EKS-MUP-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.5	3.8E-109	706	962	257

Status

Unreviewed

Ensembl Protein

ENSMPUP00000014726

UniProt Accession

G9K9I6;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 5;

Gene Name

Map3k5

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000014837	ENSMPUP00000014726	ENSMPUT00000014961

Organism

Mustela putorius furo

Functional Description

Protein Length

1398

Protein Sequence
(FASTA)

MSAEAGEGIT FSVPPFAEGG SCRRGGAAVA VEDEESQLPP PGSFWNVETA AAPGTGCPAA 60

TSGSSATRCR GNSSSGGGRR TTVAYVINEA SQGQLVVAES EALQSLREAC ETVGATLETL 120

HFGKLDFGET TVLDRFYNAD IAVVEMSDAF RQPSLFYHLG VRESFSMANN IILYCDNNSD 180

SLQSLKEIIC QKNTMCTGNY TFVPYMITPH NKVYCCDSSF MKGLTELMQP NFELLLGPIC 240

LPLVDRFIQL LKVAQASSSQ YFRESILNDI RKARNLYTGK ELAAELARIR QRVDNIEVLT 300

ADIVINLLLS YRDIQDYDSI VKLVETLEKL PTFDLASHHH VKFHYAFALN RRNLPGDRAK 360

ALDVMIPLVQ SEGQVASDMY CLVGRIYKDM FLDSNFLDTE SRDHGASWFK KAFESEPSLQ 420

SGINYAVLLL AAGHQFESSF ELRKVGVKLS SLLGKKGNLE KLQSYWEVGF FLGASVLAND 480

HMRVIQASEK LFKLKTPAWY LKSIVETILI YKHFVKLTTE QPVAKQELVD FWMDFLVEAT 540

KTNVTVVRFP VLILEPTKIY QPSYLSINNE VEEKTISIWH VLPDDKPKGE FWSTSEPQAS 600

LPISQVQPRP QAPGSILSGW KGIHEWNFSA ASIRGVSISK FEERCCFLYV LHNSDDFQIY 660

FCTELHCKKF FEMVNTITEE KGRSTEEGDC EGDSLEYDYE YDENGDRVVL GKGTYGIVYA 720

GRDLSNQVRI AIKEIPERDS RYSQPLHEEI ALHKHLKHKN IVQYLGSFSE NGFIKIFMEQ 780

VPGGSLSALL RSKWGPLKDN EQTIGFYTKQ ILEGLKYLHD NQIVHRDIKG DNVLINTYSG 840

VLKISDFGTS KRLAGINPCT ETFTGTLQYM APEIIDKGPR GYGKAADIWS LGCTIIEMAT 900

GKPPFYELGE PQAAMFKVGM FKVHPEIPES MSAEAKAFIL KCFEPDPDKR ACANDLLVDE 960

FLKVSSKKKK TQPKLSALSA GSNEYLRSIS LPVPVLVEDT SSSSEYGSVS PDTELKVDPF 1020

SFKTRAKSCG ERDVKGIRTL FLGIPDENFE DHSAPPSPEE KDSGFFMLRK DSERRATLHR 1080

ILTEDQDKVV RNLMESLAQG AEEPKLKWEH ITTLIASLRE FVRSTDRKII ATTLSKLKLE 1140

LDFDSHGISQ VQVVLFGFQD AVNKVLRNHN IKPHWMFALD SIIRKAVQTA ITILVPELRP 1200

HFSLASESDT ADQEDLEAED DHEERPSNQT IRRPHAVIED AVATSGVSTL SSTVSHDSQN 1260

AHRSLNVQLG RMKIETNRLL EELVRKEKEL QALLHQAIEE KDQEIKHLKL KSQPIDIPGL 1320

SVCPRDSPGT NTEESELTEW LRDKGADEDT ISRFLAEDYS LEDVLYYVTR DDLKCLRLRG 1380

GMLCALWKAI TDFRDTQT 1398

Nucleotide Sequence
(FASTA)

