EKS-MUP-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.6	3.6E-188	440	719	280

Status

Unreviewed

Ensembl Protein

ENSMPUP00000015056

UniProt Accession

G9KTH6;

Protein Name

Protein Synonyms/Alias

Tousled-like kinase 2;

Gene Name

Tlk2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000015165	ENSMPUP00000015056	ENSMPUT00000015293

Organism

Mustela putorius furo

Functional Description

Protein Length

750

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 60

RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSGPGTSP GRSVPPVARS SPQHSLSNPL 120

PRRVEQPLYG LDGSAAKEVS EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSAQQ 180

NSPSSTGSGN TEHSGSSQKQ ISIQHRQTQS DLTIEKISAL ENSKNSDLEK KEGRIDDLLR 240

ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT 300

TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQAPPATNEQ 360

KQRKSKTNGA ENETLTLAEY HEQEEIFKLR LGHLKKEEAE IQAELERLER VRNLHIRELK 420

RIHNEDNSQF KDHPTLNDRY LLLHLLGRGG FSEVYKAFDL TEQRYVAVKI HQLNKNWRDE 480

KKENYHKHAC REYRIHKELD HPRIVKLYDY FSLDTDSFCT VLEYCEGNDL DFYLKQHKLM 540

SEKEARSIIM QIVNALKYLN EIKPPIIHYD LKPGNILLVN GTACGEIKIT DFGLSKIMDD 600

DSYNSVDGME LTSQGAGTYW YLPPECFVVG KEPPKISNKV DVWSVGVIFY QCLYGRKPFG 660

HNQSQQDILQ ENTILKATEV QFPPKPVVTP EAKAFIRRCL AYRKEDRIDV QQLACDPYLL 720

PHIRKSVSTS SPAGAAIAST SGASNNSSSN 750

Nucleotide Sequence
(FASTA)

ATGATGGAAG AATTGCATAG CCTGGACCCT CGAAGGCAGG AATTATTAGA GGCCAGGTTT 60

ACAGGAGTTG GTGTTAGTAA GGGGCCACTC AATAGTGAGT CTTCCAACCA GAGCTTGTGC 120

AGCGTGGGGT CCTTGAGTGA TAAAGAAGTA GAGACTCCTG AGAAAAAACA GAATGACCAG 180

CGAAACCGGA AAAGAAAAGC TGAACCATAT GAAACTAGCC AAGGGAAAGG CACTCCTAGG 240

GGACATAAAA TTAGTGATTA CTTTGAGTTT GCTGGGGGAA GCGGGCCAGG AACCAGCCCT 300

GGCAGAAGTG TTCCACCAGT TGCACGATCC TCACCGCAAC ATTCCTTATC CAATCCCTTA 360

CCGCGGCGAG TAGAGCAGCC TCTCTACGGC TTAGATGGCA GTGCTGCGAA GGAAGTGTCG 420

GAAGAGCAGT CCGCTCTGCC CACCCTGATG TCAGTGATGC TGGCAAAGCC TCGGCTTGAC 480

ACGGAGCAGC TGGCACAGAG GGGAGCTGGC CTCTGCTTCA CGTTCGTTTC AGCTCAGCAA 540

AATAGTCCCT CCTCTACGGG ATCTGGCAAC ACAGAGCATT CCGGCAGCTC CCAAAAACAG 600

ATCTCCATCC AGCACAGACA GACCCAGTCT GACCTCACAA TAGAAAAAAT ATCTGCACTA 660

GAAAACAGTA AGAATTCTGA CTTAGAAAAG AAGGAGGGAA GAATAGATGA TTTGTTAAGA 720

GCCAATTGTG ATTTGAGGCG ACAAATTGAC GAACAGCAAA AGATGCTAGA GAAGTATAAA 780

GAACGATTAA ATCGATGTGT GACGATGAGC AAGAAACTCC TTATAGAAAA GTCAAAACAA 840

GAGAAGATGG CATGTAGAGA TAAAAGCATG CAAGACCGCT TGAGATTGGG ACACTTTACC 900

ACCGTTCGAC ATGGGGCCTC TTTTACTGAA CAATGGACAG ATGGTTACGC TTTCCAGAAC 960

CTTATCAAGC AACAGGAAAG GATAAATTCA CAAAGGGAAG AGATAGAAAG ACAACGGAAA 1020

ATGTTAGCAA AGCGGAAACC TCCTGCCATG GGACAGGCCC CTCCAGCAAC CAACGAGCAG 1080

AAACAGAGGA AAAGCAAGAC GAACGGAGCT GAAAATGAAA CGTTAACATT AGCAGAATAC 1140

CATGAACAAG AAGAAATCTT CAAACTCAGA TTAGGTCATC TTAAAAAGGA AGAAGCAGAG 1200

ATCCAGGCAG AGCTGGAAAG GCTAGAAAGG GTTAGAAATC TACATATCAG GGAACTAAAA 1260

AGGATACATA ATGAAGATAA TTCACAATTT AAAGATCATC CAACGCTAAA TGACAGATAC 1320

TTGTTGTTAC ATCTTTTGGG TAGAGGAGGT TTCAGTGAAG TTTACAAGGC ATTTGATCTA 1380

ACAGAACAAA GATATGTAGC TGTGAAAATT CACCAGTTAA ATAAAAACTG GAGAGATGAG 1440

AAAAAGGAGA ATTACCACAA GCATGCATGT AGGGAATACC GGATTCACAA AGAACTGGAT 1500

CATCCCAGGA TAGTTAAGCT GTATGATTAC TTTTCACTGG ACACTGACTC GTTTTGTACA 1560

GTATTAGAGT ACTGTGAGGG CAATGACCTG GACTTCTACC TGAAACAGCA CAAATTAATG 1620

TCGGAGAAAG AGGCGCGATC CATTATTATG CAGATTGTGA ATGCTTTAAA GTACTTAAAT 1680

GAAATAAAAC CTCCCATCAT ACACTATGAC CTCAAACCAG GTAATATTCT TTTAGTAAAT 1740

GGTACAGCAT GTGGAGAGAT AAAAATCACA GATTTTGGTC TTTCCAAGAT CATGGATGAT 1800

GATAGCTACA ATTCCGTGGA CGGCATGGAG CTAACGTCAC AGGGTGCTGG TACTTACTGG 1860

TATTTACCAC CAGAGTGTTT TGTGGTTGGG AAAGAGCCAC CAAAGATCTC AAATAAAGTT 1920

GACGTCTGGT CAGTGGGTGT GATCTTCTAC CAGTGTCTTT ATGGAAGGAA GCCTTTTGGC 1980

CACAACCAGT CCCAGCAAGA TATTCTACAA GAAAATACTA TTCTTAAAGC TACTGAAGTG 2040

CAGTTCCCGC CAAAGCCAGT AGTAACACCA GAAGCAAAGG CGTTTATTCG ACGATGCTTA 2100

GCCTATCGAA AAGAGGACCG CATCGATGTC CAGCAGCTGG CCTGTGACCC CTACTTGCTG 2160

CCTCACATCC GGAAGTCGGT CTCCACGAGT AGCCCCGCTG GAGCTGCTAT CGCATCGACC 2220

TCCGGGGCAT CCAATAACAG TTCTTCGAAT TGA 2253

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 440   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  499

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 500   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  559

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 560   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  619

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 620   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  679

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 680   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  719

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013