EKS-MUP-00259

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00259

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	413.3	3.9E-124	62	314	253

Status

Unreviewed

Ensembl Protein

ENSMPUP00000013350

UniProt Accession

G9KHB2;

Protein Name

Protein Synonyms/Alias

Polo-like kinase 3;

Gene Name

Plk3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000013451	ENSMPUP00000013350	ENSMPUT00000013564

Organism

Mustela putorius furo

Functional Description

Protein Length

646

Protein Sequence
(FASTA)

MEPAAGLLSP RPFPRAAAPP APPAGPGPPG SAVPGPEVEM VAGPPATEPG RLITDPSSGR 60

TYFKGRLLGK GGFARCYEAT DTETGNAYAV KVISQSRITK PHQREKILNE IELHRGLQHR 120

HIVRFSHHFE DADNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQRG 180

ILHRDLKLGN FFITENMELK MGDFGLATRL EPPEHRKKTI CGTPNYVAPE VLQRQGHGPE 240

ADVWSLGCVM YTLLCGTPPF ETVDLKETYR CIKQVHYTLP ASLSLPARQL LSAILRASPQ 300

DRPSIDQILR HDFFTKGYTP DRLPVSSCVT VPDLTPLNPA RILFVKVTKS LFGRKKKSKN 360

HPEERDEVSC LVNGLMRTSI GHQGARPEAP AASGPAPLSL VETAPEDSSP HGTLASSGDG 420

FEEGLTVATV VESALCALRN CLAFMPPAEQ NPAPLAQPEP LVWVSKWVDY SNKFGFGYQL 480

SSRRVAVLFN NGTHMALSAN RKTVHYNPTS TKHFSFSVGA VPRALQPQLG VLRYFASYME 540

QRLMKGGDLP SVEELEVPAP PLLLQWVKTD QALLMLFSDG TVQVNFYGDH TKLILSGWEP 600

LLVTFVARNR SACTYLASHL RQLGCSPDLR QRLRYALQLL RDRCPA 646

Nucleotide Sequence
(FASTA)

ATGGAGCCAG CCGCCGGCCT CCTATCCCCG CGCCCCTTCC CGCGTGCGGC CGCTCCGCCC 60

GCGCCCCCTG CCGGGCCCGG GCCGCCTGGA AGTGCAGTGC CGGGACCTGA AGTGGAGATG 120

GTGGCTGGGC CACCCGCGAC GGAACCAGGG CGCCTTATCA CAGACCCGAG CAGCGGTCGC 180

ACCTACTTCA AAGGCCGCCT GTTGGGCAAG GGGGGCTTTG CCCGCTGCTA TGAGGCCACT 240

GACACAGAGA CGGGCAACGC CTACGCGGTC AAAGTCATCT CGCAGAGCCG CATCACCAAG 300

CCGCATCAGC GCGAGAAGAT CCTAAACGAG ATTGAGCTGC ACCGCGGCCT GCAGCACCGC 360

CACATCGTGC GTTTCTCGCA CCACTTTGAG GATGCGGACA ACATATACAT TTTTCTGGAG 420

CTCTGCAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GGCACACTCT CTTGGAACCA 480

