| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00401 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TK/Src | 435.3 | 1.6E-130 | 239 | 488 | 250 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000105423 |
| UniProt Accession | P08103; Q0VH03; Q3UD17; |
| Protein Name | Tyrosine-protein kinase HCK |
| Protein Synonyms/Alias | B-cell/myeloid kinase; BMK; Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK/p59-HCK; |
| Gene Name | Hck |
| Gene Synonyms/Alias | Hck; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Non-receptor tyrosine-protein kinase found inhematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity). |
| Protein Length | 503 |
Protein Sequence
(FASTA) | | MGCVKSRFLR DGSKASKTEP SANQKGPVYV PDPTSSSKLG PNNSNSMPPG FVEGSEDTIV 60 | | VALYDYEAIH REDLSFQKGD QMVVLEEAGE WWKARSLATK KEGYIPSNYV ARVNSLETEE 120 | | WFFKGISRKD AERHLLAPGN MLGSFMIRDS ETTKGSYSLS VRDFDPQHGD TVKHYKIRTL 180 | | DSGGFYISPR STFSSLQELV LHYKKGKDGL CQKLSVPCVS PKPQKPWEKD AWEIPRESLQ 240 | | MEKKLGAGQF GEVWMATYNK HTKVAVKTMK PGSMSVEAFL AEANLMKSLQ HDKLVKLHAV 300 | | VSQEPIFIVT EFMAKGSLLD FLKSEEGSKQ PLPKLIDFSA QISEGMAFIE QRNYIHRDLR 360 | | AANILVSASL VCKIADFGLA RIIEDNEYTA REGAKFPIKW TAPEAINFGS FTIKSDVWSF 420 | | GILLMEIVTY GRIPYPGMSN PEVIRALEHG YRMPRPDNCP EELYNIMIRC WKNRPEERPT 480 | | FEYIQSVLDD FYTATESQYQ QQP 503 |
|
Nucleotide Sequence
(FASTA) | | ATGGGATGCG TGAAGTCCAG GTTCCTCCGA GATGGAAGCA AGGCCTCAAA AACAGAGCCA 60 | | AGTGCCAATC AGAAGGGCCC TGTGTATGTG CCGGATCCCA CGTCCTCCAG CAAGCTGGGA 120 | | CCAAACAACA GCAACAGCAT GCCCCCAGGG TTTGTGGAGG GCTCTGAGGA TACCATTGTG 180 | | GTCGCACTGT ACGACTATGA GGCTATTCAC CGTGAAGACC TCAGCTTCCA GAAGGGAGAC 240 | | CAGATGGTGG TTCTGGAGGA GGCTGGGGAG TGGTGGAAGG CACGGTCCCT GGCTACCAAG 300 | | AAGGAAGGCT ACATCCCAAG CAACTATGTG GCTCGAGTTA ACTCTTTGGA GACAGAAGAG 360 | | TGGTTCTTCA AGGGGATCAG CCGGAAGGAT GCAGAGCGCC ACCTCCTGGC TCCAGGCAAC 420 | | ATGCTGGGCT CCTTCATGAT CCGGGACAGT GAGACCACCA AAGGGAGCTA CTCGTTGTCT 480 | | GTTCGAGACT TTGACCCCCA GCACGGAGAC ACCGTGAAGC ACTATAAGAT CCGGACGCTG 540 | | GACAGTGGAG GCTTCTACAT CTCTCCAAGG AGCACCTTCA GCAGCCTGCA GGAACTCGTG 600 | | CTCCACTACA AGAAGGGGAA GGATGGGCTC TGCCAGAAGC TGTCAGTGCC CTGTGTGTCT 660 | | CCCAAACCCC AGAAGCCATG GGAGAAAGAT GCTTGGGAGA TTCCTCGAGA ATCCCTCCAG 720 | | ATGGAGAAGA AACTTGGAGC TGGGCAGTTT GGAGAAGTGT GGATGGCCAC CTACAACAAG 780 | | CACACCAAAG TGGCGGTGAA GACAATGAAG CCAGGGAGCA TGTCCGTGGA GGCCTTCCTG 840 | | GCTGAGGCCA ACCTGATGAA GTCGCTGCAG CATGACAAAC TGGTGAAGCT ACACGCTGTG 900 | | GTCTCTCAGG AGCCCATCTT TATTGTCACG GAGTTCATGG CCAAAGGAAG CCTGCTGGAC 960 | | TTTCTCAAGA GTGAAGAAGG CAGCAAGCAG CCACTGCCAA AACTCATTGA CTTCTCAGCC 1020 | | CAGATCTCAG AAGGCATGGC CTTCATTGAG CAGAGGAACT ACATCCACCG AGACCTGAGG 1080 | | GCTGCCAACA TCTTAGTCTC TGCATCACTG GTGTGTAAGA TTGCTGACTT TGGACTGGCA 1140 | | CGAATCATCG AGGACAATGA GTACACAGCT CGGGAAGGAG CCAAGTTCCC CATCAAGTGG 1200 | | ACAGCTCCTG AAGCCATCAA CTTTGGTTCC TTCACCATCA AGTCAGATGT CTGGTCCTTT 1260 | | GGTATCCTGC TGATGGAAAT TGTCACCTAT GGCCGGATCC CTTACCCAGG TATGTCAAAC 1320 | | CCAGAGGTGA TTCGGGCACT AGAGCATGGG TACCGTATGC CTCGACCAGA TAACTGTCCA 1380 | | GAAGAGCTCT ACAATATCAT GATCCGCTGC TGGAAGAACC GCCCCGAGGA ACGGCCCACC 1440 | | TTTGAATACA TCCAGAGTGT GCTGGATGAC TTCTACACGG CCACTGAGAG CCAGTATCAG 1500 | | CAGCAGCCTT GA 1512 |
|
| Domain Profile | S: 1 lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly 60 | l+++kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+ | Q: 239 LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLH 298 | 6899******************************************************** |
| S: 61 avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr 120 | avvs+ ePi+ivte+makGslldflk+eeg+k++lpkl+d++aq++eGma++e++n+ihr | Q: 299 AVVSQ-EPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHR 357 | ****9.****************************************************** |
| S: 121 dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv 180 | dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv | Q: 358 DLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV 417 | ************************************************************ |
| S: 181 WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee 240 | WsfGill+eivt+G++PypGm+n ev++++e+gyr+prp++cpeely+++++cwk++pee | Q: 418 WSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEE 477 | ************************************************************ |
| S: 241 rPtfetlqevl 251 | rPtfe++q+vl | Q: 478 RPTFEYIQSVL 488 | *******9976 |
|
Domain Sequence
(FASTA) | | LQMEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKS LQHDKLVKLH 60 | | AVVSQEPIFI VTEFMAKGSL LDFLKSEEGS KQPLPKLIDF SAQISEGMAF IEQRNYIHRD 120 | | LRAANILVSA SLVCKIADFG LARIIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180 | | SFGILLMEIV TYGRIPYPGM SNPEVIRALE HGYRMPRPDN CPEELYNIMI RCWKNRPEER 240 | | PTFEYIQSVL 250 |
|
| Keyword | Alternative initiation; ATP-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Exocytosis; Golgi apparatus; Immunity; Inflammatory response; Innate immunity; Kinase; Lipoprotein; Lysosome; Membrane; Myristate; Nucleotide-binding; Nucleus; Palmitate; Phagocytosis; Phosphoprotein; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
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| Prints | |
| Created Date | 20-Feb-2013 |