EKS-MUM-00312

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00312

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	434.3	5.1E-130	202	488	287

Status

Reviewed

Ensembl Protein

ENSMUSP00000000542

UniProt Accession

Q61288; Q61289; Q91YR0;

Protein Name

Serine/threonine-protein kinase receptor R3

Protein Synonyms/Alias

SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I;

Gene Name

Acvrl1

Gene Synonyms/Alias

Acvrl1; Acvrlk1, Alk-1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000000530	ENSMUSP00000113505	ENSMUST00000117984
ENSMUSG00000000530	ENSMUSP00000114829	ENSMUST00000124151
ENSMUSG00000000530	ENSMUSP00000112490	ENSMUST00000120754
ENSMUSG00000000530	ENSMUSP00000122998	ENSMUST00000130432
ENSMUSG00000000530	ENSMUSP00000113297	ENSMUST00000120028
ENSMUSG00000000530	ENSMUSP00000113536	ENSMUST00000119063
ENSMUSG00000000530	ENSMUSP00000000542	ENSMUST00000000542
ENSMUSG00000000530	ENSMUSP00000114027	ENSMUST00000121718
ENSMUSG00000000530	ENSMUSP00000115241	ENSMUST00000144229

Organism

Mus musculus

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.

Protein Length

502

Protein Sequence
(FASTA)

MTLGSFRRGL LMLSVAFGLT RGDLAKPSKL VNCTCESPHC KRPFCQGSWC TVVLVREQGR 60

HPQVYRGCGS LNQELCLGRP TEFLNHHCCY RSFCNHNVSL MLEATQTPSE EPEVDAHLPL 120

ILGPVLALPV LVALGALGLW RVRRRQEKQR DLHSDLGESS LILKASEQAD SMLGDFLDSD 180

CTTGSGSGLP FLVQRTVARQ VALVECVGKG RYGEVWRGSW HGESVAVKIF SSRDEQSWFR 240

ETEIYNTVLL RHDNILGFIA SDMTSRNSST QLWLITHYHE HGSLYDFLQR QTLEPQLALR 300

LAVSAACGLA HLHVEIFGTQ GKPAIAHRDL KSRNVLVKSN LQCCIADLGL AVMHSQSSDY 360

LDIGNNPRVG TKRYMAPEVL DEHIRTDCFE SYKWTDIWAF GLVLWEIARR TIINGIVEDY 420

RPPFYDMVPN DPSFEDMKKV VCVDQQTPTI PNRLAADPVL SGLAQMMREC WYPNPSARLT 480

ALRIKKTLQK LSHNPEKPKV IH 502

Nucleotide Sequence
(FASTA)

