EKS-MUP-00380

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00380

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	370.6	5.0E-111	383	642	260

Status

Unreviewed

Ensembl Protein

ENSMPUP00000014829

UniProt Accession

G9K9H9;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 3;

Gene Name

MAP3K3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000014940	ENSMPUP00000014829	ENSMPUT00000015064

Organism

Mustela putorius furo

Functional Description

Protein Length

647

Protein Sequence
(FASTA)

MKDLVALQMS RRPRVPGYET MKNKDTGHPN RQKKHNSSSS ALLKSPTLTT SSCAGAGEEK 60

KFLSDVRIKF EHNGERRIIP FSRPVRYEDV EHKVTTVFGQ PLDLHYMNNE LSILLKNQDD 120

LDKAIDILDR SSSMKSLRIL LLSQDRNHTS PSPHSGVSRQ VRIKASQSAG DVNTIYQPPE 180

PRSRHLSVSS QNPGRSSPPP GYVPERQQRI ARQGSYTSIN SEGEFIPETS EQCILDPLSS 240

AENSLSGSCQ SLDRSADSPS FRKSRMSRAQ SFPDNRQEFS DRETQLYDKG VKGGTYPRRY 300

HVSVHHKDYN EGRRTFPRIR RHQGNLFTLV PSSRSLSTNG ENMGLAVQYL DPRGRLRSAD 360

SENALSVQER NVPTKSPSAP INWRRGKLLG QGAFGRVYLC YDVDTGRELA SKQVQFDPDS 420

PETSKEVSAL ECEIQLLKNL QHERIVQYYG CLRDRAEKTL TIFMEYMPGG SVKDQLKAYG 480

ALTESVTRKY TRQILEGMSY LHSNMIVHRD IKGANILRDS AGNVKLGDFG ASKRLQTICM 540

SGTGMRSVTG TPYWMSPEVI SGEGYGRKAD VWSLGCTVVE MLTEKPPWAE YEAMAAIFKI 600

ATQPTNPQLP SHISEHGRDF LRRIFVEARQ RPSAEELLTH HFAQLVY 647

Nucleotide Sequence
(FASTA)

