EPS-MUP-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUP-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	280.5	1.5E-83	131	324	194

Status

Unreviewed

Ensembl Protein

ENSMPUP00000008694

UniProt Accession

G9KHZ8;

Protein Name

Protein Synonyms/Alias

Protein phosphatase, EF-hand calcium binding domain 2;

Gene Name

Ppef2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000008765	ENSMPUP00000008694	ENSMPUT00000008837

Organism

Mustela putorius furo

Functional Description

Protein Length

749

Protein Sequence
(FASTA)

MGSGTSTQHH FAFQNAENAF RAAALIQRWY RRYMARLEMR RHCTWRIFQS IEYAGQQDQV 60

KLHDFFSYLV DHFTPSSNHE RDFLNRMFTE ERFPQDAEME KPSDYESIEV PDNYTGPHLS 120

FPLLPDHATA LVEAFRLKQQ LHARYVLNLL HETRKHLVQL PNINRVSTRY SEEVTVCGDL 180

HGQLDDLIFI FYKNGLPSPE RAYVFNGDFV DRGKDSVEIL MVLFAFMLVY PKEFHLNRGN 240

HEDYMVNLRY GFTKEVMHKY KTHGKKILKI LQDVFCWLPL ATLVDEKVLI LHGGVSDMTD 300

LELLAKLDRH KIVSTLRRKT RKEKGKPAPK KAGAARPTPW FLPLKKELQR TPRRETSGRK 360

MARSLSYLSM MLMGFNTNGE QTYKVNANLS FCKMKVGNML VKQYAHIHPP LSNKKFWNLR 420

GSKYKHTGSN ISWSLQVVDI LWSDPMAQDG CKANTVRGGG CYFGPNVTEQ LLQKYNLQFL 480

IRSHECKPEG YEFCHSRKVL TIFSASNYYE VGSNRGAYVK LGPALSPHIV QYQANKATHM 540

LTMRQRISRV EESALRSLRE KLFAHSSDLL GEFKKHDTDK TGFISLSDWA EAVESVLRLG 600

LPWRMLRPQL VSSSTDSMLE YKSWLKDLAK EQRSRENIQS SLLETLYRNR SNLETIFRII 660

DSDHSGFISL DEFRQTWKLF SSHMNIDITD DCICDLARSI DFNKDGHIDI NEFLEAFRLV 720

EQSCPEGDAS DCPQTTDPED GDGSKPSTQ 749

Nucleotide Sequence
(FASTA)