ATGACCTTGG GGAGCTTCAG AAGGGGCCTT TTGATGCTGT CGGTGGCCTT TGGCCTAACC 60

AGGGGAGACT TGGCGAAGCC TTCCAAGCTG GTGAACTGCA CTTGTGAGAG CCCACACTGC 120

AAGAGACCAT TCTGCCAGGG GTCATGGTGC ACAGTGGTGC TGGTTCGGGA GCAGGGCAGG 180

CACCCCCAGG TCTATCGGGG CTGCGGGAGC CTGAACCAGG AGCTCTGCTT GGGACGTCCC 240

ACAGAGTTTC TGAACCATCA CTGCTGCTAT AGATCCTTCT GCAACCACAA CGTGTCTCTG 300

ATGCTGGAGG CCACCCAAAC TCCTTCGGAG GAGCCAGAAG TTGATGCCCA TCTGCCTCTG 360

ATCCTGGGTC CTGTGCTGGC CTTGCCGGTC CTGGTGGCCC TGGGTGCTCT AGGCTTGTGG 420

CGTGTCCGGC GGAGGCAGGA GAAGCAGCGG GATTTGCACA GTGACCTGGG CGAGTCCAGT 480

CTCATCCTGA AGGCATCTGA ACAGGCAGAC AGCATGTTGG GGGACTTCCT GGACAGCGAC 540

TGTACTACGG GCAGCGGCTC GGGGCTCCCC TTCTTGGTGC AGAGGACGGT AGCTCGGCAG 600

GTTGCGCTGG TAGAGTGTGT GGGAAAGGGC CGATATGGTG AGGTGTGGCG CGGTTCGTGG 660

CATGGCGAGA GTGTGGCGGT CAAGATTTTC TCCTCACGAG ATGAGCAGTC CTGGTTCCGG 720

GAGACGGAGA TCTACAACAC AGTTCTGCTT AGACACGACA ACATCCTAGG CTTCATCGCC 780

TCCGACATGA CTTCGCGGAA CTCGAGCACG CAGCTGTGGC TCATCACCCA CTACCATGAA 840

CACGGCTCCC TCTATGACTT TCTGCAGAGG CAGACGCTGG AGCCCCAGTT GGCCCTGAGG 900

CTAGCTGTGT CCGCGGCCTG CGGCCTGGCG CACCTACATG TGGAGATCTT TGGCACTCAA 960

GGCAAACCAG CCATTGCCCA TCGTGACCTC AAGAGTCGCA ATGTGCTGGT CAAGAGTAAC 1020

TTGCAGTGTT GCATTGCAGA CCTGGGACTG GCTGTGATGC ACTCACAAAG CAGCGATTAC 1080

CTGGATATCG GCAACAACCC CCGAGTGGGT ACCAAAAGAT ACATGGCACC CGAGGTGCTG 1140

GATGAGCACA TCCGCACAGA CTGCTTTGAG TCGTACAAGT GGACAGACAT CTGGGCCTTT 1200

GGCCTAGTGC TATGGGAGAT CGCCCGGCGG ACCATCATCA ATGGCATTGT GGAGGATTAC 1260

AGGCCACCTT TCTATGACAT GGTACCCAAT GACCCCAGTT TTGAGGACAT GAAAAAGGTG 1320

GTGTGCGTTG ACCAGCAGAC ACCCACCATC CCTAACCGGC TGGCTGCAGA TCCGGTCCTC 1380

TCCGGGCTGG CCCAGATGAT GAGAGAGTGC TGGTACCCCA ACCCCTCTGC TCGCCTCACC 1440

GCACTGCGCA TAAAGAAGAC ATTGCAGAAG CTCAGTCACA ATCCAGAGAA GCCCAAAGTG 1500

ATTCACTAG 1509

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+

Q: 202   ALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  261

         689*********************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH ei+gt+g

Q: 262   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQG  321

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlks+N+lvk++l+cciaDlGLa++++++++ ld+ +n +vGtkRYmaPEv

Q: 322   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEV  379

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l+e++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf+++v++dPs+e+mk

Q: 380   LDEHIRTDCFESYKWTDIWAFGLVLWEIARRTII-NGIVEDYRPPFYDMVPNDPSFEDMK  438

         *********************************9.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l

Q: 439   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  488

         ************************************************97

Domain Sequence
(FASTA)

ALVECVGKGR YGEVWRGSWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60

DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALRL AVSAACGLAH LHVEIFGTQG 120

KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQSSDYL DIGNNPRVGT KRYMAPEVLD 180

EHIRTDCFES YKWTDIWAFG LVLWEIARRT IINGIVEDYR PPFYDMVPND PSFEDMKKVV 240

CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPNPSARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0030425	; C:dendrite
GO:0005887	; C:integral to plasma membrane
GO:0043025	; C:neuronal cell body
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0001525	; P:angiogenesis
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0071773	; P:cellular response to BMP stimulus
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0042118	; P:endothelial cell activation
GO:0061154	; P:endothelial tube morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0043537	; P:negative regulation of blood vessel endothelial cell migration
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0045602	; P:negative regulation of endothelial cell differentiation
GO:0001937	; P:negative regulation of endothelial cell proliferation
GO:0051895	; P:negative regulation of focal adhesion assembly
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0045603	; P:positive regulation of endothelial cell differentiation
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0051291	; P:protein heterooligomerization
GO:0008217	; P:regulation of blood pressure
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0060841	; P:venous blood vessel development
GO:0035313	; P:wound healing, spreading of epidermal cells

KEGG

mmu:11482

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013