACA GTTTTAGAAT ATCTTCAAGA AAGTCCTCCT 540

GTTCCAGTCG TCGTTTGTGA AGGAACGGGC AGAGCTGCAG ATCTCCTAGC ATATATTCAT 600

AAACAAACAG AAGAGGGAGG CAATCTTCCT GATGCAGCAG AACCCGATAT TATTTCAACC 660

ATCAAAAAGA CATTTAACTT TGGCCAGAGT GAAGCAGTTC ATTTATTTCA GACATTGATG 720

GAGTGCATGA AAAGAAAGGA GCTTATCACG GTTTTCCACA TTGGATCAGA TGAACATCAA 780

GATATAGATG TAGCAATACT TACTGCACTG CTTAAAGGCA CTAATGCATC TGCATTTGAC 840

CAGCTCATCC TTACGTTGGC ATGGGATAGA GTTGACATTG CCAAAAATCA CGTGTTTGTT 900

TATGGACAGC AGTGGCTGGT TGGGTCCTTG GAACAAGCTA TGCTTGATGC TCTTGTAATG 960

GATAGAGTTG CATTTGTGAA ACTTCTTATT GAAAATGGAG TAAGCATGCA TAAATTCCTT 1020

ACCATTCCTA GACTGGAAGA ACTTTATAAC ACAAAACAAG GTCCAACTAA TCCAATGCTA 1080

TTTCATCTTG TTCGAGATGT CAAACAGGGG AATCTTCCTC CAGGATATAA GATCACCCTA 1140

ATCGATATAG GACTTGTTAT TGAATATCTT ATGGGAGGAA CCTATAGATG CACCTATACT 1200

CGGAAACGTT TTCGATTAAT ATATAATAGT CTTGGTGGAA ATAATCGGAG GTCTGGCCGA 1260

AATACCTCCA GCAGCACTCC TCAGTTGCGT AAGAGTCATG AATCTTTTGG CAATAGGGCA 1320

GATAAAAAGG AAAAAATGAG ACACAATCAT TTCATTAAAA CGGCACAGCC CTATCGACCA 1380

AAGATTGATA CAGCTGTTGA AGAAGGAAAG AAGAAAAGAG CCAAAGATGA AATTGTAGAT 1440

ATTGATGATC CAGAAACCAA GCGCTTTCCT TATCCACTTA ATGAACTGTT AATTTGGGCT 1500

TGCCTTATGA AGAGACAGGT CATGGCCCGG TTTTTATGGC AGCATGGTGA AGAATCAATG 1560

GCTAAAGCCT TAGTAGCCTG TAAGATCTAT CGTTCAATGG CCTATGAAGC AAAACAGAGT 1620

GACCTTGTAG ATGATACTTC AGAGGAATTG AAACAGTATT CTAATGATTT TGGTCAACTA 1680

GCAGTTGAAT TACTAGAACA ATCCTTCAGA CAAGATGAAA CCATGGCAAT GAAATTGCTC 1740

ACTTATGAAC TGAAAAACTG GAGTAATTCC ACCTGCCTCA AGTTAGCAGT GTCTTCAAGA 1800

CTTAGACCTT TTGTAGCTCA CACCTGTACA CAGATGTTGT TATCTGATAT GTGGATGGGA 1860

AGGCTGAATA TGAGGAAAAA TTCCTGGTAC AAGGTCATAC TAAGCATTTT AGTTCCACCT 1920

GCCATATTAA TGCTGGAATA TAAAACAAAG GCTGAGATGT CTCATATTCC ACAATCTCAA 1980

GATGCCCATC AAATGACAAT GGAAGATAGC GAAAACAACT TTCAAAACAT AGCAGAAGAG 2040

ATTCCCATGG AGGTGTTTAA AGAAGTAAGA ATATTGGACA GTAATGAAGG AAAGAATGAA 2100

ATGGAAATAC AAATAAAATC AAAAAAGCTT CCCATTACAA GAAAGTTCTA TGCCTTTTAT 2160

CATGCACCAA TTGTAAAATT CTGGTTTAAT ACGTTGGCAT ACTTAGGATT TCTGATGCTT 2220

TATACATTTG TAGTTCTTGT ACAAATGGAA CGATTACCTT CAGTTCAAGA ATGGATTGTT 2280

ATTGCTTATA TTTTTACCTA TGCTATTGAG AAAGTCCGTG AGATCTTTAT GTCTGAAGCT 2340

GGAAAAATAA GCCAGAAGAT TAAAGTGTGG TTTAGTGATT ACTTCAATAT CAGTGATACA 2400

ATTGCCATAA TTTCTTTCTT CATTGGATTT GGACTAAGAT TTGGAGCAAA ATGGAACTTT 2460

GAGAATGCAT ATGATAATCA TGTTTTTGTT GCTGGAAGAT TAATTTACTG TCTTAACATA 2520

ATATTTTGGT ATGTGCGTTT GCTAGATTTT CTAGCTGTAA ATCAACAGGC AGGACCTTAT 2580