ATGAGCGCCG AAGCGGGCGA GGGCATCACT TTCTCGGTGC CACCCTTCGC CGAGGGTGGA 60

AGCTGCCGGA GGGGAGGAGC GGCGGTGGCA GTCGAGGACG AAGAGAGCCA GCTACCGCCG 120

CCGGGCAGCT TCTGGAACGT AGAGACTGCC GCCGCCCCTG GCACCGGTTG TCCCGCCGCC 180

ACCTCTGGGA GCAGCGCCAC CCGGTGCCGG GGCAACTCTA GTAGCGGAGG CGGCCGACGG 240

ACCACGGTGG CATATGTTAT CAACGAAGCG AGCCAGGGGC AGCTGGTGGT GGCCGAGAGC 300

GAGGCCCTGC AGAGCCTGCG GGAGGCGTGT GAGACGGTGG GCGCCACCCT GGAGACCCTG 360

CATTTTGGTA AACTGGACTT TGGAGAAACC ACCGTGCTGG ACCGTTTTTA CAATGCAGAT 420

ATCGCGGTGG TCGAGATGAG TGATGCCTTC CGACAGCCGT CCTTGTTTTA CCACCTTGGA 480

GTGAGAGAAA GCTTCAGCAT GGCCAACAAC ATCATCCTCT ACTGTGATAA CAACTCAGAC 540

TCTCTGCAGT CCCTGAAGGA AATCATTTGC CAGAAGAATA CCATGTGCAC TGGGAACTAT 600

ACATTCGTCC CTTACATGAT CACTCCACAC AACAAGGTCT ACTGCTGTGA TAGCAGCTTC 660

ATGAAGGGGT TGACGGAGCT CATGCAACCG AACTTCGAGC TGCTTCTTGG ACCCATTTGC 720

TTACCTCTTG TGGATCGTTT CATTCAGCTT CTGAAGGTGG CACAAGCAAG TTCTAGCCAG 780

TATTTCCGGG AATCTATTCT CAATGATATC AGGAAAGCTC GAAATTTATA CACTGGTAAA 840

GAATTGGCAG CTGAGTTGGC AAGAATTCGG CAACGAGTAG ATAATATCGA AGTCTTGACA 900

GCAGATATTG TCATAAACCT CTTACTTTCC TACAGAGATA TCCAGGACTA TGATTCTATA 960

GTGAAGCTGG TAGAGACCTT AGAAAAGCTG CCAACCTTTG ATTTGGCTTC CCATCACCAT 1020

GTGAAGTTTC ATTATGCATT TGCACTGAAT AGGAGAAATC TCCCTGGAGA TAGAGCCAAA 1080

GCTCTTGATG TTATGATCCC GCTGGTGCAA AGTGAAGGGC AGGTTGCCTC CGATATGTAT 1140

TGCCTAGTTG GTCGAATCTA CAAAGATATG TTTTTGGACT CTAATTTCCT GGACACTGAA 1200

AGTAGAGACC ATGGAGCTTC TTGGTTCAAA AAGGCGTTTG AATCTGAGCC ATCGTTACAG 1260

TCGGGAATTA ATTATGCGGT CCTTCTCCTG GCAGCTGGGC ATCAGTTTGA ATCTTCCTTT 1320

GAGCTCCGGA AAGTTGGGGT GAAGCTGAGT AGCCTCCTTG GCAAAAAAGG AAACTTAGAA 1380

AAACTTCAGA GCTACTGGGA AGTTGGATTT TTTCTGGGTG CCAGTGTCCT GGCCAATGAC 1440

CACATGAGAG TCATCCAAGC ATCTGAAAAG CTTTTTAAAC TGAAGACACC AGCATGGTAC 1500

CTCAAGTCGA TTGTAGAGAC AATTTTGATA TATAAGCATT TTGTGAAACT AACTACAGAG 1560

CAGCCTGTGG CCAAGCAGGA GCTCGTGGAC TTCTGGATGG ACTTCTTGGT CGAGGCCACA 1620

AAGACCAATG TTACTGTCGT TAGGTTTCCA GTACTAATAT TGGAACCAAC CAAAATCTAT 1680

CAACCTTCAT ATTTGTCTAT CAACAATGAA GTTGAGGAAA AGACAATATC TATTTGGCAT 1740

GTGCTTCCTG ATGACAAGCC AAAAGGAGAG TTCTGGTCCA CCTCAGAGCC ACAGGCTTCC 1800

TTACCCATTT CACAAGTCCA GCCAAGACCT CAAGCTCCTG GCAGTATTTT AAGTGGGTGG 1860

AAAGGTATAC ATGAGTGGAA TTTCAGTGCT GCTTCTATCA GGGGAGTGAG TATTTCTAAA 1920

TTTGAAGAGC GATGCTGTTT TCTCTACGTG CTTCATAATT CTGACGATTT CCAAATCTAT 1980

TTCTGTACAG AACTGCATTG TAAAAAGTTT TTTGAAATGG TGAACACCAT CACTGAGGAG 2040

AAGGGGAGAA GCACGGAGGA AGGTGATTGT GAAGGTGACT CCTTGGAGTA TGACTACGAA 2100

TATGACGAGA ATGGTGACAG AGTCGTTTTA GGGAAAGGCA CTTACGGGAT CGTCTACGCT 2160

GGCCGAGACC TGAGCAACCA AGTCAGAATC GCTATAAAGG AAATTCCAGA GAGAGACAGC 2220

AGATACTCCC AGCCCCTGCA TGAAGAAATA GCATTGCATA AGCATCTGAA GCACAAAAAT 2280

ATTGTCCAGT ATCTGGGCTC TTTCAGTGAG AATGGCTTTA TCAAAATCTT CATGGAGCAG 2340

GTCCCAGGAG GAAGTCTTTC GGCTCTCCTT CGTTCCAAAT GGGGCCCATT GAAGGACAAT 2400

GAGCAAACAA TTGGCTTTTA TACAAAGCAG ATACTTGAAG GATTAAAATA CCTCCATGAC 2460

AATCAGATAG TCCACCGGGA TATAAAGGGC GACAATGTGT TGATTAATAC TTATAGTGGT 2520

GTTCTCAAGA TCTCGGACTT CGGGACATCA AAGAGGCTAG CTGGCATAAA TCCATGTACC 2580

GAAACTTTTA CTGGTACCCT TCAGTATATG GCACCGGAAA TCATAGACAA AGGACCACGA 2640

GGCTATGGGA AAGCAGCAGA CATCTGGTCT TTGGGCTGCA CCATCATTGA AATGGCCACA 2700

