EKS-MUP-00260

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00260

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.1	1.9E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSMPUP00000017261

UniProt Accession

G9KHB3;

Protein Name

Protein Synonyms/Alias

Polo-like kinase 4;

Gene Name

PLK4

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000017371	ENSMPUP00000017261	ENSMPUT00000017517

Organism

Mustela putorius furo

Functional Description

Protein Length

968

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DNNYVYLVLE MCHNGEMNRY LKNRMKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLTSEAKD 240

LIHQLLRRNP ADRLSLSSIL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST 300

SISGSFFDRR RLLIGQPLPN KVTIFPKNKN SSDFSSSGDG SSLYTQWGNR EQETGNNGRR 360

RVTQDMEERP HSRYLRRAHS SDRSGTSNSQ SRAITVERCH SAEMLSKSKR SGVDENEERY 420

SPTNSNVNIL HFFKEKTSSS SGSFERLDND QACSNRLCPG KTPFPFPDQT TQTEMVQQWF 480

GNLQIKDHLR ETTEHNSISP KRDFQGHPDL QDTSRNVWTD TRAKKSSDAS DNVHPAKQLN 540

TMKFMTAFQS KPEIIQQESI FGSDPLSEQS KTRGMEPPLG YQKRTLRDIT SPLTAYRLKP 600

IRQKTKKAVV SILDSEEVCV ELLKEHTSQE YVKEVLQISS DGNMITIYYP NDGRGFPLAD 660

RPPPPTDNIS RYCFDNLPEK YWRKYQYASR FVHLVRSKSP KITYFSRYAK CILMENSPDA 720

DFEVWFYDGA KIHKTEDLIQ VIEKTGKSYT LKSESEISSL KGEIKMYMDH ANEGHRICLA 780

LESIISEEEK KSGSAPFFPI IIGRKPGNTS SPKALSPPTS VDPNYLMRDR ASLNKMINNT 840

ASSKLAPMLN PPMVTNEGHG FMAAASETNI SSSSLKDCLP KSAQLLKSVF VKNVGWATQL 900

TSGAVWVQFN DGSQLVVQAG VSSISYISPN GQTTRYGENE KLPDYIKQKL QCLSSILLMF 960

SNPAPSFE 968

Nucleotide Sequence
(FASTA)

ATGGCGACTT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGGAATCT GCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTGGA AGTAGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCTGGAATGG TGCAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAGTT GAAACATCCT TCTATCTTGG AGCTGTATAA TTATTTTGAA 240

