EKS-MUP-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	347.7	5.0E-104	510	766	257

Status

Unreviewed

Ensembl Protein

ENSMPUP00000015505

UniProt Accession

G9K9I8;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 6;

Gene Name

Map3k6

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000015615	ENSMPUP00000015505	ENSMPUT00000015746

Organism

Mustela putorius furo

Functional Description

Protein Length

1146

Protein Sequence
(FASTA)

MTNNVLLCSQ ADLPDLQALR EDVFQKNSDC VGSYTLIPYV VTAAGRVLCG DAGLLRGLAD 60

GLVQAGVGTE ALLTPLVGRL VRLLETTPTD SCGYFRETIR QDIRRARERF CGEQLRQELA 120

RLQRRLDSVE LLSPDIVMNL LLSYRDVQDY SAIIELVETL KALPTCDVAE QHNVCFHYTF 180

ALNRRNRPGD REKALAVLLP LVQSEGSVVP DLCCMCGRVY KDMFFSSGFQ DAGYREQAYH 240

WYRKAFDVEP SLHSGINAAV LLIAAGQRFE DSEELQLIGM KLGCLLARKG SVEKMQYYWD 300

VGFYLGAQIL ANDLAQVALA AEQLYKLDAP IWYLVSMMET FLLYQHFRPT LELPEGPPHR 360

AHFWLHFLLQ SCQPLKTACP QGDQCLVLVL EMNKVLLPAR LEIQGTDPVS AVTLSLLEPE 420

PQDVPSSWTF PVASICGVSS SKRDERCCFL YALPPAQDVQ LCFPSVGHCQ WFCGLIQALV 480

TNPDSTTPAE EAEGVGEVLE FDYEYTETGE RLVLGKGTYG VVYAGRERHT RVRIAIKEIP 540

ERDSRFSQPL HEEIALHKRL RHKNIVRYLG STSQGGYLKI FMEEVPGGSL SSLLRSVWGP 600

LQDNESTISF YTRQTLQGLS YLHDNHIVHR DIKGDNVLIN TFSGLLKISD FGTSKRLAGI 660

TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI EMATGRPPFH ELGSPQAAMF 720

KVGMYKVHPP MPTSLSAEAQ AFLLRTFEPD PRLRASAQAL LGDPFLQPGR RSRSPGSPRH 780

ALRPSDAPSA SPTPSADPTT QPQTFPRPQA PFQHPPSPPK RCLSYGDTSQ LRVPEEPGAE 840

EPTSPEESSG LSLLHQESKR RAMLAAVLEQ ELPSLAESLG LKQEQGPRLG RNHVEQLLRC 900

LGAHIHTPNR RQLAQELRAL QGQLRAQGLR PALLHGPLFA FPDAVKQILR RRQIRPHWMF 960

VLDSLLSRAV RVALAVLGPE EETEEVPPRS EEEPQSKQQE TISRLPGEPE KAPPTPVVQL 1020

GLLRAETDRL REVLAEKERE CQALVQQALE RVHRETGTCT LAPEPPAALT VDQGLVQWLQ 1080

GLNVDSGTIQ MLLNHSFTLH ILLTCATRDD LIYTRIRGGM VCRIWRAILA QRAGSMPVTP 1140

GQQEAE 1146

Nucleotide Sequence
(FASTA)

ATGACCAACA ACGTGCTGCT CTGCTCCCAG GCTGACCTCC CGGACCTGCA GGCCCTTCGG 60

GAGGATGTTT TCCAGAAGAA CTCGGATTGT GTCGGCAGCT ACACGCTGAT TCCCTATGTG 120

GTGACAGCCG CAGGCCGAGT GCTGTGCGGT GATGCGGGCC TCCTGAGGGG ACTGGCTGAT 180

GGGCTGGTCC AGGCCGGGGT GGGCACCGAG GCCCTGCTTA CGCCCCTCGT GGGCCGGCTG 240

GTCCGGCTGC TGGAGACCAC GCCTACCGAC TCTTGTGGCT ACTTCCGGGA GACCATCCGG 300

CAGGACATCC GGAGGGCCCG GGAGCGCTTC TGCGGGGAGC AGCTGCGGCA GGAGCTGGCT 360

CGCTTGCAGC GGAGGCTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCGT CATGAACCTG 420

