EPS-MUP-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUP-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	92.0	4.9E-26	56	332	277

Status

Unreviewed

Ensembl Protein

ENSMPUP00000013275

UniProt Accession

G9KS72;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1;

Gene Name

TAB1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000013374	ENSMPUP00000013275	ENSMPUT00000013487

Organism

Mustela putorius furo

Functional Description

Protein Length

504

Protein Sequence
(FASTA)

MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG TASNRSYSAD GKGTESHPPE DSWLKFRSEN 60

NCYLYGVFNG YDGNRVTSFV AQRLSAELLL GQLSAEHTEA DVRRVLLQAF DVVERSFLES 120

IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKALER EISGGAMAVV AVLLNSKLYV 180

ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIVCGQEST 240

RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300

GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHGD TFASGGERAK FCPRHEDMTL 360

LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQLVNG 420

AHSASTLDEA TPTLTNQSPT LTLQSTTTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP 480

YVDFAEFYRL WSVDHGEQSV MTAP 504

Nucleotide Sequence
(FASTA)

ATGGCGGCGC AGAGGAGGAG CCTGCTGCAG AGCGAGCAGC AGCCAAGCTG GACAGATGAC 60

CTTCCACTCT GCCACCTCTC TGGGGTTGGT ACTGCCTCCA ACCGCAGCTA CTCTGCTGAT 120

GGTAAGGGCA CTGAGAGCCA CCCACCAGAG GACAGCTGGC TCAAGTTCAG GAGTGAGAAC 180

AACTGCTACC TGTACGGGGT CTTCAATGGC TACGATGGCA ACCGAGTGAC CAGCTTCGTG 240

GCCCAGCGGC TATCTGCCGA GCTCCTGCTG GGCCAGCTCA GTGCCGAGCA CACCGAGGCG 300

GACGTGCGGC GCGTGCTGCT GCAGGCCTTC GATGTGGTGG AAAGGAGCTT CCTGGAGTCC 360

ATCGATGACG CACTGGCTGA GAAGGCAAGC CTCCAGTCCC AGCTGCCAGA GGGTGTCCCT 420

CAGCACCAGC TGCCCCCACA GTACCAGAAG ATCCTCGAGA GACTCAAGGC TCTGGAGAGG 480

GAGATTTCCG GAGGAGCCAT GGCCGTCGTG GCTGTCCTGC TCAACAGCAA GCTCTATGTC 540

GCCAATGTCG GTACAAATCG TGCCCTTTTG TGCAAATCCA CGGTGGACGG GCTGCAGGTG 600

ACCCAGCTGA ACGTGGACCA CACCACGGAG AACGAAGACG AGCTTTTCCG CCTCTCTCAG 660

CTCGGTTTGG ATGCAGGAAA GATCAAGCAG GTGGGCATCG TCTGTGGGCA GGAGAGCACC 720

AGACGCATCG GGGATTACAA GGTCAAATAC GGCTACACTG ACATCGACCT ACTCAGCGCT 780

GCCAAGTCCA AGCCGATTAT CGCGGAGCCC GAAATCCACG GTGCGCAGCC CCTGGACGGA 840

GTGACTGGCT TCCTGGTGCT GATGTCGGAG GGGCTCTACA AGGCTCTGGA GGCCGCCCAC 900

GGGCCCGGGC AGGCCAACCA GGAGATCGCC GCCATGATCG ACACGGAGTT CGCCAAGCAG 960

ACTTCCCTGG ATGCCGTGGC CCAGGCCGTG GTAGACCGGG TGAAGCGCAT CCACGGGGAC 1020

ACCTTTGCCA GTGGCGGTGA GCGCGCCAAG TTCTGCCCGA GGCACGAGGA CATGACCCTG 1080

CTGGTGAGGA ATTTTGGCTA CCCTCTTGGT GAGATGAGCC AGCCCACGCC ATCCCCGGCT 1140

CCAGCTGCAG GAGGACGTGT GTACCCCGTC TCCGTGCCGT ACTCCAGCGC CCAGAGCACC 1200

AGCAAGACCA GCGTGACCCT CTCCCTTGTC ATGCCCTCCC AGGGCCAGCT GGTCAACGGG 1260

GCCCACAGCG CTTCCACGCT GGACGAAGCC ACGCCTACCC TCACCAACCA GAGCCCAACC 1320

CTGACACTGC AGTCCACCAC CACGCACACG CAGAGCAGCA GCTCCAGCTC CGACGGGGGC 1380

CTCTTCCGCT CCCGGCCCGC CCACTCTCTC CCGCCTGGCG AGGACGGCCG CGTCGAGCCT 1440

TACGTGGACT TTGCTGAGTT TTACCGCCTC TGGAGTGTGG ACCATGGCGA GCAGAGTGTG 1500

ATGACAGCCC CGTAG 1515

Domain Profile

S: 28    spekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFlstd  87

          +++++  +++gv++G  g++v++f++++l+  l     s e +e++v+++l +aF  ++

Q: 56    FRSENN-CYLYGVFNGYDGNRVTSFVAQRLSAELLLGQLSAEHTEADVRRVLLQAFDVVE  114

         444444.69*********************976655555599******************

S: 88    eel................................kvleeksldidk..sGstavvalik  113

         + +                                k+le+ +  +++   G+ avva++

Q: 115   RSFlesiddalaekaslqsqlpegvpqhqlppqyqKILERLKALEREisGGAMAVVAVLL  174

         *******************************999966666655555566999********

S: 114   dsklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvilkdga  166

         +sklyvanvG  ra+Lc++  +   + +l +dH++++edEl R+++ g   g++ +

Q: 175   NSKLYVANVGTNRALLCKSTvDglqVTQLNVDHTTENEDELFRLSQLGldaGKIKQVG--  232

         *****************9663366699*********************9877777776..

S: 167   RvlGvLavsRalGdlylk..............pyvtpePevtshrl.tsedefliLasDG  211

          v+G  + +R +Gd+++k              + +++ePe++  +  +  + fl+L s G

Q: 233   IVCG-QESTRRIGDYKVKygytdidllsaaksKPIIAEPEIHGAQPlDGVTGFLVLMSEG  291

         8999.599***********************999*******98765155555********

S: 212   lwdvvs........neeavslvrdvlekkeaeqeaakkLvk  244

         l++ ++        n+e+ +++     k+++++++a+ +v+

Q: 292   LYKALEaahgpgqaNQEIAAMIDTEFAKQTSLDAVAQAVVD  332

         ***98633333333566666665555567777777777666

Domain Sequence
(FASTA)

FRSENNCYLY GVFNGYDGNR VTSFVAQRLS AELLLGQLSA EHTEADVRRV LLQAFDVVER 60

SFLESIDDAL AEKASLQSQL PEGVPQHQLP PQYQKILERL KALEREISGG AMAVVAVLLN 120

SKLYVANVGT NRALLCKSTV DGLQVTQLNV DHTTENEDEL FRLSQLGLDA GKIKQVGIVC 180

GQESTRRIGD YKVKYGYTDI DLLSAAKSKP IIAEPEIHGA QPLDGVTGFL VLMSEGLYKA 240

LEAAHGPGQA NQEIAAMIDT EFAKQTSLDA VAQAVVD 277

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0019209	; F:kinase activator activity
GO:0016301	; F:kinase activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0030324	; P:lung development
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013