EKS-MUP-00018
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00018
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR535.81.5E-1619931260268
StatusUnreviewed
Ensembl ProteinENSMPUP00000008382
UniProt AccessionG9K5W0;
Protein Name
Protein Synonyms/Alias Insulin receptor;
Gene NameINSR
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000008446ENSMPUP00000008382ENSMPUT00000008517
OrganismMustela putorius furo
Functional Description
Protein Length1352
Protein Sequence
(FASTA)
MACLLTCLAF GLFLLLVCPG MDIRNNLTRL HELANCSVIE GHLQILLMFK TRPEDFRDLS 60
FPKLIMITDY LLLFRVYGLE SLKDLFPNLT VIRGSRLFFN YALVIFEMVH LKELGLYSLM 120
NITRGSVRIE KNNELCYLAT IDWSRILDSV EDNYIVLNKD DNEECGDICP GTAKGKTSCP 180
ATVINGQFVE RCWTHSHCQK VCPTICKSHG CTSEGLCCHS ECLGNCSEPD DPTKCVACRN 240
FYLDGRCVET CPPPYYHFQD WRCVNFSFCQ DLHNKCKNSR RQGCHQYVIH NNKCIPECPS 300
GYTMNSSNLM CTPCLGPCPK VCHILEGEKT IDSVTSAQEL RGCTVVNGSL IINIRGGNNL 360
AAELEANLGL IEEISGYLKI RRSYALVSLS FFRKLRLIRG ETLEIGNYSF YALDNQNLRQ 420
LWDWSKHNLT ITQGKLFFHY NPKLCLSEIH KMEEVSGTKG RQERNDIALK TNGDQASCEN 480
ELLKFSYIRT SYDKILLKWE PYWPPDFRDL LGFMLFYKEA PYQNVTEFDG QDACGSNSWT 540
VVDIDPPLRS NDPKSQNHPG WLMRGLKPWT QYAIFVKTLV TFSDERRTYG AKSDIIYVQT 600
DATNPSVPLD PISVSNSSSQ IILKWKPPSD PNGNITHYLV FWERQAEDSE LYELDYCLKG 660
LKLPSRTWSP PFEAEGSPKH NQSEHEESAG ECCSCPKTDS QILKELEESS FRKTFEDYLH 720
NVVFVPRPSR KRRALRDVAN VTAAVPTAAG FPNTSTSTPT SPEERKPFEK VVNKESLVIS 780
GLRHFTGYRI ELQACNQDAP EERCSVAAYV SARTMPEAKA DDIVGPVTHE IFENNVVHLM 840
WQEPKEPNGL IVLYEVSYRR YGDEELHLCV SRRHFALERG CRLRGLPPGN YSVRVRATSL 900
AGNGSWTEAT YFYVTDYLDV PSNIAKIIIG PLIFVFLFSV VIGSIYLFLR KRQPDGPLGP 960
LYASSNPEYL SASDVFPCSV YVPDEWEVPR EKITLLRELG QGSFGMVYEG NARDIVKGEA 1020
ETRVAVKTVN ESASLRERIE FLNEASVMKG FTCHHVVRLL GVVSKGQPTL VVMELMAHGD 1080
LKSYLRSLRP EAENNPGRPP PTLQEMIQMA AEIADGMAYL NAKKFVHRDL AARNCMVAHD 1140
FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMAPESLKD GVFTTSSDMW SFGVVLWEIT 1200
SLAEQPYQGL SNEQVLKFVM DGGYLDQPDN CPERVTDLMR MCWQFNPKMR PTFLEIVDLL 1260
KDDLHPSFPE VSFFHSEENK APESEELEME FEDMESVPLD RASHSQREEA GGRDGGSSLG 1320
LKRNYEEHIP YTHMNGGKKN GRILTLPRSN PS 1352
Nucleotide Sequence
(FASTA)
ATGGCGTGTT TGCTCACCTG TCTTGCTTTT GGCTTGTTTT TACTTCTAGT GTGTCCCGGC 60
ATGGATATCC GGAACAACCT CACGAGGTTG CATGAGCTGG CCAACTGCTC GGTCATTGAA 120
GGACATTTGC AGATACTGTT GATGTTCAAA ACAAGGCCCG AGGATTTCCG AGACCTCAGT 180
TTCCCCAAAC TCATCATGAT CACTGATTAC TTGCTGCTCT TCCGGGTCTA TGGGCTGGAG 240
AGCCTGAAGG ACCTGTTCCC CAACCTCACG GTCATCCGGG GCTCGCGCCT CTTCTTCAAC 300