ATGAAGGATC TGGTGGCCCT CCAGATGAGC CGACGTCCCC GGGTGCCTGG ATATGAGACC 60

ATGAAGAACA AAGACACAGG TCACCCAAAT AGGCAGAAAA AACACAACAG CAGCAGCTCA 120

GCCCTTCTGA AGAGCCCCAC ACTAACAACA AGCTCATGTG CAGGGGCCGG TGAGGAAAAG 180

AAATTTTTGA GCGACGTCAG AATCAAGTTT GAGCACAACG GGGAGAGGCG AATTATACCG 240

TTCAGCCGGC CTGTGAGATA TGAAGATGTG GAACACAAGG TGACAACAGT GTTTGGGCAG 300

CCTCTTGATC TGCATTACAT GAACAATGAG CTCTCCATCC TGCTGAAGAA CCAAGATGAT 360

CTTGATAAAG CAATTGACAT ATTAGACAGA AGCTCAAGCA TGAAAAGCCT TAGGATATTG 420

CTGCTGTCCC AGGACAGAAA TCATACCAGT CCCTCTCCCC ATTCTGGGGT GTCCAGGCAG 480

GTGCGGATCA AAGCTTCCCA GTCTGCAGGA GATGTCAATA CCATCTACCA GCCCCCTGAG 540

CCCCGAAGCA GGCACCTCTC TGTCAGCTCC CAGAACCCTG GCCGAAGCTC GCCTCCCCCT 600

GGCTATGTGC CTGAGCGACA GCAACGCATT GCCCGGCAGG GTTCCTACAC TAGCATCAAC 660

AGTGAGGGGG AGTTCATCCC GGAGACCAGC GAGCAGTGTA TACTGGATCC CCTGAGCAGT 720

GCTGAAAATT CCTTGTCAGG AAGCTGCCAA TCCTTGGACA GGTCGGCAGA CAGCCCATCC 780

TTCCGCAAAT CAAGAATGTC CCGAGCTCAG AGCTTCCCAG ACAACAGACA GGAGTTCTCT 840

GATCGGGAAA CTCAGCTGTA TGACAAAGGG GTCAAAGGTG GAACCTACCC CCGGCGCTAC 900

CACGTGTCTG TGCACCACAA GGACTACAAT GAGGGCAGAA GAACGTTTCC ACGAATACGG 960

CGTCATCAAG GCAACCTCTT TACCCTGGTG CCGTCCAGCC GCTCCCTGAG CACAAATGGC 1020

GAGAACATGG GTCTGGCAGT GCAATACCTG GACCCCAGAG GGCGGCTGCG GAGTGCGGAC 1080

AGCGAGAATG CCCTCTCCGT GCAGGAGAGG AATGTGCCGA CCAAGTCTCC TAGTGCCCCC 1140

ATCAATTGGC GCCGTGGGAA GCTCCTGGGC CAGGGTGCCT TTGGCAGGGT CTATCTGTGC 1200

TATGATGTGG ATACAGGACG TGAACTTGCT TCCAAACAAG TCCAGTTTGA TCCAGACAGC 1260

CCCGAGACAA GCAAGGAGGT GAGCGCTCTG GAGTGTGAGA TCCAGCTGCT GAAGAACCTG 1320

CAGCACGAGC GCATAGTGCA GTACTACGGC TGCCTGCGGG ACCGTGCCGA GAAGACTCTG 1380

ACCATCTTCA TGGAGTACAT GCCGGGGGGC TCAGTGAAAG ACCAGCTGAA GGCCTACGGA 1440

GCTCTGACAG AGAGTGTGAC CCGCAAGTAT ACCCGGCAGA TTCTAGAGGG CATGTCCTAC 1500

CTGCATAGCA ACATGATCGT TCACCGAGAC ATCAAGGGAG CCAACATCCT CCGAGATTCT 1560

GCCGGGAACG TGAAGCTGGG GGATTTCGGG GCCAGCAAGC GTCTGCAGAC CATCTGCATG 1620

TCAGGCACAG GCATGCGCTC AGTCACTGGC ACGCCCTACT GGATGAGCCC CGAGGTGATC 1680

AGTGGTGAGG GCTACGGAAG GAAGGCAGAC GTGTGGAGCT TGGGCTGCAC TGTGGTAGAG 1740

ATGCTGACAG AGAAACCACC TTGGGCAGAG TATGAAGCCA TGGCTGCCAT TTTCAAGATC 1800

GCCACCCAGC CCACCAATCC TCAGCTGCCG TCCCACATCT CTGAGCACGG CCGGGACTTC 1860

CTGAGGCGCA TATTTGTGGA GGCCCGCCAG AGACCTTCGG CTGAGGAGCT GCTCACACAC 1920

CACTTTGCAC AGCTCGTGTA CTGA 1944

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w++++++g+G+fg+vy+++dvdtg+ la K+v+++p++ +++kev+al++Ei+llk+l+H

Q: 383   WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQH  442

         899*********************************************************

S: 61    enivkyyGv..eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLH  118

         e+iv+yyG+  ++ e++l+if+Ey++gGs++++l++yg+l+esv++kyt+qileg++yLH

Q: 443   ERIVQYYGClrDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLH  502

         *********77778999*******************************************

S: 119   ekkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         +++ivHRDiKgaNil ds+g+vkl+DFGaskrl++++++ + ++s+tGt+++m+PEvi++

Q: 503   SNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISG  562

         **********************************************************99

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         +  gygrkaD+Wslgc+v+emlt+k+P+ae+ e++a++fk++++ t+P++p+++se+g+d

Q: 563   E--GYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRD  619

         8..****************************.9***************************

S: 239   flekcleldpkkrpsaeeLLkhef  262

         fl++++ +++++rpsaeeLL+h+f

Q: 620   FLRRIF-VEARQRPSAEELLTHHF  642

         ******.8999***********99

Domain Sequence
(FASTA)

WRRGKLLGQG AFGRVYLCYD VDTGRELASK QVQFDPDSPE TSKEVSALEC EIQLLKNLQH 60

ERIVQYYGCL RDRAEKTLTI FMEYMPGGSV KDQLKAYGAL TESVTRKYTR QILEGMSYLH 120

SNMIVHRDIK GANILRDSAG NVKLGDFGAS KRLQTICMSG TGMRSVTGTP YWMSPEVISG 180

EGYGRKADVW SLGCTVVEML TEKPPWAEYE AMAAIFKIAT QPTNPQLPSH ISEHGRDFLR 240

RIFVEARQRP SAEELLTHHF 260

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>