EKS-MUP-00174
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00174
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC470.51.5E-141407667261
StatusUnreviewed
Ensembl ProteinENSMPUP00000011922
UniProt AccessionG9KIJ8;
Protein Name
Protein Synonyms/Alias Protein kinase C, epsilon;
Gene NamePrkce
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000012014ENSMPUP00000011922ENSMPUT00000012117
OrganismMustela putorius furo
Functional Description
Protein Length736
Protein Sequence
(FASTA)
MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT 60
NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 120
PEGRVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP 180
TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD EVGSQRFSVN 240
MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA 300
KVLADLGVTP DKITNSGQRR KKLIAGAESP QPTSGSSPSE EDRSKSAPTS PCDQEIKELE 360
NNIRKALSFD NRGEEHRAAG GAGQLASPGE NGEVRQGQAK RLGLEEFTFI KVLGKGSFGK 420
VMLAELKGKD EVYAVKVLKK DVILQDDDVD CTMTEKRILA LARKHPYLTQ LYCCFQTKDR 480
LFFVMEYVNG GDLMFQIQRS RKFDEPRSRF YAAEVTSALM FLHQHGVIYR DLKLDNILLD 540
AEGHCKLADF GMCKEGILNG VTTTTFCGTP DYIAPEILQE LEYGPSVDWW ALGVLMYEMM 600
AGQPPFEADN EDDLFESILH DDVLYPVWLS KEAVSILKAF MTKNPHKRLG CVASQNGEDA 660
IKQHPFFKEI DWVLLEQKKI KPPFKPRIKT KRDVNNFDQD FTREEPVLTL VDEAIVKQIN 720
QEEFKGFSYF GEDLMP 736
Nucleotide Sequence
(FASTA)
ATGGTAGTGT TCAATGGCCT TCTTAAGATC AAAATCTGCG AGGCCGTGAG CTTGAAGCCC 60
ACAGCCTGGT CGCTGCGCCA TGCGGTGGGA CCCCGGCCGC AGACTTTCCT TCTCGACCCC 120
TACATCGCCC TCAACGTGGA CGACTCTCGC ATCGGCCAAA CAGCCACCAA GCAGAAGACC 180
AACAGCCCGG CCTGGCACGA TGAGTTCGTC ACTGATGTGT GCAACGGGCG CAAGATCGAG 240
CTGGCCGTCT TCCACGATGC CCCCATCGGC TACGACGACT TCGTGGCCAA CTGCACCATC 300
CAGTTTGAGG AGCTGCTGCA GAACGGGAGC CGGCACTTCG AGGACTGGAT TGATCTGGAA 360
CCAGAAGGAA GAGTGTATGT GATCATTGAT CTGTCGGGGT CGTCGGGTGA AGCCCCTAAA 420
GACAATGAAG AGCGCGTGTT CAGGGAGCGC ATGCGGCCCA GGAAGAGGCA GGGGGCTGTC 480
AGGCGCAGGG TTCACCAGGT CAACGGCCAC AAGTTCATGG CTACCTACCT TCGGCAGCCC 540
ACCTACTGCT CCCACTGCAG AGATTTTATC TGGGGTGTCA TAGGAAAGCA GGGATACCAA 600
TGTCAAGTTT GCACTTGCGT GGTCCACAAG CGATGCCATG AGCTCATAAT TACGAAGTGT 660
GCTGGATTAA AGAAACAGGA AACTCCCGAT GAGGTGGGCT CTCAGCGGTT CAGCGTCAAC 720
ATGCCCCACA AGTTCGGGAT CCACAACTAC AAGGTCCCCA CCTTCTGCGA CCACTGTGGG 780
TCCTTGCTCT GGGGCCTCCT ACGGCAGGGT TTGCAGTGCA AAGTCTGCAA GATGAACGTT 840
CACCGACGCT GTGAAACCAA CGTGGCCCCC AACTGTGGGG TGGACGCCAG AGGAATTGCC 900
AAAGTCCTGG CTGACCTAGG CGTCACTCCA GACAAAATCA CCAACAGTGG CCAGAGGAGG 960
AAAAAGCTCA TTGCTGGCGC TGAGTCCCCA CAGCCCACTT CTGGAAGCTC ACCGTCGGAG 1020
GAAGATCGAT CCAAGTCAGC ACCCACCTCC CCTTGTGACC AGGAAATAAA AGAACTTGAA 1080
AACAACATCC GGAAGGCCTT GTCTTTTGAC AATCGAGGGG AGGAGCACCG GGCAGCAGGT 1140
GGTGCCGGCC AGCTGGCGAG CCCCGGCGAG AACGGCGAAG TGCGGCAGGG CCAGGCCAAG 1200
CGCCTGGGTC TGGAGGAGTT CACCTTCATC AAGGTGCTGG GCAAAGGCAG CTTTGGCAAG 1260
GTCATGTTGG CAGAGCTGAA AGGCAAGGAT GAAGTATATG CAGTGAAGGT CTTAAAGAAG 1320
GATGTCATCC TCCAGGATGA TGACGTGGAC TGCACGATGA CAGAGAAGAG GATTTTGGCG 1380
CTGGCACGGA AACACCCATA CTTAACCCAA CTCTATTGCT GCTTTCAGAC CAAGGACCGC 1440
CTCTTCTTCG TCATGGAGTA TGTAAATGGT GGCGACCTCA TGTTCCAGAT TCAGCGCTCC 1500
CGAAAATTCG ATGAGCCTCG TTCCCGGTTC TATGCTGCAG AGGTCACGTC AGCTCTCATG 1560
TTCCTCCACC AACATGGAGT CATCTACAGG GATTTGAAAC TGGACAACAT CCTTCTGGAT 1620
GCAGAAGGTC ACTGCAAGCT GGCTGACTTT GGGATGTGCA AGGAAGGGAT TCTGAACGGC 1680
GTCACAACCA CCACATTCTG CGGAACTCCT GACTACATCG CGCCTGAGAT CCTGCAGGAG 1740
TTGGAGTACG GCCCCTCCGT GGACTGGTGG GCCTTGGGGG TGCTGATGTA CGAGATGATG 1800
GCTGGGCAGC CCCCCTTTGA GGCCGACAAT GAGGACGACC TGTTCGAGTC CATCCTCCAC 1860
GATGACGTGC TCTACCCTGT CTGGCTCAGC AAGGAGGCCG TCAGCATCCT GAAAGCATTC 1920
