EKS-MUP-00177

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00177

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	443.2	3.3E-133	296	564	269

Status

Unreviewed

Ensembl Protein

ENSMPUP00000016999

UniProt Accession

G9KIK1;

Protein Name

Protein Synonyms/Alias

Protein kinase C, iota;

Gene Name

PRKCI

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000017108	ENSMPUP00000016999	ENSMPUT00000017253

Organism

Mustela putorius furo

Functional Description

Protein Length

638

Protein Sequence
(FASTA)

MDRWLRPPSP GMWAFGASEV GGTRAGRRAG PGRREEPRGS GCPGEATLGS APRAEWTGGG 60

SGDHSHQVRV KAYYRGDIMI THFEPSISFE GLCSEVRDMC SFDNEQLFTM KWIDEEGDPC 120

TVSSQLELEE AFRLYELNKD SELLIHVFPC VPERPGMPCP GEDKSIYRRG ARRWRKLYCA 180

NGHTFQAKRF NRRAHCAICT DRIWGLGRQG YKCINCKLLV HKKCHKLVTI ECGRHSMPPE 240

PMMPMDQSSM HSDHAQTVIP YNPSSHESLD QVGEEKEAMN TRESGKASSS LGLQDFDLLR 300

VIGRGSYAKV LLVRLKKTDR IYAMKVVKKE LVNDDEDIDW VQTEKHVFEQ ASNHPFLVGL 360

HSCFQTESRL FFVIEYVNGG DLMFHMQRQR KLPEEHARFY SAEISLALNY LHERGIIYRD 420

LKLDNVLLDS EGHIKLTDYG MCKEGLRPGD TTSTFCGTPN YIAPEILRGE DYGFSVDWWA 480

LGVLMFEMMA GRSPFDIVGS SDNPDQNTED YLFQVILEKQ IRIPRSLSVK AASVLKSFLN 540

KDPKERLGCH PQTGFADIQG HPFFRNVDWD MMEQKQVVPP FKPNISGEFG LDNFDSQFTN 600

EPVQLTPDDD DIVRKIDQSE FEGFEYINPL LMSAEECV 638

Nucleotide Sequence
(FASTA)