GGGAAACCAC CTTTTTATGA GCTGGGAGAA CCACAAGCAG CTATGTTCAA GGTGGGAATG 2760

TTTAAAGTCC ACCCAGAGAT CCCAGAGTCC ATGTCAGCAG AGGCCAAGGC ATTCATACTG 2820

AAGTGTTTTG AACCTGACCC TGACAAGAGA GCCTGTGCTA ACGACTTGCT TGTTGATGAG 2880

TTCTTAAAGG TTTCGAGCAA AAAGAAAAAG ACACAACCTA AGCTTTCAGC CCTTTCAGCT 2940

GGATCAAATG AGTATCTTCG AAGCATATCC TTGCCTGTGC CTGTCCTGGT CGAGGACACG 3000

AGCAGCAGCA GCGAGTACGG CTCAGTTTCT CCTGACACAG AGTTAAAGGT GGACCCCTTC 3060

TCTTTCAAAA CGAGAGCCAA ATCCTGTGGA GAAAGAGATG TAAAAGGAAT ACGGACGCTC 3120

TTTTTGGGCA TTCCGGATGA AAATTTTGAA GATCACAGTG CTCCCCCTTC CCCTGAAGAA 3180

AAAGATTCTG GTTTCTTCAT GTTGAGAAAG GACAGTGAGA GACGCGCCAC CCTTCATAGG 3240

ATCCTGACGG AAGACCAAGA CAAAGTTGTG AGAAACTTAA TGGAATCATT GGCTCAGGGG 3300

GCTGAAGAAC CTAAACTAAA ATGGGAACAT ATCACAACCC TCATTGCAAG CCTCAGAGAA 3360

TTTGTGAGAT CCACGGACCG AAAAATCATC GCCACCACAC TGTCCAAGCT GAAGCTGGAA 3420

CTTGACTTCG ACAGCCACGG CATTAGCCAG GTTCAGGTGG TGCTCTTCGG TTTTCAGGAT 3480

GCTGTCAATA AAGTTCTTCG GAATCATAAT ATCAAGCCAC ACTGGATGTT TGCCTTAGAC 3540

AGTATCATCC GAAAGGCGGT GCAGACGGCC ATCACCATTC TGGTGCCAGA ACTGAGGCCA 3600

CACTTTAGCC TCGCATCTGA GAGCGATACC GCTGATCAAG AAGACTTGGA GGCAGAAGAT 3660

GACCATGAGG AACGGCCTTC GAACCAAACT ATTCGAAGAC CTCATGCTGT CATTGAAGAT 3720

GCTGTAGCTA CCTCAGGGGT GAGCACGCTC AGTTCTACTG TATCCCACGA CTCCCAAAAT 3780

GCCCACCGGT CCCTCAATGT GCAACTTGGA AGGATGAAAA TAGAAACTAA TAGATTACTA 3840

GAAGAATTGG TTCGGAAAGA AAAAGAATTA CAAGCACTCC TTCATCAAGC TATTGAAGAA 3900

AAAGACCAAG AAATTAAACA CCTGAAGCTT AAGTCCCAAC CAATAGATAT TCCTGGATTG 3960

TCCGTATGCC CCCGGGATTC TCCTGGCACA AATACTGAAG AGTCTGAGCT TACTGAGTGG 4020

CTGAGAGATA AGGGAGCTGA TGAAGACACT ATAAGTCGGT TTTTGGCTGA GGATTATTCA 4080

CTAGAGGATG TTCTCTACTA TGTTACACGT GATGATTTAA AATGCCTCAG ACTAAGGGGA 4140

GGGATGCTCT GCGCGCTGTG GAAGGCCATC ACCGACTTTC GAGATACACA GACTTGA 4197

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 706   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  760

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+

Q: 761   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  820

         *******************************9*****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 821   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  877

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+

Q: 878   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  937

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ kc+e dp+kr++a++LL +efl

Q: 938   FILKCFEPDPDKRACANDLLVDEFL  962

         **********************996

Domain Sequence
(FASTA)

DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180

ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240

DPDKRACAND LLVDEFL 257

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0008656	; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004672	; F:protein kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0000186	; P:activation of MAPKK activity
GO:0070301	; P:cellular response to hydrogen peroxide
GO:0010421	; P:hydrogen peroxide-mediated programmed cell death
GO:0008631	; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254	; P:JNK cascade
GO:0043065	; P:positive regulation of apoptotic process

KEGG

InterPros

IPR025136

; DUF4071.

Pfam

PF13281

; DUF4071; 1.

SMARTs

Prosites

Prints

Created Date

20-Feb-2013