EKS-MUP-00168
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00168
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb427.22.1E-128416675260
StatusUnreviewed
Ensembl ProteinENSMPUP00000012800
UniProt AccessionG9KLU8;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRps6ka4
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000012899ENSMPUP00000012800ENSMPUT00000013008
OrganismMustela putorius furo
Functional Description
Protein Length772
Protein Sequence
(FASTA)
MGDEDEDEGC AVELRITEAN LTGHEEKVSV ENFELLKVLG TGAYGKVFLV RKAVGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QHFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKSGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLRRLLCKD PKKRLGAGPQ GAQEVKNHPF 300
FQGLDWVALA ARKIPAPFQP QIRSELDVGN FAEEFTRLEP VYSPPGSPPP GDPRIFQGYS 360
FVAPSILFDH NNAVMMTDVL EASGAGDRPG RAAVARSAMM QDSPFFQQYE LDLREPALGQ 420
GSFSVCRRCR QRQSGQEFAV KILSRRLEGN TQREVAALRL CQLHPNVVKL HDVHHDQLHT 480
YLVLELLRGG ELLEHIRKKR HFSESEASQI LRSLVSAVSF MHEEAGVVHR DLKPENILYA 540
DDTPGAPVKI IDFGFARLRP QSPAGPMQTP CFTLQYAAPE LLAQQGYDES CDLWSLGVIL 600
YMMLSGQVPF QGASGQGGQS QAAEIMCKIR EGRFSLDGEA WQGVSEEAKE LVRGLLTVDP 660
AKRLKLEGLR GSSWLQDGSA RSSPPLRTPD VLESSGPAVR SGLNATFMAF NRGKREGFFL 720
KSVENAPLAK RRKQKLRSAT TSRRVSPAPA AAGRAPAAKG APRRANGPLP PS 772
Nucleotide Sequence
(FASTA)
ATGGGGGACG AGGACGAGGA CGAGGGCTGC GCCGTGGAGC TGCGGATCAC CGAAGCCAAC 60
CTGACCGGGC ACGAGGAGAA GGTGAGCGTG GAGAACTTCG AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGGAAAGCCG TCGGGCACGA TGCAGGGAAG 180
CTGTACGCGA TGAAGGTGCT GCGCAAGGCC GCGCTGGTGC AGCGCGCCAA GACGCAGGAG 240
CACACGCGCA CCGAGCGCTC GGTGCTGGAA CTCGTGCGCC AGGCGCCCTT CCTGGTCACG 300
CTGCACTATG CCTTCCAGAC AGACGCCAAG CTGCACCTCA TCCTGGACTA CGTGAGTGGA 360
GGCGAGATGT TCACCCACCT CTACCAGCGC CAGCACTTCA AAGAGGCCGA GGTGCGCGTG 420
TACGGGGGCG AGATCGTGCT GGCCCTGGAG CACCTGCACA AGCTGGGTAT CATCTACCGG 480
GATCTGAAGC TGGAGAACGT GCTGCTGGAC TCCGAGGGCC ACATCGTCCT CACGGACTTC 540
GGGCTTAGCA AGGAGTTCCT GACGGAGGAG AAAGAACGAA CCTTCTCCTT CTGTGGCACC 600
ATCGAGTACA TGGCTCCCGA AATCATCCGC AGCAAGTCAG GGCACGGCAA GGCTGTGGAC 660
TGGTGGAGCC TGGGCATCCT GCTCTTCGAG CTGCTGACCG GGGCCTCGCC CTTCACCCTG 720
GAGGGTGAGA GGAACACGCA GGCAGAGGTG TCCCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCCCCCC GGATCGGGCC CGTGGCACAG GACCTGCTGC GAAGGCTACT TTGCAAGGAC 840
CCCAAGAAGC GGCTGGGTGC GGGGCCCCAG GGGGCCCAGG AAGTCAAGAA CCACCCCTTC 900
TTCCAGGGTT TGGATTGGGT TGCTCTAGCT GCCAGGAAAA TTCCAGCCCC TTTCCAACCC 960
CAGATCCGCT CTGAGCTGGA TGTGGGCAAC TTTGCAGAAG AATTTACTCG GTTGGAACCT 1020
