EPS-MUM-00123

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00123

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	620.0	1.6E-186	185	496	312

Status

Unreviewed

Ensembl Protein

ENSMUSP00000003183

UniProt Accession

G5E819;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

Ppp5c

Gene Synonyms/Alias

Ppp5c; mCG_16544;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000003099	ENSMUSP00000122783	ENSMUST00000142597
ENSMUSG00000003099	ENSMUSP00000003183	ENSMUST00000003183

Organism

Mus musculus

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MAMAEGERTE CAETPRDEPP ADGTLKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPG 60

NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 120

TVVKVKPNDK DAKMKYQECS KIVKQKAFER AIAGDEHRRS VVDSLDIESM TIEDEYSGPK 180

LEDGKVTITF MKDLMQWYKD QKKLHRKCAY QILVQVKEVL CKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENQL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 480

HPNVKPMAYA NTLLQLGMM 499

Nucleotide Sequence
(FASTA)

ATGGCGATGG CGGAGGGCGA GCGGACTGAG TGTGCTGAGA CCCCCCGGGA CGAACCCCCG 60

GCCGATGGCA CTCTGAAGCG GGCAGAGGAG CTCAAGACAC AGGCCAACGA CTACTTCAAA 120

GCCAAGGACT ACGAGAACGC GATCAAGTTC TACAGTCAGG CCATCGAGTT GAACCCCGGC 180

AATGCCATCT ACTATGGCAA CCGCAGCCTG GCCTACCTGC GCACTGAGTG CTATGGCTAT 240

GCACTGGGCG ACGCCACACG GGCCATCGAG CTTGACAAGA AGTACATCAA AGGCTACTAC 300

CGCCGGGCGG CCAGCAACAT GGCACTGGGC AAGTTCCGGG CTGCCCTGCG TGACTACGAG 360

ACGGTGGTGA AAGTGAAGCC TAATGACAAG GATGCCAAGA TGAAGTACCA GGAGTGCAGC 420

AAGATTGTGA AGCAGAAGGC CTTTGAGAGG GCCATTGCGG GTGACGAGCA CAGACGCTCT 480

GTCGTGGACT CTCTGGACAT TGAAAGCATG ACCATTGAAG ATGAGTACAG CGGGCCCAAG 540

CTTGAGGATG GCAAAGTGAC AATCACCTTC ATGAAAGACC TCATGCAGTG GTACAAGGAT 600

CAGAAGAAAC TGCACCGGAA GTGCGCCTAC CAGATCCTAG TACAGGTGAA AGAAGTCCTC 660

TGCAAGCTGA GCACGCTGGT GGAGACGACG CTGAAAGAGA CAGAGAAGAT TACAGTGTGC 720

GGGGACACCC ATGGCCAGTT CTACGACCTC CTCAACATAT TTGAGCTCAA CGGTTTACCC 780

TCAGAGACCA ACCCCTATAT ATTTAATGGC GATTTTGTGG ACCGTGGTTC CTTCTCCGTT 840

GAAGTGATCC TCACCCTCTT CGGCTTTAAG CTCCTGTATC CAGATCATTT CCATCTACTT 900

CGAGGCAACC ACGAGACAGA CAACATGAAC CAGATCTACG GGTTCGAGGG CGAGGTGAAG 960

GCCAAGTACA CAGCCCAGAT GTATGAGCTC TTCAGCGAGG TGTTCGAGTG GCTTCCGCTG 1020

GCGCAGTGTA TCAATGGCAA AGTGCTGATC ATGCACGGAG GCCTATTCAG CGAAGATGGT 1080

GTCACTCTGG ATGACATCCG AAAGATTGAG CGGAATCGGC AGCCCCCAGA CTCAGGTCCC 1140

ATGTGTGACC TGCTGTGGTC AGATCCCCAG CCACAGAATG GGCGCTCCGT CAGCAAGCGT 1200

GGTGTGAGTT GCCAGTTTGG GCCTGATGTC ACCAAGGCCT TCCTGGAGGA GAATCAACTG 1260

GACTATATCA TCCGCAGCCA TGAAGTCAAA GCCGAGGGCT ACGAGGTGGC CCATGGTGGC 1320

CGCTGTGTCA CTGTCTTTTC TGCCCCCAAC TATTGTGACC AGATGGGAAA CAAAGCCTCC 1380

TACATCCACC TCCAGGGCTC CGACCTGCGG CCCCAGTTCC ACCAATTCAC AGCAGTGCCT 1440

CACCCCAATG TCAAGCCCAT GGCATACGCC AACACGCTTC TGCAGCTAGG AATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+i f+k+l++++k++kkl+rk+a++ilv+v++vl kl++++e+++ke++kitvcGdth

Q: 185   KVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKEVLCKLSTLVETTLKETEKITVCGDTH  244

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 365   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENQLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih++++dlr+++++f+av+hp+v

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+ll+l

Q: 485   KPMAYANTLLQL  496

         *********997

Domain Sequence
(FASTA)

KVTITFMKDL MQWYKDQKKL HRKCAYQILV QVKEVLCKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENQLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL QGSDLRPQFH QFTAVPHPNV 300

KPMAYANTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0043005	; C:neuron projection
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine

KEGG

mmu:19060

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013