EKS-MUP-00371
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00371
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK341.62.8E-10299356258
StatusUnreviewed
Ensembl ProteinENSMPUP00000017601
UniProt AccessionG9K9H0;
Protein Name
Protein Synonyms/Alias Mitogen-activated protein kinase kinase kinase 10;
Gene NameMap3k10
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000017712ENSMPUP00000017601ENSMPUT00000017860
OrganismMustela putorius furo
Functional Description
Protein Length936
Protein Sequence
(FASTA)
MEEEEGGTAK EWGTTPTGPV WTAVFDYEAA GDEELTLRRG DRVQVLSQDC AVSGDEGWWT 60
GQLPSGRVGV FPSNYVAPGA PAAPAGLQLP QEIPFHELQL EEIIGVGGFG KVYRALWRGE 120
EVAVKAARLD PERDPAVTAE QVRQEARLFG ALKHPNIIAL RGACLSPPHL CLVMEYARGG 180
ALSRVLAGRR VPPHVLVNWA VQVARGMNYL HNDAPVPIIH RDLKSINILI LEAIENHNLA 240
DTVLKITDFG LAREWHKTTK MSAAGTYAWM APEVIRLSLF SKSSDVWSFG VLLWELLTGE 300
VPYREIDALA VAYGVAMNKL TLPIPSTCPE PFARLLEECW DPDPHGRPDF GSILKRLEVI 360
EQSALFQMPL ESFHSLQEDW KLEIQHMFDD LRTKEKELRS REEELLRAAQ EQRFQEEQLR 420
RREQELAERE MDIVERELHL LMCQLSQEKP RVRKRKGNFK RSRLLKLREG GSHISLPSGF 480
EHKITVQASP TLDKRKGSDG ASPPASPSII PRLRAIRLTP VDGGGSSSGS SGGGSGTWGR 540
SGPPKKEELV GGKKKGRTWG PSSTLQKERA GGEERLKALG EGSKQWSSSA PNLGKSPKHT 600
PIAPGFASLN EMEEFAEADG GNSVPPSPYT TPSYLTVPLP AEPSPGAPAP LSRPGHGGRR 660
RCELALLGCA TLLGAVGLGA DVAEARAADC EEQRRWLDGL FPRAGRFPRG LSPPGRSPGR 720
RDDAASGPGL APSATLVSLS SVSDCNSTRS LLRSDSDEAA PAAPSPPPSP PSTNPLVDLE 780
LESFKKDPRQ SLTPTHVTAA RAVSRGHRRT PSDGALGQRG VPEPAAPRPG PRDPLDFPRL 840
PDPQTLFPTH RRPPEFPGRP TTLTFAPRPR PAASRPRLDP WKLVSFGRTL GISPPSRPDT 900
PESPGLPGMQ PTLLDMDMEG QSQDSTVPLC GAHGSR 936
Nucleotide Sequence
(FASTA)
ATGGAGGAGG AGGAGGGGGG GACGGCCAAG GAGTGGGGCA CGACCCCCAC GGGGCCCGTC 60
TGGACCGCGG TGTTCGACTA CGAGGCGGCG GGCGATGAGG AGCTGACCCT GCGGAGGGGC 120
GACCGCGTCC AGGTGCTTTC CCAGGACTGT GCGGTGTCGG GCGACGAGGG CTGGTGGACC 180
GGGCAGCTAC CCAGCGGCCG TGTGGGCGTT TTCCCCAGCA ACTACGTAGC CCCCGGCGCC 240
CCCGCCGCGC CCGCGGGCCT CCAGCTGCCC CAGGAGATCC CTTTCCACGA GCTGCAGCTA 300
GAGGAGATCA TCGGTGTAGG GGGCTTTGGC AAGGTCTACC GGGCCCTGTG GCGCGGCGAG 360
GAGGTGGCTG TCAAGGCCGC CCGGCTGGAC CCTGAGCGGG ACCCGGCAGT GACAGCAGAG 420
CAGGTGCGCC AGGAGGCCCG GCTCTTCGGA GCCCTGAAGC ACCCCAACAT CATTGCCCTC 480
CGAGGTGCCT GCCTCAGCCC CCCACACCTC TGCCTGGTGA TGGAGTATGC CAGGGGGGGC 540
GCACTGAGCA GGGTGCTGGC AGGCCGCCGG GTGCCCCCTC ATGTGCTGGT CAACTGGGCT 600
GTGCAGGTGG CCCGGGGCAT GAACTACCTA CACAATGATG CCCCTGTGCC CATCATCCAC 660
CGGGACCTCA AGTCCATCAA CATCCTTATC CTGGAGGCCA TCGAGAACCA CAACCTCGCA 720