TACGCACTGG TCATCTTCGA GATGGTTCAC CTGAAGGAAC TCGGCCTCTA TAGCTTGATG 360
AACATTACCC GGGGCTCCGT CCGCATCGAG AAAAATAACG AGCTGTGCTA CCTGGCCACC 420
ATCGACTGGT CGCGCATCCT GGATTCTGTG GAGGATAATT ATATTGTGCT GAACAAAGAC 480
GACAACGAGG AGTGTGGGGA CATTTGTCCG GGCACGGCGA AGGGCAAGAC CAGCTGCCCT 540
GCCACTGTCA TCAACGGGCA GTTTGTCGAG CGGTGTTGGA CACACAGCCA CTGCCAGAAA 600
GTCTGTCCCA CCATCTGCAA GTCGCACGGC TGCACCTCGG AGGGCCTCTG CTGCCACAGC 660
GAGTGCTTAG GCAATTGCTC CGAGCCCGAC GACCCCACCA AGTGCGTGGC CTGTCGCAAC 720
TTCTACCTGG ACGGCAGGTG CGTGGAGACC TGCCCGCCCC CGTACTATCA CTTCCAGGAC 780
TGGCGCTGCG TGAACTTCAG CTTTTGCCAG GACCTGCACA ACAAATGCAA GAACTCCCGG 840
AGGCAGGGCT GCCACCAGTA CGTCATTCAC AACAACAAGT GCATCCCCGA GTGCCCCTCT 900
GGTTACACGA TGAATTCCAG CAACCTGATG TGCACTCCAT GCCTGGGCCC CTGTCCCAAG 960
GTCTGCCACA TCCTGGAAGG CGAGAAGACC ATTGACTCGG TGACATCTGC CCAGGAGCTT 1020
CGAGGCTGCA CGGTGGTCAA CGGAAGCCTC ATCATCAACA TCCGAGGGGG CAACAACCTG 1080
GCAGCTGAGC TGGAGGCCAA CCTCGGACTC ATTGAGGAAA TTTCTGGGTA TCTGAAAATC 1140
CGGAGATCCT ACGCTCTTGT GTCACTTTCC TTTTTCCGGA AGTTACGGCT GATTCGAGGA 1200
GAGACCTTGG AAATCGGGAA CTACTCTTTC TACGCCTTGG ACAACCAGAA CCTAAGGCAG 1260
CTTTGGGATT GGAGCAAACA CAACCTCACC ATCACTCAGG GGAAACTCTT CTTCCACTAT 1320
AATCCCAAAC TCTGCTTGTC AGAAATTCAC AAGATGGAGG AAGTTTCGGG AACCAAGGGG 1380
CGCCAGGAGA GGAACGACAT TGCCCTGAAG ACCAACGGGG ACCAGGCGTC TTGTGAGAAC 1440
GAACTCCTTA AATTCTCTTA CATTCGGACA TCGTACGACA AGATCTTGCT AAAATGGGAG 1500
CCATACTGGC CCCCTGACTT CCGAGACCTT TTGGGGTTCA TGCTTTTCTA CAAAGAGGCC 1560
CCTTACCAGA ATGTGACCGA GTTCGACGGG CAGGACGCAT GTGGCTCCAA CAGCTGGACC 1620
GTGGTGGACA TTGACCCCCC TCTGCGGTCC AATGACCCCA AGTCGCAGAA CCACCCAGGG 1680
TGGCTGATGC GGGGTCTCAA GCCCTGGACC CAGTACGCCA TTTTTGTCAA GACCTTGGTT 1740
ACCTTTTCTG ATGAACGCCG CACGTACGGG GCCAAGAGTG ACATCATCTA TGTGCAGACG 1800
GATGCCACTA ACCCTTCCGT CCCCCTGGAT CCAATCTCCG TTTCGAATTC CTCGTCCCAG 1860
ATTATCCTCA AGTGGAAACC TCCCTCGGAC CCCAACGGCA ACATCACACA CTACCTGGTT 1920
TTCTGGGAGA GGCAGGCGGA AGACAGTGAG CTGTACGAGC TGGACTATTG CCTCAAAGGG 1980
TTGAAGCTGC CGTCCCGGAC CTGGTCTCCG CCGTTCGAGG CTGAGGGCTC CCCGAAGCAC 2040
AACCAGAGTG AACACGAGGA GTCCGCCGGC GAGTGCTGCT CCTGCCCCAA GACAGACTCC 2100
CAGATCCTCA AGGAGCTGGA GGAGTCCTCT TTTAGGAAGA CCTTTGAGGA TTACCTGCAC 2160
AATGTGGTGT TCGTCCCCAG GCCGTCGCGG AAACGCAGGG CCCTCAGGGA CGTGGCCAAC 2220
GTGACAGCGG CCGTGCCCAC AGCTGCCGGT TTCCCCAACA CCTCGACTAG CACGCCCACG 2280
AGCCCGGAGG AGCGCAAGCC TTTTGAGAAG GTGGTAAACA AGGAGTCCCT GGTCATCTCT 2340
GGGCTGCGTC ATTTCACCGG CTACCGTATC GAGCTGCAGG CTTGCAACCA GGACGCCCCC 2400
GAGGAGAGGT GCAGCGTGGC GGCCTATGTC AGCGCCAGGA CCATGCCCGA AGCCAAGGCA 2460