GTCTACTCAC CCCCTGGCAG CCCCCCACCT GGGGACCCTC GCATCTTCCA GGGATACTCC 1080
TTCGTGGCGC CCTCCATCCT GTTTGACCAT AACAACGCGG TGATGATGAC AGATGTGCTG 1140
GAAGCATCTG GCGCTGGAGA CCGGCCTGGC CGGGCAGCAG TGGCCAGGAG TGCCATGATG 1200
CAGGACTCGC CCTTCTTCCA GCAGTACGAG CTGGACCTGC GGGAGCCGGC GCTGGGCCAG 1260
GGCAGCTTCT CGGTGTGTCG CCGCTGTCGC CAGCGCCAGA GCGGCCAAGA GTTCGCGGTC 1320
AAGATCCTCA GCCGCAGGCT GGAGGGGAAC ACGCAGCGAG AAGTGGCCGC CCTACGGCTT 1380
TGCCAGTTGC ATCCAAACGT GGTGAAGTTG CACGACGTGC ATCACGACCA GCTGCACACG 1440
TACCTGGTTC TGGAGCTGCT GCGGGGCGGG GAGCTGCTGG AGCACATCCG CAAGAAGCGG 1500
CACTTCAGCG AGTCCGAGGC GAGCCAGATC TTGCGCAGCC TCGTGTCGGC CGTGAGCTTC 1560
ATGCACGAGG AGGCGGGCGT GGTGCATCGG GACCTCAAGC CCGAGAACAT TCTGTACGCC 1620
GATGACACGC CCGGAGCCCC CGTGAAGATC ATCGACTTTG GGTTTGCGCG GCTGCGCCCG 1680
CAGAGCCCCG CGGGGCCCAT GCAGACGCCG TGCTTCACGC TGCAGTACGC CGCTCCCGAG 1740
CTGCTGGCGC AGCAGGGCTA TGACGAGTCC TGCGACCTCT GGAGCCTGGG CGTCATTCTG 1800
TACATGATGC TGTCGGGGCA GGTCCCCTTC CAGGGGGCCT CGGGCCAGGG TGGGCAGAGC 1860
CAGGCGGCCG AGATCATGTG CAAGATTCGT GAGGGGCGCT TCTCTCTTGA TGGGGAGGCC 1920
TGGCAGGGCG TGTCTGAGGA AGCCAAGGAG CTGGTCCGAG GGCTCCTGAC GGTGGACCCT 1980
GCCAAGCGGC TGAAGCTTGA GGGGCTGCGG GGAAGCTCAT GGCTACAGGA TGGCAGCGCG 2040
CGCTCCTCGC CCCCACTCCG GACACCCGAC GTGCTGGAGT CCTCGGGGCC AGCTGTGCGC 2100
TCCGGGCTCA ACGCCACTTT CATGGCCTTC AACCGCGGCA AGCGCGAGGG CTTTTTCCTG 2160
AAGAGCGTGG AGAACGCGCC GCTGGCGAAG AGGCGGAAAC AGAAGCTGCG GAGCGCCACC 2220
ACCTCCCGCC GCGTCTCCCC TGCACCCGCC GCTGCGGGCA GGGCCCCCGC CGCCAAGGGA 2280
GCCCCCAGAC GAGCCAACGG CCCTCTGCCG CCCTCCTAG 2319
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ + +t++e+++l++++ hpn+v+l+dv++
Q: 416   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEGNTQREVAALRLCQLHPNVVKLHDVHH  475
         579****************************9****************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 476   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  535
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 536   NILYADDTPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQQGYDESCDLW  594
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 595   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  654
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+ +swl
Q: 655   LLTVDPAKRLKLEGLRGSSWL  675
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEGNTQREV AALRLCQLHP NVVKLHDVHH 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRGSSWL 260
KeywordATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013