ATGGATCGAT GGTTGCGCCC GCCCTCCCCC GGAATGTGGG CCTTTGGAGC GAGCGAGGTG 60

GGAGGGACCC GAGCGGGGAG GCGTGCTGGG CCCGGGCGGC GGGAGGAGCC GCGCGGTTCC 120

GGCTGCCCCG GCGAGGCGAC CCTTGGGTCC GCGCCGCGGG CGGAGTGGAC AGGCGGCGGC 180

AGCGGGGACC ATTCCCACCA GGTCCGGGTG AAAGCCTACT ATCGCGGGGA TATCATGATA 240

ACCCATTTTG AACCTTCAAT CTCCTTCGAG GGCCTTTGCA GTGAGGTTCG AGATATGTGT 300

TCCTTTGACA ATGAACAGCT TTTCACCATG AAATGGATAG ATGAGGAAGG AGACCCGTGT 360

ACAGTATCAT CTCAGTTGGA GTTAGAAGAA GCCTTTAGGC TTTATGAGCT AAACAAGGAT 420

TCTGAACTCC TGATTCATGT CTTCCCTTGT GTACCAGAAC GTCCTGGAAT GCCATGTCCA 480

GGAGAAGACA AATCTATCTA TCGCAGAGGT GCGCGCCGCT GGAGAAAGCT TTATTGTGCA 540

AATGGCCACA CTTTCCAAGC CAAGCGTTTC AACAGGCGTG CCCACTGTGC CATCTGTACT 600

GACCGAATAT GGGGACTTGG ACGTCAGGGG TATAAGTGCA TCAACTGCAA ACTCCTCGTT 660

CATAAGAAGT GCCACAAACT TGTCACCATC GAATGTGGGC GGCATTCTAT GCCACCGGAA 720

CCAATGATGC CCATGGACCA GTCATCCATG CATTCAGACC ATGCACAGAC AGTAATTCCA 780

TATAATCCTT CAAGTCATGA GAGTTTGGAC CAAGTTGGTG AAGAAAAGGA GGCAATGAAT 840

ACCAGGGAAA GTGGCAAAGC TTCATCCAGT TTAGGTCTTC AGGACTTTGA TTTGCTTCGG 900

GTAATAGGCA GAGGAAGTTA TGCCAAAGTA CTATTGGTGC GATTAAAAAA AACAGATCGT 960

ATTTATGCAA TGAAAGTTGT GAAAAAAGAG CTGGTCAATG ATGATGAGGA TATTGATTGG 1020

GTACAGACAG AGAAGCACGT TTTTGAACAG GCATCCAATC ATCCTTTTCT TGTTGGGCTG 1080

CATTCTTGCT TTCAGACAGA AAGCAGATTG TTCTTTGTCA TAGAATATGT AAATGGAGGA 1140

GATCTAATGT TTCATATGCA GCGACAAAGA AAACTTCCTG AAGAACATGC CAGATTTTAC 1200

TCTGCAGAAA TCAGTCTAGC ATTAAATTAT CTTCATGAAC GAGGGATAAT TTATAGAGAT 1260

TTGAAATTGG ACAATGTATT GCTGGACTCA GAAGGACACA TTAAACTCAC TGACTACGGC 1320

ATGTGTAAGG AAGGATTACG GCCAGGAGAT ACAACCAGCA CTTTTTGTGG TACTCCCAAT 1380

TACATTGCTC CTGAAATTTT AAGAGGAGAA GATTATGGTT TCAGTGTCGA TTGGTGGGCC 1440

CTTGGAGTAC TAATGTTTGA GATGATGGCA GGAAGATCTC CATTTGATAT TGTTGGAAGC 1500

TCTGATAACC CTGATCAAAA CACAGAGGAT TATCTCTTCC AAGTTATTTT GGAAAAGCAA 1560

ATACGCATAC CGCGTTCTCT CTCTGTAAAA GCTGCAAGTG TCCTGAAGAG TTTTCTCAAC 1620

AAGGACCCAA AGGAACGATT AGGTTGTCAT CCACAAACAG GATTTGCTGA TATTCAGGGA 1680

CACCCATTTT TTCGAAATGT TGATTGGGAT ATGATGGAGC AAAAGCAGGT GGTACCTCCC 1740

TTTAAACCAA ATATTTCTGG GGAATTTGGT TTGGACAACT TCGATTCTCA GTTTACTAAT 1800

GAACCTGTCC AGCTCACTCC AGATGATGAT GACATCGTGA GGAAGATCGA TCAGTCTGAA 1860

TTCGAAGGTT TTGAGTACAT CAATCCTCTT TTGATGTCTG CAGAAGAATG TGTCTGA 1917

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkktd++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 296   FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  355

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 356   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  415

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 416   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  475

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 476   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  535

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         k++l+kdp++rlG++ ++g +di+ h+ff

Q: 536   KSFLNKDPKERLGCHpQTGFADIQGHPFF  564

         **************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVRL KKTDRIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240

KSFLNKDPKE RLGCHPQTGF ADIQGHPFF 269

Keyword

ATP-binding; Kinase; Metal-binding; Nucleotide-binding; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0043220	; C:Schmidt-Lanterman incisure
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004697	; F:protein kinase C activity
GO:0007015	; P:actin filament organization
GO:0045216	; P:cell-cell junction organization
GO:0035089	; P:establishment of apical/basal cell polarity
GO:0042462	; P:eye photoreceptor cell development
GO:0035556	; P:intracellular signal transduction
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:2000353	; P:positive regulation of endothelial cell apoptotic process
GO:0090004	; P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252	; P:positive regulation of glial cell proliferation
GO:0046326	; P:positive regulation of glucose import
GO:0010976	; P:positive regulation of neuron projection development
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013