EKS-MUP-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	444.1	2.9E-133	241	569	329

Status

Unreviewed

Ensembl Protein

ENSMPUP00000011379

UniProt Accession

G9K4D0;

Protein Name

Protein Synonyms/Alias

Homeodomain interacting protein kinase 3;

Gene Name

HIPK3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000011469	ENSMPUP00000011379	ENSMPUT00000011567

Organism

Mustela putorius furo

Functional Description

Protein Length

1259

Protein Sequence
(FASTA)

MSVFLSGGRR LFLKWLAVWG LILSFDAGQR QGATAPRQPD DREGMASQVL VYPPYVYQTQ 60

SSAFCSVKKL KVEPSSCVFQ ERNYPRTYVN GKNVGNSHPP TKGSVFQTKI PFNRPRGHNF 120

SLQTSAVVLK NTAGATKVIA AQAQQAQVEA PPIGAWRHRL NFLEGPQRCG LKRKSEELDN 180

HSSAMQIVDE LSILPAMLQT NMGNPVTVVT ATTGTKQNCT SGEGDYQLVQ HEVLCSMKNT 240

YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEY 300

NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRPILQQV ATALKKLKSL 360

GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKTVC STYLQSRYYR APEIILGLPF 420

CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLNVG TKSTRFFCRE 480

TDISHSGWRL KTLEEHEAET GMKSKEARKY IFNSLDDIVH VNTVMDLEGS DLLAEKADRR 540

EFVSLLKKML LIDADLRITP AETLNHPFVN MKHLLDFPHS NHVKSCFHIM DICKSHPNSC 600

DTNNHNKTSL LRPVASSSTA NLTANFTKIG TLRNQALTTS AHSVVHHGIP LQAGTAHFGC 660

GDAFQQTLII CPPAIQGIPA THGKPTSYSL RVDNTVPLVT QAPAVQPLQI RPGVLSQTWS 720

GRTQQMLVPA WQQVTPMAPA TTALTSEGVA GSQRLGDWGK MISHSNHYSS VMPQPLLTNQ 780

ITLSAPQPIS VGIAHVVWPQ PATVKKNKLC HNRGILVKLM EWEPGREEIN AFSWSNSLQN 840

TIVPHSTFIS PKIVNGKDVE EVRCIETQDN RNSEAEARDC CETSVRQDSD ESVSDKQRQT 900

IIIADSPSPA VSVITISSDT DEEEPAQRHS LRECKDSLDC EACQSTLNID RMCSLSSPDS 960

TLSTSSSGQS SPSPCKRPNS MSDEEQESGC DTVDGSPTSD SSGHDSPFAE SSFVEDTHQN 1020

TELVTSANTE TKPAVCTVVV PPMGLENGLN ADDHMANTDS ICQPLIKGRS APGRLNQPST 1080

VGNRQQKLTS AFQQQHLNFS QVQHFGSGHQ EWNGNFGHRR QQAYIPNSVT SNPFTLSHGS 1140

PNHTAVHAHL AGNAHLGGQP TLLPYPSSAA LSSAAPVAHL LASPCTSRPM LQHPTYNISH 1200

PSGIVHQVPV GINPRLLPSP TIHQTPYKPI FPPHSYIAAS PAYTGFPLSP TKLSQYPYM 1259

Nucleotide Sequence
(FASTA)

