EKS-MUP-00125

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00125

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	452.8	3.5E-136	1082	1339	258

Status

Unreviewed

Ensembl Protein

ENSMPUP00000013195

UniProt Accession

G9KBK2;

Protein Name

Protein Synonyms/Alias

Macrophage stimulating 1 receptor;

Gene Name

Mst1r

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000013293	ENSMPUP00000013195	ENSMPUT00000013406

Organism

Mustela putorius furo

Functional Description

Protein Length

1399

Protein Sequence
(FASTA)

MELLPLPSQP SLLLLLLVLV LPPLLTRGSW QCPRTPFAAL RNFDVEYEVP SFSAGGPVQA 60

VTTYEGGEDG SAVFVATRNR LYVLGPGLEP VESLATGPIG DPGCQTCAAC GPGPHGPQGD 120

TDAQVLVLEP ALPALVSCGS SLHGRCFLHE LEPGGTALHL APPICLFSAH HNQPEECPDC 180

VASPLGTVVT VVEQGHASYF YVASSLDETV AASFSPRSVS IRRLKADASG FAPGFAALSV 240

LPQYLASYPI EYVYSFRAGA FVYFLTVQRA SVTAAPGALH TRLARLNAAE PELGDYRELV 300

LDCRFAPKRR RRGAAEGGQP YPVLRAAHTA PVGSRLATEL SIREGQEVLF GVFRARRDSS 360

PGVNPNSVVC AFPIDLVDTV IEQGVKRCCE SPVPQGMRRG LDFFQSHSFC PNPPGQEAPS 420

LNTSCHHFPL LVHGSLSRVD LFNGLLGPVQ VTALHVTRLD NVTVAHMGTA DGRILQVELA 480

RSLNYLLYVS NFSLGCCGQP MRPDVSRLGD HLFFASGDQV FQVPIQGPGC HHFLTCGSCL 540

RAQRFMGCGW CGDTCGRQKE CPGSWQQDHC PPELTEFYPQ SGPRRGSTRL TLCGSNFYPH 600

PPEPVREGTH QVTVGQSPCR LLPKDSSNPR PVFQKDFVEE LECEVEPLDM QLAGPANISL 660

TVSNMSPGKH FRVYGTSTLQ GFSFMEPVLR AVKPLFGPRA GGTRLTLEGE GLSLGTSQAV 720

LVNGTECPLE RVSEGQLLCT TPPAAATASV PIHLQVGGAV VPGSWNFSYL EDPVVLGISP 780

NCGYIGSQVT VQGQHLTSAW RLVLSFHDGL RAVENSCERQ LPEQQSCRLP EYVVRSPQGW 840

VTGNLSAQGD GAAGFILPGF RFLPPPHPPS TDLAPLKPEE HAVKFEYIGL GAVADCVDVN 900

VTMDGKSCQH ELRGDVVICP LPPSLQLDMD GVPLQVCVDG ECHILGRVVR PGPEGVPQGL 960

LLGLLLALLL LVAALAAALI FSYWRRKQLG DLASLDRMAG AMPLPVLRSG SDYRNGLAAP 1020

DADGLDGPDS TSREHKASSS DSGDGSCVPL LRTASIQLGD LDSALLAEVK DVLIPHERVV 1080

THSDRVIGKG HFGVVYHGEY IDEDQNRIHC AIKSLSRITE GQEVEAFLRE GLLMRGLRHP 1140

NVLALIGIVL PPEGLPRVLL PYMRHGDLLR FIRSPQRNPT VKDLVSFGLQ VARGMEYLAE 1200

QKFVHRDLAA RNCMLDESFT VKVADFGLAR DVLDKEYYSV RQHRHARLPV KWMALESLQT 1260

YRFTTKSDVW SFGVLLWELL TRGAPPYPHM DPFDLTQFLA QGRRLPQPEY CPNSLYAVML 1320

RCWAADPTVR PTFKVLVEEV EHVAARLLGD HYVQLPAAYV NLGASTSDEA SKPPEQSQTT 1380

PVHRSTARPR PLSEPPQPT 1399

Nucleotide Sequence
(FASTA)