ATGGGAAGTG GTACCTCAAC CCAACATCAC TTTGCTTTCC AGAACGCAGA GAATGCCTTC 60

CGGGCAGCAG CCCTCATCCA GAGATGGTAC CGGCGCTACA TGGCGCGCCT GGAGATGAGG 120

CGGCACTGCA CCTGGCGCAT CTTCCAGTCC ATAGAGTACG CCGGGCAGCA GGACCAGGTC 180

AAGCTCCATG ACTTCTTCAG CTATCTTGTG GATCACTTTA CCCCCAGCAG CAACCACGAG 240

CGCGACTTCC TGAACCGCAT GTTCACTGAG GAGAGATTCC CCCAGGATGC TGAGATGGAG 300

AAGCCCAGCG ACTACGAATC CATTGAGGTC CCAGACAATT ACACAGGACC ACACCTCTCC 360

TTCCCGCTCC TTCCCGACCA CGCGACGGCC CTGGTGGAAG CTTTCAGACT GAAACAACAG 420

CTGCACGCTC GCTACGTCTT GAACCTTCTG CACGAGACCA GGAAGCACCT GGTGCAGCTG 480

CCGAACATCA ACCGGGTCTC CACCCGGTAC AGCGAGGAGG TCACCGTGTG CGGAGACTTA 540

CATGGCCAGC TGGATGATTT AATATTTATA TTTTATAAGA ATGGCCTCCC GTCACCAGAG 600

AGGGCCTACG TCTTTAATGG TGACTTCGTG GATCGAGGCA AGGATTCAGT CGAGATCCTG 660

ATGGTTCTTT TCGCCTTCAT GTTGGTCTAC CCGAAAGAGT TCCATCTTAA CCGAGGAAAC 720

CATGAGGACT ATATGGTGAA CTTACGATAT GGCTTTACCA AGGAAGTGAT GCATAAATAT 780

AAGACACATG GCAAGAAAAT ACTAAAAATA CTGCAGGATG TTTTCTGTTG GCTTCCTCTG 840

GCCACTCTGG TTGATGAGAA AGTCCTGATT CTTCATGGTG GAGTGTCAGA CATGACCGAC 900

CTGGAGCTTT TGGCTAAACT AGACAGGCAC AAGATCGTCT CCACCCTGAG GCGCAAAACG 960

AGGAAGGAGA AGGGGAAACC GGCGCCGAAG AAGGCGGGCG CGGCGCGGCC CACCCCGTGG 1020

TTCCTGCCCC TGAAAAAGGA GTTGCAGCGG ACTCCGAGGC GGGAAACCTC CGGGAGAAAG 1080

ATGGCGCGCT CCCTGAGCTA TCTATCCATG ATGTTGATGG GTTTCAACAC CAACGGAGAA 1140

CAAACTTATA AAGTAAATGC AAATCTCTCC TTTTGCAAAA TGAAAGTGGG TAACATGCTT 1200

GTCAAACAGT ATGCACATAT ACACCCTCCT CTGAGTAATA AAAAATTCTG GAACCTCAGG 1260

GGTTCAAAAT ATAAGCATAC GGGAAGCAAC ATCTCTTGGT CTCTGCAGGT GGTCGATATC 1320

CTGTGGAGCG ATCCCATGGC CCAGGATGGC TGCAAGGCCA ACACCGTGCG AGGAGGAGGC 1380

TGTTATTTTG GCCCTAATGT GACAGAACAG TTGCTGCAGA AATACAACCT GCAGTTCCTG 1440

ATCCGCTCGC ACGAATGCAA ACCAGAGGGC TACGAGTTCT GCCACAGCCG CAAGGTCTTG 1500

ACCATCTTTT CTGCCTCCAA CTACTATGAA GTTGGCAGCA ACAGGGGGGC CTATGTCAAG 1560

CTGGGGCCGG CCCTGAGCCC GCACATCGTG CAGTATCAAG CGAACAAGGC AACCCACATG 1620

CTGACTATGA GGCAGAGGAT TAGCAGAGTA GAGGAGTCTG CGCTGAGATC TCTGCGGGAA 1680

AAGTTATTTG CTCATTCCTC AGATCTTCTT GGTGAATTTA AGAAGCATGA CACAGATAAA 1740

ACTGGTTTCA TCTCCCTGAG TGACTGGGCA GAAGCCGTGG AGTCGGTGCT GCGGCTGGGA 1800

CTGCCATGGC GGATGCTGAG GCCACAGCTG GTGAGCAGCT CCACGGACTC CATGCTGGAG 1860

TACAAGTCCT GGCTGAAGGA CTTGGCCAAG GAACAACGGA GCCGGGAGAA CATCCAGTCA 1920

AGTTTGCTGG AAACACTGTA TCGGAACCGA TCCAACCTGG AGACCATCTT TAGGATCATA 1980

GACAGTGACC ATTCAGGGTT CATCTCATTG GACGAGTTCA GGCAGACTTG GAAGCTGTTC 2040

AGCTCTCATA TGAACATTGA CATCACAGAT GACTGCATCT GTGACCTTGC CCGGAGCATT 2100

GACTTCAACA AGGATGGCCA CATCGACATC AATGAGTTCC TGGAGGCCTT CCGCCTTGTG 2160

GAGCAATCCT GCCCAGAGGG CGATGCCTCA GACTGCCCCC AGACCACAGA CCCTGAGGAC 2220

GGGGATGGCA GCAAGCCAAG CACACAGTAA 2250

Domain Profile

S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63

         l+e+f+ k++lha+yvl++l+e++k l qlpni++vst  s+evtv+GdlhG+lddl+++

Q: 131   LVEAFRLKQQLHARYVLNLLHETRKHLVQLPNINRVSTRYSEEVTVCGDLHGQLDDLIFI  190

         89**********************************************************

S: 64    lkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnary  123

         ++knGlPs +++yvfnGdfvdrGk ++e+l+vl +++lv+P++ +lnrGnhed ++n+ry

Q: 191   FYKNGLPSPERAYVFNGDFVDRGKDSVEILMVLFAFMLVYPKEFHLNRGNHEDYMVNLRY  250

         ************************************************************

S: 124   GfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksverk  183

         Gf+kev++kyk++gk+il+il++v+ wlPl+++vd++vl++hGG+s+ t+l+ll +++r+

Q: 251   GFTKEVMHKYKTHGKKILKILQDVFCWLPLATLVDEKVLILHGGVSDMTDLELLAKLDRH  310

         ************************************************************

S: 184   krksvllpPeessr  197

         k +s l+  +  ++

Q: 311   KIVSTLRRKTRKEK  324

         ******98875544

Domain Sequence
(FASTA)

LVEAFRLKQQ LHARYVLNLL HETRKHLVQL PNINRVSTRY SEEVTVCGDL HGQLDDLIFI 60

FYKNGLPSPE RAYVFNGDFV DRGKDSVEIL MVLFAFMLVY PKEFHLNRGN HEDYMVNLRY 120

GFTKEVMHKY KTHGKKILKI LQDVFCWLPL ATLVDEKVLI LHGGVSDMTD LELLAKLDRH 180

KIVSTLRRKT RKEK 194

Keyword

Calcium.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0043409	; P:negative regulation of MAPK cascade
GO:0010801	; P:negative regulation of peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.

Pfam

SMARTs

SM00054

; EFh; 2.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.

Prints

Created Date

20-Feb-2013