CTGCTCTCCT ACCGCGACGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT AGAGACCCTG 480

AAGGCCTTGC CTACCTGCGA TGTGGCCGAG CAGCACAACG TCTGCTTCCA CTATACGTTT 540

GCCCTAAACC GGAGGAACAG GCCTGGGGAC CGGGAGAAAG CATTGGCCGT GCTGCTGCCG 600

CTGGTCCAGA GCGAGGGCTC CGTGGTGCCT GACCTCTGCT GCATGTGCGG CCGTGTCTAC 660

AAGGACATGT TCTTCAGCTC TGGCTTCCAG GATGCTGGGT ACCGGGAGCA GGCCTACCAC 720

TGGTATCGAA AGGCTTTTGA CGTAGAGCCC AGCCTTCACT CGGGCATCAA TGCGGCTGTG 780

CTGCTCATCG CTGCAGGCCA GCGCTTCGAG GACTCTGAGG AGCTCCAGCT CATAGGCATG 840

AAGCTGGGCT GCCTGCTGGC CCGAAAAGGC TCTGTGGAGA AGATGCAGTA TTATTGGGAT 900

GTAGGCTTCT ACCTGGGAGC TCAGATCCTC GCCAATGACC TTGCCCAGGT GGCGCTGGCC 960

GCAGAGCAGC TCTACAAGCT CGATGCTCCC ATATGGTACC TGGTGTCCAT GATGGAAACC 1020

TTCCTGCTGT ACCAGCACTT CAGACCTACG CTGGAGCTTC CTGAAGGACC CCCGCACCGT 1080

GCCCACTTCT GGCTCCACTT CTTGCTGCAG TCCTGTCAGC CACTCAAGAC GGCTTGTCCC 1140

CAAGGGGACC AGTGCTTGGT GCTGGTCTTG GAGATGAACA AGGTGCTGCT GCCTGCCAGG 1200

CTGGAGATTC AGGGTACGGA CCCAGTGAGC GCAGTGACCC TGAGCCTGCT GGAGCCCGAA 1260

CCCCAGGACG TTCCCTCCAG CTGGACTTTC CCAGTGGCTT CCATCTGCGG GGTCAGCTCC 1320

TCCAAGCGGG ATGAGCGCTG CTGCTTCCTC TACGCGCTGC CCCCTGCGCA GGATGTGCAG 1380

CTCTGCTTCC CCAGCGTGGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA AGCCTTGGTG 1440

ACAAATCCGG ATTCCACAAC GCCCGCGGAA GAGGCAGAGG GTGTGGGGGA GGTGCTGGAG 1500

TTTGATTATG AGTACACGGA GACGGGTGAG CGACTGGTGC TGGGCAAGGG CACCTACGGG 1560

GTGGTGTACG CCGGCCGCGA GCGGCACACG CGGGTGCGCA TAGCCATTAA GGAGATCCCG 1620

GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TTGCTCTGCA CAAGCGCCTT 1680

CGCCACAAGA ACATCGTGCG CTACCTGGGC TCCACCAGCC AGGGCGGCTA CCTCAAGATC 1740

TTTATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCTTTGC TGCGGTCGGT GTGGGGCCCC 1800