GACACGGTGC TCAAGATCAC AGACTTTGGC CTCGCCCGCG AGTGGCACAA GACCACCAAA 780
ATGAGCGCTG CAGGGACTTA CGCCTGGATG GCTCCAGAGG TTATCCGTCT CTCCCTCTTC 840
TCCAAAAGCA GTGATGTCTG GAGCTTCGGG GTGCTGCTCT GGGAGCTGCT GACGGGTGAG 900
GTCCCCTACC GTGAAATCGA CGCCTTGGCC GTGGCATATG GCGTGGCTAT GAACAAGCTG 960
ACGCTGCCCA TCCCCTCCAC GTGCCCCGAG CCCTTTGCCC GCCTCCTGGA GGAATGCTGG 1020
GACCCAGACC CCCACGGGCG GCCAGATTTC GGGAGCATCT TGAAGCGGCT TGAAGTCATC 1080
GAACAGTCAG CCCTGTTCCA GATGCCACTG GAGTCCTTCC ACTCACTGCA GGAAGACTGG 1140
AAGCTGGAAA TTCAGCACAT GTTCGATGAC CTCCGGACCA AAGAGAAGGA GCTCCGGAGT 1200
CGGGAGGAGG AGCTGCTGCG TGCTGCTCAG GAGCAGCGCT TCCAGGAGGA GCAGCTGCGG 1260
CGGCGGGAGC AGGAGCTGGC AGAGCGCGAG ATGGACATCG TGGAGCGGGA GCTGCACCTG 1320
CTCATGTGCC AGCTGAGCCA GGAGAAGCCG CGGGTCCGCA AACGCAAGGG CAACTTCAAG 1380
CGCAGCCGCC TCCTCAAGCT GCGGGAAGGC GGCAGCCACA TCAGCCTGCC CTCCGGCTTC 1440
GAGCATAAGA TCACAGTCCA GGCCTCTCCA ACCCTGGACA AGCGGAAAGG ATCCGATGGG 1500
GCCAGCCCCC CAGCAAGCCC CAGCATCATT CCCCGGCTGA GGGCCATTCG CCTGACTCCT 1560
GTGGATGGTG GTGGCAGCAG CAGTGGCAGC AGCGGTGGTG GCAGTGGGAC ATGGGGCCGC 1620
AGCGGGCCCC CAAAGAAGGA AGAACTGGTT GGAGGCAAGA AGAAGGGCCG GACCTGGGGA 1680
CCCAGCTCCA CCCTGCAGAA GGAGAGGGCT GGAGGGGAGG AGAGGCTGAA GGCCCTGGGG 1740
GAAGGAAGCA AACAGTGGTC ATCAAGCGCC CCCAACCTGG GCAAATCCCC CAAACATACA 1800
CCGATCGCCC CAGGCTTCGC CAGCCTCAAT GAGATGGAGG AGTTCGCGGA GGCGGACGGA 1860
GGCAACAGCG TGCCCCCCTC CCCCTACACC ACCCCGTCCT ACCTCACCGT GCCCCTGCCT 1920
GCCGAGCCCT CCCCGGGGGC GCCCGCGCCA CTCTCCCGGC CGGGCCACGG CGGCCGGCGG 1980
CGCTGCGAGC TGGCCCTGCT GGGCTGCGCC ACGCTGCTGG GCGCCGTGGG TCTGGGCGCA 2040
GACGTGGCCG AGGCGCGCGC GGCGGACTGT GAGGAGCAGC GGCGCTGGCT GGACGGCCTC 2100
TTCCCCCGCG CCGGCCGCTT CCCGCGGGGC CTCAGCCCGC CCGGGCGCTC GCCCGGCCGC 2160
CGCGACGACG CGGCCTCCGG CCCGGGCCTG GCGCCCTCGG CCACCCTGGT GTCGCTGTCG 2220
TCCGTGTCTG ACTGCAACTC CACGCGTTCG CTGCTGCGCT CCGACAGTGA CGAGGCCGCG 2280
CCGGCCGCGC CCTCCCCGCC GCCCTCCCCG CCCAGCACCA ACCCCCTAGT GGACCTGGAG 2340
CTGGAGAGCT TCAAGAAAGA CCCCCGCCAG TCGCTCACGC CCACCCACGT CACGGCCGCG 2400
CGCGCAGTGA GCCGCGGGCA CCGGCGGACG CCTTCGGACG GGGCGCTGGG GCAGCGGGGG 2460
GTGCCTGAGC CCGCGGCTCC CCGCCCTGGC CCTCGAGACC CCCTGGACTT CCCTCGCCTG 2520
CCCGACCCCC AGACCTTGTT CCCGACCCAC CGCCGGCCCC CTGAGTTCCC TGGCCGCCCT 2580
ACCACCCTGA CCTTCGCCCC AAGACCCCGG CCAGCTGCCA GTCGCCCCCG CCTGGACCCC 2640
TGGAAACTGG TCTCCTTTGG CCGGACACTT GGCATCTCGC CTCCCAGCAG GCCGGACACC 2700
CCAGAGAGCC CCGGACTCCC TGGCATGCAG CCCACGCTGC TTGACATGGA CATGGAGGGG 2760
CAGAGCCAGG ACAGCACCGT GCCCCTGTGC GGGGCCCATG GCTCCCGCTG A 2811