ATGGAGCTTC TCCCGCTGCC CTCCCAGCCC TCGCTGTTAC TGCTGCTGCT GGTGCTGGTG 60

CTGCCGCCGC TCCTGACCAG AGGGTCCTGG CAGTGCCCAC GCACTCCCTT CGCTGCCTTG 120

CGCAATTTTG ACGTGGAGTA CGAGGTGCCC AGCTTCTCGG CCGGAGGTCC AGTACAGGCT 180

GTAACGACCT ACGAGGGCGG CGAGGACGGG AGTGCGGTAT TCGTGGCTAC ACGCAATCGC 240

CTGTACGTGC TTGGGCCTGG CTTAGAGCCA GTAGAGAGCC TGGCTACGGG TCCTATTGGG 300

GACCCTGGCT GCCAGACATG TGCAGCCTGT GGCCCGGGCC CCCATGGCCC ACAGGGAGAC 360

ACAGATGCAC AGGTGCTGGT ACTGGAGCCG GCGCTGCCGG CGCTGGTCAG CTGCGGCTCT 420

AGCTTGCATG GCCGCTGCTT CCTGCACGAG CTTGAGCCGG GAGGGACAGC TTTGCACCTG 480

GCACCGCCAA TCTGCCTCTT CTCCGCCCAC CACAACCAAC CCGAGGAGTG CCCTGACTGC 540

GTGGCCAGCC CTCTGGGCAC CGTTGTGACT GTAGTTGAGC AGGGCCATGC TTCCTACTTC 600

TACGTGGCAT CCTCACTGGA CGAGACTGTG GCAGCGAGCT TCAGCCCGCG CTCAGTGTCC 660

ATCCGGCGCC TCAAGGCCGA TGCCTCCGGA TTCGCACCGG GCTTCGCAGC GCTGTCGGTG 720

CTGCCCCAGT ACCTCGCTTC CTACCCTATC GAGTACGTGT ACAGTTTCCG TGCCGGAGCC 780

TTTGTCTATT TCCTGACCGT GCAGCGGGCC AGCGTGACAG CCGCCCCGGG AGCCTTGCAC 840

ACGCGCCTGG CACGGCTCAA CGCTGCTGAG CCCGAGCTGG GAGACTACCG TGAGCTGGTC 900

CTGGACTGCC GATTCGCGCC TAAACGCCGG CGCCGCGGGG CCGCCGAGGG AGGACAGCCC 960

TACCCGGTGC TGAGAGCGGC CCACACCGCT CCGGTGGGCA GCCGGTTGGC CACTGAGCTG 1020

AGCATCCGGG AGGGCCAGGA AGTGCTATTT GGAGTCTTCA GGGCCAGGAG AGACAGCAGC 1080

CCCGGTGTGA ATCCCAACTC TGTCGTCTGT GCTTTTCCCA TCGACCTGGT GGACACTGTC 1140

ATCGAGCAGG GTGTGAAGCG CTGCTGTGAG TCTCCTGTCC CCCAGGGCAT GCGGCGAGGC 1200

CTCGACTTCT TCCAGTCGCA TAGTTTTTGC CCCAACCCGC CTGGCCAGGA GGCCCCCAGC 1260

CTCAACACCA GCTGCCATCA CTTCCCTCTG CTGGTCCATG GGAGCCTGTC ACGGGTGGAC 1320

CTCTTCAACG GGCTCTTAGG ACCTGTGCAG GTCACTGCAC TGCATGTGAC ACGCCTCGAC 1380

AACGTCACAG TGGCCCACAT GGGCACAGCT GATGGGCGCA TCCTGCAGGT GGAGCTGGCC 1440

AGATCTCTCA ACTATTTGCT GTATGTGTCC AACTTCTCAC TGGGCTGCTG TGGGCAGCCC 1500

ATGAGACCAG ATGTCAGTCG CCTCGGAGAC CACCTGTTCT TTGCCTCTGG GGACCAGGTC 1560

TTCCAAGTAC CTATCCAGGG TCCCGGCTGC CATCACTTCC TCACTTGTGG GAGCTGTCTG 1620

CGGGCACAGC GTTTCATGGG CTGTGGCTGG TGTGGGGACA CGTGTGGCCG GCAGAAGGAA 1680

TGTCCTGGCT CCTGGCAACA GGATCATTGC CCACCTGAGC TTACTGAGTT CTACCCACAG 1740

AGTGGACCCC GAAGGGGCAG CACAAGGCTG ACCCTATGCG GCTCCAACTT CTACCCACAC 1800

CCTCCAGAGC CGGTACGTGA AGGTACCCAT CAGGTCACTG TGGGCCAAAG TCCCTGCCGA 1860

