EKS-MUP-00193

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00193

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	474.0	1.2E-142	386	655	270

Status

Unreviewed

Ensembl Protein

ENSMPUP00000012730

UniProt Accession

G9K885;

Protein Name

Protein Synonyms/Alias

LIM domain kinase 2;

Gene Name

LIMK2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000012826	ENSMPUP00000012730	ENSMPUT00000012935

Organism

Mustela putorius furo

Functional Description

Protein Length

693

Protein Sequence
(FASTA)

MSRLDKCFPE NLWRGKLCIY QSTGQPFHCK SINSVLLCMI RIPSCTSCYF GPLNSLVLCA 60

GEDTWKCRGC GDHVSPSQRR YRTVNEAWHS SCFRCSECQD SLTNWYYEKD GKLYCHKDYW 120

GKFGEFCHGC SLLMTGPVMV AGEFKYHPEC FACMSCKVII EDGDAYALVQ HATLYCGKCH 180

NEVVLAPMFE RLSTESVQDQ LPYSVTHISM PATTEGRRGF SVSVERACSN YATTVQVKEV 240

NRMHISPNNR NAIHPGDRIL EINGTPVRTL RVEEVEDAIN QTSQTLQLLI EHDPVSQRLD 300

QLRLDARLSP HMQNAAHSHT LSTLDTKENL EGTLRRRSLR RSNSISKSPG PSSPKEPLLF 360

SRDISRSESL RCSSSNSQQI FRPCDLIHGE VLGKGFFGQA IKVTHKATGK VMVMKELIRC 420

DEETQKTFLT EVKVMRSLDH PNVLKFIGVL YKDKKLNLLT EYIEGGTLKD FLRSVDPFPW 480

QQKVQFAKGI ASGMAYLHSM CIIHRDLNSH NCLIKLDKTV VVADFGLSRL IVEERKKPPV 540

EKATTKKRTL RKNDRKKRYT VVGNPYWMAP EMLNGKSYDE TVDVFSFGIV LCEIIGQVYA 600

DPDCLPRTLD FGLNVKLFWE KFVPTDCPPA FFPLAAICCK LEPESRPAFS KLEDSFEALC 660

LYLGELGIPL PAELEELDHT VSMQYGLTRD SPT 693

Nucleotide Sequence
(FASTA)

