EKS-MUP-00360
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00360
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.46.1E-135270519250
StatusUnreviewed
Ensembl ProteinENSMPUP00000017650
UniProt AccessionG9KR43;
Protein Name
Protein Synonyms/Alias V-src sarcoma viral oncoprotein-like protein;
Gene NameSRC
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000017762ENSMPUP00000017650ENSMPUT00000017910
OrganismMustela putorius furo
Functional Description
Protein Length536
Protein Sequence
(FASTA)
MGSNKSKPKD ASQRRRSLEP AENTHGGGGG AFPTSQTPSK PASADGHRGP STAFPSAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD 120
WWLAHSLSTG QTGYIPSNYV APSDSIQAEE WYFGKITRRE SERLLLNAEN PRGTFLVRES 180
ETTKGAYCLS VSDFDNAKGL NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL 240
CHRLTTVCPT SKPQTQGLAK DAWEIPRESL RLEVKLGQGC FGEVWMGTWN GTTRVAIKTL 300
KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKGETGKY 360
LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN LVCKVADFGL ARLIEDNEYT 420
ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELTT KGRVPYPGMV NREVLDQVER 480
GYRMPCPPEC PESLHDLMCQ CWRKEPEERP TFEYLQAFLE DYFTSTEPQY QPGENL 536
Nucleotide Sequence
(FASTA)
ATGGGCAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAAC GGCGCCGCAG CCTGGAGCCA 60
GCTGAGAATA CCCACGGTGG CGGCGGGGGC GCCTTCCCCA CCTCACAGAC ACCCAGCAAG 120
CCAGCCTCCG CTGATGGACA CCGAGGCCCC AGTACGGCCT TCCCCTCCGC AGCTGCTGAG 180
CCCAAGCTGT TTGGGGGCTT CAACTCCTCA GACACAGTCA CCTCCCCGCA GAGGGCGGGG 240
CCGCTGGCTG GTGGAGTGAC CACCTTTGTG GCCCTCTATG ACTATGAGTC TCGGACAGAG 300
ACCGACTTGT CCTTCAAGAA AGGGGAGCGG CTCCAGATTG TCAACAACAC AGAGGGAGAC 360
TGGTGGCTGG CCCACTCGCT CAGCACGGGA CAGACGGGTT ACATCCCCAG CAACTATGTG 420
GCGCCCTCCG ACTCTATCCA GGCTGAAGAG TGGTACTTTG GCAAGATCAC CAGACGGGAG 480
TCAGAGCGGT TACTGCTCAA TGCGGAGAAC CCAAGAGGGA CCTTCCTGGT GCGAGAAAGT 540
GAGACCACGA AAGGAGCCTA CTGCCTCTCC GTGTCTGATT TCGACAACGC CAAGGGCCTC 600
AACGTGAAGC ACTACAAGAT CCGCAAGCTG GACAGTGGTG GCTTCTACAT CACCTCCCGC 660
ACCCAGTTCA ACAGTCTGCA GCAGCTGGTG GCCTACTACT CCAAACATGC TGACGGCCTG 720
TGCCACCGCC TCACCACCGT GTGCCCCACG TCCAAGCCCC AGACTCAGGG CCTGGCCAAG 780
GATGCCTGGG AGATCCCTCG GGAGTCCCTA CGGCTGGAGG TTAAGCTGGG CCAGGGATGT 840
TTTGGAGAGG TGTGGATGGG GACCTGGAAC GGAACCACCA GAGTGGCCAT CAAAACCCTG 900
AAGCCAGGCA CCATGTCTCC AGAGGCCTTC CTGCAGGAGG CTCAGGTCAT GAAGAAACTG 960
AGGCACGAGA AGCTCGTGCA GCTGTACGCT GTGGTGTCCG AGGAGCCCAT CTACATCGTC 1020
ACGGAGTACA TGAGCAAGGG GAGCCTGCTG GACTTTCTCA AGGGGGAGAC AGGCAAGTAC 1080
CTGCGGCTGC CGCAGCTGGT GGACATGGCT GCTCAGATCG CCTCAGGCAT GGCCTATGTG 1140
GAACGGATGA ACTATGTCCA CCGGGACCTC CGTGCTGCCA ACATCTTGGT TGGAGAGAAC 1200
CTCGTGTGCA AAGTGGCTGA CTTCGGGCTG GCTCGGCTCA TTGAAGACAA CGAATACACA 1260
GCCCGACAAG GTGCCAAATT CCCCATCAAG TGGACGGCTC CAGAAGCGGC CCTCTACGGC 1320
CGGTTCACCA TCAAGTCAGA TGTGTGGTCC TTTGGGATCC TGCTGACGGA ACTCACGACA 1380
AAGGGTCGGG TGCCCTACCC TGGGATGGTC AACCGAGAGG TGCTGGACCA GGTTGAGCGG 1440
GGCTACCGGA TGCCCTGCCC ACCTGAGTGT CCCGAATCCC TGCACGACCT CATGTGCCAG 1500
TGCTGGCGGA AGGAGCCGGA GGAACGGCCC ACCTTCGAGT ACCTGCAGGC CTTCCTGGAG 1560
GACTACTTCA CGTCCACCGA GCCCCAGTAC CAGCCCGGAG AGAACCTATA G 1611
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 270   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  329
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 330   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  388
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 389   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  448
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 449   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  508
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 509   RPTFEYLQAFL  519
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Kinase; Nucleotide-binding; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-CII-00206
EKS-CIS-00121
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
Created Date20-Feb-2013