TTGCTGCCCA AGGACAGTTC AAACCCCAGA CCAGTGTTCC AGAAAGACTT TGTAGAGGAG 1920

CTTGAGTGTG AGGTGGAGCC CTTGGACATG CAGCTGGCTG GGCCCGCCAA TATCAGCCTC 1980

ACTGTGAGCA ACATGTCTCC AGGCAAGCAC TTCCGGGTAT ATGGCACCTC CACGCTGCAA 2040

GGCTTCTCTT TCATGGAGCC AGTGCTGAGA GCAGTAAAAC CCCTCTTTGG CCCACGGGCA 2100

GGGGGCACCC GCCTCACCCT TGAAGGCGAG GGCCTCTCTT TAGGCACCAG TCAGGCTGTG 2160

CTGGTCAACG GGACTGAGTG CCCACTGGAA CGGGTTAGCG AGGGACAGCT TTTATGTACC 2220

ACGCCCCCTG CGGCAGCTAC GGCCAGCGTT CCCATTCACC TGCAGGTAGG GGGCGCTGTG 2280

GTGCCTGGCT CCTGGAACTT CAGCTACCTG GAAGACCCCG TTGTGCTGGG CATCAGCCCC 2340

AACTGTGGCT ACATAGGCTC CCAGGTCACT GTCCAGGGCC AGCATCTGAC TTCCGCATGG 2400

CGCCTAGTGC TGTCATTCCA TGATGGGCTC AGAGCAGTGG AAAACAGTTG TGAGCGGCAG 2460

CTCCCGGAGC AGCAGTCATG CCGCCTGCCT GAATATGTGG TCCGAAGCCC CCAGGGGTGG 2520

GTGACAGGGA ACCTGAGCGC CCAGGGGGAT GGAGCTGCTG GCTTTATACT GCCTGGCTTT 2580

CGCTTTCTGC CCCCACCCCA TCCTCCCAGC ACCGACCTGG CCCCACTGAA GCCAGAGGAG 2640

CATGCTGTTA AGTTTGAGTA TATTGGGCTG GGCGCTGTGG CTGATTGTGT GGATGTGAAC 2700

GTGACCATGG ATGGTAAGAG CTGCCAACAT GAGCTCCGGG GCGATGTGGT CATCTGCCCT 2760

CTGCCCCCCT CCCTGCAACT TGACATGGAT GGCGTCCCAC TGCAGGTCTG CGTGGATGGT 2820

GAATGTCACA TCCTGGGCAG GGTGGTACGG CCGGGCCCAG AGGGGGTTCC CCAGGGGCTA 2880

CTCCTCGGTC TCCTGCTGGC CCTTCTCCTG CTTGTGGCTG CGCTGGCTGC TGCACTGATC 2940

TTCAGCTACT GGCGGAGGAA ACAGCTAGGT GACCTGGCAT CCTTGGACCG GATGGCCGGA 3000

GCCATGCCTC TACCTGTGCT TCGGTCTGGC TCTGACTACA GAAATGGCCT TGCAGCCCCT 3060

GATGCCGATG GTCTGGATGG TCCAGATTCC ACCAGCCGGG AACATAAAGC ATCCTCCTCA 3120

GACAGTGGGG ATGGGTCCTG CGTCCCACTG CTGCGGACGG CATCCATCCA GCTTGGGGAC 3180

TTGGACTCTG CGCTCCTGGC CGAGGTCAAG GATGTGCTGA TCCCCCATGA GCGGGTGGTC 3240

ACCCACAGTG ACCGAGTCAT TGGCAAAGGC CACTTTGGAG TTGTCTATCA TGGAGAATAC 3300

ATAGACGAGG ACCAGAATCG AATCCACTGT GCCATCAAGT CGCTGAGTCG CATCACGGAG 3360

GGGCAGGAGG TGGAGGCCTT CCTGCGCGAG GGGCTGCTGA TGCGCGGTCT GCGTCACCCG 3420

AACGTGCTGG CTCTCATTGG CATCGTGCTG CCCCCGGAAG GGCTGCCCCG TGTGCTGCTG 3480

CCCTACATGC GCCACGGAGA CCTGCTTCGG TTCATCCGCT CGCCCCAGCG GAATCCCACA 3540

GTGAAGGACC TTGTCAGCTT CGGCCTTCAG GTGGCCCGCG GCATGGAGTA CCTGGCAGAG 3600

CAGAAGTTTG TGCACAGGGA CCTGGCTGCT CGGAACTGCA TGCTGGACGA GTCATTCACT 3660