ATGAGCAGGC TGGATAAGTG CTTCCCAGAG AACTTGTGGA GGGGGAAATT ATGCATTTAT 60

CAGAGCACTG GCCAGCCCTT TCATTGTAAG TCCATTAACT CAGTTTTACT CTGCATGATA 120

AGAATCCCGT CCTGTACCTC CTGCTACTTT GGGCCTCTAA ACTCCCTGGT TTTGTGTGCA 180

GGTGAAGATA CCTGGAAGTG TCGGGGCTGT GGGGACCATG TCTCTCCAAG CCAGCGGCGG 240

TACAGGACTG TCAACGAAGC CTGGCACAGC TCTTGCTTCC GGTGTTCAGA ATGCCAGGAT 300

TCCCTCACCA ACTGGTACTA TGAGAAGGAT GGGAAGCTTT ACTGCCACAA GGACTACTGG 360

GGGAAGTTCG GGGAGTTCTG CCATGGATGC TCTCTGCTGA TGACAGGACC TGTCATGGTG 420

GCTGGGGAGT TCAAGTACCA CCCAGAGTGC TTTGCCTGTA TGAGCTGCAA GGTGATCATT 480

GAGGATGGGG ATGCATACGC CCTGGTGCAG CATGCCACTC TCTACTGTGG GAAGTGCCAT 540

AATGAGGTGG TTCTGGCACC CATGTTTGAG AGGCTCTCCA CTGAGTCTGT TCAGGACCAG 600

CTGCCCTACT CCGTCACACA CATCTCCATG CCAGCCACCA CTGAGGGCAG ACGGGGCTTC 660

TCCGTGTCCG TGGAAAGGGC CTGCTCCAAC TACGCCACCA CTGTGCAAGT CAAAGAGGTC 720

AACCGGATGC ACATCAGTCC CAACAACCGC AACGCCATCC ACCCTGGGGA TCGTATCCTG 780

GAGATCAATG GGACCCCTGT CCGCACACTC CGAGTGGAAG AGGTAGAGGA TGCGATTAAC 840

CAGACAAGCC AGACACTTCA GCTCTTGATT GAACATGATC CTGTCTCCCA GCGCCTGGAT 900

CAGCTGCGGC TGGATGCACG ACTCTCTCCC CACATGCAGA ATGCTGCACA CTCCCATACC 960

CTCAGCACCC TGGACACCAA GGAGAATCTT GAAGGGACAC TCAGGAGACG CTCCCTGAGG 1020

CGCAGTAACA GCATCTCCAA GTCCCCTGGC CCCAGCTCCC CAAAGGAGCC CCTGCTCTTT 1080

AGCCGTGACA TCAGCCGCTC AGAATCCCTC CGCTGTTCCA GCAGTAACTC ACAGCAGATC 1140

TTCCGGCCAT GTGACCTGAT CCACGGGGAG GTCCTGGGGA AAGGCTTCTT TGGGCAGGCC 1200

ATCAAGGTAA CACACAAAGC AACTGGCAAA GTGATGGTCA TGAAGGAGTT AATTCGGTGT 1260

GATGAGGAAA CACAGAAGAC TTTCCTGACT GAGGTGAAGG TGATGCGAAG CCTAGACCAC 1320

CCCAATGTGC TCAAGTTCAT TGGTGTGCTA TACAAGGACA AGAAGCTGAA CTTGCTGACA 1380

GAGTACATTG AGGGGGGCAC GCTGAAGGAC TTTCTGCGCA GTGTGGACCC GTTTCCCTGG 1440

CAGCAGAAGG TCCAATTTGC CAAAGGCATC GCCTCTGGAA TGGCCTATTT GCACTCCATG 1500

TGTATCATCC ACCGGGATCT GAACTCCCAC AACTGCCTTA TCAAGCTGGA CAAGACCGTG 1560

GTGGTGGCAG ACTTTGGGCT GTCACGGCTC ATAGTTGAGG AGAGGAAAAA GCCCCCAGTG 1620

GAGAAGGCCA CCACCAAGAA ACGCACCTTG CGTAAGAATG ACCGCAAGAA GCGCTATACA 1680

GTGGTGGGAA ACCCCTACTG GATGGCCCCT GAGATGCTGA ATGGAAAGAG CTATGATGAG 1740

ACGGTGGATG TCTTCTCTTT TGGGATCGTT CTCTGCGAGA TCATCGGGCA GGTGTATGCA 1800

GATCCTGACT GCCTGCCCCG AACACTGGAC TTTGGCCTCA ACGTAAAGCT CTTCTGGGAG 1860

AAGTTTGTCC CCACAGACTG CCCCCCAGCC TTCTTCCCCC TGGCTGCCAT CTGCTGCAAA 1920

CTGGAGCCCG AGAGCAGACC AGCATTCTCA AAACTGGAGG ACTCCTTTGA GGCTCTCTGC 1980

CTGTACCTGG GAGAGCTGGG CATCCCGCTG CCTGCAGAGC TGGAAGAGCT GGACCACACT 2040

GTGAGCATGC AGTACGGCCT GACCCGGGAC TCACCCACCT AG 2082

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 386   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  445

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l+s +++pw+q+v++ak+iasG++ylhs++iihr

Q: 446   FIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVQFAKGIASGMAYLHSMCIIHR  505

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerkk+      +k+r+l+k+drkkr+tvvG+P

Q: 506   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPpvekatTKKRTLRKNDRKKRYTVVGNP  565

         *******************************999999999********************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 566   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPT  625

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la++cc+l+pesrp+f++le++

Q: 626   DCPPAFFPLAAICCKLEPESRPAFSKLEDS  655

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV DPFPWQQKVQ FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KKPPVEKATT KKRTLRKNDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT 240

DCPPAFFPLA AICCKLEPES RPAFSKLEDS 270

Keyword

Kinase; LIM domain; Metal-binding; Transferase; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005801	; C:cis-Golgi network
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding
GO:0007283	; P:spermatogenesis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 1.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013