EKS-MUP-00403

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00403

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	346.7	1.0E-103	168	444	277

Status

Unreviewed

Ensembl Protein

ENSMPUP00000017048

UniProt Accession

G9K634;

Protein Name

Protein Synonyms/Alias

Interleukin-1 receptor-associated kinase 2;

Gene Name

IRAK2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000017157	ENSMPUP00000017048	ENSMPUT00000017302

Organism

Mustela putorius furo

Functional Description

Protein Length

580

Protein Sequence
(FASTA)

MSCYIYQLPA WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER VQGVSITREL 60

LWWWGMRQAT VQQLVDLLCR LQLYRAAQIV LNWHGQTHGP SLSGHAPARA NLPPPSADDP 120

HSLKTDFPVS SDSKGFSTSI PKQETLVSQA EDSLFWSEAD VVQATENFNQ NHKISEGTFA 180

DIYKGQRHGT PFVFKKLREV AYSGPGSVEK FFQAEVQICR RCCHPNVLPL LGFCTGNQLC 240

SLIYPYMANG SLQDRLQGQG GTDALLWPQR ASICSGLLRA VGHLHSLEII HGNVKSSNVL 300

LDQTFTPKLA HPMAHLCPDN KRSRYTMMKT HLFQASAAYL PEDFIRVGQL TKRVDIFSCG 360

IVLAEVLTGI PAMDNNRSPV YLKDLLLSEI PSSTTSLCCR KTDMEKVMAM EICQRYLEKR 420

AGRLPEDCAE ALAMATCLCL RRRNASLAEV CGYVAIVDKR LRGQETLLPW SGLSEVTGSS 480

SNTPEETDDV DNSSLDASYS MRVAPRAGAA ASLPSTEDGE GRLQVCGGAQ ADSSAASASL 540

EPSQDETSWK IEINEAKKKL MENIVFYKEG KLDSIELFGP 580

Nucleotide Sequence
(FASTA)