CTGCAGGACA ATGAGAGCAC CATCAGTTTC TACACCCGCC AGACCCTGCA GGGCCTCAGC 1860

TACCTGCATG ACAACCACAT AGTGCATCGG GACATCAAGG GGGACAATGT GCTGATCAAC 1920

ACCTTCAGTG GGCTGCTCAA GATTTCTGAC TTTGGCACCT CCAAGAGGCT GGCGGGCATC 1980

ACACCTTGCA CTGAGACCTT CACAGGGACC CTCCAGTATA TGGCACCAGA AATCATTGAC 2040

CAGGGCCCAC GAGGGTATGG GAAGGCAGCT GACATCTGGT CACTGGGCTG CACTGTTATC 2100

GAGATGGCAA CAGGCCGCCC CCCCTTCCAT GAGCTAGGGA GCCCACAGGC GGCCATGTTT 2160

AAGGTGGGCA TGTACAAGGT GCATCCGCCA ATGCCCACTT CTCTGTCAGC GGAGGCCCAA 2220

GCCTTTCTTC TCCGAACGTT TGAGCCAGAC CCCCGCCTCC GAGCCAGTGC TCAAGCACTG 2280

CTGGGGGACC CCTTCCTGCA GCCGGGGAGG AGGAGCCGCA GCCCTGGCTC CCCAAGACAT 2340

GCACTGCGGC CCTCAGATGC CCCTTCAGCC AGCCCCACTC CTTCAGCTGA CCCGACCACC 2400

CAGCCCCAGA CATTCCCACG CCCTCAGGCA CCCTTTCAGC ACCCACCCAG TCCCCCGAAG 2460

CGCTGCCTCA GTTATGGAGA TACCAGCCAG CTCCGGGTGC CTGAGGAACC GGGGGCCGAG 2520

GAGCCCACGT CCCCTGAGGA GAGTTCCGGG CTGAGCCTGC TGCACCAAGA GAGCAAGCGC 2580

AGGGCCATGC TGGCCGCGGT GCTGGAGCAG GAGCTGCCCT CGCTGGCGGA GAGTCTGGGC 2640

CTGAAGCAGG AACAGGGGCC CCGGCTGGGC AGGAATCATG TGGAACAGCT ACTGCGCTGC 2700

CTCGGGGCGC ACATCCACAC TCCCAACCGC CGGCAGCTGG CCCAGGAGCT GCGGGCGCTG 2760

CAAGGGCAGC TGCGGGCCCA AGGCCTCCGG CCTGCACTTC TGCACGGACC GCTCTTCGCC 2820

TTCCCGGACG CGGTGAAGCA GATCCTCCGC CGGCGCCAGA TCCGCCCACA CTGGATGTTC 2880

GTGCTGGACT CGCTGCTCAG CCGAGCGGTG CGGGTAGCCC TCGCCGTGTT GGGCCCAGAA 2940

GAGGAGACAG AGGAGGTCCC ACCGAGGTCA GAGGAGGAAC CCCAGTCCAA GCAGCAGGAG 3000

ACCATCAGCC GGCTCCCGGG GGAACCAGAG AAGGCCCCCC CAACCCCAGT GGTGCAGCTG 3060

GGCCTCTTGC GAGCAGAGAC TGACAGGCTC CGAGAGGTCC TGGCCGAGAA GGAGCGGGAG 3120

TGCCAGGCCC TGGTGCAGCA AGCTCTGGAG CGGGTACACA GGGAGACAGG GACCTGCACC 3180

CTGGCCCCAG AGCCCCCTGC TGCTCTCACG GTGGACCAGG GCTTGGTGCA GTGGCTACAG 3240

GGACTGAATG TGGATTCAGG CACTATCCAG ATGCTGCTGA ACCACAGCTT CACCCTCCAT 3300

ATCCTGCTGA CCTGTGCCAC TCGAGATGAC CTCATCTATA CACGCATCAG GGGAGGAATG 3360

GTGTGCCGTA TCTGGAGAGC CATCTTGGCC CAGCGAGCAG GATCTATGCC AGTCACCCCT 3420

GGCCAACAGG AGGCTGAATG A 3441

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya+++ +t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n

Q: 510   ERLVLGKGTYGVVYAGRERHTRVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  564

         5779**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+q l+gl+yLH+

Q: 565   IVRYLGSTSQGGYLKIFMEEVPGGSLSSLLRsVWGPLQdnESTISFYTRQTLQGLSYLHD  624

         *******************************99****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++

Q: 625   NHIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  681

         *****************9*********************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mfkvg+ k++P++p++ls+e+++

Q: 682   GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFKVGMYKVHPPMPTSLSAEAQA  741

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +++e dp+ r+sa+ LL ++fl

Q: 742   FLLRTFEPDPRLRASAQALLGDPFL  766

         **********************996

Domain Sequence
(FASTA)

ERLVLGKGTY GVVYAGRERH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL 60

GSTSQGGYLK IFMEEVPGGS LSSLLRSVWG PLQDNESTIS FYTRQTLQGL SYLHDNHIVH 120

RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180

ADIWSLGCTV IEMATGRPPF HELGSPQAAM FKVGMYKVHP PMPTSLSAEA QAFLLRTFEP 240

DPRLRASAQA LLGDPFL 257

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>