EKS-MUP-00479

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00479

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	428.4	7.1E-129	18	273	256

Status

Unreviewed

Ensembl Protein

ENSMPUP00000008891

UniProt Accession

G9KSM2;

Protein Name

Protein Synonyms/Alias

TBC1 domain containing kinase;

Gene Name

TBCK

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000008962	ENSMPUP00000008891	ENSMPUT00000009036

Organism

Mustela putorius furo

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSY SKVLCIAFEV LQGLQYMNKH GIVHRALSPH 120

NILLDRKGHV KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHVSSEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTIIVLA EEHGCLDIIK 240

DLPENVINLL KKCLTFHPSK RPTANDLMQD KVFSEVSPLY TPFTKPASLF SSSLRCADLT 300

LPEDISQLCK DINSDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII RERDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPV 720

PDSSGVRSST PFFSTECPDP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF 780

KTPPKKTKSS KPKLLVVDIR NSEDFIRGHI SGSINIPFSA AFTAEGELTQ GPFTAVLQSF 840

KGKVIVIVGH VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTVPS PQI 893

Nucleotide Sequence
(FASTA)

ATGTTTCCCC TGAAGGATGC TGAAATGGGT GCCTTTACTT TTTTTGCCTC GGCTCTGCCA 60

CACGATGTTT GTGGAAGCAA TGGGCTTCCT CTCACACCAA ATTCCATCAA AATTTTAGGG 120

CGATTTCAAA TCCTTAAGAC CATCACCCAT CCCAGACTTT GCCAATATGT GGATATTTCT 180

AGGGGAAAGC ATGAAAGACT GGTGGTGGTA GCTGAACACT GTGAACGGAG TCTAGAAGAC 240

TTGCTTCGAG AGAGGAAACC TGTGAGCTAT TCAAAGGTTT TGTGCATTGC ATTTGAGGTA 300

CTTCAAGGTC TGCAATATAT GAACAAACAT GGTATAGTAC ACCGAGCACT GTCTCCTCAT 360

AATATTCTTT TGGACCGAAA GGGACATGTT AAATTGGCTA AATTTGGACT TTATCACATG 420

ACAGCTCATG GTGATGATGT TGATTTCCCA ATTGGGTATC CATCATACTT GGCACCTGAG 480

GTAATTGCAC AAGGAATTTT CAAAACCACT GATCATGTGT CAAGTGAAAA ACCATTGCCT 540

TCTGGCCCCA AATCAGATGT GTGGTCTCTT GGAATCATTT TATTTGAGCT TTGTGTGGGA 600

AGAAAATTAT TTCAGAGCTT GGATATTTCT GAAAGACTAA AATTTTTGCT TACATTGGAT 660

TGCGTAGATG ACACTATAAT AGTTCTGGCC GAAGAGCATG GTTGTCTGGA CATCATAAAG 720

GACCTTCCCG AAAATGTGAT AAATCTTTTG AAGAAGTGTC TCACCTTCCA CCCTTCCAAG 780

AGGCCAACTG CCAATGACTT AATGCAGGAC AAGGTATTTA GTGAAGTGTC ACCTTTATAT 840

ACTCCCTTTA CCAAACCTGC CAGTCTGTTT TCATCTTCTT TGAGATGTGC TGATTTGACT 900

CTGCCTGAGG ATATCAGTCA GCTATGTAAA GATATAAACA GTGATTACCT GGCAGAAAGA 960

TCTATTGAAG AAGTGTATTA CCTTTGGTGT TTAGCGGGAG GTGACTTGGA GAAAGAGCTG 1020

GTCAACAAGG AGATCATTCG GTCTAAACCA CCTATCTGCA CACTCCCCAA TTTTCTCTTT 1080

GAAGATGGTG AAAGCTTTGG ACAGGGTCGA GACAGAAGCT CACTATTAGA TGACACCACC 1140

GTGACATTGT CCTTATGCCA GCTAAGAAAT AGATTAAAAG ATGTTGGTGG AGAAGCATTT 1200

