EKS-MUP-00363
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUP-00363
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src439.53.2E-132240489250
StatusUnreviewed
Ensembl ProteinENSMPUP00000017776
UniProt AccessionG9K3X0;
Protein Name
Protein Synonyms/Alias Hemopoietic cell kinase;
Gene NameHCK
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMPUG00000017886ENSMPUP00000017776ENSMPUT00000018036
OrganismMustela putorius furo
Functional Description
Protein Length504
Protein Sequence
(FASTA)
MGCMKSKFLQ DRGKVSKTEP STNPHSPVYV PDPTSTSKRR PDNSNNIPPG SADVGPDDII 60
VIALYDYEAI HHEDLSFQKG DQMVVLEESG EWWKARSLVT RKEGYIPSNY VARINSLETE 120
EWFFKDISRK EAERQLLAPG NVLGSFMIRD SETTKGSYSL SVRDYDPQHR DTVKHYKIRT 180
LDSGGFYISP RSTFNTLQEL VAHYKKGSDG LCQKLTVPCV SSKPQKPWEK DAWEIPRESL 240
KLEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF LAEANLMKTL QHDKLVKLHA 300
VVTEEPIYII TEFMAKGSLL DFLKSTEGSK QPLPKLIDFS AQIAEGMAFI EQRNYIHRDL 360
RAANILVSAS LVCKIADFGL ARVIEDNEYT AREGAKFPIK WTAPEAINFG SFTIKSDVWS 420
FGILLMEIVT YGRIPYPGMT NPEVIRALER GYRMPRPEHC PEELYSIMTR CWKNRPEERP 480
TFEYIQSVLD DFYTATESQY QQQP 504
Nucleotide Sequence
(FASTA)
ATGGGGTGCA TGAAGTCCAA ATTCCTCCAG GACAGAGGCA AGGTCTCAAA AACCGAGCCC 60
AGCACCAACC CACACAGCCC TGTGTATGTG CCGGATCCCA CGTCTACAAG CAAGCGGCGT 120
CCTGACAACA GCAATAACAT CCCACCAGGG TCTGCGGATG TAGGTCCCGA TGACATCATT 180
GTGATCGCGC TATATGATTA CGAGGCCATT CACCATGAAG ACCTCAGTTT CCAGAAGGGA 240
GATCAGATGG TGGTACTGGA AGAGTCTGGG GAGTGGTGGA AGGCTCGATC CCTGGTGACC 300
CGGAAGGAAG GCTACATCCC AAGCAACTAT GTTGCCCGCA TTAACTCTCT GGAGACAGAG 360
GAGTGGTTCT TCAAGGACAT CAGCCGGAAG GAAGCAGAGC GCCAGCTCCT GGCCCCTGGC 420
AATGTACTGG GCTCCTTCAT GATCCGGGAC AGCGAGACCA CCAAAGGAAG CTATTCTCTG 480
TCTGTGCGAG ACTACGACCC CCAGCACAGG GACACGGTGA AGCATTACAA GATCCGGACC 540
CTGGACAGTG GGGGCTTCTA CATCTCCCCA CGGAGCACCT TCAATACCCT GCAGGAGTTG 600
GTGGCCCACT ACAAGAAGGG GAGTGATGGA CTCTGCCAGA AGCTGACGGT GCCCTGCGTG 660
TCCTCCAAGC CCCAGAAGCC ATGGGAGAAA GATGCCTGGG AGATCCCCCG GGAATCCCTC 720
AAGTTGGAGA AGAAACTTGG AGCGGGGCAG TTTGGGGAAG TCTGGATGGC CACCTACAAC 780
AAGCACACCA AGGTGGCCGT GAAGACGATG AAGCCGGGAA GCATGTCGGT GGAGGCCTTC 840
CTGGCAGAGG CCAACCTGAT GAAGACCCTG CAGCACGACA AGCTAGTGAA GCTGCACGCA 900
GTGGTCACAG AGGAACCCAT CTACATCATC ACGGAGTTCA TGGCCAAAGG AAGCCTGCTG 960
GACTTCCTGA AAAGTACAGA GGGCAGCAAG CAGCCATTGC CCAAGCTCAT TGACTTCTCA 1020
GCCCAGATTG CAGAAGGCAT GGCCTTCATC GAGCAGAGGA ATTACATTCA CCGAGATCTC 1080
CGAGCTGCCA ATATCCTGGT CTCTGCATCC CTGGTGTGTA AGATCGCCGA CTTTGGCCTG 1140
GCACGTGTCA TCGAGGACAA TGAATACACA GCTCGGGAAG GGGCCAAGTT CCCCATCAAG 1200
TGGACAGCTC CTGAAGCCAT CAACTTTGGC TCTTTCACCA TCAAGTCAGA CGTCTGGTCC 1260
TTTGGTATTC TGCTGATGGA GATCGTCACC TATGGCCGGA TCCCTTACCC AGGGATGACA 1320
AACCCAGAGG TGATCCGGGC GCTGGAGCGT GGGTACCGCA TGCCTCGACC AGAGCACTGC 1380
CCTGAGGAGC TCTACAGCAT CATGACACGC TGCTGGAAGA ACCGCCCTGA GGAGCGGCCC 1440
ACCTTCGAAT ATATCCAGAG CGTGCTGGAC GACTTCTACA CGGCCACCGA GAGCCAGTAC 1500
CAACAGCAGC CATGA 1515
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 240   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  299
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv+e ePiyi+te+makGslldflk++eg+k++lpkl+d++aq+aeGma++e++n+ihr
Q: 300   AVVTE-EPIYIITEFMAKGSLLDFLKSTEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR  358
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 359   DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  418
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGmtn ev++++ergyr+prpe+cpeely+++++cwk++pee
Q: 419   WSFGILLMEIVTYGRIPYPGMTNPEVIRALERGYRMPRPEHCPEELYSIMTRCWKNRPEE  478
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 479   RPTFEYIQSVL  489
         *******9976
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60
AVVTEEPIYI ITEFMAKGSL LDFLKSTEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM TNPEVIRALE RGYRMPRPEH CPEELYSIMT RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Kinase; Nucleotide-binding; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013