EKS-MUP-00033
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00033
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak324.74.8E-978221098277
StatusUnreviewed
Ensembl ProteinENSMPUP00000015689
UniProt AccessionG9K6I1;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000015797ENSMPUP00000015689ENSMPUT00000015930
OrganismMustela putorius furo
Functional Description
Protein Length1107
Protein Sequence
(FASTA)
MAPPSEETPL IPQRSCSLSS SEAGALHVLL PPRGPGPPQR LSFSYGDHSA EELCVWAAKA 60
SGILPVYHSL FALATEDLSC WFPPSHIFSV EDSSTQVLVY RLRFYFPNWF GLEKCHRFGL 120
RKDLASAVLD LPVLEHLFAQ HRNDLVSGRL SVGLSLKEQG ECLSLAVLDL ARMAREQVQQ 180
PEEMLKTVSY KVCLPPDLRD LIQGLSFVTR KRIRRTVRRA LRRVTACQAD RHSLMAKYIM 240
DLERLDPARA VETFPVNLPG AAGGEDAKGL LRVAGDSGIA WSSGGQEALQ PFCDFPEIVD 300
ISIKQAPCVG PAGEHRLVTV TRTDNQILEA EFPGLPAALS FVALVDGYFR LISDSRHFFC 360
KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TQGSRPGSYV LRRSPQDFDC FLLTVCVQTP 420
LGPDYKGCLI RCDPTGTFSL AGLGRPHSSL RELLAACWNG GLHVDGVALS LTFCCTPKPK 480
EKSNLIVVRR GCSPPTSSPL QTQSQGQLSQ MTFHKIPADS LEWHENLGHG SFTKIYRGCR 540
HEVVEGEARK TEVLLKVMNA KHKNCMESFL EAASLMSQVS YQHLVLLHGV CMAGDSIMVQ 600
EFAHLGALDT YLRKSGHLVP ASWKLQVIKQ LAYALNYLED KGLPHGNVSA RKVLLARKGA 660
DGNLPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLLEPR TLGLEADKWG FGATVWEVFS 720
GIPIPISTLD PAKKLQFYKE QQQLPAPKWM ELAMLIQQCM VYEAGQRPSF RAIIRDLNSL 780
ITSDYELLSD PTPGALTPRD GLWNGAQLYA YQDPTIFEER HLKYISQLGK GNFGSVELCR 840
YDPLGDNTGA LVAVKQLQHS GPDQQKDFQR EIQTLKALHS DFIVKYRGVS YGPGRQSLRL 900
VMEYLPSGCL RDFLQRHRAR LDANRLLLYA SQICKGMEYL GSRRYVHRDL AARNILVESE 960
THVKIADFGL AKLLPLDKDY YVVHKPGQSP IFWYAPESLS DNIFSRQSDV WSFGVILYEL 1020
FTYGNKSCSP SAEFLRMMGM MGCDRDVPAL CCLLELLAEG QRLPAPAACP GEVHELMKLC 1080
WASSPKDRPT FSALGPQLDA LWSASRG 1107
Nucleotide Sequence
(FASTA)
ATGGCGCCTC CAAGTGAGGA GACACCCCTG ATCCCTCAAC GTTCCTGCAG CCTCTCATCT 60
TCAGAGGCAG GTGCCCTGCA CGTGCTGCTG CCTCCTCGGG GCCCTGGACC CCCACAGCGC 120
CTATCCTTCT CCTATGGAGA CCATTCAGCT GAAGAGCTGT GTGTTTGGGC TGCTAAGGCC 180
AGTGGCATCC TGCCTGTGTA CCACTCCCTC TTTGCCCTGG CCACGGAGGA CCTGTCCTGC 240
TGGTTCCCCC CAAGCCATAT CTTCTCCGTG GAGGACTCAA GCACCCAAGT CCTGGTCTAC 300
AGGCTCCGCT TTTACTTCCC CAACTGGTTT GGGCTAGAGA AGTGCCACCG CTTCGGGCTG 360
CGCAAGGACT TGGCCAGCGC CGTCCTTGAC CTACCAGTCC TGGAGCACCT CTTCGCTCAG 420
CATCGAAATG ACCTGGTGAG CGGCCGCCTC TCCGTGGGCC TCAGTCTCAA GGAGCAGGGG 480
GAATGTCTCA GCCTGGCAGT GCTGGACCTG GCCCGGATGG CCCGCGAGCA GGTTCAGCAA 540
CCTGAGGAGA TGCTGAAGAC TGTCAGCTAT AAGGTCTGCC TGCCCCCCGA CCTGCGCGAC 600
CTGATTCAGG GCCTGAGCTT CGTGACGCGG AAGCGCATCC GGAGGACCGT GCGCCGGGCC 660
