EKS-MUP-00365
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00365
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src430.42.0E-129245494250
StatusUnreviewed
Ensembl ProteinENSMPUP00000015151
UniProt AccessionG9K7Z3;
Protein Name
Protein Synonyms/Alias Lymphocyte-specific protein tyrosine kinase;
Gene NameLCK
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000015261ENSMPUP00000015151ENSMPUT00000015390
OrganismMustela putorius furo
Functional Description
Protein Length509
Protein Sequence
(FASTA)
MGCSCSSNSE EDWMENIDVC ENCHYPIVPL DGKATLPIRN GSEVRDPLVI YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LERNGEWWKA QSLTTGQEGF IPFNFVAKAN 120
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 180
YKIRNLDQGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV 240
PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PPGIKLTINK LLDMAAQIAE GMAFIEERNY 360
IHRDLRAANI LVSDTLSCKI ADFGLARLIV DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY HLMMLCWKER 480
PEDRPTFDYL RSVLEDFFTA TEGQYQPQP 509
Nucleotide Sequence
(FASTA)
ATGGGCTGTA GCTGCAGCTC AAACTCTGAA GAAGACTGGA TGGAAAACAT CGATGTATGT 60
GAGAACTGCC ATTACCCCAT AGTCCCACTG GATGGCAAGG CCACGCTGCC CATCCGCAAT 120
GGCTCTGAGG TGCGGGATCC ACTGGTCATC TATGAAGGCT CCAACCCCCC AGCCTCACCA 180
TTGCAAGACA ACCTGGTTAT CGCTCTGCAC AGCTACGAGC CCTCTCACGA TGGAGACTTG 240
GGCTTCGAGA AGGGTGAACA GCTCCGTATC CTGGAGCGGA ACGGCGAATG GTGGAAGGCA 300
CAGTCCCTGA CCACCGGCCA GGAAGGTTTC ATTCCCTTCA ACTTCGTGGC CAAAGCGAAC 360
AGCCTGGAGC CCGAACCCTG GTTCTTCAAG AACCTGAGCC GCAAGGACGC TGAGCGGCAG 420
CTCCTGGCGC CCGGGAACAC GCACGGCTCC TTCCTGATCC GGGAGAGCGA GAGCACCGCC 480
GGATCGTTTT CACTGTCCGT GCGGGACTTC GACCAGAACC AGGGAGAGGT GGTGAAACAT 540
TACAAAATCC GTAACCTGGA CCAAGGCGGC TTCTACATCT CGCCCCGCAT CACTTTTCCT 600
GGCCTGCACG AGCTGGTCCG CCATTACACC AATGCTTCGG ACGGGCTGTG CACGCGGTTG 660
AGTCGCCCCT GCCAGACCCA GAAGCCCCAG AAGCCTTGGT GGGAGGACGA GTGGGAGGTT 720
CCCAGGGAGA CGCTGAAGCT GGTGGAGCGG CTGGGGGCTG GCCAGTTCGG GGAAGTGTGG 780
ATGGGGTACT ACAACGGGCA CACAAAGGTG GCAGTCAAGA GCCTGAAGCA GGGAAGCATG 840
TCCCCCGACG CCTTCCTGGC CGAGGCCAAC CTCATGAAGC AGCTGCAACA CCAGAGACTG 900
GTCCGGCTCT ACGCGGTGGT CACCCAGGAG CCCATCTACA TCATCACGGA ATACATGGAG 960
AACGGGAGCC TGGTAGATTT CCTCAAGACC CCCCCAGGCA TCAAGCTGAC CATCAACAAA 1020
CTCCTGGACA TGGCAGCCCA AATTGCAGAG GGCATGGCAT TCATTGAAGA GCGGAATTAT 1080
ATCCACCGTG ACCTGAGGGC TGCCAACATC CTCGTTTCTG ACACCCTGAG CTGCAAGATT 1140
GCAGACTTTG GCCTAGCACG CCTCATTGTG GACAATGAGT ACACAGCCAG GGAGGGAGCC 1200
AAGTTTCCCA TTAAGTGGAC AGCACCGGAA GCCATTAACT ATGGGACATT CACCATCAAG 1260
TCGGATGTGT GGTCTTTTGG GATCCTGCTG ACGGAGATTG TCACCCATGG CCGCATTCCT 1320
TACCCAGGGA TGACCAATCC TGAGGTGATT CAGAACCTAG AGCGAGGCTA CCGTATGGTG 1380
CGACCTGACA ACTGTCCCGA GGAGCTGTAC CACCTCATGA TGCTTTGCTG GAAGGAGCGC 1440
CCAGAGGACC GGCCCACCTT TGACTACCTG CGCAGTGTGC TGGAGGACTT CTTCACGGCC 1500
ACAGAGGGCC AGTACCAGCC TCAGCCCTGA 1530
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 245   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  304
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m++Gsl+dflk+  g kl+++kl+d+aaq+aeGma++ee+n+ihr
Q: 305   AVVTQ-EPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNYIHR  363
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l +k+adfGlarli d+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 364   DLRAANILVSDTLSCKIADFGLARLIVDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  423
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGmtn ev++++ergyr+ rp++cpeely+l++ cwk++pe+
Q: 424   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPED  483
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++l++vl
Q: 484   RPTFDYLRSVL  494
         *******9876
Domain Sequence
(FASTA)
LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60
AVVTQEPIYI ITEYMENGSL VDFLKTPPGI KLTINKLLDM AAQIAEGMAF IEERNYIHRD 120
LRAANILVSD TLSCKIADFG LARLIVDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180
SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVRPDN CPEELYHLMM LCWKERPEDR 240
PTFDYLRSVL 250
KeywordKinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAJ-00376
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PAT-00349
EKS-PES-00333
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0010628; P:positive regulation of gene expression
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0050856; P:regulation of T cell receptor signaling pathway
GO:0051209; P:release of sequestered calcium ion into cytosol
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013