EKS-MUP-00190

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00190

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ryk	491.3	6.3E-148	201	467	267

Status

Unreviewed

Ensembl Protein

ENSMPUP00000009385

UniProt Accession

G9KM74;

Protein Name

Protein Synonyms/Alias

RYK receptor-like tyrosine kinase;

Gene Name

Ryk

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000009460	ENSMPUP00000009385	ENSMPUT00000009539

Organism

Mustela putorius furo

Functional Description

Protein Length

478

Protein Sequence
(FASTA)

MDMPQVNISA QGEVPRTLSV FRVELSCTGK VDSEVMILMQ LNLTVNSSKN FTVLNFKRRK 60

MCYKKLEEVK TSALDKNSSR TIYDPVHAAP TTSTRVFYIS VGVCCAVIFL VAIILAVLHL 120

HSMKRIELDD SISASSSSQG LSQPSTQTTQ YLRADTPNNA TPITSSSGYP TLRIEKNDLR 180

SVTLLEAKAK VKDIAISRER ITLKDVLQEG TFGRIFHGIL VDEKDPNKEK QAFVKTVKDQ 240

ASEIQVTMML TESCKLRGLH HRNLLPITHV CIEEGEKPMV ILPYMNWGNL KLFLRQCKLV 300

EANNPQAISQ QDLVHMAIQI ACGMSYLARR EVIHKDLAAR NCVIDDTLQV KITDNALSRD 360

LFPMDYHCLG DNENRPVRWM ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF 420

EMAAYLKDGY RIAQPINCPD ELFAVMACCW ALDPEERPKF QQLVQCLTEF HAALGAYV 478

Nucleotide Sequence
(FASTA)

ATGGACATGC CCCAGGTCAA CATTTCTGCT CAGGGGGAAG TTCCACGTAC TTTATCAGTG 60

TTTCGAGTCG AACTTTCCTG TACTGGCAAA GTAGATTCTG AGGTTATGAT ACTAATGCAG 120

CTCAACTTGA CAGTAAATTC TTCAAAAAAC TTTACAGTCT TAAACTTCAA ACGAAGGAAA 180

ATGTGCTACA AAAAACTTGA AGAAGTAAAA ACTTCAGCCT TGGACAAAAA CTCTAGCAGA 240

ACTATTTATG ATCCTGTGCA TGCAGCTCCA ACCACTTCTA CACGTGTGTT TTATATCAGC 300

GTGGGCGTTT GCTGTGCAGT GATATTTCTT GTAGCAATAA TATTAGCTGT TTTGCACCTT 360

CACAGTATGA AAAGAATTGA ACTGGATGAC AGTATCAGTG CCAGCAGTAG TTCCCAAGGG 420

CTGTCTCAGC CATCTACCCA GACGACTCAG TATCTGAGAG CCGACACACC CAACAATGCA 480

ACTCCTATCA CCAGCTCCTC AGGTTATCCT ACCTTGCGGA TAGAGAAGAA CGACCTGAGA 540

AGTGTCACTC TTTTGGAGGC CAAAGCTAAG GTGAAGGATA TAGCAATATC CAGGGAGAGG 600

ATAACTTTAA AAGATGTACT CCAAGAAGGT ACTTTTGGGC GTATTTTCCA TGGGATTTTA 660

GTAGATGAAA AAGACCCAAA TAAAGAAAAG CAAGCATTTG TAAAAACAGT TAAAGATCAA 720

GCTTCTGAAA TTCAGGTGAC AATGATGCTC ACTGAAAGTT GTAAGCTACG AGGTCTTCAT 780

CACAGAAATC TTCTTCCTAT TACGCATGTG TGTATAGAAG AAGGAGAAAA GCCCATGGTG 840

ATATTGCCTT ACATGAATTG GGGGAATCTT AAATTGTTTT TACGTCAGTG TAAATTAGTA 900

GAGGCCAATA ATCCACAGGC AATTTCTCAA CAAGACCTGG TACACATGGC TATTCAGATT 960

GCCTGTGGAA TGAGCTATCT GGCCAGACGG GAAGTTATCC ACAAAGACCT GGCTGCCAGG 1020

AACTGTGTCA TTGATGACAC ACTCCAAGTT AAGATCACAG ACAATGCCCT CTCCAGAGAC 1080

TTGTTTCCCA TGGATTATCA CTGTCTGGGG GACAACGAAA ACAGGCCAGT TCGGTGGATG 1140

GCTCTGGAAA GTCTGGTTAA TAATGAGTTC TCCAGTGCTA GTGATGTGTG GGCCTTCGGA 1200

GTGACACTGT GGGAGCTCAT GACTCTGGGC CAGACGCCCT ATGTGGACAT TGATCCCTTT 1260

GAGATGGCCG CATACCTGAA AGATGGTTAT CGAATCGCCC AGCCAATCAA CTGTCCTGAT 1320

GAGCTATTTG CTGTGATGGC TTGTTGCTGG GCCTTAGATC CAGAGGAGAG GCCCAAGTTC 1380

CAGCAGCTGG TACAGTGTCT CACGGAGTTC CACGCAGCCC TGGGGGCCTA TGTCTGA 1437

Domain Profile

S: 1     lrlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvs  60

         ++lk++lqeGtfGri++G+l dekd+nkek+++vktvkdqaseiqv+++l+e+++l+g++

Q: 201   ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLH  260

         6799********************************************************

S: 61    hrnilsvllvsieeaekPlvvypalnkgnlkkflricklkdkekaqalstkqlvelaiqi  120

         hrn+l++++v+iee ekP+v++p++n+gnlk flr+ckl++++++qa+s+++lv++aiqi

Q: 261   HRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQI  320

         ************************************************************

S: 121   asalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkWl  180

         a++++yl++rev+hkd+aarncvidd+lqvk+td+alsrdlfP+dy+clGdnenrP++W+

Q: 321   ACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWM  380

         ************************************************************

S: 181   slealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncPd  240

         +le+l+++e+ssasdvWa+Gv+lWel+tlg++Py++idpfe++aylkdGyr+aqP+ncPd

Q: 381   ALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPD  440

         ************************************************************

S: 241   elftvmaccWallpeerPsfeqlvscl  267

         elf+vmaccWal+peerP+f+qlv+cl

Q: 441   ELFAVMACCWALDPEERPKFQQLVQCL  467

         **************************8

Domain Sequence
(FASTA)

ITLKDVLQEG TFGRIFHGIL VDEKDPNKEK QAFVKTVKDQ ASEIQVTMML TESCKLRGLH 60

HRNLLPITHV CIEEGEKPMV ILPYMNWGNL KLFLRQCKLV EANNPQAISQ QDLVHMAIQI 120

ACGMSYLARR EVIHKDLAAR NCVIDDTLQV KITDNALSRD LFPMDYHCLG DNENRPVRWM 180

ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF EMAAYLKDGY RIAQPINCPD 240

ELFAVMACCW ALDPEERPKF QQLVQCL 267

Keyword

Kinase; Receptor; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0042813	; F:Wnt-activated receptor activity
GO:0071679	; P:commissural neuron axon guidance
GO:0022038	; P:corpus callosum development
GO:0050919	; P:negative chemotaxis
GO:0048843	; P:negative regulation of axon extension involved in axon guidance
GO:0043410	; P:positive regulation of MAPK cascade
GO:0048705	; P:skeletal system morphogenesis
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR003306	; WIF.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF02019	; WIF; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50814	; WIF; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013