EKS-MUP-00247

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00247

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	317.5	5.6E-95	3	237	235

Status

Unreviewed

Ensembl Protein

ENSMPUP00000014643

UniProt Accession

G9KII3;

Protein Name

Protein Synonyms/Alias

Protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 2;

Gene Name

PRKAA1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000014752	ENSMPUP00000014643	ENSMPUT00000014876

Organism

Mustela putorius furo

Functional Description

Protein Length

517

Protein Sequence
(FASTA)

VGKHELTGHK VAVKILNRQK IRSLDVVGKI RREIQNLKLF RHPHIIKLYQ VISTPSDIFM 60

VMEYVSGGEL FDYICKNGRL DEKESRRLFQ QILSGVDYCH RHMVVHRDLK PENVLLDAHM 120

NAKIADFGLS NMMSDGEFLR TSCGSPNYAA PEVISGRLYA GPEVDIWSSG VILYALLCGT 180

LPFDDDHVPT LFKKICDGIF YTPQYLNPSV ISLLKHMLQV DPMKRATIKD IREHEWFKQD 240

LPKYLFPEDP SYSSTMIDDE ALKEVCEKFE CSEEEVLSCL YNRNHQDPLA VAYHLIIDNR 300

RIMNEAKDFY LATSPPDSFL DDHHLTRPHP ERVPFLVAET PRARHTLDEL NPQKSKHQGV 360

RKAKWHLGIR SQSRPNDIMA EVCRAIKQLD YEWKVVNPYY LRVRRKNPVT STYSKMSLQL 420

YQVDSRTYLL DFRSIDDEIT EAKSGTATPQ RSGSVSNYRS CQRNDSDAEA QGKSSEASLT 480

SSMTSLDSSP VDLTPRPGSH TIEFFEMCAN LIKILAQ 517

Nucleotide Sequence
(FASTA)