GACGACATCG TCGGCCCCGT GACCCACGAA ATCTTCGAGA ACAATGTCGT TCACTTGATG 2520
TGGCAGGAGC CGAAGGAACC CAACGGTCTG ATTGTGCTGT ATGAAGTCAG TTACCGACGC 2580
TATGGAGATG AGGAGCTGCA CCTCTGTGTC TCCCGCAGAC ACTTCGCTCT GGAGCGCGGC 2640
TGCAGGCTGC GCGGGCTGCC GCCAGGGAAT TACAGCGTGC GAGTCCGGGC CACCTCCCTG 2700
GCAGGCAACG GATCCTGGAC AGAAGCCACC TATTTCTACG TGACAGACTA TTTAGATGTC 2760
CCATCGAATA TTGCAAAAAT CATCATCGGC CCCCTCATCT TTGTCTTTCT CTTCAGTGTT 2820
GTGATTGGAA GTATTTACCT GTTCCTGCGG AAGAGGCAGC CGGATGGGCC GCTGGGACCG 2880
CTGTATGCAT CTTCAAACCC TGAGTACCTC AGTGCCAGTG ATGTGTTCCC ATGTTCTGTG 2940
TATGTGCCGG ACGAGTGGGA GGTGCCTCGG GAGAAGATCA CTCTCCTGCG GGAGCTGGGG 3000
CAGGGCTCCT TCGGCATGGT GTACGAGGGC AACGCCAGGG ACATCGTCAA GGGCGAGGCG 3060
GAGACCCGCG TGGCGGTGAA GACGGTCAAC GAGTCGGCCA GTCTGCGGGA GAGGATCGAG 3120
TTTCTCAACG AGGCCTCCGT CATGAAGGGC TTCACCTGTC ATCACGTGGT CCGCCTCCTG 3180
GGGGTGGTGT CCAAAGGCCA GCCGACGCTG GTGGTGATGG AGCTGATGGC CCACGGAGAC 3240
CTCAAGAGCT ACCTCCGCTC CCTGCGGCCG GAGGCTGAGA ATAACCCCGG CCGCCCTCCC 3300
CCTACCCTGC AAGAGATGAT TCAGATGGCA GCGGAGATCG CCGACGGGAT GGCCTACCTG 3360
AATGCCAAGA AGTTCGTGCA CCGGGATCTT GCAGCCCGGA ACTGCATGGT GGCCCACGAT 3420
TTCACCGTCA AAATTGGAGA CTTTGGGATG ACCAGAGACA TCTATGAAAC GGATTACTAC 3480
CGGAAAGGAG GCAAGGGTCT GCTCCCTGTG CGGTGGATGG CACCGGAATC CCTGAAGGAC 3540
GGGGTCTTTA CCACTTCTTC TGACATGTGG TCCTTTGGCG TGGTCCTCTG GGAAATCACC 3600
AGCTTGGCAG AACAGCCTTA CCAAGGCCTG TCAAATGAAC AGGTGTTGAA ATTTGTCATG 3660
GATGGAGGGT ATCTGGACCA ACCCGACAAT TGTCCAGAGA GAGTCACCGA CCTGATGCGT 3720
ATGTGCTGGC AGTTCAATCC CAAGATGCGG CCCACTTTCC TGGAGATCGT CGACCTGCTC 3780
AAGGACGACC TGCACCCCAG CTTTCCGGAA GTTTCCTTCT TCCACAGCGA GGAGAACAAG 3840
GCGCCTGAGA GCGAGGAGCT GGAGATGGAG TTTGAGGACA TGGAGAGCGT CCCCCTGGAT 3900
CGGGCCTCCC ACTCTCAGAG GGAGGAGGCC GGGGGCCGGG ATGGAGGGTC CTCCTTGGGC 3960
CTAAAGAGGA ACTATGAGGA GCACATCCCC TATACCCACA TGAATGGGGG CAAGAAAAAC 4020
GGACGGATTC TGACTCTGCC GAGGTCGAAT CCTTCCTAA 4059
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+llrelGqGsfGmvyeG+a+d+vkge+etrva+ktvne+as reriefl+easvmk f+
Q: 993   ITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFT  1052
         789*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrpe+en+++++pp+l+++iqmaae
Q: 1053  CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAE  1112
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+akkfvhrdlaarncmva+d+tvkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 1113  IADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1172