GAGGTGCGCT ATTACCTGCG CCAGATCCTT TCCGGACTCA AGTACTTGCA CCAGCGGGGT 540

ATCCTGCATC GGGACCTCAA GCTGGGGAAT TTTTTTATCA CCGAGAACAT GGAACTGAAG 600

ATGGGGGACT TTGGGCTGGC AACCCGGTTG GAACCCCCGG AACATAGGAA GAAAACCATC 660

TGTGGCACCC CCAACTATGT GGCTCCAGAA GTGCTGCAGA GACAGGGCCA TGGCCCGGAG 720

GCAGACGTGT GGTCCCTGGG CTGTGTCATG TACACACTGC TGTGTGGGAC TCCCCCCTTT 780

GAGACAGTTG ACTTGAAGGA GACGTATCGC TGCATCAAAC AGGTTCACTA CACACTGCCC 840

GCCAGCCTCT CACTGCCTGC CCGGCAGCTT CTGTCTGCCA TCCTTCGAGC CTCACCCCAA 900

GACCGCCCCT CAATCGATCA GATCCTGCGC CATGACTTCT TTACCAAGGG CTACACCCCC 960

GACCGGCTCC CTGTCAGCAG CTGTGTGACA GTCCCAGACC TGACACCCCT TAACCCAGCT 1020

AGGATCCTAT TTGTCAAAGT TACCAAGAGC CTCTTTGGCA GGAAGAAGAA GAGTAAAAAC 1080

CATCCTGAGG AGCGGGACGA GGTCTCCTGT TTGGTGAACG GCCTCATGCG GACGTCCATT 1140

GGCCATCAAG GTGCCAGGCC AGAGGCTCCA GCAGCTTCCG GCCCTGCCCC CCTCAGCTTG 1200

GTAGAGACAG CACCTGAAGA CAGCTCACCC CATGGGACCC TGGCGAGCAG TGGAGATGGG 1260

TTTGAAGAAG GTCTGACTGT GGCCACAGTC GTGGAGTCAG CCCTCTGTGC TCTGAGAAAC 1320

TGCTTGGCCT TCATGCCGCC AGCGGAACAG AACCCAGCTC CGCTTGCACA GCCAGAGCCT 1380

CTGGTATGGG TCAGCAAGTG GGTGGACTAC TCCAACAAAT TTGGCTTTGG GTATCAGCTG 1440

TCCAGCCGCC GTGTGGCTGT GCTTTTCAAC AATGGCACAC ACATGGCCCT CTCAGCCAAC 1500

AGAAAGACCG TGCACTACAA CCCCACCAGC ACAAAGCACT TCTCCTTCTC TGTGGGTGCT 1560

GTGCCTCGGG CCCTGCAGCC TCAGCTGGGT GTCCTCCGGT ATTTTGCCTC CTACATGGAG 1620

CAGCGTCTCA TGAAGGGTGG AGATCTGCCC AGTGTGGAAG AGCTGGAGGT GCCGGCGCCC 1680

CCACTCCTGC TGCAGTGGGT CAAGACGGAT CAGGCCCTCC TTATGCTGTT CAGTGACGGC 1740

ACTGTCCAGG TAAACTTCTA TGGAGACCAC ACCAAGCTGA TCCTCAGTGG CTGGGAACCC 1800

CTGCTTGTGA CTTTTGTGGC GCGTAATCGC AGTGCTTGTA CTTACCTCGC TTCCCACCTC 1860

CGGCAGCTGG GCTGCTCCCC AGACCTGCGG CAGCGGCTCC GCTATGCTCT GCAGCTGCTC 1920

CGGGACCGCT GCCCAGCCTA G 1941

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y +g+llGkGgfa+cye++d+et++++avkv+++s+++k++qrek+ +eie+hr l+h++

Q: 62    YFKGRLLGKGGFARCYEATDTETGNAYAVKVISQSRITKPHQREKILNEIELHRGLQHRH  121

         789*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv+++++fed++n+y++lelcsr+sla+++k+r++l epevryylrqi+sglkylh++ i

Q: 122   IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI  181

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f++e++e+k+gdfGlatrle++e+rkkt+cGtPny+aPevl+++gh+ e+

Q: 182   LHRDLKLGNFFITENMELKMGDFGLATRLEPPEHRKKTICGTPNYVAPEVLQRQGHGPEA  241

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytll+G+PPfet +lkety++ik+ +y+lP+sls +a++l++++l+++P++

Q: 242   DVWSLGCVMYTLLCGTPPFETVDLKETYRCIKQVHYTLPASLSLPARQLLSAILRASPQD  301

         ************************************************************

S: 241   rpsleevlkdefl  253

         rps++++l+++f+

Q: 302   RPSIDQILRHDFF  314

         ************8

Domain Sequence
(FASTA)

YFKGRLLGKG GFARCYEATD TETGNAYAVK VISQSRITKP HQREKILNEI ELHRGLQHRH 60

IVRFSHHFED ADNIYIFLEL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQRGI 120

LHRDLKLGNF FITENMELKM GDFGLATRLE PPEHRKKTIC GTPNYVAPEV LQRQGHGPEA 180

DVWSLGCVMY TLLCGTPPFE TVDLKETYRC IKQVHYTLPA SLSLPARQLL SAILRASPQD 240

RPSIDQILRH DFF 253

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005795	; C:Golgi stack
GO:0005730	; C:nucleolus
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0090166	; P:Golgi disassembly
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:2000777	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:0006974	; P:response to DNA damage stimulus
GO:0006970	; P:response to osmotic stress
GO:0009314	; P:response to radiation
GO:0000302	; P:response to reactive oxygen species
GO:0000084	; P:S phase of mitotic cell cycle

KEGG

InterPros

IPR000959	; POLO_box_duplicated_dom.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00659

; POLO_box; 2.

SMARTs

Prosites

PS50078

; POLO_BOX; 2.

Prints

Created Date

20-Feb-2013