CTGCGCCGTG TGACCGCCTG CCAGGCTGAC AGGCATTCGC TCATGGCCAA GTACATCATG 720
GACCTGGAGA GGCTCGACCC GGCCAGGGCG GTCGAGACCT TCCCCGTGAA CCTCCCCGGG 780
GCTGCTGGTG GTGAGGATGC GAAGGGGCTG CTCCGAGTGG CTGGTGACAG CGGCATCGCC 840
TGGAGTTCGG GAGGACAGGA GGCCCTCCAG CCCTTCTGCG ACTTTCCAGA AATTGTGGAC 900
ATCAGCATCA AGCAGGCTCC GTGTGTTGGC CCGGCCGGGG AGCACCGCCT GGTCACCGTC 960
ACCAGGACGG ACAACCAGAT CCTGGAGGCC GAGTTCCCGG GGCTGCCCGC CGCGTTGTCC 1020
TTTGTGGCGC TTGTCGATGG CTACTTCCGG CTGATCTCCG ACTCCAGGCA CTTCTTCTGC 1080
AAGGAGGTTG CGCCGCCACG GCTGCTGGAA GAAGTGGCCG AGCAGTGCCA CGGCCCCATC 1140
ACCCTGGATT TTGCCATCAA CAAACTCAAG ACCCAGGGCT CACGTCCCGG CTCCTACGTT 1200
CTCCGCCGCA GTCCCCAGGA TTTTGACTGC TTCCTCCTCA CTGTCTGTGT TCAGACCCCC 1260
CTGGGTCCTG ATTACAAGGG CTGCCTCATC CGCTGTGACC CCACAGGAAC CTTCTCCCTG 1320
GCTGGCCTCG GCCGTCCCCA CAGCAGTCTT CGAGAGCTCT TGGCAGCCTG CTGGAATGGT 1380
GGGCTGCACG TGGATGGGGT TGCGCTAAGC CTCACTTTCT GCTGCACCCC CAAACCCAAA 1440
GAAAAGTCCA ACCTCATTGT GGTACGGAGG GGTTGTAGCC CACCCACATC ATCCCCTCTT 1500
CAGACCCAAT CCCAAGGCCA GCTGAGTCAG ATGACGTTTC ACAAGATCCC TGCTGACAGC 1560
CTGGAGTGGC ATGAGAACCT GGGTCATGGA TCGTTCACCA AGATTTACCG GGGTTGTCGC 1620
CATGAGGTCG TGGAGGGGGA GGCCCGGAAG ACAGAGGTGC TGCTCAAAGT GATGAATGCC 1680
AAGCATAAAA ACTGCATGGA GTCATTTCTG GAAGCTGCGA GTCTGATGAG CCAAGTGTCA 1740
TACCAGCACC TCGTGTTGCT CCATGGCGTG TGCATGGCTG GAGACAGTAT CATGGTGCAG 1800
GAATTTGCAC ACCTGGGAGC GCTGGACACC TACCTGCGCA AGTCTGGCCA CCTGGTGCCA 1860
GCCAGCTGGA AGCTGCAGGT GATCAAACAG CTGGCCTATG CCCTCAACTA TCTGGAGGAC 1920
AAAGGCCTCC CCCATGGCAA TGTCTCAGCC CGGAAGGTGC TCCTTGCTCG CAAAGGGGCT 1980
GATGGGAACC TGCCCTTCAT CAAGCTTAGT GACCCTGGGG TCAGCCCTGC TGTGCTAAGC 2040
CTGGAGATGC TCACAGACAG GATCCCATGG GTGGCCCCTG AGTGTCTCCT GGAGCCCCGG 2100
ACACTTGGCT TGGAAGCTGA CAAGTGGGGT TTTGGTGCCA CAGTCTGGGA GGTGTTCAGC 2160
GGGATCCCGA TACCCATCAG CACCCTGGAT CCTGCCAAGA AGCTTCAGTT TTATAAAGAA 2220
CAGCAGCAGC TCCCTGCCCC CAAGTGGATG GAGCTCGCCA TGCTGATCCA ACAGTGCATG 2280
GTCTACGAGG CAGGCCAGAG GCCCTCCTTC CGTGCCATCA TCCGCGACCT GAACAGCCTC 2340
ATCACTTCAG ATTATGAGCT CCTCTCAGAC CCCACACCTG GTGCCTTGAC GCCCCGTGAT 2400
GGGCTATGGA ATGGCGCCCA GCTCTACGCC TACCAAGACC CTACTATTTT CGAGGAGAGA 2460
CACCTCAAGT ACATCTCACA GCTGGGCAAG GGCAACTTTG GCAGCGTGGA ACTGTGCCGC 2520
TATGACCCGC TGGGCGACAA CACAGGCGCC CTAGTGGCAG TGAAGCAGCT GCAACACAGC 2580
GGGCCAGACC AGCAGAAGGA CTTCCAGAGG GAGATCCAGA CCCTCAAAGC CCTCCACAGT 2640
GACTTCATTG TCAAGTACCG CGGTGTCAGC TATGGCCCAG GCCGCCAGAG CCTGCGGCTG 2700
GTGATGGAGT ACCTGCCCAG CGGCTGCCTG AGGGACTTCC TACAGCGGCA CCGCGCGCGC 2760
CTCGATGCCA ACCGCCTGCT CCTCTACGCC TCACAGATCT GCAAGGGCAT GGAGTACCTG 2820
GGCTCCCGCC GCTATGTGCA CCGCGACCTT GCCGCGCGTA ACATCCTGGT GGAGAGCGAG 2880