GTAATGATGA TTGGAAAAAT GGTAGCCAAT ATGTTCTACA TTGTAGTGAT TATGGCTCTT 2640

GTATTACTTA GTTTTGGTGT TCCCAGAAAG GCAATACTTT ATCCTCGTGA AGCACCATCT 2700

TGGACTCTTG CTAAAGATAT AGTTTTTCAT CCATACTGGA TGATTTTTGG TGAAGTTTAC 2760

GCATATGAAA TTGATGTGTG TGCAAATGAT TCCACTATCT CTCAAATCTG TGGTCCTGGA 2820

ACATGGTTGA CTCCATTTCT TCAAGCAGTC TACCTCTTTG TACAGTATAT CATTATGGTC 2880

AATCTTCTTA TTGCATTTTT CAACAATGTG TATTTACAAG TGAAGGCAAT TTCCAATATT 2940

GTATGGAAGT ACCAACGTTA TCATTTTATT ATGGCTTATC ATGAGAAACC TGTTCTGCCT 3000

CCACCACTTA TCATTCTTAG CCATATAGTT TCTTTGTTTT GCTGCATATG TAAAAGAAGA 3060

AAAAAAGATA AGACTTCAGA TGGACCAAAA CTTTTTTTAA CAGAAGAAGA TCAAAAGAAA 3120

CTACATGACT TTGAAGAACA GTGTGTTGAG ATGTATTTTA ATGAAAAAGA TGACAAATTC 3180

CATTCTGGGA GTGAAGAGAG AATTCGTGTC ACTTTTGAAA GGGTGGAGCA GATGTGCATT 3240

CAAATTAAAG AAGTTGGAGA TCGTGTCAAC TATATAAAAA GATCATTACA GTCGTTAGAT 3300

TCTCAAATTG GCCATTTGCA AGATCTTTCA GCCCTGACTG TAGATACATT AAAAACACTC 3360

ACTGCTCAGA AAGCTTCGGA AGCTAGCAAA GTTCACAATG AAATCACACG AGAATTGAGC 3420

ATTTCCAAAC ATTTGGCTCA AAATCTTATT GACGATGGCC CTGTAAGACC TTCTGTATGG 3480

AAAAAGCACA GTGTTGTAAA TACACTTAGC ACCTCGCTTC CTCAAGGTGG TCTTGAAAGT 3540

ACTAATCCCT TTCTTTGTAA TATTTTTATG AAAGATGAAA AAGATCCCCA ATGTAATATA 3600

TTTGGTCAGG ATTTACCTGT GATACCCCAG AGAAAAGAAT TCAATTTCCC AGAGGCTGGT 3660

TCCTCTTGTG GTGCCTTATT CCCAAGTGCT ATTTCTCCTC CAGAACTGCG ACAGAGAATA 3720

CATGGGGTAG AAATGTTAAA AATGTTCAGT AAAAATCAAA AATTAGGCAG TTCTTCTAAC 3780

AGCATACCAC ATCTGTCGTC CCCTCCAACC AAATTTTTTG TTAGTACACC TTCCCAGCCA 3840

AGCTGTAAAA GCCACTTAGA AACTGTAACC AAAGATCAAG AAATTGTTTG CGCTAAAGCT 3900

GCAGAAGGGG ATAATGTAGA ATTTGGAGCA TTTGTAGGAC ACAGAGATAG CATAGATTAT 3960

TTACAGAAGT TTAAAGAAGC ATCGAACAAG ATAAAAGAAA TATTATCCAA TGATGTTCCT 4020

TCTGAAAACA CTTTGAAACA TGTGAGTTCT CATGGTGGAT TTACTGAATG TCGCAAAACT 4080

TCTATTCCTC TTCATTCAGA ACAAGTGGAA AGTAGCAGTA GAAGGCCATC TACACAAGAA 4140

ACTCATGAAG TAGATTCCAA AGCAGCTTTA CTACCGGATT GGTTACAAGA TAGACCATCA 4200

AACAGAGACC TGCCAACTGA AGAAGGAACA TTAAATGGTC TCGCTTCTCC ATTTAAACCA 4260

GTTATGGATA CAAATTACTA CTACTCAGCT GTGGAAAGAA ATAATTTGAT GAGATTATCC 4320

CAGAGCATTC CATTTACTCC TGTGCCTCCA AGAGGTGAGC CTGTCACAGT ATATCGCTTG 4380

GAAGAAAGTT CACCCAGTAT ACTGAATAAC AGCATGTCTT CTTGGTCACA GCTTGGCCTC 4440

TGTGCCAAAA TAGAGTTTTT AAGTAAAGAG GAGATGGGAG GCGGTTTACG GAGAGCTGTC 4500

AAAGTACAGT GTACCTGGTC AGAACATGAT ATCCTCAAAT CAGGTCATCT TTATATTATC 4560

AAATCTTTTC TTCCTGAGGT GGTTAACACA TGGTCAAGTA TTTATAAAGA AGATACAGTT 4620

