EKS-MUP-00396

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00396

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	598.7	3.7E-180	612	970	359

Status

Unreviewed

Ensembl Protein

ENSMPUP00000013885

UniProt Accession

G9KFT2;

Protein Name

Protein Synonyms/Alias

Platelet-derived growth factor receptor, beta polypeptide;

Gene Name

Pdgfrb

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000013990	ENSMPUP00000013885	ENSMPUT00000014105

Organism

Mustela putorius furo

Functional Description

Protein Length

1137

Protein Sequence
(FASTA)

MPTPEGISSK DTMQLPSTRP APVLKGQVLL LPLLLLLGPQ SSWGLVITPP GPELVLNVSS 60

NFVLTCSGPA PVVWERMSQE LPQKMAKTQD GTFSSTLTLT NVTGIDTGEY FCAYKGSDGL 120

EPGERKRLYI FVPDPTMGFL PVDPEELFIF LTEITEITIP CRVTDPKLVV TLHEKKVDIP 180

LPIPYDHQRG FSGTFEDKTY VCKTTVGDRE VDSEAYYVYS LQVSSINVSV NAVQTVVRQG 240

ENITIMCIVT GNEVVNFEWT YPRMESGRLV EPVTDFLFNI PSHIRSILHI PAAELGDSGT 300

YICNVSESVN EHRDEKSINV TVVESGYVRL LGELDALQFA ELHRSRTLQV VFEAYPPPTV 360

LWLKDNRTLG DSSAGEISLS TRNVSETRYV SELTLVRVKV AEAGCYTVRV FHEDAEAQLS 420

FQLQVNVPVR VLELSESHPA SGEQTVRCRG RGMPQPHLTW STCSDLKRCP RELPPTPLGN 480

SSEEESQLET NVTYWPEDQE FEVVSTLRLR RVDQPLSVRC TLHNLLGHDM QEVTVVPHSL 540

PFKVVVISAI LALVVLTVIS LIILIMLWQK KPRYEIRWKV IESVSSDGHE YIYVDPMQLP 600

YDSTWELPRD QLVLGRTLGS GAFGQVVEAT AHGLSHSQAT MKVAVKMLKS TARSSEKQAL 660

MSELKIMSHL GPHLNVVNLL GACTKGGPIY IITEYCRYGD LVDYLHRNKH TFLQRCSDKR 720

RPPSAELYSN ALPVGLPLPS HVSLPGESDG GYMDMSKDES VDYVPMLDMK GGVKYADIES 780

SSYMAPYDNY VPTAPERTCR ATLINESPVL SYTDLVGFSY QVANGMEFLA SKNCVHRDLA 840

ARNVLICEGK LVKICDFGLA RDIMRDSNYI SKGSTFLPLK WMAPESIFNS LYTTLSDVWS 900

FGILLWEIFT LGGTPYPELP MNEQFYNAIK RGYRMAQPAH ASDEIYEIMQ KCWEEKFEIR 960

PPFSQLVLLL ERLLGEGYKK KYQQVDEEFL RSDHPAVLRS QARLPGFHGL RSPLDTSSVL 1020

YTAVQPNEGD NDYIIPLPDP KPEAADEGPL ESSPSLASST LNEVNTSSTI SCDSPLEPQE 1080

EPEPQPEPPT ELAPPCPTRS SPSASQHPPP AGLASHLLSL SRKLLPLACG TPATGVG 1137

Nucleotide Sequence
(FASTA)