ATGACCAAGA ACCCGCACAA GCGCCTGGGC TGTGTGGCAT CCCAGAACGG CGAGGACGCC 1980
ATCAAGCAGC ACCCATTCTT CAAGGAGATC GACTGGGTGC TCCTGGAGCA GAAGAAGATC 2040
AAGCCGCCCT TCAAACCTCG AATTAAAACC AAAAGAGACG TCAATAACTT TGACCAAGAT 2100
TTTACCCGGG AAGAGCCAGT GCTCACGCTT GTGGACGAAG CCATTGTGAA GCAGATCAAC 2160
CAGGAGGAAT TCAAAGGCTT CTCCTACTTT GGTGAAGACC TGATGCCCTG A 2211
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p
Q: 407   FTFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  466
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g
Q: 467   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  526
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         +iyrdlkldn+lldaeGh+kladfG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s
Q: 527   VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  586
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+
Q: 587   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH  646
         ************************************************************
S: 241   krlGv..keegeedikehaff  259
         krlG+  +++ge++ik+h+ff
Q: 647   KRLGCvaSQNGEDAIKQHPFF  667
         *****6559***********9
Domain Sequence
(FASTA)
FTFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60
YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120
VIYRDLKLDN ILLDAEGHCK LADFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180
VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPH 240
KRLGCVASQN GEDAIKQHPF F 261
KeywordATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00162
EKS-ANC-00164
EKS-BOT-00170
EKS-CAE-00130
EKS-CAJ-00174
EKS-CAF-00177
EKS-CAP-00170
EKS-DAR-00463
EKS-DRM-00083
EKS-FEC-00160
EKS-GAG-00146
EKS-GAA-00205
EKS-GOG-00168
EKS-HOS-00176
EKS-ICT-00165
EKS-LOA-00169
EKS-MAM-00168
EKS-MEG-00135
EKS-MIM-00077
EKS-MUM-00175
EKS-MYL-00179
EKS-NOL-00163
EKS-ORN-00215
EKS-ORC-00157
EKS-ORL-00201
EKS-OTG-00176
EKS-PAT-00161
EKS-PES-00150
EKS-POA-00166
EKS-RAN-00165
EKS-SUS-00146
EKS-TAG-00198
EKS-TAR-00222
EKS-TAS-00059
EKS-TEN-00214
EKS-XET-00158
EKS-XIM-00208
EKS-SAC-00081
Gene Ontology
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0005794; C:Golgi apparatus
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004699; F:calcium-independent protein kinase C activity
GO:0008047; F:enzyme activator activity
GO:0035276; F:ethanol binding
GO:0030546; F:receptor activator activity
GO:0071361; P:cellular response to ethanol
GO:0071456; P:cellular response to hypoxia
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0035641; P:locomotory exploration behavior
GO:0002281; P:macrophage activation involved in immune response
GO:0030838; P:positive regulation of actin filament polymerization
GO:0071777; P:positive regulation of cell cycle cytokinesis
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:2001031; P:positive regulation of cellular glucuronidation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0010763; P:positive regulation of fibroblast migration
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032024; P:positive regulation of insulin secretion
GO:0050996; P:positive regulation of lipid catabolic process
GO:0043410; P:positive regulation of MAPK cascade
GO:0070257; P:positive regulation of mucus secretion
GO:0032230; P:positive regulation of synaptic transmission, GABAergic
GO:0090303; P:positive regulation of wound healing
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0051209; P:release of sequestered calcium ion into cytosol
GO:0043278; P:response to morphine
GO:0035669; P:TRAM-dependent toll-like receptor 4 signaling pathway
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013