CTGCATCTCT GTCTCAGAGA AATTCAGCAA CAGAGAGCAG CACAGAAGCT CACATTTGCC 4680

TTCAACCAGA TGAAACCCAA ATCCATACCA TATTCTCCAA GGTTCCTTGA AGTTTTCCTG 4740

CTGTATTGCC ATTCAGCAGG ACAGTGGTTT GCTGTGGAAG AATGTATGAC TGGAGAATTT 4800

AGAAAATACA ACAATAATAA TGGTGATGAG ATTATTCCAA CTAATACACT GGAAGAGATC 4860

ATGCTAGCCT TTAGCCACTG GACTTATGAA TATACAAGAG GGGAGTTACT GGTACTTGAT 4920

TTACAAGGTG TGGGTGAAAA TTTGACTGAT CCATCTGTGA TTAAAGCAGA AGAAAAGAGA 4980

TCCTGTGATA TGGTTTTTGG CCCAGCAAAT CTAGGTGAAG ATGCAATAAA AAACTTCAGA 5040

GCAAAACATC ACTGTAATTC TTGTTGTAGA AAGCTTAAAC TTCCAGATCT GAAGAGGAAT 5100

GACTATACAC CTGATAAAAT TCTGTTTCCT CAGGATGAGC CTTCAGATTT GACTCTTCAG 5160

CCTGGAAATT CCACCAAAGA ATCAGAATCA ACTAATTCTA TTCGTCTGAT GTTATAA 5217

Domain Profile

S: 1     ssesWsqqetivlikvlskeekkGalRkalrv..........kkgslflvkeelkevvry  50

         s++sWsq +++++i++lskee+ G+lR+a++v          k+g+l+++k++l+evv++

Q: 1471  SMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVqctwsehdilKSGHLYIIKSFLPEVVNT  1530

         699*********************************************************

S: 51    vakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqll  110

         +++iyke++vlhl+lr++++qraaqkl+++fnq+kPk+i+y+pr++evfL +++s++q++

Q: 1531  WSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWF  1590

         ************************************************************

S: 111   tvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTD  170

         +vEe+++Gef+Kynnnngdei+++n+lee+mlafsH+tyeyt+gellV+DlqGvge+lTD

Q: 1591  AVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTD  1650

         ************************************************************

S: 171   pqiat....ksrgtkfgkanlgeraiknFfakhhCNeiC  205

         p++++    +s++++fg+anlge+aiknF+akhhCN++C

Q: 1651  PSVIKaeekRSCDMVFGPANLGEDAIKNFRAKHHCNSCC  1689

         *****99999*****************************

Domain Sequence
(FASTA)

SMSSWSQLGL CAKIEFLSKE EMGGGLRRAV KVQCTWSEHD ILKSGHLYII KSFLPEVVNT 60

WSSIYKEDTV LHLCLREIQQ QRAAQKLTFA FNQMKPKSIP YSPRFLEVFL LYCHSAGQWF 120

AVEECMTGEF RKYNNNNGDE IIPTNTLEEI MLAFSHWTYE YTRGELLVLD LQGVGENLTD 180

PSVIKAEEKR SCDMVFGPAN LGEDAIKNFR AKHHCNSCC 219

Keyword

Receptor.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0001726	; C:ruffle
GO:0005262	; F:calcium channel activity
GO:0016301	; F:kinase activity
GO:0031032	; P:actomyosin structure organization
GO:0016340	; P:calcium-dependent cell-matrix adhesion
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

Pfam

SMARTs

Prosites

Prints

Created Date

20-Feb-2013