ATGTCTGTTT TCCTGTCGGG AGGGAGACGG CTGTTTTTAA AATGGTTAGC AGTGTGGGGT 60

CTTATACTTT CCTTTGATGC TGGGCAGAGG CAGGGAGCCA CAGCTCCTCG TCAGCCAGAT 120

GATCGTGAGG GTATGGCCTC ACAAGTCTTG GTCTACCCAC CGTATGTTTA TCAAACTCAG 180

TCAAGTGCCT TTTGTAGTGT GAAGAAACTC AAAGTAGAGC CAAGCAGTTG TGTATTCCAG 240

GAAAGAAACT ATCCACGGAC CTATGTGAAT GGTAAAAACG TTGGAAATTC TCATCCTCCC 300

ACGAAGGGTA GTGTTTTTCA GACAAAGATA CCATTTAACA GACCTCGAGG ACACAACTTT 360

TCATTGCAGA CAAGTGCTGT TGTTTTAAAA AACACTGCGG GTGCTACAAA GGTCATAGCA 420

GCTCAGGCGC AGCAAGCTCA AGTGGAGGCA CCTCCGATTG GGGCGTGGCG ACACAGGTTA 480

AATTTCCTCG AAGGCCCCCA GCGATGTGGA TTGAAGCGCA AGAGTGAGGA GTTGGATAAT 540

CATAGCAGCG CAATGCAGAT TGTCGATGAA TTGTCCATAC TTCCTGCAAT GTTGCAAACC 600

AACATGGGAA ATCCAGTGAC AGTTGTGACA GCCACCACAG GAACCAAACA GAATTGTACC 660

TCTGGAGAGG GTGACTATCA GTTAGTACAG CATGAAGTCT TATGCTCCAT GAAAAATACT 720

TATGAAGTTC TTGATTTTCT TGGTCGAGGC ACTTTTGGCC AGGTAGTCAA ATGCTGGAAA 780

AGAGGGACAA ATGAAATCGT AGCAATCAAA ATTTTGAAGA ATCACCCTTC TTATGCACGT 840

CAAGGTCAAA TAGAAGTGAG CATATTAGCA AGGCTCAGTA CTGAAAATGC TGATGAATAT 900

AACTTTGTAC GAGCTTATGA ATGCTTTCAG CACCGTAACC ATACTTGTTT AGTCTTTGAG 960

ATGCTGGAAC AAAACTTATA TGACTTTCTG AAACAAAACA AGTTCAGTCC CCTGCCACTA 1020

AAAGTAATTC GACCAATTCT TCAGCAAGTG GCCACTGCAC TGAAAAAATT GAAAAGTCTT 1080

GGTTTAATTC ATGCTGACCT CAAACCAGAG AATATTATGT TGGTGGATCC TGTTCGGCAG 1140

CCATACCGGG TTAAGGTGAT AGACTTTGGG TCGGCCAGTC ATGTATCAAA GACTGTTTGT 1200

TCAACATACC TACAGTCTCG GTACTACAGA GCTCCAGAGA TTATTTTGGG GTTGCCGTTT 1260

TGTGAAGCCA TAGACATGTG GTCATTGGGA TGTGTGATTG CAGAGTTATT CCTTGGATGG 1320

CCACTCTACC CAGGAGCCTT GGAGTATGAC CAGATCCGAT ATATTTCTCA GACTCAAGGT 1380

TTACCGGGAG AACAGTTGTT AAATGTGGGC ACGAAATCCA CAAGATTTTT TTGCAGAGAA 1440

ACAGATATTT CTCATTCTGG TTGGAGATTA AAGACACTAG AAGAGCATGA GGCAGAGACA 1500

GGAATGAAGT CTAAAGAAGC CAGAAAGTAC ATATTCAACA GCCTGGATGA TATAGTGCAT 1560

GTGAACACAG TGATGGATTT GGAAGGAAGT GATCTTTTGG CTGAGAAAGC TGATAGAAGA 1620

GAATTTGTTA GTCTGTTGAA GAAAATGTTG CTGATTGATG CAGATTTAAG AATTACTCCA 1680

GCTGAGACTT TGAACCATCC TTTTGTTAAT ATGAAACATC TTCTAGATTT CCCTCATAGC 1740

AACCATGTAA AGTCCTGTTT TCATATTATG GATATTTGTA AGTCCCACCC AAATTCATGT 1800

GACACAAATA ATCACAATAA AACTTCACTT TTAAGACCAG TTGCTTCAAG CAGTACTGCT 1860

AATCTGACAG CAAATTTTAC TAAAATTGGC ACATTAAGAA ATCAGGCATT AACCACGTCC 1920

GCTCATTCAG TGGTACACCA TGGAATTCCT CTGCAGGCCG GGACTGCTCA TTTTGGTTGT 1980

GGTGATGCCT TTCAGCAGAC CCTGATTATC TGTCCCCCAG CTATTCAAGG TATTCCTGCA 2040

ACACACGGTA AACCTACTAG TTATTCACTA AGAGTAGATA ACACAGTTCC CCTTGTAACT 2100

CAGGCCCCAG CTGTACAGCC ACTACAGATC CGACCCGGAG TTCTCTCTCA GACCTGGTCT 2160

GGCCGAACGC AGCAGATGCT CGTACCTGCC TGGCAGCAGG TCACACCCAT GGCTCCTGCG 2220

ACTACTGCGT TAACCTCTGA GGGGGTGGCT GGTTCCCAAA GGCTCGGAGA CTGGGGGAAA 2280

ATGATTTCAC ACAGTAATCA TTATAGCTCA GTGATGCCAC AACCTCTTCT AACCAATCAG 2340

ATAACTCTAT CGGCCCCGCA GCCAATTAGT GTGGGCATCG CGCATGTTGT GTGGCCTCAG 2400

CCTGCCACTG TGAAGAAAAA CAAGCTGTGC CACAACAGAG GTATTTTGGT AAAACTAATG 2460

GAATGGGAGC CAGGAAGAGA GGAAATAAAT GCTTTCAGTT GGAGTAATTC GTTGCAGAAT 2520

ACGATTGTCC CACATTCAAC ATTTATTTCT CCAAAGATCG TAAATGGGAA GGATGTCGAA 2580

GAAGTACGTT GTATAGAAAC ACAGGACAAT CGTAACTCAG AAGCAGAGGC AAGAGACTGT 2640