ATGTCCTGCT ACATCTACCA GCTGCCCGCC TGGGTGCTGG ACGACCTGTG CCGCAACATG 60

GACACGCTCA GCGAGTGGGA CTGGATGCAG TTCGCCTCCT ACGTGATCAC AGACCTGACG 120

CAGCTGCGGA AGATCAAGTC AATGGAGCGG GTGCAGGGTG TGAGCATCAC TCGGGAGCTG 180

CTGTGGTGGT GGGGCATGCG GCAGGCCACC GTCCAGCAGC TGGTGGATCT CCTGTGCCGC 240

CTGCAGCTCT ACCGTGCCGC CCAGATCGTT CTGAACTGGC ACGGCCAGAC CCATGGTCCC 300

TCCCTTTCAG GGCATGCTCC AGCCAGAGCC AACCTCCCGC CTCCTTCTGC AGATGACCCT 360

CATTCCTTAA AAACTGACTT TCCTGTTTCA TCCGATTCAA AGGGCTTTAG TACCTCCATT 420

CCTAAGCAGG AAACACTTGT GAGCCAAGCT GAAGACAGCC TTTTCTGGAG CGAGGCAGAT 480

GTGGTCCAGG CAACTGAAAA CTTCAACCAA AACCACAAAA TCAGTGAGGG GACCTTTGCT 540

GACATCTACA AAGGGCAAAG GCATGGCACA CCATTTGTCT TCAAGAAGCT CAGAGAGGTG 600

GCCTACTCAG GTCCAGGATC AGTCGAAAAA TTCTTCCAGG CAGAGGTACA AATTTGTCGC 660

AGATGTTGCC ACCCCAACGT CTTACCTTTG CTGGGCTTCT GCACTGGAAA TCAGCTTTGC 720

AGCCTGATCT ACCCGTACAT GGCAAATGGC TCTTTACAGG ACAGACTCCA GGGTCAGGGA 780

GGCACAGACG CCCTCCTCTG GCCCCAGCGC GCCAGCATCT GCTCTGGGCT GCTTCGTGCT 840

GTGGGGCACC TGCACAGCTT GGAGATCATC CATGGCAATG TCAAGAGCTC CAATGTTTTG 900

CTAGACCAAA CCTTCACCCC CAAGCTGGCT CATCCAATGG CTCACCTGTG TCCTGACAAC 960

AAAAGGTCAA GATACACCAT GATGAAGACT CATCTTTTCC AGGCCTCAGC TGCGTATCTG 1020

CCGGAAGATT TCATCAGGGT GGGGCAGCTG ACAAAACGAG TAGACATCTT CAGCTGTGGA 1080

ATTGTGCTAG CTGAGGTCCT CACCGGCATC CCTGCAATGG ATAACAACCG AAGCCCCGTT 1140

TACCTGAAGG ATTTACTCCT CAGTGAAATC CCAAGCAGCA CCACCTCACT GTGCTGCAGA 1200

AAGACAGACA TGGAAAAGGT GATGGCTATG GAGATCTGCC AGAGGTACCT GGAGAAGAGA 1260

GCTGGGAGGC TGCCAGAGGA CTGTGCTGAG GCCTTGGCCA TGGCCACCTG CCTCTGCCTG 1320

AGGAGGCGGA ATGCCAGCTT GGCTGAGGTG TGTGGCTATG TGGCCATTGT GGACAAGCGG 1380

CTCAGAGGTC AAGAGACGCT GCTTCCTTGG AGTGGGCTTT CTGAGGTCAC AGGCTCTTCC 1440

TCCAATACTC CAGAAGAAAC AGATGACGTG GACAATTCCA GCCTTGATGC CTCCTACTCC 1500

ATGAGGGTAG CACCCAGGGC TGGGGCTGCT GCCTCACTCC CTTCAACAGA GGATGGAGAA 1560

GGCAGGCTGC AGGTCTGTGG CGGAGCACAG GCAGACTCCT CAGCGGCCTC TGCCAGTCTG 1620

GAGCCTTCCC AGGATGAGAC TTCATGGAAA ATCGAGATCA ATGAGGCCAA AAAGAAACTG 1680

ATGGAGAATA TCGTGTTCTA CAAAGAAGGG AAACTGGACA GCATTGAGCT TTTTGGCCCC 1740

TGA 1743

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60

         f+++++i+eG+f+++y+g++++t +++kkl+e a + + +++++f++E++++ r++H+n+

Q: 168   FNQNHKISEGTFADIYKGQRHGTPFVFKKLREVAYSGPGSVEKFFQAEVQICRRCCHPNV  227

         899*********************************************************

S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120

         l+llg+++ ++  +L+Y+ym+nGsL+drLq q+g++ L WpqR+si++G++ra+ +LH+

Q: 228   LPLLGFCTGNQLCSLIYPYMANGSLQDRLQGQGGTDALLWPQRASICSGLLRAVGHLHSL  287

         ************************************************************

S: 121   spslihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeef  180

           ++ihg++ks+N+LLD+++tpKl+ +++a+++p+++++++t+++t+ +++++aYlpe+f

Q: 288   --EIIHGNVKSSNVLLDQTFTPKLA-HPMAHLCPDNKRSRYTMMKTHLFQASAAYLPEDF  344

         ..***********************.**********************************

S: 181   irvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekv.........  231

         irvgqlt++vD++S+GiVl+EvltG++a+d++r+++yLkdll +ei+++++

Q: 345   IRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSEIPSSTTslccrktdm  404

         **************************************************99********

S: 232   ......eilekfldkkagkleeellealielalaclaeka  265

               ei++++l+k+ag+l+e+++eal+ +++ cl +++

Q: 405   ekvmamEICQRYLEKRAGRLPEDCAEALAMATCLCLRRRN  444

         ************************************9765

Domain Sequence
(FASTA)

FNQNHKISEG TFADIYKGQR HGTPFVFKKL REVAYSGPGS VEKFFQAEVQ ICRRCCHPNV 60

LPLLGFCTGN QLCSLIYPYM ANGSLQDRLQ GQGGTDALLW PQRASICSGL LRAVGHLHSL 120

EIIHGNVKSS NVLLDQTFTP KLAHPMAHLC PDNKRSRYTM MKTHLFQASA AYLPEDFIRV 180

GQLTKRVDIF SCGIVLAEVL TGIPAMDNNR SPVYLKDLLL SEIPSSTTSL CCRKTDMEKV 240

MAMEICQRYL EKRAGRLPED CAEALAMATC LCLRRRN 277

Keyword

Kinase; Receptor; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0016301	; F:kinase activity
GO:0070498	; P:interleukin-1-mediated signaling pathway
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0032088	; P:negative regulation of NF-kappaB transcription factor activity
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0001959	; P:regulation of cytokine-mediated signaling pathway

KEGG

InterPros

Pfam

SMARTs

Prosites

Prints

Created Date

20-Feb-2013