EKS-MUP-00231

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00231

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	428.0	1.2E-128	46	306	261

Status

Unreviewed

Ensembl Protein

ENSMPUP00000012866

UniProt Accession

G9K9M9;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase-activated protein kinase 3;

Gene Name

Mapkapk3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000012966	ENSMPUP00000012866	ENSMPUT00000013075

Organism

Mustela putorius furo

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MDGETAEEQG GPVPPQGAPC GPGSASAPAV GGRREPKKYA VTDDYQLSKQ VLGLGVNGKV 60

LECFHRRTGQ KCALKLLYDS PKARQEVDHH WQASGGPHIV QILDVYENLH RSKRCLLIVM 120

ECMEGGELFS RIQERGDQAF TEREAAEIMR DIGTAIQFLH SQNIAHRDVK PENLLYTSKE 180

KDAVLKLTDF GFAKETTQNA LQTPCYTPYY VAPEVLGPEK YDKSCDMWSL GVIMYILLCG 240

FPPFYSNTGQ AISPGMKRRI RLGQYGFPNP EWSEVSEDAK QLIRLLLKTD PTERLTITQF 300

MNHPWINQSM VVPQTPLHTA RVLQEDRDHW DEVKEEMTSA LATMRVDYDQ VQIKDLKTSN 360

NRLLNKRRKK QAGGSSASQG CNNQ 384

Nucleotide Sequence
(FASTA)

ATGGATGGCG AGACAGCAGA GGAGCAGGGG GGTCCTGTGC CCCCGCAAGG TGCACCCTGC 60

GGACCTGGCT CGGCCAGCGC TCCTGCCGTC GGGGGGCGGC GGGAGCCCAA GAAGTATGCG 120

GTGACCGATG ACTACCAGTT GTCCAAGCAG GTGCTGGGCC TGGGTGTGAA CGGCAAGGTG 180

CTGGAGTGCT TCCACAGGCG CACTGGGCAG AAGTGTGCCC TGAAGCTCCT GTATGACAGC 240

CCCAAGGCCC GGCAGGAGGT GGACCACCAC TGGCAGGCCT CTGGCGGCCC TCACATCGTG 300

CAGATCCTGG ACGTATATGA GAACTTGCAT CGCAGCAAGC GCTGCCTCCT CATCGTCATG 360

GAGTGCATGG AAGGTGGTGA GCTCTTCAGT CGGATTCAGG AGCGTGGCGA CCAGGCCTTC 420

ACTGAGAGAG AAGCTGCAGA GATCATGCGG GATATCGGCA CCGCCATCCA GTTCTTGCAC 480

AGCCAGAACA TTGCCCACCG AGATGTCAAG CCTGAAAACC TGCTCTACAC ATCCAAGGAG 540

AAAGATGCAG TACTCAAGCT CACCGACTTT GGCTTTGCCA AAGAGACCAC CCAAAATGCC 600

CTGCAGACAC CCTGCTATAC TCCCTATTAC GTGGCTCCTG AGGTCTTGGG TCCAGAGAAG 660

TATGACAAGT CGTGTGACAT GTGGTCCCTG GGCGTCATCA TGTACATCCT CCTATGTGGC 720

TTCCCGCCTT TCTACTCCAA CACGGGCCAG GCCATCTCCC CAGGGATGAA GAGGAGGATC 780

CGCCTGGGCC AGTACGGCTT CCCCAATCCT GAGTGGTCGG AGGTTTCTGA AGATGCGAAG 840

CAGCTGATCC GCCTCCTGCT GAAGACAGAC CCCACCGAGC GGTTGACCAT CACACAGTTC 900

ATGAACCATC CCTGGATCAA CCAATCGATG GTGGTGCCAC AGACCCCCCT CCATACCGCC 960

CGTGTGCTGC AGGAGGATAG AGACCACTGG GATGAGGTCA AGGAAGAGAT GACCAGCGCC 1020

CTGGCAACCA TGCGAGTGGA CTACGACCAG GTGCAGATCA AGGACCTGAA GACCTCTAAC 1080

AACAGGCTGC TCAACAAGCG GAGGAAGAAG CAGGCGGGGG GCTCCTCTGC CTCACAGGGC 1140

TGCAACAACC AGTAG 1155

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         +l+++vlG G++gkvlec++++tg+k+alk+l+d++k+r+ev++h+qasg ++iv+++dv

Q: 46    QLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVQILDV  105

         5789********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en ++ +++ll+v+e++eGGel+sriqer  +afte+ea+e+++di++a++flhs+nia

Q: 106   YENLHRSKRCLLIVMECMEGGELFSRIQERgdQAFTEREAAEIMRDIGTAIQFLHSQNIA  165

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+skek+a++kl+Dfg+ake +++++l+tpc+t++yvaPevl++ek

Q: 166   HRDVKPENLLYTSKEKDAVLKLTDFGFAKE-TTQNALQTPCYTPYYVAPEVLGPEK----  220

         *****************************7.7899*********************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcG+pPfys++g+ais+++k+ri+ g+y fP++eWsevse+a

Q: 221   -YDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDA  279

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir lLk+dp+erlti++++nhpw+

Q: 280   KQLIRLLLKTDPTERLTITQFMNHPWI  306

         **************************8

Domain Sequence
(FASTA)

QLSKQVLGLG VNGKVLECFH RRTGQKCALK LLYDSPKARQ EVDHHWQASG GPHIVQILDV 60

YENLHRSKRC LLIVMECMEG GELFSRIQER GDQAFTEREA AEIMRDIGTA IQFLHSQNIA 120

HRDVKPENLL YTSKEKDAVL KLTDFGFAKE TTQNALQTPC YTPYYVAPEV LGPEKYDKSC 180

DMWSLGVIMY ILLCGFPPFY SNTGQAISPG MKRRIRLGQY GFPNPEWSEV SEDAKQLIRL 240

LLKTDPTERL TITQFMNHPW I 261

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0044351	; P:macropinocytosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032496	; P:response to lipopolysaccharide
GO:0006950	; P:response to stress
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013