GATAACAATT ATGTGTATCT AGTATTAGAA ATGTGCCATA ATGGAGAAAT GAACAGGTAT 300

CTAAAGAACA GAATGAAACC ATTCTCAGAA AACGAAGCTC GACACTTTAT GCACCAGATC 360

ATCACAGGAA TGTTGTATCT CCATTCTCAT GGCATATTAC ATCGGGATCT CACACTTTCT 420

AACCTCTTAC TTACCCGTAA TATGAACATC AAGATTGCCG ACTTTGGGCT GGCAACTCAG 480

TTGAAAATGC CACATGAGAA GCACTATACT TTGTGTGGAA CTCCTAATTA TATTTCACCA 540

GAAATTGCAA CTCGAAGTGC ACATGGACTT GAATCTGATG TTTGGTCCTT GGGCTGTATG 600

TTTTATACGT TGCTTATTGG GAGACCTCCT TTTGACACTG ACACAGTCAA GAACACATTA 660

AATAAAGTAG TATTGGCAGA TTATGAAATG CCAACTTTTT TGACAAGTGA GGCTAAGGAC 720

CTTATTCACC AGTTACTTCG CAGAAATCCA GCAGATCGTT TAAGTCTGTC TTCAATATTA 780

GACCATCCTT TTATGTCCCG AAATTCTTCA ACAAAAAGTA AAGATTTAGG AACTGTAGAA 840

GACTCAATTG ATAGTGGACA TGCCACAATT TCTACTGCAA TTACAGCTTC TTCCAGTACC 900

AGTATAAGTG GTAGTTTCTT TGATAGGAGA AGACTTTTGA TTGGTCAGCC ACTCCCAAAT 960

AAAGTGACTA TATTTCCAAA GAATAAAAAT TCAAGTGATT TTTCCTCTTC AGGAGATGGA 1020

AGCAGTCTTT ATACTCAGTG GGGAAATCGA GAACAAGAAA CCGGTAATAA TGGGAGGCGA 1080

AGAGTAACCC AGGATATGGA AGAAAGGCCA CATTCTCGAT ACCTTCGTAG AGCCCATTCC 1140

TCTGATAGAT CTGGCACTTC TAATAGTCAG TCTCGAGCCA TAACAGTGGA ACGATGTCAC 1200

TCAGCAGAAA TGCTTTCAAA ATCCAAAAGA TCAGGAGTAG ATGAAAATGA AGAAAGATAC 1260

TCACCTACAA ACAGCAATGT CAATATTTTG CATTTCTTTA AGGAAAAGAC ATCCAGTAGT 1320

TCTGGATCTT TTGAAAGACT TGATAATGAT CAAGCCTGCT CCAATCGTCT TTGTCCAGGG 1380

AAAACTCCTT TTCCATTTCC AGACCAGACA ACTCAGACTG AAATGGTGCA ACAGTGGTTT 1440

GGGAATCTGC AAATAAAGGA TCATTTAAGA GAAACTACTG AGCACAACAG CATTAGCCCA 1500

AAAAGAGATT TCCAAGGCCA TCCAGACTTG CAGGACACAT CAAGAAATGT TTGGACTGAT 1560

ACGAGAGCCA AAAAGAGTTC TGATGCTTCT GATAATGTTC ATCCTGCAAA ACAGTTGAAT 1620

ACCATGAAAT TTATGACTGC ATTTCAAAGT AAACCTGAGA TAATTCAACA GGAATCTATT 1680

TTTGGCTCAG ATCCTCTTTC TGAGCAAAGC AAAACTAGGG GTATGGAGCC ACCATTGGGT 1740

TATCAGAAAC GTACGCTACG AGACATTACA TCTCCTTTGA CTGCTTACAG GTTAAAACCG 1800

ATTAGACAGA AAACCAAAAA GGCTGTGGTT AGCATACTTG ATTCAGAGGA GGTATGTGTG 1860

GAGCTTCTAA AGGAACATAC ATCACAAGAA TATGTGAAAG AAGTTCTTCA AATATCTAGT 1920

GATGGAAATA TGATTACTAT TTATTATCCC AATGATGGAA GAGGTTTTCC TCTTGCTGAC 1980

AGACCACCAC CCCCTACTGA CAACATCAGT AGGTACTGCT TTGACAATTT ACCAGAGAAA 2040

TACTGGCGAA AATATCAATA TGCTTCCAGA TTTGTACACC TTGTAAGATC TAAATCACCC 2100

AAAATCACTT ATTTTTCGAG ATATGCTAAA TGCATTTTAA TGGAGAATTC CCCTGATGCT 2160

GATTTTGAGG TTTGGTTTTA TGATGGAGCA AAGATACACA AAACCGAAGA TTTAATTCAG 2220

GTGATTGAAA AGACTGGGAA ATCTTATACC TTAAAAAGTG AAAGTGAAAT TAGTAGCTTG 2280

AAAGGGGAAA TAAAAATGTA TATGGACCAT GCAAATGAGG GCCATCGTAT TTGCTTAGCA 2340

CTGGAATCCA TAATTTCAGA GGAGGAAAAG AAAAGTGGAA GTGCTCCCTT TTTCCCAATA 2400

ATTATAGGAA GAAAACCTGG AAATACTAGT TCACCTAAGG CCTTATCACC TCCTACTTCT 2460

GTGGATCCAA ACTACCTGAT GCGTGATAGA GCATCTTTGA ATAAAATGAT AAATAATACT 2520

GCTTCTTCAA AACTGGCACC AATGCTTAAT CCTCCTATGG TTACAAATGA AGGACATGGC 2580

TTTATGGCTG CAGCTTCTGA AACAAACATC TCTTCTAGTA GTCTAAAAGA TTGTCTTCCT 2640

AAATCAGCAC AACTTTTGAA ATCTGTTTTT GTGAAAAATG TTGGTTGGGC TACACAGTTA 2700

ACTAGTGGAG CTGTGTGGGT TCAGTTCAAT GATGGGTCCC AGTTGGTTGT CCAGGCAGGA 2760

GTATCTTCTA TCAGTTATAT ATCACCAAAT GGTCAAACAA CTAGGTATGG AGAAAATGAA 2820

AAATTACCAG ATTACATCAA ACAGAAATTA CAGTGTCTTT CTTCCATCCT TTTGATGTTT 2880

TCTAATCCAG CTCCTAGTTT TGAATAA 2907

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRmKPFSENEARHFMHQIITGMLYLHSHG  131

         ********************************99**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ l++eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLTSEAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl+++l+++f+

Q: 252   DRLSLSSILDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED NNYVYLVLEM CHNGEMNRYL KNRMKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLTSEAKDL IHQLLRRNPA 240

DRLSLSSILD HPFM 254

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication
GO:0060707	; P:trophoblast giant cell differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013