ACGCACGTCA AGATCGCCGA CTTCGGCCTC GCCAAGCTGC TGCCGCTCGA CAAAGACTAC 2940
TACGTGGTCC ACAAGCCCGG CCAGAGCCCC ATCTTCTGGT ACGCCCCAGA GTCTCTCTCT 3000
GACAACATCT TCTCGCGCCA GTCGGACGTC TGGAGCTTCG GGGTCATCCT GTACGAGCTT 3060
TTCACCTACG GGAACAAGAG CTGCAGCCCC TCAGCCGAGT TCCTGCGGAT GATGGGGATG 3120
ATGGGATGTG ATAGAGACGT CCCGGCCCTC TGCTGCCTCC TGGAACTTCT GGCTGAGGGC 3180
CAGAGGCTGC CGGCGCCTGC TGCCTGCCCT GGTGAGGTTC ATGAGCTCAT GAAGCTGTGC 3240
TGGGCCTCTA GCCCGAAAGA CCGACCAACA TTCAGTGCCT TGGGCCCTCA GCTGGACGCA 3300
CTATGGAGTG CGAGCCGGGG GTAG 3324
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk+i++Lgkg+f++v+++r+d+ gd+t++ va+k+L++sg+d+++df+re+++l++l+++
Q: 822   LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQKDFQREIQTLKALHSD  881
         799*********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk++gv++ +g++  rlVmey++sG+L+++L++++++l++++ll +a+q++k+meYL+
Q: 882   FIVKYRGVSYGPGRQslRLVMEYLPSGCLRDFLQRHRARLDANRLLLYASQICKGMEYLG  941
         ************************************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         ++++vhrd+aarn+Lve+e +      vk++d+glak+++ d +Yy+v ++++s+i+w+a
Q: 942   SRRYVHRDLAARNILVESETH------VKIADFGLAKLLPLDkDYYVVHKPGQSPIFWYA  995
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle..........rkl  222
         pe+ls++  +s++sdvWsFgv lyel+t  +k++sp    lr++++            +l
Q: 996   PESLSDNI-FSRQSDVWSFGVILYELFTyGNKSCSPsaefLRMMGMMgcdrdvpalcCLL  1054
         ********.*******************9999********9999888888******99**
S: 223   elleekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265
         ell e++rlp+p  cp e++elm+ c++ +p++rp+F+a+  +l
Q: 1055  ELLAEGQRLPAPAaCPGEVHELMKLCWASSPKDRPTFSALGPQL  1098
         **************************************998776
Domain Sequence
(FASTA)
LKYISQLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQHSG PDQQKDFQRE IQTLKALHSD 60
FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL DANRLLLYAS QICKGMEYLG 120
SRRYVHRDLA ARNILVESET HVKIADFGLA KLLPLDKDYY VVHKPGQSPI FWYAPESLSD 180
NIFSRQSDVW SFGVILYELF TYGNKSCSPS AEFLRMMGMM GCDRDVPALC CLLELLAEGQ 240
RLPAPAACPG EVHELMKLCW ASSPKDRPTF SALGPQL 277
KeywordATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-EQC-00030
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LOA-00032
EKS-MAM-00030
EKS-MOD-00032
EKS-MUM-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-ORA-00026
EKS-OTG-00032
EKS-PAT-00027
EKS-POA-00030
EKS-PTV-00031
EKS-RAN-00034
EKS-SAH-00030
EKS-SUS-00027
EKS-XET-00033
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030183; P:B cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013