EKS-MUM-00184
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00184
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/SRPK843.21.7E-25378563486
StatusReviewed
Ensembl ProteinENSMUSP00000002081
UniProt AccessionQ9Z0G2;
Protein NameSRSF protein kinase 3
Protein Synonyms/Alias Muscle-specific serine kinase 1; MSSK-1; Serine/arginine-rich protein-specific kinase 3; SR-protein-specific kinase 3; Serine/threonine-protein kinase 23;
Gene NameSrpk3
Gene Synonyms/Alias Srpk3; Mssk1, Stk23;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000002007ENSMUSP00000002081ENSMUST00000002081
OrganismMus musculus
Functional DescriptionSerine/arginine-rich protein-specific kinase whichspecifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development.
Protein Length565
Protein Sequence
(FASTA)
MSANAGGSGS VDCGGSSSSS QTSCGPESSG SELTPATPAP RLLQGLLGSD DEEQEDPKDY 60
CKGGYYPVKI GDLFNGRYHV VRKLGWGHFS TVWLCWDIQR KRFVALKVVK SAGHYTETAV 120
DEIKLLKCVR DSDPSDPKRE TIVQLIDDFR ISGVNGVHVC MVLEVLGHQL LKWIIKSNYQ 180
GLPVPCVKSI VRQVLHGLDY LHTKCKIIHT DIKPENILLC VGDAYIRRLA AEATEWQQSG 240
AQPPSRSTVS TAPQEVLIGK LSKNKRKKMR RKRKQQKRLL EERLRDLQRL EAMEAAVQAE 300
DSSSRLERGS GSTSSSGCHP EGTRAGPSPA SSSPVPGGER SLSPSSQTSG FSGSLFSTAS 360
CSILSGSSNQ RETGGLLSPS TPFGASNLLV NPLEPQNADK IKIKIADLGN ACWVHKHFTE 420
DIQTRQYRAV EVLIGAEYGP PADIWSTACM AFELATGDYL FEPHSGEDYS RDEDHIAHIV 480
ELLGDIPPAF ALSGRYSREF FNRRGELRHI PNLKHWGLYE VLMEKYEWPL EQATQFSAFL 540
LPMMEYIPEK RASAADCLQH PWLNP 565
Nucleotide Sequence
(FASTA)
ATGAGTGCCA ATGCCGGTGG TAGTGGTAGT GTGGATTGTG GCGGCAGCAG CAGCAGCTCT 60
CAGACTTCCT GTGGGCCTGA GTCCTCAGGC TCTGAATTAA CTCCAGCCAC ACCAGCACCT 120
CGTTTGCTGC AGGGACTCCT GGGCTCTGAT GATGAGGAAC AGGAAGACCC TAAGGACTAT 180
TGCAAGGGTG GTTACTACCC AGTGAAGATC GGTGATTTGT TCAATGGGCG GTACCATGTG 240
GTGCGAAAGC TAGGCTGGGG CCATTTCTCT ACAGTCTGGC TCTGCTGGGA TATTCAGCGC 300
AAGCGCTTTG TGGCCCTGAA AGTGGTGAAG AGTGCAGGAC ATTACACTGA GACAGCCGTG 360
GATGAGATCA AGCTCCTGAA ATGTGTCAGG GACAGTGACC CTAGTGACCC CAAAAGGGAG 420
ACCATTGTTC AACTTATCGA TGACTTCAGG ATCTCAGGAG TAAATGGAGT CCATGTATGC 480
ATGGTGCTAG AGGTCCTGGG CCACCAGCTC CTCAAGTGGA TCATCAAATC CAACTACCAG 540
GGTCTGCCTG TGCCCTGTGT TAAGAGCATT GTTAGACAGG TGCTGCATGG TCTGGATTAC 600
CTCCATACTA AGTGCAAGAT CATCCATACG GACATCAAGC CTGAGAACAT CTTACTGTGT 660
GTTGGAGATG CCTACATCAG GCGCCTGGCT GCTGAAGCCA CAGAGTGGCA GCAGTCAGGG 720
GCCCAGCCCC CATCCCGTTC CACAGTCAGC ACTGCCCCCC AGGAGGTCTT GATTGGCAAG 780
CTGTCCAAAA ACAAGAGGAA GAAGATGAGG CGCAAAAGGA AGCAACAGAA GAGGCTGCTG 840
GAGGAGCGGC TGAGGGACTT GCAGAGGCTA GAGGCTATGG AGGCCGCAGT ACAAGCTGAG 900
GACTCCAGCT CAAGACTAGA ACGGGGCAGC GGCTCCACCT CTTCTTCAGG CTGCCACCCG 960
GAGGGCACCA GAGCTGGCCC TTCTCCAGCC TCTTCTTCCC CTGTGCCTGG GGGGGAACGA 1020
AGCCTTAGTC CCAGCTCGCA GACCTCAGGT TTTTCAGGGT CCCTGTTCTC CACGGCTTCC 1080
TGCTCCATCC TCTCAGGTTC ATCTAATCAG CGTGAGACTG GAGGTCTTCT ATCTCCTAGC 1140
ACACCATTTG GTGCTTCCAA TCTCCTAGTG AACCCTCTGG AGCCCCAAAA TGCAGACAAG 1200
ATCAAGATCA AGATTGCAGA CCTTGGCAAC GCCTGCTGGG TGCACAAGCA CTTCACTGAG 1260
GATATTCAGA CTCGGCAGTA CAGGGCCGTG GAGGTGCTGA TCGGTGCCGA GTATGGGCCC 1320
CCAGCTGACA TCTGGAGCAC AGCATGCATG GCTTTTGAGC TGGCCACTGG TGACTACCTA 1380
TTTGAGCCCC ACTCTGGAGA AGACTACAGT CGTGATGAGG ACCACATTGC TCATATCGTG 1440
GAACTTCTAG GAGACATCCC TCCAGCTTTT GCCCTCTCAG GCCGATATTC ACGGGAGTTC 1500
TTCAACCGTA GAGGAGAGCT GCGCCACATC CCCAACCTCA AGCACTGGGG CCTATATGAG 1560
GTGCTCATGG AGAAGTATGA GTGGCCCCTG GAGCAGGCCA CACAGTTCAG TGCCTTCCTG 1620
TTGCCCATGA TGGAGTACAT CCCTGAGAAG CGGGCCAGTG CTGCCGACTG CCTCCAGCAT 1680
CCCTGGCTTA ATCCATAG 1698
Domain Profile
S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60