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdGvft++sd+wsfGvvlwei++laeqpyqGlsneqvlkfv+dgg+l++p+ncp
Q: 1173  MAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP  1232
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         e++t+lmr+cwq+npk+rp+fleiv+ll
Q: 1233  ERVTDLMRMCWQFNPKMRPTFLEIVDLL  1260
         *************************976
Domain Sequence
(FASTA)
ITLLRELGQG SFGMVYEGNA RDIVKGEAET RVAVKTVNES ASLRERIEFL NEASVMKGFT 60
CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT LQEMIQMAAE 120
IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180
MAPESLKDGV FTTSSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 240
ERVTDLMRMC WQFNPKMRPT FLEIVDLL 268
KeywordReceptor.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00014
EKS-BOT-00015
EKS-CAE-00002
EKS-CAF-00017
EKS-CAP-00016
EKS-CII-00007
EKS-CIS-00008
EKS-DAR-00021
EKS-FEC-00016
EKS-GAG-00016
EKS-GAA-00025
EKS-GOG-00019
EKS-HOS-00018
EKS-ICT-00017
EKS-LAC-00018
EKS-LOA-00015
EKS-MEG-00014
EKS-MOD-00015
EKS-MUM-00015
EKS-MYL-00018
EKS-NOL-00018
EKS-ORN-00026
EKS-ORA-00016
EKS-ORC-00014
EKS-ORL-00021
EKS-OTG-00016
EKS-PAT-00017
EKS-PES-00017
EKS-POA-00016
EKS-RAN-00017
EKS-TAG-00016
EKS-TAR-00027
EKS-TEN-00026
EKS-XET-00016
EKS-XIM-00023
Gene Ontology
GO:0005901; C:caveola
GO:0005899; C:insulin receptor complex
GO:0005524; F:ATP binding
GO:0005525; F:GTP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0032148; P:activation of protein kinase B activity
GO:0071363; P:cellular response to growth factor stimulus
GO:0031017; P:exocrine pancreas development
GO:0007186; P:G-protein coupled receptor signaling pathway
GO:0003007; P:heart morphogenesis
GO:0008286; P:insulin receptor signaling pathway
GO:0030238; P:male sex determination
GO:0030335; P:positive regulation of cell migration
GO:0048639; P:positive regulation of developmental growth
GO:0045740; P:positive regulation of DNA replication
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0045821; P:positive regulation of glycolysis
GO:0043410; P:positive regulation of MAPK cascade
GO:0045840; P:positive regulation of mitosis
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0060267; P:positive regulation of respiratory burst
GO:0046777; P:protein autophosphorylation
GO:0045995; P:regulation of embryonic development
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0019087; P:transformation of host cell by virus
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR013783; Ig-like_fold.
Pfam
SMARTs
Prosites
Prints
Created Date20-Feb-2013