EKS-MUP-00167
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00167
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb443.52.2E-133449709261
StatusUnreviewed
Ensembl ProteinENSMPUP00000007988
UniProt AccessionG9KLV0;
Protein Name
Protein Synonyms/Alias Ribosomal protein S6 kinase, 90kDa, polypeptide 5;
Gene NameRPS6KA5
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000008046ENSMPUP00000007988ENSMPUT00000008113
OrganismMustela putorius furo
Functional Description
Protein Length821
Protein Sequence
(FASTA)
MWQGAPLVLS ASYLFGSAHT VGFFTGPRVP PLDPRCLASG RMSALVSSLI GTKLDSTNLT 60
GHAEKVGIEN FELLKVLGTG AYGKVFLVRK ISGHDAGKLY AMKVLKKATI VQKAKTTEHT 120
RTERQVLEHI RQSPFLVTLH YAFQTETKLH LILDYINGGE LFTHLSQRER FTEHEVRIYV 180
GEIVLALEHL HKLGIIYRDI KLENILLDSN GHVVLTDFGL SKEFVAEEAE RAYSFCGTIE 240
YMAPDIVRGG DSGHDKAVDW WSLGVLMYEL LTGASPFTVD GEKNSQAEIS RRILKSEPPY 300
PQEMSALAKD LIQRLLMKDP KKRLGCGPRD ADEIKEHLFF QKINWDDLAA KKVPAPFKPV 360
IRDELDVSNF AEEFTEMDPT YSPAAVPQSS ERLFQGYSFV APSILFKRNA AVIDPLQFHM 420
GVERPGVTNV ARSAMMKDSP FYQHYDLDLK DKPLGEGSFS ICRKCTHKKS NQAFAVKIIS 480
KRMEANTQKE ITALKLCEGH PNIVRLHEVF HDQLHTFLVM ELLNGGELFE RIKKKKHFSE 540
TEASYIMRKL VSAVSHMHDV GVVHRDLKPE NLLFTDENDN LEIKVIDFGF ARLKPPDNQP 600
LKTPCFTLHY AAPELLNHNG YDESCDLWSL GVILYTMLSG QVPFQSHDKS LTCTSAVEIM 660
KKIKKGDFSF EGEAWKNVSQ EAKDLIQGLL TVDPNKRLKM SGLRYNEWLQ DGSQLSSNPL 720
MTPDILGSSG AAVQTCVKAT FHAFNKYKRE GFCLQNVDKA PLAKRRKMKK TSTSTETRSS 780
SSESSHSSSS HSHGKTTPTK TLPPGNPADP SNPDTLFQFS D 821
Nucleotide Sequence
(FASTA)
ATGTGGCAAG GTGCCCCCTT GGTACTCTCT GCCTCATACC TCTTTGGTAG TGCTCATACT 60
GTGGGCTTCT TCACTGGCCC GCGCGTGCCT CCGCTGGACC CACGCTGCTT GGCATCAGGG 120
AGGATGTCTG CTCTGGTGTC GTCACTGATT GGCACAAAAT TGGATTCAAC TAATTTAACT 180
GGACATGCCG AGAAGGTGGG GATTGAAAAT TTTGAGCTCC TCAAAGTCCT AGGAACCGGA 240
GCTTATGGAA AAGTATTTCT GGTTCGTAAA ATCAGCGGTC ACGATGCTGG CAAGCTGTAC 300
GCCATGAAAG TCTTGAAGAA GGCCACAATA GTGCAAAAGG CCAAAACCAC AGAGCACACA 360
AGGACCGAGC GGCAAGTCCT GGAGCACATC AGGCAATCAC CGTTCTTGGT GACCCTGCAC 420
TACGCTTTCC AGACAGAAAC CAAACTTCAT CTCATTTTAG ATTATATAAA TGGTGGAGAA 480
CTTTTTACTC ATCTTTCTCA AAGAGAGCGT TTCACAGAGC ACGAGGTACG GATCTATGTT 540
GGAGAGATCG TGCTTGCCCT CGAACATCTC CACAAGTTGG GAATTATATA CCGTGACATT 600
AAGCTTGAGA ACATTCTACT TGATTCTAAT GGCCATGTGG TGCTGACAGA TTTTGGTCTG 660
AGTAAGGAGT TTGTGGCTGA AGAAGCTGAA AGAGCATATT CCTTTTGTGG GACTATTGAA 720
TACATGGCTC CGGATATTGT CAGAGGGGGA GATTCAGGCC ATGACAAGGC AGTTGACTGG 780
TGGAGTTTAG GTGTTCTCAT GTATGAATTA CTAACTGGAG CATCTCCTTT CACTGTCGAT 840
GGGGAGAAGA ATTCCCAAGC TGAGATATCT CGGAGAATAT TAAAAAGTGA GCCTCCATAT 900
CCTCAAGAAA TGAGTGCTTT AGCTAAAGAC CTAATTCAGC GTCTTTTGAT GAAAGATCCC 960
AAGAAAAGAT TGGGATGTGG CCCACGTGAC GCGGATGAAA TCAAAGAACA TCTCTTTTTT 1020
CAGAAAATAA ATTGGGATGA TTTAGCCGCC AAAAAAGTGC CCGCGCCATT TAAGCCTGTC 1080
ATCCGAGACG AATTAGACGT GAGTAACTTT GCAGAAGAGT TCACGGAGAT GGACCCCACC 1140