GTCAAGGTGG CTGATTTTGG CCTGGCCCGC GACGTGCTGG ACAAGGAGTA CTACAGTGTT 3720

CGGCAGCATC GCCACGCTCG CCTCCCTGTC AAATGGATGG CGCTGGAGAG CCTGCAGACC 3780

TACAGATTCA CCACCAAGTC TGACGTGTGG TCATTTGGTG TGCTGTTGTG GGAGCTGCTG 3840

ACACGGGGAG CCCCACCATA CCCCCATATG GACCCTTTCG ACCTCACTCA ATTCCTGGCC 3900

CAGGGTCGGC GCCTGCCCCA GCCTGAGTAT TGTCCCAATT CTCTGTATGC CGTGATGCTC 3960

CGCTGCTGGG CGGCTGACCC CACAGTGAGA CCCACGTTCA AGGTGCTGGT GGAGGAAGTA 4020

GAGCACGTGG CGGCCAGGCT GCTCGGGGAC CACTACGTGC AGCTGCCTGC AGCCTACGTA 4080

AACCTGGGTG CTAGTACCTC AGATGAGGCC AGCAAGCCCC CAGAACAGTC GCAGACCACG 4140

CCCGTGCACA GGAGCACAGC TCGGCCCCGG CCTCTCTCAG AGCCTCCACA GCCCACGTGA 4200

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         ++++viGkGhfGvvy+ge++d+++++i++a+ksl+rit+ ++ve+flregl+m++l hpn

Q: 1082  HSDRVIGKGHFGVVYHGEYIDEDQNRIHCAIKSLSRITEGQEVEAFLREGLLMRGLRHPN  1141

         7899********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vl+l+Gi+l++eglp v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla++

Q: 1142  VLALIGIVLPPEGLPRVLLPYMRHGDLLRFIRSPQRNPTVKDLVSFGLQVARGMEYLAEQ  1201

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlardvldke+y+v+++r+arlpvkw+aleslqt+

Q: 1202  KFVHRDLAARNCMLDESFTVKVADFGLARDVLDKEYYSVRQHRHARLPVKWMALESLQTY  1261

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         + fttksdvwsfGvllwelltrga+py+++++fdlt++l++grrl++peycp++ly vml

Q: 1262  R-FTTKSDVWSFGVLLWELLTRGAPPYPHMDPFDLTQFLAQGRRLPQPEYCPNSLYAVML  1320

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsi  260

         +cw a+p  rp+f  lv

Q: 1321  RCWAADPTVRPTFKVLVEE  1339

         *************999876

Domain Sequence
(FASTA)

HSDRVIGKGH FGVVYHGEYI DEDQNRIHCA IKSLSRITEG QEVEAFLREG LLMRGLRHPN 60

VLALIGIVLP PEGLPRVLLP YMRHGDLLRF IRSPQRNPTV KDLVSFGLQV ARGMEYLAEQ 120

KFVHRDLAAR NCMLDESFTV KVADFGLARD VLDKEYYSVR QHRHARLPVK WMALESLQTY 180

RFTTKSDVWS FGVLLWELLT RGAPPYPHMD PFDLTQFLAQ GRRLPQPEYC PNSLYAVMLR 240

CWAADPTVRP TFKVLVEE 258

Keyword

ATP-binding; Kinase; Nucleotide-binding; Receptor; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0001725	; C:stress fiber
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0009615	; P:response to virus

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013