EKS-MUM-00302
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00302
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK437.76.5E-131111431321
StatusReviewed
Ensembl ProteinENSMUSP00000083064
UniProt AccessionQ9Z188; Q3UFR5; Q70UR5; Q9EPM2;
Protein NameDual specificity tyrosine-phosphorylation-regulated kinase 1B
Protein Synonyms/Alias
Gene NameDyrk1b
Gene Synonyms/Alias Dyrk1b;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000002409ENSMUSP00000083064ENSMUST00000085901
ENSMUSG00000002409ENSMUSP00000133719ENSMUST00000172761
ENSMUSG00000002409ENSMUSP00000133364ENSMUST00000173223
ENSMUSG00000002409ENSMUSP00000133431ENSMUST00000172467
OrganismMus musculus
Functional DescriptionDual-specificity kinase which possesses both serine/threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
Protein Length629
Protein Sequence
(FASTA)
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA ASAPLRKLSV DLIKTYKHIN 60
EVYYAKKKRR AQQAPPQDSS TKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG 120
SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF 180
MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL 240
KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG 300
CILVEMHTGE PLFSGSNEVD QMSRIVEVLG IPPAPMLEQA PKARKYFERL PGGGWTLRRT 360
KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR MLEYEPAARI 420
SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS SSTASSISSS GGSSGSSNDN 480
RAYRYSNRYC GGPGPPITDC EMNSPQVLPS QPLRPWAGGD VPHKTHQAPI SASTLPGTGA 540
QLPPLPRCLG RPPSPTSPPP PELMDVSLVG SPPDCSPPPP APAPQHPAAS ALRTRMTGGR 600
PPLPPPDDPA TLGPRLGLHG VPQSTAASS 629
Nucleotide Sequence
(FASTA)
ATGGCCGTCC CACCAGGCCA TGGTCCTTTC TCTGGCTTTC CGGGGCCCCA GGAACACACA 60
CAGGTACTAC CTGATGTGCG GCTCCTGCCC CGGAGACTGC CCCTGGCCTT CCGGGATGCG 120
GCCTCAGCCC CGCTGCGCAA GCTCTCGGTG GACCTCATCA AGACCTACAA GCACATCAAT 180
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAACAGG CGCCACCCCA GGACTCGAGC 240
ACCAAAAAGG AGAAGAAGGT CCTGAACCAC GGTTATGATG ACGACAACCA CGACTACATT 300
GTGCGCAGTG GCGAGCGCTG GCTAGAGCGC TATGAGATTG ACTCTCTTAT TGGCAAAGGC 360
TCCTTTGGCC AGGTGGTGAA AGCCTATGAT CACCAGACTC AGGAGCTGGT GGCCATCAAG 420
ATCATCAAGA ACAAAAAGGC CTTCCTGAAC CAGGCACAGA TTGAGCTACG GCTGTTGGAG 480
CTGATGAACC AGCATGATAC AGAGATGAAG TACTACATAG TACACCTTAA GCGGCACTTC 540
ATGTTCCGGA ATCACCTGTG CCTGGTGTTT GAGCTGCTGT CCTACAACCT GTACGACCTC 600
CTCCGCAACA CACACTTTCG GGGTGTCTCA CTGAACCTGA CGAGGAAGCT GGCACAGCAG 660
CTCTGCACAG CTCTGCTCTT TCTGGCCACC CCCGAGCTCA GCATCATCCA CTGCGACCTC 720
AAGCCTGAGA ACATCCTGCT CTGCAACCCC AAGCGCAGTG CCATCAAGAT CGTGGACTTC 780
GGCAGTTCCT GCCAGCTTGG CCAGCGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 840
TCACCCGAGG TGCTCCTGGG TACACCCTAT GACCTGGCCA TTGACATGTG GTCCCTGGGC 900
TGCATCCTCG TGGAGATGCA CACCGGAGAG CCCCTCTTCA GTGGCTCTAA TGAGGTGGAC 960
CAGATGAGCC GTATTGTGGA GGTGTTGGGC ATCCCTCCCG CACCCATGCT GGAACAGGCA 1020
CCCAAGGCTC GAAAGTACTT TGAGCGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACA 1080
AAGGAACTCA GGAAGGATTA CCAGGGCCCT GGGACACGGC GGCTGCAGGA GGTGCTGGGC 1140
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CCGGCCACAG CCCCGCCGAC 1200
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAAT ATGAGCCCGC CGCCCGCATC 1260
