EKS-MUM-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	515.6	9.0E-155	90	383	294

Status

Reviewed

Ensembl Protein

ENSMUSP00000001675

UniProt Accession

Q7TSE6; B2KFR4; Q6P6K6; Q8BWK4;

Protein Name

Serine/threonine-protein kinase 38-like

Protein Synonyms/Alias

NDR2 protein kinase; Nuclear Dbf2-related kinase 2;

Gene Name

Stk38l

Gene Synonyms/Alias

Stk38l; Ndr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000001630	ENSMUSP00000001675	ENSMUST00000001675
ENSMUSG00000001630	ENSMUSP00000107271	ENSMUST00000111644

Organism

Mus musculus

Functional Description

Involved in the regulation of structural processes indifferentiating and mature neuronal cells.

Protein Length

464

Protein Sequence
(FASTA)

MAMTAGATTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE VAMEEEGLAD 60

EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA FGEVRLVQKK DTGHIYAMKI 120

LRKADMLEKE QVAHIRAERD ILVEADGAWV VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM 180

KKDTLTEEET QFYISETVLA IDAIHQLGFI HRDVKPDNLL LDAKGHVKLS DFGLCTGLKK 240

AHRTEFYRNL THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY 300

NKLCDWWSLG VIMYEMLIGF PPFCSETPQE TYRKVMSWKE TLAFPPEVPV SEKAKDLILR 360

FCTDSENRIG NGGVEEIKGH PFFEGVDWGH IRERPAAIPI EIRSIDDTSN FDDFPESDIL 420

QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT QRGSIPTYMK AGKL 464

Nucleotide Sequence
(FASTA)

ATGGCAATGA CGGCAGGGGC AACAACTACC TTTCCTATGA GCAACCATAC CCGGGAAAGA 60

GTAACTGTGG CCAAGCTCAC ACTGGAGAAT TTTTACAGCA ACCTAATTTT ACAGCATGAA 120

GAGAGAGAAA CCAGGCAGAA GAAGTTAGAA GTGGCTATGG AAGAAGAAGG ATTGGCAGAT 180

GAGGAGAAAA AGTTACGTCG ATCGCAGCAT GCTCGTAAAG AAACAGAGTT CTTACGCCTT 240

AAGAGGACCA GACTTGGCCT AGATGACTTT GAGTCTCTGA AGGTTATAGG AAGAGGAGCT 300

TTCGGAGAGG TGCGGCTGGT CCAGAAGAAA GACACGGGGC ACATCTATGC CATGAAGATC 360

CTGAGGAAAG CTGACATGCT TGAGAAAGAG CAGGTGGCTC ATATCCGAGC AGAAAGGGAC 420

ATTTTGGTGG AAGCAGATGG AGCCTGGGTG GTGAAGATGT TCTACAGTTT TCAGGACAAA 480

CGGAATCTCT ATCTCATCAT GGAATTTCTT CCTGGAGGTG ACATGATGAC ATTGCTGATG 540

AAGAAGGACA CCTTAACAGA AGAAGAGACA CAGTTCTACA TCTCAGAGAC TGTCTTGGCG 600

ATAGATGCAA TTCACCAGCT GGGCTTCATC CACCGGGACG TCAAACCAGA CAACCTTTTA 660

CTGGATGCCA AGGGACATGT AAAATTATCT GATTTTGGTT TGTGCACGGG GTTAAAGAAA 720

GCTCACAGGA CTGAATTCTA CAGAAACCTC ACACATAACC CGCCAAGCGA CTTCTCATTT 780

CAGAACATGA ATTCAAAGCG GAAAGCAGAG ACATGGAAGA AGAACAGGAG ACAGCTGGCT 840

TACTCCACAG TTGGAACACC AGACTACATT GCTCCAGAAG TATTCATGCA GACTGGCTAC 900

AACAAATTGT GTGACTGGTG GTCCTTGGGA GTGATTATGT ACGAGATGCT AATAGGCTTT 960

CCACCTTTCT GCTCTGAAAC ACCACAAGAA ACATACAGAA AAGTTATGAG CTGGAAGGAG 1020

ACTCTGGCAT TTCCTCCGGA AGTGCCCGTC TCTGAGAAAG CCAAGGACTT GATTCTCAGA 1080

TTTTGTACTG ATTCTGAAAA CAGAATTGGG AATGGTGGTG TGGAAGAAAT CAAAGGTCAT 1140

CCGTTCTTTG AGGGTGTAGA CTGGGGGCAC ATAAGGGAAA GACCAGCAGC TATTCCTATA 1200

GAAATCCGGA GTATAGATGA CACCTCAAAC TTTGATGACT TCCCTGAGTC TGATATCTTA 1260

CAGCCAGTGC CGAATACCAC AGAGCCCGAC TACAAATCCA AAGACTGGGT TTTTCTCAAT 1320

TACACCTACA AAAGGTTTGA AGGGCTGACC CAGAGAGGCT CCATTCCTAC ATACATGAAA 1380

GCTGGGAAGT TATGA 1395

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt+++ya+kilrk+d+l+k+qvah++aerdil+ead +w

Q: 90    FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAW  149

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk+nlyl+me+lPGGd+mtll+kk++l+ee+++fyi+e+vla++++h+lGf

Q: 150   VVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGF  209

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+dakGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+++++  ++ +

Q: 210   IHRDVKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKA  269

         *************************************************65555555555

S: 181   rkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPflaetpq  240

            kknrr+lays+vGtpdyiapev++++gynklcdwWslGvi+yeml+G+pPf++etpq

Q: 270   ETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGFPPFCSETPQ  329

         555*********************************************************

S: 241   etykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         ety+kv++wketl+fp+ev++se+akdli r+++d+e+r+g+ Gv+eik hpff

Q: 330   ETYRKVMSWKETLAFPPEVPVSEKAKDLILRFCTDSENRIGNGGVEEIKGHPFF  383

         *****************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHIYAMK ILRKADMLEK EQVAHIRAER DILVEADGAW 60

VVKMFYSFQD KRNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYISETVL AIDAIHQLGF 120

IHRDVKPDNL LLDAKGHVKL SDFGLCTGLK KAHRTEFYRN LTHNPPSDFS FQNMNSKRKA 180

ETWKKNRRQL AYSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG FPPFCSETPQ 240

ETYRKVMSWK ETLAFPPEVP VSEKAKDLIL RFCTDSENRI GNGGVEEIKG HPFF 294

Keyword

Acetylation; Actin-binding; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0051128	; P:regulation of cellular component organization

KEGG

mmu:232533

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013