TACCCACTAC TTGAAGATGA CCAGTCTAAT TTACCTCATT CAAACAGCAA TAATGAGTTG 1260

TCTGCAGCTG CCACTCTCCC TTTAATCATC CGAGAGAGGG ACACAGAGTA CCAACTAAAC 1320

AGAATCATTC TCTTTGACAG GCTGCTAAAG GCTTATCCGT ATAAAAAAAA TCAAATCTGG 1380

AAAGAAGCAA GAGTTGACAT TCCTCCTCTT ATGAGAGGTT TAACCTGGGC TGCTCTTTTG 1440

GGAGTTGAGG GGGCTATTCA TGCCAAGTAT GATGCAATTG ATAAAGATAC TCCAATTCCT 1500

ACAGATAGAC AAATTGAAGT GGATATTCCT CGGTGTCATC AGTATGATGA ACTATTATCA 1560

TCACCAGAAG GTCATGCAAA ATTTAGGCGT GTATTAAAAG CCTGGGTTGT GTCTCATCCT 1620

GATCTTGTGT ATTGGCAAGG TCTTGATTCA CTTTGTGCTC CATTCCTATA TTTAAATTTC 1680

AATAATGAAG CCTTGGCTTA TGCATGTATG TCTGCTTTTA TCCCCAAATA CCTGTATAAC 1740

TTCTTCTTGA AAGACAACTC ACATGTAATA CAAGAGTATC TGACCGTGTT CTCACAGATG 1800

ATTGCATTCC ATGATCCAGA GCTGAGCAAT CATCTCAATG AGATTGGATT TATCCCAGAT 1860

CTCTATGCTA TCCCTTGGTT TCTCACCATG TTTACTCATG TATTTCCACT GCACAAGATT 1920

TTCCACCTCT GGGATACCCT ACTCCTTGGG AATTCCTCTT TCCCATTCTG TATTGGAGTA 1980

GCAATTCTCC AGCAGCTACG GGACCGGCTT TTGGCTAATG GCTTTAATGA GTGCATTCTT 2040

CTCTTCTCTG ATTTACCAGA AATTGACATT GAACGCTGTG TACGGGAATC AATCAACCTA 2100

TTCTGCTGGA CTCCTAAAAG TGCTACTTAC AGACAGCATG CTCAACCTCC AAAGCCAGTT 2160

CCTGATAGCA GTGGAGTCAG AAGTTCGACA CCTTTTTTCT CCACTGAGTG TCCAGATCCT 2220

CCAAAAACAG ATTTGTCAAG AGAATCTATC CCATTAAATG ACCTAAAATC AGAAGTATCA 2280

CCCCGGATTT CAGCAGAGGA CCTGATTGAC TTGTGTGAAC TCACAGTGAC AGGCCATTTC 2340

AAAACACCCC CCAAGAAGAC AAAGTCCAGT AAACCAAAGC TCCTGGTAGT TGACATCCGG 2400

AATAGTGAAG ATTTTATTCG GGGTCATATT TCAGGCAGCA TCAACATTCC ATTTAGTGCT 2460

GCCTTCACTG CAGAAGGGGA ACTTACCCAG GGCCCTTTTA CTGCTGTGCT CCAGAGCTTC 2520

AAAGGGAAGG TCATTGTCAT CGTGGGGCAT GTGGCAAAGC ACACAGCAGA GTTTGCAGCA 2580

CATCTTGTGA AGATGAAATA TCCAAGAATC TGCATTCTAG ATGGTGGCAT TAATAAGATC 2640

AAGCCAACAG GCCTCCTCAC TGTCCCATCT CCTCAAATAT GA 2682

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh+ivhral+p++illdrkg+ vkLak+G

Q: 78    LEDLLRERKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGifkttdhvsSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+t+i+laee++cldiik+l+e++++llkkCLt+

Q: 197   LCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKDLPENVINLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+ ++l+++kvf

Q: 257   HPSKRPTANDLMQDKVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSYSKVLCIA FEVLQGLQYM NKHGIVHRAL SPHNILLDRK GHVKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIF KTTDHVSSEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFLL TLDCVDDTII VLAEEHGCLD IIKDLPENVI NLLKKCLTFH 240

PSKRPTANDL MQDKVF 256

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0016301	; F:kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013