TGTGAAACAT CTGTCCGGCA GGACTCTGAT GAATCAGTTT CCGACAAACA GCGGCAAACC 2700

ATCATCATTG CTGACTCCCC AAGCCCAGCA GTGAGTGTGA TCACTATTAG CAGTGACACT 2760

GATGAGGAGG AGCCAGCCCA GAGACACTCA CTCAGAGAAT GTAAAGATAG TCTGGATTGT 2820

GAAGCTTGCC AGAGCACTTT GAATATCGAT CGGATGTGTT CATTAAGTAG TCCTGACAGT 2880

ACTTTGAGCA CCAGCTCCTC AGGGCAGTCC AGCCCATCCC CTTGCAAGAG ACCGAACAGC 2940

ATGTCAGATG AAGAACAGGA AAGTGGTTGT GATACTGTGG ATGGCTCTCC AACGTCAGAC 3000

TCTTCGGGAC ATGACAGTCC CTTTGCAGAG AGTAGCTTTG TGGAAGACAC TCATCAGAAC 3060

ACGGAGCTCG TGACCTCGGC CAACACAGAG ACCAAACCAG CTGTTTGTAC TGTTGTGGTG 3120

CCACCAATGG GACTAGAGAA TGGATTAAAT GCCGATGACC ATATGGCCAA CACGGATTCT 3180

ATATGCCAGC CATTAATAAA AGGCCGATCC GCTCCTGGGA GATTAAACCA GCCTTCCACG 3240

GTGGGTAATC GTCAGCAGAA ACTGACATCA GCATTCCAGC AGCAGCATTT GAATTTCAGT 3300

CAGGTTCAGC ACTTTGGATC TGGGCATCAA GAGTGGAATG GAAACTTCGG ACATCGAAGA 3360

CAGCAAGCTT ATATACCTAA CAGTGTGACC AGTAATCCAT TCACTCTTTC TCATGGAAGT 3420

CCCAATCACA CAGCTGTGCA TGCCCATCTG GCTGGAAATG CACACCTTGG AGGACAGCCT 3480

ACTCTACTTC CATACCCATC ATCAGCTGCC CTCAGTAGTG CTGCACCAGT GGCCCACCTC 3540

TTAGCCTCTC CATGTACCTC AAGACCTATG TTACAGCATC CAACTTACAA TATCTCTCAT 3600

CCCAGTGGCA TAGTTCACCA AGTCCCGGTG GGCATAAATC CCCGTCTGTT ACCATCCCCA 3660

ACCATTCATC AGACTCCGTA CAAACCAATC TTCCCACCAC ATTCTTACAT TGCAGCATCA 3720

CCTGCATATA CTGGATTTCC ATTGAGTCCA ACAAAACTCA GCCAGTATCC ATATATGTGA 3780

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++

Q: 241   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ENADE  299

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         yn+vr++e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+

Q: 300   YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS  359

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 360   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP  419

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp e+ll+ ++k+++ff

Q: 420   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFcr  479

         **********************************************************99

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

          t+ +++ ++lkt          ks++++k+++n  +++ ++++ ++ e ++ l+ek+d+

Q: 480   eTDISHSGWRLKTLeeheaetgmKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADR  539

         8888999999999999*******************************************9

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + f++llk+ml +d++ Ritp+e+l+hpfv

Q: 540   ReFVSLLKKMLLIDADLRITPAETLNHPFV  569

         99***************************7

Domain Sequence
(FASTA)

YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEY 60

NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRPILQQV ATALKKLKSL 120

GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKTVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLNVG TKSTRFFCRE 240

TDISHSGWRL KTLEEHEAET GMKSKEARKY IFNSLDDIVH VNTVMDLEGS DLLAEKADRR 300

EFVSLLKKML LIDADLRITP AETLNHPFV 329

Keyword

Homeobox; Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009299	; P:mRNA transcription
GO:0043508	; P:negative regulation of JUN kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013