TACTCCCCCG CAGCGGTGCC CCAGAGCTCC GAGAGGCTGT TCCAGGGCTA TTCCTTCGTT 1200
GCTCCTTCCA TTCTGTTCAA GCGCAACGCA GCTGTCATAG ACCCTCTTCA GTTTCACATG 1260
GGAGTTGAAC GTCCTGGGGT GACCAATGTT GCCAGGAGCG CAATGATGAA GGACTCCCCG 1320
TTCTATCAGC ACTACGACCT AGATCTGAAG GACAAGCCGC TGGGAGAGGG AAGTTTTTCA 1380
ATTTGTCGAA AGTGCACACA CAAAAAAAGT AACCAAGCAT TCGCCGTCAA AATAATCAGC 1440
AAAAGGATGG AAGCCAATAC TCAGAAGGAA ATCACAGCTC TGAAGCTCTG TGAAGGACAC 1500
CCCAATATCG TGAGGCTGCA CGAAGTTTTT CACGATCAGC TTCACACGTT CCTGGTGATG 1560
GAACTTCTGA ACGGGGGAGA GCTGTTTGAA CGCATTAAGA AAAAGAAACA CTTCAGTGAG 1620
ACGGAAGCCA GCTACATCAT GCGGAAGCTC GTTTCGGCCG TGAGCCACAT GCATGATGTG 1680
GGCGTGGTGC ACCGGGACCT GAAGCCAGAG AATTTATTGT TCACTGATGA AAATGACAAT 1740
TTGGAAATCA AAGTAATCGA TTTTGGGTTT GCACGCTTAA AGCCACCTGA TAACCAGCCT 1800
CTCAAGACGC CCTGCTTCAC CCTGCACTAT GCAGCCCCCG AGCTCTTGAA TCATAACGGC 1860
TATGACGAGT CCTGTGACCT CTGGAGCCTG GGCGTCATTT TGTATACAAT GTTGTCAGGG 1920
CAAGTTCCAT TCCAATCTCA TGACAAAAGT TTGACATGCA CCAGTGCAGT GGAAATCATG 1980
AAGAAAATTA AAAAGGGAGA TTTCTCCTTT GAAGGAGAAG CCTGGAAGAA TGTATCCCAA 2040
GAAGCTAAAG ATTTGATCCA AGGACTCCTC ACAGTCGATC CAAATAAAAG GCTTAAAATG 2100
TCGGGCTTGA GATACAACGA ATGGCTTCAA GATGGCAGTC AGCTGTCCTC AAATCCTCTG 2160
ATGACTCCAG ACATTCTAGG GTCTTCAGGA GCTGCTGTGC AAACCTGTGT GAAAGCAACC 2220
TTCCACGCCT TTAACAAATA CAAGAGAGAG GGCTTTTGCC TTCAGAATGT CGACAAGGCC 2280
CCTTTGGCGA AGAGAAGGAA GATGAAGAAG ACCAGCACCA GTACAGAGAC GCGCAGCAGC 2340
TCGAGCGAAA GTTCTCACTC GTCCTCCTCT CACTCTCACG GGAAAACCAC GCCCACTAAG 2400
ACCCTGCCGC CCGGCAACCC CGCGGACCCC AGTAACCCGG ATACGCTCTT CCAGTTCTCA 2460
GACTGA 2466
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++c hk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++
Q: 449   LKDKPLGEGSFSICRKCTHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVRLHE  508
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 509   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  568
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 569   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  627
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 628   WSLGVILYTMLSGQVPFqshdKSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  687
         *****************98888899***********************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 688   GLLTVDPNKRLKMSGLRYNEWL  709
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCTHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVRLHE 60
VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD KSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Kinase; Nucleotide-binding; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MEG-00130
EKS-MOD-00162
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PEM-00087
EKS-POA-00160
EKS-SAH-00157
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013