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         +lee+ig g fgkvy+a wr++evavK++r + e+  + ++e++++ea+l+ +l+hpnii
Q: 99    QLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERdpAVTAEQVRQEARLFGALKHPNII  158
         789*******************************988999********************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119
         +l+G+cl++p+l+lvmey++gg+Ls+vl++   r+++++vlv+wa+q+ArGm+YLh++ap
Q: 159   ALRGACLSPPHLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHNDAP  215
         ******************************...9**************************
S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172
         ++iihrdLks n+L+       + ++++lki+dFG are++k+tkmsaagt+awmaPEv+
Q: 216   VPIIHRDLKSINILIleaienhNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVI  275
         ********************99999***********************************
S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232
         + + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++L
Q: 276   RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARL  335
         ************************************************************
S: 233   mkecwnedpekRpsfseivks  253
         ++ecw+ dp+ Rp+f +i+k 
Q: 336   LEECWDPDPHGRPDFGSILKR  356
         *****************9986
Domain Sequence
(FASTA)
QLEEIIGVGG FGKVYRALWR GEEVAVKAAR LDPERDPAVT AEQVRQEARL FGALKHPNII 60
ALRGACLSPP HLCLVMEYAR GGALSRVLAG RRVPPHVLVN WAVQVARGMN YLHNDAPVPI 120
IHRDLKSINI LILEAIENHN LADTVLKITD FGLAREWHKT TKMSAAGTYA WMAPEVIRLS 180
LFSKSSDVWS FGVLLWELLT GEVPYREIDA LAVAYGVAMN KLTLPIPSTC PEPFARLLEE 240
CWDPDPHGRP DFGSILKR 258
KeywordKinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-BOT-00379
EKS-CAJ-00382
EKS-CAF-00385
EKS-CAP-00410
EKS-DAR-00758
EKS-DRM-00176
EKS-FEC-00366
EKS-GAG-00318
EKS-GAA-00461
EKS-GOG-00369
EKS-HOS-00385
EKS-ICT-00357
EKS-LAC-00393
EKS-LOA-00388
EKS-MOD-00368
EKS-MUM-00411
EKS-MYL-00376
EKS-NOL-00352
EKS-ORN-00485
EKS-ORC-00355
EKS-ORL-00447
EKS-OTG-00380
EKS-PAT-00359
EKS-PEM-00200
EKS-POA-00368
EKS-RAN-00393
EKS-SUS-00331
EKS-TEN-00479
EKS-TUT-00103
EKS-XET-00491
EKS-XIM-00474
Gene Ontology
GO:0005737; C:cytoplasm
GO:0004709; F:MAP kinase kinase kinase activity
GO:0003714; F:transcription corepressor activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046330; P:positive regulation of JNK cascade
GO:0043507; P:positive regulation of JUN kinase activity
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR015785; MAPKKK9/10/11-like.
Pfam
SMARTs
Prosites
Prints
Created Date20-Feb-2013