AGCCCTCTGG GCGCTCTGCA GCATGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 1320
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCGGCGC CCCTTGACAC CTGCCCCTCC 1380
TCTAGCACCG CCAGCTCCAT CTCCAGCTCT GGAGGTTCCA GTGGCTCCTC CAACGACAAC 1440
AGAGCCTACC GATACAGCAA CCGATATTGT GGGGGCCCAG GGCCCCCCAT CACTGACTGT 1500
GAGATGAACA GCCCCCAGGT CCTACCCTCC CAGCCTCTGC GCCCCTGGGC AGGGGGTGAT 1560
GTGCCCCACA AGACACATCA AGCCCCTATC TCTGCCTCAA CATTGCCGGG GACTGGGGCT 1620
CAGTTACCCC CATTGCCCCG TTGCCTTGGA CGACCCCCAT CACCAACATC ACCACCACCC 1680
CCAGAGTTGA TGGATGTGAG CCTGGTGGGC AGCCCTCCAG ACTGCTCTCC ACCTCCTCCA 1740
GCACCTGCCC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC AGGAGGTCGA 1800
CCACCTCTCC CACCCCCTGA TGACCCTGCC ACTCTGGGGC CTCGCCTGGG TCTCCATGGT 1860
GTACCCCAGA GCACAGCAGC CAGCTCATGA 1890
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         ye++++igkGsfgqVvka+d++t+e vaikiiknkk+f++qaq+E+++Le +n++d+e+k
Q: 111   YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK  170
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119
         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rklaqq+++aL +L+ 
Q: 171   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAt  230
         **********************************************************99
S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++
Q: 231   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGTP  289
         99*************************************.********************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238
         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq++ ivevlg+pp+ +le+a ka+k+f++
Q: 290   YDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFER  349
         ************************************************************
S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288
              ++l+++          ++r+ ++vl+v++ +     p+ +++ge+ ++ +d+l f
Q: 350   LPGGGWTLRRTkelrkdyqgPGTRRLQEVLGVQTGG-----PGGRRAGEPGHSPADYLrF  404
         ********9997888888777778888888887777.....99*****************
S: 289   kdllkrmleldpakRitpkealkhpfv  315
         +dl+ rmle++pa+Ri+p  al+h f+
Q: 405   QDLVLRMLEYEPAARISPLGALQHGFF  431
         *************************97
Domain Sequence
(FASTA)
YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK 60
YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT 120
PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY 180
DLAIDMWSLG CILVEMHTGE PLFSGSNEVD QMSRIVEVLG IPPAPMLEQA PKARKYFERL 240
PGGGWTLRRT KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR 300
MLEYEPAARI SPLGALQHGF F 321
KeywordAcetylation; Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00254
EKS-ANC-00260
EKS-BOT-00271
EKS-CAJ-00277
EKS-CAF-00279
EKS-CAP-00306
EKS-DIO-00022
EKS-EQC-00266
EKS-FEC-00257
EKS-HOS-00277
EKS-ICT-00254
EKS-LOA-00282
EKS-MAM-00273
EKS-MOD-00268
EKS-MUP-00270
EKS-MYL-00273
EKS-NOL-00251
EKS-OTG-00277
EKS-PAT-00257
EKS-PES-00242
EKS-POA-00262
EKS-PRC-00022
EKS-RAN-00288
EKS-SUS-00233
EKS-SCP-00047
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0003713; F:transcription coactivator activity
GO:0007520; P:myoblast fusion
GO:0045893; P:positive regulation of transcription, DNA-dependent
KEGG
mmu:13549;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013