GTTGGCAAAC ATGAGTTGAC TGGGCATAAA GTTGCTGTGA AGATACTGAA TCGACAGAAG 60

ATTCGAAGCC TTGATGTGGT AGGAAAAATC CGCAGAGAAA TTCAGAACCT CAAGCTTTTC 120

AGGCATCCTC ATATAATTAA ACTGTACCAG GTCATCAGTA CACCATCTGA TATTTTCATG 180

GTGATGGAAT ATGTCTCAGG AGGAGAGCTA TTTGATTATA TCTGTAAAAA TGGAAGGCTG 240

GATGAGAAAG AAAGTCGGCG CCTGTTTCAA CAGATCCTTT CTGGTGTGGA TTACTGTCAC 300

AGGCATATGG TGGTCCATAG AGATTTGAAG CCTGAAAATG TCCTGCTTGA TGCACACATG 360

AATGCAAAGA TAGCTGATTT TGGTCTTTCA AACATGATGT CAGATGGTGA ATTTTTAAGA 420

ACAAGTTGTG GCTCACCCAA TTATGCTGCC CCAGAAGTAA TTTCAGGAAG ATTGTATGCA 480

GGTCCAGAGG TAGATATATG GAGCAGTGGG GTTATTCTCT ATGCTTTATT ATGTGGAACC 540

CTTCCATTTG ATGATGATCA TGTGCCAACT CTTTTTAAGA AGATATGTGA TGGGATCTTT 600

TATACCCCTC AGTATTTAAA TCCGTCTGTG ATTAGCCTTT TGAAACATAT GCTACAGGTG 660

GATCCCATGA AGAGGGCCAC AATCAAAGAT ATCAGGGAAC ATGAATGGTT TAAACAAGAC 720

CTTCCAAAAT ATCTTTTTCC GGAGGATCCA TCATATAGTT CAACCATGAT TGATGATGAA 780

GCCTTAAAAG AAGTATGTGA AAAATTTGAG TGTTCAGAAG AGGAGGTTCT CAGCTGCCTT 840

TATAACAGAA ATCACCAGGA CCCTTTGGCA GTTGCCTACC ACCTCATAAT AGATAACAGG 900

AGAATAATGA ATGAGGCCAA AGATTTTTAC TTGGCAACAA GCCCACCTGA TTCTTTTCTT 960

GATGATCACC ATTTGACTCG GCCCCATCCT GAAAGAGTAC CATTCTTGGT TGCTGAAACA 1020

CCAAGGGCAC GCCATACCCT CGATGAATTA AATCCACAGA AATCCAAACA TCAAGGTGTA 1080

AGGAAAGCAA AATGGCATTT GGGAATTAGG AGTCAAAGTC GACCGAATGA TATCATGGCA 1140

GAAGTTTGTA GGGCAATTAA ACAGCTGGAT TATGAATGGA AGGTTGTAAA CCCCTATTAT 1200

TTGCGTGTTC GAAGGAAGAA TCCTGTGACA AGTACATATT CCAAAATGAG CCTACAGTTA 1260

TACCAAGTGG ACAGTAGAAC ATACTTACTG GATTTCCGTA GTATTGACGA TGAAATTACT 1320

GAAGCCAAAT CAGGAACTGC TACTCCACAG AGATCGGGAT CTGTAAGCAA CTATCGATCT 1380

TGCCAAAGGA ATGATTCAGA TGCTGAGGCT CAAGGAAAAT CCTCAGAAGC TTCTCTTACC 1440

TCATCTATGA CCTCACTTGA CTCTTCTCCT GTTGACTTAA CTCCGAGACC TGGAAGTCAC 1500

ACAATAGAAT TTTTTGAGAT GTGTGCAAAT CTAATTAAAA TTCTTGCACA GTAA 1554

Domain Profile

S: 19    khketkekvavKiikkkkl.seeslekikrEieilkklkhpniikllevietkkklylvl  77

         kh++t++kvavKi++++k+ s + + ki+rEi+ lk ++hp+iikl++vi+t +++++v+

Q: 3     KHELTGHKVAVKILNRQKIrSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVM  62

         7999**************96667788**********************************

S: 78    eyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkeni  137

         ey+sggeLfdyi ++grl+eke+r+lf+q++s+v+Y+h++ +vHrDlKpeN+lld+++n

Q: 63    EYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNA  122

         ************************************************************

S: 138   kiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklP  197

         kiaDFGl+n++++g+ l+t+cGsp+YaaPe+++g+ Y gp+vD+Ws Gv+Lyal++g+lP

Q: 123   KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLP  182

         ************************************************************

S: 198   fdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         fd++++ +l++ki +g + +p++l+++++sLl+++L+vdp kRati++i++hew+

Q: 183   FDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF  237

         ******************************************************7

Domain Sequence
(FASTA)

KHELTGHKVA VKILNRQKIR SLDVVGKIRR EIQNLKLFRH PHIIKLYQVI STPSDIFMVM 60

EYVSGGELFD YICKNGRLDE KESRRLFQQI LSGVDYCHRH MVVHRDLKPE NVLLDAHMNA 120

KIADFGLSNM MSDGEFLRTS CGSPNYAAPE VISGRLYAGP EVDIWSSGVI LYALLCGTLP 180

FDDDHVPTLF KKICDGIFYT PQYLNPSVIS LLKHMLQVDP MKRATIKDIR EHEWF 235

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0004679	; F:AMP-activated protein kinase activity
GO:0005524	; F:ATP binding
GO:0003682	; F:chromatin binding
GO:0035174	; F:histone serine kinase activity
GO:0042149	; P:cellular response to glucose starvation
GO:0019395	; P:fatty acid oxidation
GO:0042593	; P:glucose homeostasis
GO:0006006	; P:glucose metabolic process
GO:0008610	; P:lipid biosynthetic process
GO:0043066	; P:negative regulation of apoptotic process
GO:0050995	; P:negative regulation of lipid catabolic process
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0010508	; P:positive regulation of autophagy
GO:0042752	; P:regulation of circadian rhythm

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013