EKS-MUP-00263

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00263

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	464.6	1.7E-139	209	522	314

Status

Unreviewed

Ensembl Protein

ENSMPUP00000010008

UniProt Accession

G9L0E9;

Protein Name

Protein Synonyms/Alias

Dual-specificity tyrosine--phosphorylation regulated kinase 3 isoform a;

Gene Name

Dyrk3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000010083	ENSMPUP00000010008	ENSMPUT00000010168

Organism

Mustela putorius furo

Functional Description

Protein Length

587

Protein Sequence
(FASTA)

MGGTARGPGQ KDAGPPGVGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPLPR 60

RLNITTEQLT RDHTQRFLSG GEVKVEQLFQ EFGNRRSDTL QTDGINDSEK CSPAASQGKS 120

SDSSNAMKAS SSAKTSKAVP LTPEQALKQY KHHLTAYEKL EIVNYPEIYF VGPNAKKRHG 180

VIGGPNNGGY DDADGAYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV 240

RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK 300

KNKFQGFSVQ LVRKFAQSIL QSLDALHKNK IIHCDLKPEN ILLKHHGRSA TKVIDFGSSC 360

FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC 420

MMELLGMPPP KLLEQSKRAK YFINSKGLPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS 480

KDWVTALKGC DDYLFIEFLK RCLQWDPSAR LTPAQALRHP WISKSVPRPV TIEKVSGKRV 540

VNPANAFQGL GSKLPPVVGI ANKLKANLMS ETSGGIPLCS VLPKLIS 587

Nucleotide Sequence
(FASTA)

ATGGGAGGCA CGGCTCGCGG GCCGGGGCAG AAGGATGCGG GGCCGCCCGG AGTCGGACTC 60

CCGCCCCAGC AGCGGAGATT GGGGGATGGT GTCTATGATA CCTTCATGAT GATAGATGAA 120

ACCAAATGCC CACCCTGTTC CAATGTACTC TGCAATCCTT CTGAACCGCC TCTGCCCAGA 180

AGACTAAATA TCACCACCGA GCAGTTAACC AGAGATCATA CTCAGCGCTT TCTGAGCGGA 240

GGTGAGGTGA AGGTAGAACA GCTGTTTCAA GAATTTGGCA ACAGAAGATC TGATACTCTT 300

CAGACAGATG GCATCAACGA CTCTGAAAAG TGCTCTCCTG CCGCCTCTCA GGGTAAAAGT 360

TCAGATAGCT CCAATGCGAT GAAAGCCAGC AGTTCTGCCA AAACATCCAA AGCAGTGCCC 420

CTGACTCCCG AGCAAGCCCT GAAGCAGTAC AAACACCACC TGACTGCCTA CGAGAAGCTG 480

GAGATCGTCA ACTACCCCGA GATTTACTTC GTGGGCCCAA ATGCCAAAAA AAGACACGGA 540

GTGATCGGCG GGCCCAATAA CGGTGGCTAT GACGATGCAG ACGGGGCCTA TATTCACGTG 600

CCTCGTGACC ATCTAGCTTA TCGATACGAG GTGCTGAAGA TTATCGGCAA GGGCAGTTTT 660

GGGCAGGTGG CCCGGGTCTA CGATCACAAA CTTCGACAGT ACGTGGCCCT GAAGATGGTG 720

CGCAATGAAA AGCGCTTCCA TCGGCAAGCC GCTGAGGAGA TCCGGATTCT GGAGCATCTT 780

AAAAAGCAGG ACAAAACTGG GAGCATGAAT GTCATCCACA TGCTGGAAAG TTTCACCTTC 840

CGGAACCACG TTTGCATGGC CTTCGAATTG CTGAGCATAG ACCTTTATGA GCTCATTAAA 900

AAAAACAAGT TTCAGGGTTT TAGCGTCCAG TTAGTTCGCA AGTTTGCCCA ATCCATCTTG 960

CAGTCCTTGG ATGCTCTCCA CAAAAATAAG ATCATTCACT GTGACCTGAA GCCAGAAAAC 1020

ATTCTCCTAA AGCACCACGG GCGCAGTGCG ACCAAGGTCA TTGACTTCGG GTCCAGCTGT 1080

TTCGAATACC AGAAGCTTTA CACGTACATC CAGTCTCGGT TCTACAGAGC TCCCGAGATC 1140

ATCTTAGGGA GCCGCTACAG CACGCCTATA GACATATGGA GTTTTGGCTG CATCCTTGCA 1200

GAACTTCTAA CAGGACAGCC TCTCTTCCCG GGAGAGGATG AGGGAGACCA GCTGGCCTGC 1260

ATGATGGAGC TGCTCGGGAT GCCACCACCG AAACTTCTGG AGCAATCCAA ACGTGCCAAG 1320

TACTTCATTA ACTCCAAGGG CCTACCTCGC TACTGTTCTG TGACTACTCA GGCAGATGGG 1380

AGGGTCGTGC TTGTGGGGGG TCGCTCACGT AGGGGGAAAA AGCGGGGCCC CCCAGGCAGC 1440

AAAGACTGGG TGACAGCACT GAAGGGATGT GATGACTACT TGTTTATAGA GTTTTTGAAA 1500

AGGTGCCTTC AGTGGGACCC CTCTGCCCGT TTGACCCCAG CTCAAGCACT GAGACATCCT 1560

TGGATTAGTA AGTCTGTGCC CAGACCTGTC ACCATCGAAA AGGTATCAGG CAAACGGGTG 1620

GTAAATCCTG CAAACGCTTT CCAGGGACTG GGTTCCAAGC TGCCTCCAGT TGTCGGAATA 1680

GCCAATAAGC TTAAAGCTAA CTTAATGTCC GAAACCAGTG GTGGTATACC TCTGTGCAGT 1740

GTACTGCCGA AACTCATTAG CTAA 1764

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV++++d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 209   YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  268

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c+ fells++Lyel+kknkf+g+s++lvrk+aq+il++L++L++

Q: 269   MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK  328

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs+ kviDFGss+++ qk +ytyiqsrfYraPEiilg +y+

Q: 329   NKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQK-LYTYIQSRFYRAPEIILGSRYS  387

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iD+WS+Gc+laEl+tG+pLfpGe+e dqla+++e+lg+pp+klle++k+ak+f+++k+

Q: 388   TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKG  447

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

          p+y+ +t+++d +++lv ++++++kkr +p+sk++++alk ++d+lf+++lkr+l++dp

Q: 448   LPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWVTALKGCDDYLFIEFLKRCLQWDP  507

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 508   SARLTPAQALRHPWI  522

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVARVYD HKLRQYVALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHVCMAF ELLSIDLYEL IKKNKFQGFS VQLVRKFAQS ILQSLDALHK 120

NKIIHCDLKP ENILLKHHGR SATKVIDFGS SCFEYQKLYT YIQSRFYRAP EIILGSRYST 180

PIDIWSFGCI LAELLTGQPL FPGEDEGDQL ACMMELLGMP PPKLLEQSKR AKYFINSKGL 240

PRYCSVTTQA DGRVVLVGGR SRRGKKRGPP GSKDWVTALK GCDDYLFIEF LKRCLQWDPS 300

ARLTPAQALR HPWI 314

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004672	; F:protein kinase activity
GO:0030218	; P:erythrocyte differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013