         yhv+rkLGWGhfstvWL+wd+q+krfvalkvvksa hyteta+deikllk+vr+sdpsdp
Q: 78    YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDP  137
         9***********************************************************
S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120
         kre++vql+ddf+isGvnGvhvc+v+evLG++Llk+iiksny+Glp+++vk+i+rqvL+g
Q: 138   KRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHG  197
         ************************************************************
S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180
         Ldylh+kCkiihtdikPen+Ll+v d+yirrlaaeatewq++ga+pps+s+vstapq++ 
Q: 198   LDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQSGAQPPSRSTVSTAPQEVL  257
         ************************************************************
S: 181   ieklsknkkkklkkkqkrqaellekrlqeleeleaaeanseaedqelkedaekgeleeie  240
         i+klsknk+kk+++k+k+q++lle+rl++l++lea+ea+ +aed+++++++++g+++++ 
Q: 258   IGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSG  317
         ************************************************************
S: 241   adveeevanedeaseeee...essltsssdaesksgel.seastellsesleqlacgsvl  296
         ++ e ++a  ++as++     e+sl++ss+++++sg+l s+as+++ls+s++q+++g++l
Q: 318   CHPEGTRAGPSPASSSPVpggERSLSPSSQTSGFSGSLfSTASCSILSGSSNQRETGGLL  377
         *************99988888****************98999******************
S: 297   s...........vnplepknadkikvkiadLGnaCwvhkhftediqtrqyrslevliGag  345
         s           vnplep+nadkik+kiadLGnaCwvhkhftediqtrqyr++evliGa+
Q: 378   SpstpfgasnllVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAE  437
         ************************************************************
S: 346   ygtpadiWstaClafeLatGdyLfephsgedysrdedhiakiiellGkiPrklilkGkys  405
         yg+padiWstaC+afeLatGdyLfephsgedysrdedhia+i+ellG+iP++++l+G+ys
Q: 438   YGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYS  497
         ************************************************************
S: 406   reffnkkgeLrhitkLkpwsLlevLvekyewskeeaaefsdfLlPmleldpekrasaaec  465
         reffn++geLrhi +Lk+w+L+evL+ekyew+ e+a++fs+fLlPm+e++pekrasaa+c
Q: 498   REFFNRRGELRHIPNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADC  557
         ************************************************************
S: 466   lkhpwL  471
         l+hpwL
Q: 558   LQHPWL  563
         *****8
Domain Sequence
(FASTA)
YHVVRKLGWG HFSTVWLCWD IQRKRFVALK VVKSAGHYTE TAVDEIKLLK CVRDSDPSDP 60
KRETIVQLID DFRISGVNGV HVCMVLEVLG HQLLKWIIKS NYQGLPVPCV KSIVRQVLHG 120
LDYLHTKCKI IHTDIKPENI LLCVGDAYIR RLAAEATEWQ QSGAQPPSRS TVSTAPQEVL 180
IGKLSKNKRK KMRRKRKQQK RLLEERLRDL QRLEAMEAAV QAEDSSSRLE RGSGSTSSSG 240
CHPEGTRAGP SPASSSPVPG GERSLSPSSQ TSGFSGSLFS TASCSILSGS SNQRETGGLL 300
SPSTPFGASN LLVNPLEPQN ADKIKIKIAD LGNACWVHKH FTEDIQTRQY RAVEVLIGAE 360
YGPPADIWST ACMAFELATG DYLFEPHSGE DYSRDEDHIA HIVELLGDIP PAFALSGRYS 420
REFFNRRGEL RHIPNLKHWG LYEVLMEKYE WPLEQATQFS AFLLPMMEYI PEKRASAADC 480
LQHPWL 486
KeywordATP-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Myogenesis; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00172
EKS-BOT-00179
EKS-CAJ-00183
EKS-CAF-00186
EKS-CAP-00203
EKS-DAR-00476
EKS-DIO-00089
EKS-ECT-00050
EKS-HOS-00185
EKS-ICT-00172
EKS-LOA-00178
EKS-MAM-00178
EKS-MIM-00078
EKS-MUP-00182
EKS-MYL-00187
EKS-ORN-00227
EKS-ORA-00158
EKS-ORC-00166
EKS-OTG-00185
EKS-PAT-00169
EKS-POA-00175
EKS-RAN-00174
EKS-SAH-00171
EKS-SOA-00038
EKS-SUS-00155
EKS-TAR-00233
EKS-TUB-00040
EKS-XET-00211
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030154; P:cell differentiation
GO:0007519; P:skeletal muscle tissue development
KEGG
mmu:56504;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013