ATGCCCACCC CTGAAGGCAT TAGCAGCAAG GACACCATGC AGCTTCCGAG CACCAGGCCA 60

GCTCCTGTCC TTAAAGGCCA GGTGCTGTTG CTGCCCCTGC TGTTGCTGCT GGGCCCACAG 120

TCCTCATGGG GCCTGGTCAT CACACCCCCG GGGCCAGAGC TTGTCCTCAA TGTCTCCAGC 180

AACTTCGTTC TGACCTGCTC GGGCCCCGCT CCAGTGGTGT GGGAACGGAT GTCCCAGGAG 240

CTCCCACAGA AAATGGCCAA GACCCAGGAT GGCACCTTCT CCAGCACACT GACACTGACC 300

AATGTCACTG GGATAGACAC AGGAGAATAC TTCTGCGCCT ACAAAGGCTC CGATGGGCTG 360

GAGCCTGGTG AGCGAAAACG GCTCTACATC TTTGTGCCCG ATCCCACGAT GGGCTTTCTC 420

CCGGTTGACC CCGAGGAGCT ATTCATTTTC CTCACGGAAA TAACTGAGAT CACGATTCCG 480

TGCCGAGTGA CGGATCCGAA GCTCGTGGTG ACACTGCATG AGAAGAAAGT GGATATCCCA 540

CTACCCATCC CCTACGACCA CCAACGTGGC TTCTCTGGTA CATTCGAGGA TAAGACCTAT 600

GTCTGCAAAA CCACCGTTGG GGACAGGGAA GTGGATTCTG AAGCCTACTA TGTCTACAGC 660

CTCCAGGTGT CATCCATCAA CGTCTCAGTG AATGCAGTTC AAACTGTGGT CCGTCAGGGC 720

GAGAACATCA CCATCATGTG CATCGTGACC GGAAATGAGG TGGTCAACTT TGAATGGACC 780

TACCCACGCA TGGAGAGTGG GCGGCTGGTG GAGCCAGTGA CTGACTTCCT CTTCAATATA 840

CCCTCGCACA TACGCTCCAT CCTGCACATC CCTGCTGCTG AGCTTGGCGA TTCAGGGACC 900

TACATCTGCA ATGTATCAGA AAGTGTGAAT GAGCATCGGG ATGAAAAGTC CATCAATGTC 960

ACTGTGGTTG AGAGTGGCTA CGTGAGGCTG CTGGGAGAGC TGGACGCCCT ACAATTCGCT 1020

GAGCTGCACC GCAGCCGGAC TCTGCAGGTC GTGTTCGAGG CCTACCCGCC GCCCACTGTC 1080

CTGTGGCTCA AGGACAACCG CACGCTAGGC GACTCCAGCG CTGGCGAGAT CTCCCTGTCC 1140

ACACGCAACG TGTCTGAGAC CCGGTACGTG TCGGAACTGA CGCTGGTGCG GGTGAAGGTG 1200

GCGGAGGCTG GCTGCTACAC CGTGCGGGTC TTCCATGAGG ACGCGGAGGC CCAGCTCTCC 1260

TTCCAGCTGC AGGTCAACGT GCCTGTCCGT GTGCTGGAGC TGAGTGAAAG CCACCCTGCC 1320

AGCGGGGAGC AGACGGTCCG CTGTCGCGGT CGCGGCATGC CCCAGCCACA CCTCACTTGG 1380

TCTACCTGCA GCGACCTCAA AAGATGTCCA CGCGAGCTGC CGCCCACGCC GCTGGGGAAC 1440

AGTTCGGAGG AGGAGAGCCA GCTGGAGACT AACGTGACAT ACTGGCCCGA GGACCAGGAG 1500

TTCGAGGTGG TGAGCACACT GCGCCTGCGC CGTGTGGACC AACCGCTGTC TGTGCGCTGC 1560

ACTCTGCACA ACCTGCTGGG ACACGACATG CAGGAGGTCA CCGTGGTGCC GCATTCTCTG 1620

CCCTTCAAGG TGGTGGTGAT CTCGGCCATC CTGGCCTTGG TGGTCCTCAC AGTCATCTCC 1680

CTCATCATCC TTATCATGCT GTGGCAGAAG AAGCCACGTT ACGAGATCCG GTGGAAGGTG 1740

ATTGAATCCG TGAGCTCCGA CGGCCATGAG TACATCTATG TAGATCCTAT GCAGCTGCCC 1800

TATGACTCCA CCTGGGAGCT GCCAAGGGAC CAGCTTGTGC TCGGACGCAC CCTGGGCTCC 1860

GGAGCCTTTG GGCAGGTGGT GGAGGCCACG GCTCACGGCC TGAGTCACTC GCAGGCCACG 1920

ATGAAAGTGG CAGTCAAGAT GCTGAAATCC ACAGCCCGCA GCAGCGAGAA GCAGGCCCTC 1980

ATGTCAGAGC TGAAGATCAT GAGTCACCTC GGGCCCCATC TGAACGTGGT CAACTTGCTG 2040

GGGGCCTGCA CCAAAGGAGG ACCCATCTAC ATCATCACCG AGTACTGCCG CTACGGCGAC 2100

CTCGTAGACT ACCTGCACCG CAACAAGCAC ACTTTCCTGC AGCGCTGCTC CGACAAGCGC 2160

CGACCGCCCA GCGCTGAGCT CTACAGCAAC GCCCTCCCTG TCGGGCTTCC GCTGCCCAGC 2220

CATGTGTCTC TGCCCGGGGA GAGCGACGGT GGCTACATGG ACATGAGCAA AGACGAGTCG 2280

GTAGACTACG TGCCCATGTT GGACATGAAA GGAGGCGTCA AATATGCAGA CATTGAGTCC 2340

TCTAGCTACA TGGCCCCTTA TGACAACTAC GTCCCCACCG CTCCTGAGAG GACCTGTCGG 2400

GCCACTCTGA TCAACGAGTC CCCAGTGCTT AGCTACACGG ATCTCGTGGG CTTCAGCTAC 2460

CAGGTGGCAA ATGGCATGGA GTTCCTGGCC TCCAAGAACT GTGTCCACCG AGATCTGGCA 2520

GCCAGAAATG TGCTCATCTG TGAGGGCAAG CTGGTCAAGA TCTGTGACTT CGGCCTGGCT 2580

CGTGACATCA TGCGAGACTC GAACTATATC TCCAAAGGCA GCACCTTCCT GCCTCTGAAG 2640

TGGATGGCCC CCGAGAGCAT CTTCAACAGC CTCTATACCA CCCTGAGCGA CGTGTGGTCC 2700

TTTGGGATCC TACTCTGGGA GATCTTCACC CTGGGTGGCA CCCCATACCC AGAGCTGCCC 2760

ATGAACGAGC AGTTCTATAA TGCCATCAAG CGGGGGTACC GCATGGCCCA GCCTGCCCAC 2820

GCCTCCGACG AGATTTACGA GATCATGCAG AAGTGCTGGG AAGAGAAGTT TGAGATCCGG 2880

