| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00235 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| STE/STE7 | 366.8 | 1.6E-109 | 47 | 307 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000106622 |
| UniProt Accession | Q8CE90; O35406; O35720; O35871; O35872; O54780; O70242; O70243; Q8BSP1; Q9QWG6; Q9R1Z3; Q9R1Z4; Q9R1Z5; Q9R1Z6; |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 7 |
| Protein Synonyms/Alias | MAP kinase kinase 7; MAPKK 7; JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; c-Jun N-terminal kinase kinase 2; JNK kinase 2; JNKK 2; |
| Gene Name | Map2k7 |
| Gene Synonyms/Alias | Map2k7; Mkk7; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. |
| Protein Length | 346 |
Protein Sequence
(FASTA) | | MLGLPSTLFT PRSMESIEID QKLQEIMKQT GYLTIGGQRY QAEINDLENL GEMGSGTCGQ 60 | | VWKMRFRKTG HIIAVKQMRR SGNKEENKRI LMDLDVVLKS HDCPYIVQCF GTFITNTDVF 120 | | IAMELMGTCA EKLKKRMQGP IPERILGKMT VAIVKALYYL KEKHGVIHRD VKPSNILLDE 180 | | RGQIKLCDFG ISGRLVDSKA KTRSAGCAAY MAPERIDPPD PTKPDYDIRA DVWSLGISLV 240 | | ELATGQFPYK NCKTDFEVLT KVLQEEPPLL PGHMGFSGDF QSFVKDCLTK DHRKRPKYNK 300 | | LLEHSFIKHY EILEVDVASW FKDVMAKTES PRTSGVLSQH HLPFFR 346 |
|
Nucleotide Sequence
(FASTA) | | ATGCTGGGGC TCCCATCAAC CTTGTTCACA CCGCGCAGTA TGGAGAGCAT CGAGATTGAC 60 | | CAGAAGCTGC AGGAGATCAT GAAGCAGACA GGGTACCTGA CTATCGGGGG CCAGCGTTAT 120 | | CAGGCAGAAA TCAATGACTT GGAGAACTTG GGTGAGATGG GCAGTGGTAC CTGTGGTCAG 180 | | GTGTGGAAGA TGCGGTTCCG GAAGACAGGC CACATCATTG CTGTTAAGCA AATGCGGCGC 240 | | TCTGGGAACA AGGAAGAGAA TAAGCGCATT TTGATGGACC TGGATGTAGT ACTCAAGAGC 300 | | CATGACTGCC CTTACATCGT TCAGTGCTTT GGCACCTTCA TCACCAACAC AGACGTCTTT 360 | | ATTGCCATGG AGCTCATGGG CACATGTGCA GAGAAGCTGA AGAAACGAAT GCAGGGCCCC 420 | | ATTCCAGAGC GAATCCTGGG CAAGATGACT GTGGCGATTG TGAAAGCACT GTACTATCTG 480 | | AAGGAGAAGC ATGGCGTCAT CCATCGCGAT GTCAAACCCT CCAACATCCT GCTAGATGAG 540 | | CGGGGCCAGA TCAAGCTCTG TGACTTTGGC ATCAGTGGCC GCCTTGTTGA CTCCAAAGCC 600 | | AAAACACGGA GTGCTGGCTG TGCTGCCTAT ATGGCTCCCG AGCGCATCGA CCCTCCAGAT 660 | | CCCACCAAGC CTGACTATGA CATCCGAGCT GATGTGTGGA GCCTGGGCAT CTCACTGGTG 720 | | GAGCTGGCAA CAGGACAGTT CCCCTATAAG AACTGCAAGA CGGACTTTGA GGTCCTCACC 780 | | AAAGTCCTAC AGGAAGAGCC CCCACTCCTG CCTGGTCACA TGGGCTTCTC AGGGGACTTC 840 | | CAGTCATTTG TCAAAGACTG CCTTACTAAA GATCACAGGA AGAGACCAAA GTATAATAAG 900 | | CTACTTGAAC ACAGCTTCAT CAAGCACTAT GAGATACTCG AGGTGGATGT CGCGTCCTGG 960 | | TTTAAGGATG TCATGGCGAA GACCGAGTCC CCAAGGACTA GTGGAGTCCT GAGTCAGCAC 1020 | | CATCTGCCCT TCTTCAGGTA G 1041 |
|
| Domain Profile | S: 1 lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi 60 | le+l+e+G+G++g+V+k++++k+g+i+avK++r++ +kee+k+il++l+v+ ks+++pyi | Q: 47 LENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYI 106 | 7899******************************************************** |
| S: 61 vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke 120 | v+++G+f++++dv+i+melm t+ +k+ k++ ++ ipe++lgk++va+vkal ylke | Q: 107 VQCFGTFITNTDVFIAMELMG-TCAEKLKKRM---QGPIPERILGKMTVAIVKALYYLKE 162 | *********************.*****99996...9************************ |
| S: 121 klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg.... 175 | k+ +iHRDvKPsNiL++++G++KlCDFG+sg+lvds Ak++ +G+++YmaPEri++ | Q: 163 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRsAGCAAYMAPERIDPpdpt 222 | *******************************************************99999 |
| S: 176 kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee.efseefqe 234 | k++Y++++dvWslG++lvelatg++py+++k+++e+l+++++eepp lp + fs +fq+ | Q: 223 KPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHmGFSGDFQS 282 | 9************************************************9999******* |
| S: 235 fvskClkkdekeRpklkellkhafi 259 | fv++Cl+kd+++Rpk+++ll+h+fi | Q: 283 FVKDCLTKDHRKRPKYNKLLEHSFI 307 | ************************7 |
|
Domain Sequence
(FASTA) | | LENLGEMGSG TCGQVWKMRF RKTGHIIAVK QMRRSGNKEE NKRILMDLDV VLKSHDCPYI 60 | | VQCFGTFITN TDVFIAMELM GTCAEKLKKR MQGPIPERIL GKMTVAIVKA LYYLKEKHGV 120 | | IHRDVKPSNI LLDERGQIKL CDFGISGRLV DSKAKTRSAG CAAYMAPERI DPPDPTKPDY 180 | | DIRADVWSLG ISLVELATGQ FPYKNCKTDF EVLTKVLQEE PPLLPGHMGF SGDFQSFVKD 240 | | CLTKDHRKRP KYNKLLEHSF I 261 |
|
| Keyword | Acetylation; Alternative splicing; Apoptosis; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Stress response; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |