EKS-MUP-00039

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00039

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/Trbl	457.9	7.3E-138	66	308	243

Status

Unreviewed

Ensembl Protein

ENSMPUP00000013479

UniProt Accession

G9KV00;

Protein Name

Protein Synonyms/Alias

Tribbles-like protein 2;

Gene Name

Trib2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000013582	ENSMPUP00000013479	ENSMPUT00000013695

Organism

Mustela putorius furo

Functional Description

Protein Length

343

Protein Sequence
(FASTA)

MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC 60

IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII 120

LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK 180

FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL 240

GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ 300

EILDHPWFST DFSVSNSGYG AKEGSDQLVP DVNMEENLDP FFN 343

Nucleotide Sequence
(FASTA)

ATGAACATAC ACAGGTCTAC CCCCATCACA ATAGCAAGAT ATGGGAGATC GCGGAACAAA 60

ACCCAGGATT TCGAAGAGTT GTCGTCTATA AGGTCCGCCG AACCCAGCCA GAGTTTCAGC 120

CCGAACCTCG GCTCCCCGAG CCCGCCCGAG ACTCCGAACT TGTCGCATTG CGTTTCTTGC 180

ATCGGGAAAT ACTTATTGTT GGAACCTCTG GAGGGAGACC ACGTTTTTCG TGCCGTGCAT 240

CTGCACAGTG GGGAGGAGCT GGTGTGCAAG GTGTTCGATA TAAGCTGCTA CCAGGAATCC 300

CTGGCCCCGT GCTTTTGCCT GTCTGCCCAC AGCAACATCA ACCAAATCAC CGAAATCATC 360

CTGGGAGAGA CCAAAGCCTA TGTGTTCTTT GAGCGAAGCT ATGGGGACAT GCATTCGTTT 420

GTCCGCACCT GCAAGAAACT GAGGGAAGAG GAGGCGGCCA GACTGTTCTA CCAGATCGCC 480

TCGGCCGTGG CCCACTGCCA CGATGGGGGG CTGGTGCTGC GGGATCTGAA GCTGCGGAAA 540

TTCATCTTTA AGGACGAAGA AAGGACTCGG GTCAAGCTGG AAAGCCTGGA AGATGCCTAC 600

ATTCTGCGGG GAGATGACGA CTCCCTCTCC GACAAGCACG GCTGCCCGGC TTACGTGAGC 660

CCAGAGATCT TGAACACCAG TGGCAGCTAC TCGGGCAAAG CAGCCGACGT GTGGAGCCTG 720

GGCGTGATGC TCTACACCAT GTTGGTAGGG CGGTACCCTT TCCATGACAT TGAGCCCAGT 780

TCCCTCTTCA GCAAGATCCG ACGTGGCCAG TTCAACATTC CAGAGACTCT GTCGCCCAAG 840

GCCAAGTGCC TCATACGAAG CATCCTGCGG CGGGAGCCCT CAGAGCGGCT GACCTCGCAG 900

GAAATTCTGG ACCATCCTTG GTTTTCTACA GATTTTAGCG TCTCAAATTC AGGATATGGT 960

GCTAAGGAAG GGTCAGATCA GCTGGTGCCG GATGTCAACA TGGAAGAGAA CTTGGACCCT 1020

TTCTTTAACT GA 1032

Domain Profile

S: 1     lleleegekvyraldiftGeellckvfeieelqevlrpyiqlsahseiaritevllgeek  60

         lle+ eg++v+ra+++++Geel+ckvf+i+++qe+l+p+++lsahs+i++ite++lge+k

Q: 66    LLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETK  125

         799*********************************************************

S: 61    ayvlfeksygdlhsyvrsakrlreeeaaalfkqiasavahchksglvlrdlklrkfvfsd  120

         ayv+fe+sygd+hs+vr++k+lreeeaa+lf+qiasavahch+ glvlrdlklrkf+f+d

Q: 126   AYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKD  185

         ************************************************************

S: 121   eertklklesledslilkGeddslsdkhgcPayvsPeilstrgsysGkaadvwslGvily  180

         eert++klesled++il+G+ddslsdkhgcPayvsPeil+t+gsysGkaadvwslGv+ly

Q: 186   EERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLY  245

         ************************************************************

S: 181   tllvGryPfhdsepsalfskirrGqfaiPetlskkarclirsllrkepserltaseillh  240

         t+lvGryPfhd+eps+lfskirrGqf+iPetls+ka+clirs+lr+epserlt++eil+h

Q: 246   TMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDH  305

         ************************************************************

S: 241   Pwl  243

Pw+

Q: 306   PWF  308

**8

Domain Sequence
(FASTA)

LLEPLEGDHV FRAVHLHSGE ELVCKVFDIS CYQESLAPCF CLSAHSNINQ ITEIILGETK 60

AYVFFERSYG DMHSFVRTCK KLREEEAARL FYQIASAVAH CHDGGLVLRD LKLRKFIFKD 120

EERTRVKLES LEDAYILRGD DDSLSDKHGC PAYVSPEILN TSGSYSGKAA DVWSLGVMLY 180

TMLVGRYPFH DIEPSSLFSK IRRGQFNIPE TLSPKAKCLI RSILRREPSE RLTSQEILDH 240

PWF 243

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0055106	; F:ubiquitin-protein ligase regulator activity
GO:0045599	; P:negative regulation of fat cell differentiation
GO:0045081	; P:negative regulation of interleukin-10 biosynthetic process
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR024104	; Tribbles/Ser_Thr_kinase_40.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013