CCTCCTTTCT CCCAGCTGGT GCTGCTTCTC GAGAGGCTGC TGGGTGAGGG GTACAAAAAG 2940

AAGTACCAGC AGGTCGATGA GGAGTTTCTG AGGAGCGACC ACCCGGCCGT CCTTCGGTCC 3000

CAAGCCCGTT TGCCTGGCTT CCATGGCCTC CGATCGCCCC TGGACACCAG CTCTGTCCTC 3060

TACACTGCTG TGCAGCCCAA CGAGGGTGAC AATGACTACA TCATCCCCCT GCCTGACCCA 3120

AAACCCGAGG CTGCTGATGA GGGCCCACTG GAGAGTTCTC CCAGCCTTGC CAGCTCCACC 3180

CTGAATGAAG TCAACACCTC CTCTACCATC TCCTGTGACA GTCCCCTGGA GCCCCAAGAG 3240

GAGCCGGAGC CCCAGCCCGA GCCCCCGACA GAGCTGGCCC CACCCTGCCC CACCCGAAGC 3300

TCTCCCTCTG CCTCCCAGCA CCCACCGCCT GCTGGGCTGG CCTCCCATCT ACTGTCACTT 3360

TCTAGAAAGC TCTTGCCCCT GGCCTGTGGC ACCCCAGCCA CTGGGGTGGG TTAG 3414

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG

Q: 612   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  671

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl++ ++k++++++el+s+a

Q: 672   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRCSDKRRPPSAELYSNA  731

         ************************************************************

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

         l+++  l s++sl  es++ y+d++kd                ++d++ss++++++++++

Q: 732   LPVGLPLPSHVSLPGESDGGYMDMSKDesvdyvpmldmkggvkYADIESSSYMAPYDNYV  791

         ************************************************************

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

           a er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk

Q: 792   PTAPERTCRATLINE-SPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  850

         **************9.9*******************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+

Q: 851   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  910

         ************************************************************

S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll

Q: 911   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  970

         ********************************************************9986

Domain Sequence
(FASTA)

LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60

PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQRCSDKRR PPSAELYSNA 120

LPVGLPLPSH VSLPGESDGG YMDMSKDESV DYVPMLDMKG GVKYADIESS SYMAPYDNYV 180

PTAPERTCRA TLINESPVLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240

VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300

GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359

Keyword

ATP-binding; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Transferase; Transmembrane.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005019	; F:platelet-derived growth factor beta-receptor activity
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0030325	; P:adrenal gland development
GO:0060326	; P:cell chemotaxis
GO:0001701	; P:in utero embryonic development
GO:0001822	; P:kidney development
GO:0006807	; P:nitrogen compound metabolic process
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046488	; P:phosphatidylinositol metabolic process
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0038091	; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777	; P:protein autophosphorylation
GO:0050730	; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705	; P:skeletal system morphogenesis
GO:0048745	; P:smooth muscle tissue development
GO:0001894	; P:tissue homeostasis
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 2.
SM00408	; IGc2; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832

; VEGFRECEPTOR.

Created Date

20-Feb-2013